Abstract: The present invention provides an improved method of administering a pharmaceutical composition, such as an anesthetic through the skin of a patient without the use of a sharp or needle. This method includes the step of irradiating the stratum corneum of a region of the skin of the patient using a laser. By a selection of parameters, the laser irradiates the surface of the skin precisely to a selectable depth, without causing clinically relevant damage to healthy proximal tissue. A pharmaceutical composition is then applied to the region of irradiation.

Abstract: The invention relates to a method of treating an infection or sterilization including applying a dye such as methylene blue, toluidene blue, polymyxin B, or combinations thereof to the area of infection or area to be sterilized and exposing the area of infection or area of sterilization with a light having a light wavelength and light dosage and a light dosage rate. The dye may have a concentration ranging from about 10 &mgr;g/ml to about 500 &mgr;g/ml. The wavelength may range from about 610 nm to about 670 nm. The light dosage may range from about 0 J/cm2 to about 200 J/cm2. The light dosage rate may range from about 0 mw/cm2 to about 150 mw/cm2. The treatable infections include staphylococcus, Candida albicans, Escherichia coli, enterococcus, streptococcus, Pseudomanus aeruginosa, Hemophilus influenzae, or E-coli. The invention also relates to an infection treatment kit.

Abstract: A diode pumped, multi axial mode, intracavity doubled, intracavity tripled laser, includes at least two resonator mirrors defining a resonator cavity. A laser crystal and a doubling crystal are positioned in the resonator cavity. A tripling crystal is also positioned in the resonator cavity. A diode pump source supplies a pump beam to the laser crystal and produces a laser crystal beam with a plurality of axial modes that are incident on the doubling crystal. This produces a frequency doubled output beam. Further, a diode pumped, multi axial mode, intracavity nonlinearly-converted laser is provided and includes at least two resonator mirrors defining a resonator cavity, a laser crystal and a nonlinear conversion apparatus positioned in the resonator cavity. A nonlinear conversion apparatus is also positioned in the resonator cavity.

Abstract: An electromagnetically induced cutting mechanism provides accurate cutting operations on industrial materials. The electromagnetically induced cutter is adapted to interact with atomized fluid particles. A non-thermal material remover comprises a fluid and energy guide for conducting electromagnetically induced mechanical cutting forces onto a target surface.

Abstract: Radiation is delivered to a wound in a series of sufficiently short pulses, with adequate cooling between individual pulses, to produce cumulative thermal denaturation and welding of the skin edges at the immediate area of the wound site, while avoiding unnecessary thermal damage to surrounding healthy tissue.

Abstract: A point light source is disclosed for a laser scanning microscope (7). At least two lasers (1 and/or 2 and/or 3; 4) with different wavelengths may be coupled in the microscope (7). To combine the advantages of a multiline laser with those of the use of several independent one-line lasers, the point light source is characterised by at least two laser light sources the beam of which are fed into a beam combiner (5), and by an optical fibre (6) which leads directly or indirectly from the beam combiner (5) to the microscope (7).

Abstract: A method for modifying the curvature of a live cornea to correct a patient's vision. The live cornea is first separated into first and second opposed internal surfaces. Next, a laser beam or a mechanical cutting device can be directed onto one of the first and second internal surfaces, or both, if needed or desired. The laser beam or mechanical cutting device can be then used to incrementally and sequentially ablate or remove a three-dimensional portion of the cornea for making the cornea less curved. An ocular material is then introduced to the cornea to modify the curvature. The ocular material can be either a gel or a solid lens or a combination thereof. In one embodiment, a pocket is formed in the central portion of the cornea to receive an ocular material. In another embodiment, a plurality of internal tunnels are formed in the cornea to receive the ocular material. The ocular material can be either a fluid such as a gel or a solid member.

Abstract: Methods for modifying a live cornea to correct a patient's vision. In the case of hyperopia, at least one slit is first made in the cornea for inserting a knife, a fiber optic cable or micro-cutting tool therein to separate an internal area of the cornea into first and second opposed internal surfaces such that a substantially circular area centered about the main optical axis of the cornea remains attached between the first and second internal surfaces. The laser beam or micro-cutting tool can be directed onto one of the first and second internal surfaces, or both, if needed or desired to incrementally and sequentially remove three-dimensional portions of the cornea. If a laser beam is used, then a flexible template can be inserted between the internal surfaces of the cornea for accurately controlling the pattern to be ablated within the cornea.

Abstract: A laser apparatus and method for permanently removing a plurality of hair follicles from the skin of a patient. The laser apparatus includes a housing having first and second lasers contained therein for emitting at least first and second pulses of coherent light energy; first and second fiber optic bundles connected to the first and second lasers, respectively, for transmitting the pulses of coherent light energy from the first and second lasers; the first and second fiber optic bundles connected to a common fiber optic bundle for combining and transmitting at least first and second pulses of coherent light energy from each of the first and second lasers through the common fiber optic bundle; and a sequence control device for controlling the first and second lasers to emit at least first and second pulses of coherent light energy either sequentially or simultaneously, with a time delay of less than 20 milliseconds between the sequential pulses from the first and second lasers.

Abstract: A method for improving cardiac microcirculation using low level laser therapy. After a cardiac procedure, a therapist or surgeon maintains contact between a laser probe and a region of myocardium, and applies laser energy with the probe directly to the myocardium, the laser energy having a wavelength of about 630 nm to about 904 nm, with laser apparatus having a mean power output of about 100 mW to about 500 mW, at a dosage of about 1 joule/point to about 10 joules/point. Treatment times, total dosage, and number of treatment points are determined by the therapist trained in LLLT. The method is used immediately post-procedure after cardiac surgeries such as coronary bypass and angioplasty.

Abstract: A noncontact laser microsurgical apparatus and method for marking a cornea of a patient's or donor's eye in transplanting surgery or keratoplasty, and in incising or excising the corneal tissue in keratotomy, and for tissue welding and for thermokeratoplasty. The noncontact laser microsurgical apparatus comprises a laser source and a projection optical system for converting laser beams emitted from the laser source into coaxially distributed beam spots on the cornea. The apparatus further includes a multiple-facet prismatic axicon lens system movably mounted for varying the distribution of the beam spots on the cornea. In a further embodiment of the method of the present invention, an adjustable mask pattern is inserted in the optical path of the laser source to selectively block certain portions of the laser beams to thereby impinge only selected areas of the cornea.

Abstract: An ophthalmological surgery system and method for performing ablative photodecomposition of the corneal surface by offset image scanning. The image of a variable aperture, such as a variable width slit and variable diameter iris diaphragm, is scanned in a preselected pattern to perform ablative sculpting of predetermined portions of a corneal surface. The scanning is performed with a movable image offset displacement mechanism capable of effecting radial displacement and angular rotation of the profiled beam exiting from the variable aperture. The profiled beam is rotated by rotating the aperture in conjunction with the offset displacement mechanism. The invention enables wide area treatment with a laser having a narrower beam, and can be used in the treatment of many different conditions, such as hyperopia, hyperopic astigmatism, irregular refractive aberrations, post ablation smoothing and phototherapeutic keratectomy.

Abstract: A method for modifying the curvature of a live cornea to correct a patient's vision. First, at least one relatively small opening is made in the cornea for inserting a fiber optic cable or micro-cutting tool therein to create a pocket or cavity with first and second opposed internal surfaces. The laser beam or micro-cutting tool can be directed onto one of the first and second internal surfaces, or both, if needed or desired to incrementally and sequentially ablate or remove three-dimensional portions of the cornea. If a laser beam is used, then a flexible template can be inserted into the opening in the cornea for accurately controlling the pattern to be ablated within the cornea. Preferably, the live cornea is then left alone to collapse and obtain its new refractive power by waiting a set period of time. After waiting the set period of time, the cornea is then examined to determine the new refractive power of the cornea.

Abstract: An Er:YAG laser system has a resonant cavity including an Er:YAG rod pulse-pumped by a pulsed flashlamp. The pump-pulse repetition rate and average power is selected to provide a known essentially constant thermal-lensing power in the Er:YAG rod. Design parameters of the Er:YAG rod and the resonant cavity are selected to compensate for this thermal-lensing power. A shutter in the resonant cavity, when closed or open, respectively prevents or allows a laser output-pulse to be generated in response to a pump-pulse. Laser output-pulse duration is continuously variable and is controlled by controlling the duration of flashlamp-pulses. A sequence of laser output-pulses is controlled by opening and closing the shutter. This arrangement has the advantage that the laser output-pulse repetition rate can be selected to be the flashlamp-pulse repetition rate or some sub-multiple thereof while maintaining thermal-lensing power in the rod essentially constant and compensated for.

Abstract: A method of percutaneous and subcutaneous laser treatment of the tissue of a patient is provided. The tip of an optical fiber is passed through the skin, advanced through the tissue subcutaneously to a desired treatment area and withdrawn. Laser energy can be emitted at different levels during any or all of the skin penetration, advancement, tissue treatment and withdrawal phases. The present invention is useful for surgical treatments, and is especially suitable for minimally invasive plastic or cosmetic surgical and dermatological procedures without bleeding and with less edema, erythema and swelling and faster healing than conventional surface laser energy application, abrasion, scalpel surgery or chemical peel procedures.

Abstract: A laser apparatus and method for permanently removing a plurality of hair follicles from the skin of a patient. The laser apparatus includes a housing having a single laser for sequentially emitting a series of pulses of coherent light energy having a pulse width in the range of ½ ms to 40 ms; a fiber optic bundle connected to the laser for transmitting said series of pulses of coherent light energy to the skin of a patient; and a sequence control device for controlling the laser to emit the series of pulses of coherent light energy sequentially, with a time delay of less than 100 milliseconds between the sequential pulses of the single laser. The laser apparatus includes a handpiece assembly for holding a section of the fiber optic bundle for directing the series of pulses of coherent light energy to the same spot of the patient's skin to remove the plurality of hair follicles, veins, or capillaries.

Abstract: A laser apparatus and method for permanently removing a plurality of hair follicles from the skin of a patient. The laser apparatus and method includes a housing having at least first and second lasers contained therein for emitting at least first and second pulses of coherent light energy having a pulse width in the range of 1/2 ms to 40 ms; a first fiber optic bundle connected to the first laser for transmitting at least a first pulse of coherent light energy to the skin of a patient, and a second fiber optic bundle connected to the second laser for transmitting at least a second pulse of coherent light energy to the skin of a patient; and a sequence control device for controlling at least first and second lasers to emit at least first and second pulses of coherent light energy either sequentially or simultaneously, with a time delay of less than 100 milliseconds between the sequential pulses of the first and second lasers.

Abstract: A multiple wavelength laser system includes an active laser gain medium comprising metal vapor which, when excited, produces laser radiation at a plurality of wavelengths. A plurality of medically useable wavelengths are coaxially transmitted from the laser system for simultaneous use in a medical procedure. One of the wavelengths produced is closely matched to a light absorption peak of either water or Hemoglobin, and another wavelength is matched to the other of these light absorption peaks or a targeted photosensitive agent or chemical. The disclosed laser system can also include a laser gain medium comprising a plurality of metal vapors to produce the plurality of wavelengths desired. In preferred embodiments, the metal vapors can include barium, thulium, and/or samarium. A laser conversion device such as an OPO crystal may also be included to convert a portion of the radiation to one or more additional medically useable wavelengths.

Abstract: The invention relates to a medical device including a tube and expandable member and one or more light sources disposed in an elongated member disposed in the tube. The light sources emit energy for photodynamic therapy through a window to the treatment area. The treatment device may further include a heat and/or light dissipating layer, such as a layer of gold alloy paint, or other light blocking material.

Abstract: A pulsed light source for cutting away biological tissue has a control unit that controls the light source in such a way that the light source supplies a series of pulses of predetermined duration and radiation intensity. The control unit may be operated to cause the light source to supply short pulses (10) at a predetermined and/or controllable rate of repetition with a radiation intensity sufficient to cut away the tissues, and radiation followed by light emission (11) or the like with a radiation intensity that is not sufficient to cut away the tissues but is sufficient to generate heat.

Abstract: A method and apparatus for treating the epidermis with actinic light includes a solid state diode system with a continuous output. The light beam is generated by either a high power light emitting diode or a laser diode or a combination thereof. A computer controlled pattern generator (CCPG) directs the continuous light beam to trace predetermined patterns on a selected area of the skin. This integrated continuous light source and patterned treatment technique obviate the need for high peak power pulsed systems, while providing sufficient energy density at the target site to effect hair removal and other skin treatment modalities. The moving light beam has a computer controlled dwell time to generate a relatively high amount of energy in a short period of time at the target. The optimum dwell time is about 0.5 ms to 500 ms, and the wavelength is in the range of 600 nm to 990 nm. The spot size is in the range of 0.01 to 10.0 mm and the treatment area is in the range of 0.01 to 100 cm.sup.2.

Abstract: A method for treating a neoplasm, such as a malignant tumor, in humans and other animals, is disclosed. A chromophore and an immunoadjuvant are introduced into the neoplasm. The neoplasm is then lased at an irradiance sufficient to induce neoplastic cellular destruction and to stimulate the self-immunological defense system against neoplastic cellular multiplication.

Abstract: The present invention provides a method for removing hair from a selected skin area comprising the steps of (a) applying a liposome composition comprising a photosensitizer to the selected skin area so that the composition is introduced into hair follicle ducts of the skin area, wherein the photosensitizer is present in the composition in an amount effective to undergo a reaction and damage the hair follicles upon application to the skin area of light at an appropriate wavelength, energy and duration to penetrate the skin and activate the photosensitizer; (b) removing from the skin area substantially all of the liposome composition which is not introduced into the hair follicle ducts; and (c) applying light to the skin area at an appropriate wavelength, energy and duration to penetrate the skin and cause the photosensitizer to undergo a reaction to damage the hair follicles. The present invention also provides a composition useful for hair removal.

Abstract: A method for corneal laser surgery includes directing the focal point of a focused laser beam at a start point in the stroma. The focal point is then moved along a predetermined path in the cornea to photodisrupt tissue and to create a flap or a plug of corneal tissue. Specifically, the flap or plug is crated with an undercut region that interlocks with an overlap region to restrain movement of the flap or plug in an anterior direction. Stromal tissue under the flap or plug can then be removed when the plug or flap is forceably lifted from the cornea. The flap or plug is subsequently replaced in its interlocking relationship with the remainder of the corneal tissue. The diminished stromal tissue reshapes the cornea in a manner which improves the vision of the patient.

Abstract: It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue. Specifically to provide an elastin or elastin-based biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The biomaterial can also be used as a stent or conduit covering or coating or lining. It is also an object of the invention to provide a method of securing an elastin or elastin-based biomaterial to an existing tissue without the use of sutures or staples.

Abstract: To achieve highly efficient laser irradiation and well-balanced light coagulation treatment within a same treatable site by using laser beam of different wavelengths, an apparatus is disclosed which comprises a plurality of laser light sources for treatment which emit laser beams of different wavelengths, a condition setting device for determining irradiation condition of the laser light sources, a control device for controlling the laser light sources according to the settings determined at the condition setting device so as to sequentially irradiate laser beams, and a guide device for directing emitted laser beams into an eye of a patient.

Abstract: A method, apparatus and system for template-controlled, precision laser interventions is described that greatly improves the accuracy, speed, range, reliability, versatility, safety, and efficacy of interventions such as laser microsurgery, particularly ophthalmic surgery, and industrial micromachining. The instrument and system are applicable to those specialties wherein the positioning accuracy of laser lesions is critical, wherever accurate containment of the spatial extent of a laser lesion is desirable, and/or whenever precise operations on a target or series of targets subject to movement during the procedure are to be effected.

Abstract: A laser method for selective photocoagulation of subsurface skin (dermis) for the purpose of increasing skin tone, reducing wrinkles, removing hair, removing tattoos or treating varicose veins without damaging the skin surface (epidermis). A diffuser lens in the laser apparatus is employed to focus the laser energy to the dermis. The laser apparatus includes a highly transmissive contact tip and cooling means to reduce heat build-up in the contact tip, as monitored by a thermocouple mechanism. The present invention can be used alone or in conjunction with superficial laser resurfacing or chemical peels to increase skin tone.

Abstract: A method for treating an area of skin or nail affected with a pathogen, the method comprising the step of irradiating the area of skin or nail with a light beam having at least one wavelength absorbable by the pathogen.

Abstract: A solid state laser source for surgical applications which produces short-pulse, mid-infrared radiation. Specifically, the laser preferably emits radiation near the absorption peak of water, with energy levels up to 20 mJ, pulse durations shorter than 50 ns and preferably shorter than 30 ns, with beam quality of less than 8 times the diffraction limit. The short pulses reduce unwanted thermal effects and changes in adjacent tissue to potentially sub-micron levels. The laser source produces pulse repetition rates in excess of 10 Hz when pumped by a flashlamp, but in a diode pumped embodiment, the repetition rate may exceed 30 Hz. Of particular interest is an erbium-doped YAG laser which is especially well suited to the needs of mid-infrared corneal ablation procedures for correcting refractive errors, when constructed according to principles disclosed by the invention.

Abstract: A apparatus and method for controlling an apparatus for removing tissue from the eye performs various types of corrections using a relatively large beam, but oscillating, or dithering, that being to prevent reinforcing ridges from being formed during the tissue removal process. Further, various types of correction, such as hyperopia and astigmatism correction, are performed using a large beam that is scanned over the area to be ablated using overlapping shots. Further, the epithelium in the area to be treated is removed using an infrared fluorescent dye to dye the epithelium, and then observing the fluorescent patterns from the epithelium area to be removed. Once a certain area is no longer fluorescent after laser shots, smaller shots are then applied, selectively removing the epithelium from the remaining regions. Again, the fluorescence patterns are observed, and the process is repeated until no epithelium remains.

Abstract: Mammalian skin is treated and advantageously smoothed, for example to remove wrinkles, lines, warts and scars therefrom, by topically applying thereto a composition which comprises at least one laser-absorbing chromophore formulated into a physiologically acceptable carrier, diluent or vehicle therefor, and laser-irradiating the skin thus treated with an intensity sufficient to locally convert the light energy into heat energy in the applied composition and advantageously effecting tissue ablation of the surface of the treated skin, said applied composition and the thickness thereof having an absorbance at the emission wavelength of the laser such that the light energy transmitted into the skin generates no undesired irreversible tissue or cell damage.

Abstract: A method and device for stimulating the immune system employs a laser diode to provide a source of infrared radiation with a wavelength around 1917 nm through a tube or guide to the skin of a patient near an ailment or other infirmity such as a disease to be treated. Control circuitry for pulsing the beam at a rate of 7.5 hz is provided.

Abstract: An apparatus (1) is provided for treating a target area (22) of a tooth (10). The apparatus (1) generally comprises a coolant delivery system (20) and an ultraviolet laser system (15). The coolant delivery system (20) delivers coolant (52) to the target area (22) while a light guide (44) focuses ultraviolet radiation thereon. The ultraviolet radiation (18) and coolant (52) combine to ablate a desired material without generating excess heat which may otherwise char surface tissue or cause thermal damage.

Abstract: A process for destroying relatively deep formations of unwanted sub-epidermal tissue by heating water in the formations with a laser to denature proteins therein. In an exemplary embodiment, a laser beam is operated to irradiate a target region of highly vascularized dermal tissue in a blood-circulating living being, such as a human. The laser light preferably has a wavelength of about 1.45-1.68 .mu.m. This operating parameter provides the laser beam with a low enough water absorption coefficient to facilitate adequate penetration in to the target area while still providing enough energy to heat water to a temperature capable of spatially conforming vascularized tissue in the target area.

Abstract: A variable pulse width lasing device for selectively reducing the amount of laser energy provided during a surgical procedure is described. The device includes a central processing unit, a laser resonator, pulse width detector and a pulse modulator. The central processing unit provides a switch activation command to the modulator. The modulator also receives a laser pulse produced by the laser resonator which has an initial pulse width and a wavelength which is compatible for transmission through an optical fiber. The modulator varies the width of the laser pulse for providing an output pulse at a selected pulse width and energy level.

Abstract: A method of performing photorefractive keratectomy (PRK) wherein the surface smoothness is enhanced. The present invention minimizes the ablation zone dimension including central ablation depth, reducing the need for overcorrection. The present invention reduces regression and scarring (haze) providing enhanced clinical outcomes with faster rehabilitation, greater refractive stability, and improved corneal clarity. Moreover, improved clinical outcomes are achieved by adjusting the initial corneal correction to take into account the effects of regression based upon non-linear predictive formulas which vary with the square of the slope of ablation smoothness (roughness) per micron of ablation depth.

Abstract: A method and apparatus for the removal of, and at least inhibiting the regrowth of, unwanted hair by applying optical radiation to the follicle, including the hair shaft therein, of an energy, a duration and wavelength to enhance the optical absorption characteristics of at least some component, (i.e., melanosomes, tissue, etc.) of the follicle without appreciably damaging skin outside the follicle; and subsequently applying optical radiation to the follicle of a wavelength which is more readily absorbed by the components of the follicle having optical absorption characteristics enhanced during step (a) then by unenhanced components and of an energy and duration to heat such enhanced components sufficiently to substantially destroy the follicle.

Abstract: The apparatus and the method of ablating matter from a substrate using a laser, an optical system, and a screen arranged within the beam path of the laser. A laser spot is formed which exhibits light and dark sections. By adjusting the screen before each laser pulse, the entire surface area of the laser spot is subjected to the same number of laser pulses.

Abstract: A non-invasive apparatus and method for treating open angle glaucoma in a human eye comprises thermally ablating a targeted region of the trabecular meshwork of a human eye by irradiating the region with a beam of pulsed laser radiation. The beam of pulsed radiation has a wavelength between 350 and 1300 nanometers, energy of 10 to 500 millijoules per pulse, and pulse duration of 0.1 to 50 microseconds. The beam is non-invasively delivered gonioscopically through the cornea onto a targeted region of the trabecular meshwork. The targeted region of the trabecular meshwork is illuminated at a spot size of between 50 and 300 microns in diameter.

Abstract: A method for laser ablation of a tissue including directing at least one first pulsed laser beam of ultraviolet light and at least one second pulsed laser beam of infrared light to an area on the tissue to thereby ablate said tissue. The ultraviolet light has a wavelength of between 180 to 225 nm while the infrared light has a wavelength of between 1.4 to 11.0 .mu.m, and more specifically around 3.0 .mu.m. The tissue to be ablated may be the corneal tissue of the eye.

Abstract: A method for performing concurrent spherical and cylindrical corrections to the corneal surface of the eye to reduce myopia and astigmatism. A laser beam irradiates the corneal surface via a variable diameter iris and a slot produced by a pair of translatable blades. The width of the slot and the diameter of the iris are varied as the laser is pulsed to produce a toric ablation of the corneal surface. Alternatively, the laser beam is passed through a succession of apertures in a tilted variable aperture element to produce toric ablation. The total number of laser pulses required to effect both types of correction is equal to the number required for the spherical correction alone, reducing the laser power and the procedure time. The toric ablation produces no steep end walls as with standard cylindrical ablation procedures, thereby eliminating hyperopic shift and minimizing flattening along the ablated cylinder axis.

Abstract: A beam profiler comprising: an intensity modifier constructed and arranged to separately modify the intensity profile of different subbeam portions of an initial beam to thereby create respective subbeams each having a respective predetermined modification; and a subbeam-directing optical system constructed and arranged to direct the multiple subbeams along respective subbeam beam paths that substantially overlap in an overlap plane, whereby, a resulting beam of radiation is created at the overlap plane that has an intensity profile equal to the optical incoherent summation of the predetermined intensity profiles of said overlapping subbeams. The intensity modifier preferably comprises an array of intensity-modifying profiling elements disposed across the initial beam each producing a corresponding subbeam.

Abstract: The present invention provides an improved method of measuring analytes in bodily fluids without the use of a sharp. The method having the steps of irradiating the skin of a patient by focused pulses of electromagnetic energy emitted by a laser. By proper selection of wavelength, energy fluence, pulse temporal width and irradiation spot size, the pulses precisely irradiate the skin to a selectable depth, without causing clinically relevant damage to healthy portions of the skin. After irradiation, interstitial fluid is collected into a container or left on the skin. The interstitial fluid is then tested for a desired analyte to approximate the analyte concentration in other bodily fluids. Alternatively, after the forced formation of a microblister, the epidermis covering the microblister is lysed and the interstitial fluid is subsequently collected and tested.

Abstract: An Rf energy applicator with a working end that carries a bi-polar Rf electrode system for creating a Rf-tissue interaction or ionothermal effect in subsurface tissue (a first ionothermal system) which effect is focused by concurrent actuation of a photonic tissue-sensitizing system or photoconductance system (a second ionothermal system). The photonic energy system is adapted to create a "lens electrode" in subsurface tissue that enhances the targeted tissue's conductance of Rf current which serves as a means of focusing Rf ionothermal effects at a subsurface level. A dosimetry control system is provided that controls the dose and timing of Rf energy delivery as well as the dosimetry of photonic energy delivery. The ionothermal applicator has a handle portion coupled a tubular extending member. The distal termination of the probe has at least one pair of opposing conductive electrodes in a spaced relationship around a perimeter of the distal termination of the extending member.

Abstract: An apparatus for treating neonatal jaundice is in the form of a garment (10, 40) which has semiconductor light sources (14, 214, 314) affixed thereto for radiating toward the "inside" of the garment when the infant is dressed in the garment. A portable energy source such as batteries (318) or a fuel cell (360) powers the array of light sources. A method according to the invention vests the infant in the garment, and energizes the light sources by coupling a battery to the light sources, or fueling and starting the fuel cell. The therapy is continued for as long as desired or needed.

Abstract: The invention includes the use of a beam homogenizer (scattering surface) at the input aperture of a tapered optical fiber to avoid hot spots (2) in the tapered section which would otherwise destroy the fiber (10).

Abstract: A diode laser irradiation system for treating biological tissue of a subject without exposing the tissue to damaging thermal effects. The system includes a manipulable wand for contact with the tissue, a diode laser disposed in the wand for irradiating the tissue with coherent optical energy at a power output level of less than one thousand milliwatts, and laser setting controls for operating the diode laser to achieve a rate of absorption and conversion to heat in the irradiated tissue in a range between a minimum rate sufficient to elevate the average temperature of the irradiated tissue to a level above the basal body temperature of the subject, and a maximum rate which is less than the rate at which the irradiated tissue is converted into a collagenous.

Abstract: Microclustered water is produced from a starting water. First, the starting water is boiled to produce steam. Next, the steam is passed across a magnetic field, and the steam is condensed at a temperature greater than 0.degree. C. in the presence of light in the far infra-red to ultraviolet spectrum range to produce condensed steam. At least one metasilicate salt stabilizer and a dietary supplement template are added to the condensed steam. The concentration of dietary supplement template is 1% or less. The condensed steam is exposed to a pressure greater than 1 atmosphere; and then depressurized to produce the microclustered water. The microclustered water produces an .sup.17 O NMR resonance signal less than 115 Hz, has a conductivity of at least 3.7 .mu.s/cm, and has a surface tension of less than 61 dynes/cm.

Abstract: Noncontact apparatus and method for preforming laser thermal keratoplasty capable of scanning of treatment areas with shapes that reduce regression. The apparatus includes laser sources, a projection optical system, observation system, and control system The projection system uses two steering mirrors to control laser beam position on the cornea. This projection system enables precise control of the area of corneal heat shrinkage using relatively low-powered lasers, such as diode lasers. Desired changes in corneal refractive power are produced by selected patterns of photothermal shrinkage of corneal collagen tissue. The selected patterns are arrangements of oblong shapes that are preferably tapered at the ends of the long axis. The oblong shape and tapering distribute tension in the cornea over a wider area of collagen shrinkage and improve the stability of refractive correction.