Abstract: Systems and methods of improving vision using an ophthalmological laser system are provided. A predetermined pattern characterized by a plurality of positions along a plurality of spatially distributed iris tissues of an eye of a patient is obtained. A laser illumination light beam is aligned in accordance with one or more of the plurality of positions along the plurality of spatially distributed iris tissues. The laser illumination light beam is delivered in the predetermined pattern to the plurality of spatially distributed iris tissues of the patient. At least a subset of the spatially distributed iris tissues is cauterized by the delivery of the laser illumination light beam in the predetermined pattern, thereby resulting in a permanent decrease in diameter of the pupil of the eye.

Abstract: A system for cataract surgery on an eye of a patient is described.

Abstract: Methods and apparatus treat the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL.

Abstract: Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.

Abstract: An apparatus for determining an ametropia of an eye 3 comprises a measurement light source 15 and beam formation optics 17 and an analysis module 35 comprising a detector 39 and analysis optics 37. The analysis optics are configured to focus a parallel light beam, entering through the optical interface 27, along a predetermined line extending transverse to a direction of the analysis beam path. The detector is a spatially resolving detector, wherein an acute angle between a surface normal of the detection area and the predetermined line is less than 80°. A controller 53 is configured to obtain light intensity data detected by the detector and to determine ametropia-data representing the ametropia of the eye based on the light intensity data.

Abstract: The present invention provides a method of measuring the elasticity of crystalline lens and an apparatus for measuring the elasticity of the crystalline lens for measuring stiffness of the crystalline lens 1, wherein the crystalline lens 1 is irradiated with pulse laser light to generate photoelastic waves from the crystalline lens 1, and the photoelastic waves from the crystalline lens 1 are measured.

Abstract: An ophthalmic system may comprise an imaging device having a field of view oriented toward the eye of the patient; a patient interface housing defining a passage therethrough, having a distal end coupled to one or more seals configured to be directly engaged with one or more surfaces of the eye of the patient, and wherein the proximal end is configured to be coupled to the patient workstation such that at least a portion of the field of view of the imaging device passes through the passage; and two or more registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative to the patient interface housing within the field of view of the imaging device such that they may be imaged by the imaging device in reference to predetermined geometric markers on the eye of the patient which may also be imaged by the imaging device.

Abstract: Systems and methods for performing robotically-assisted surgical procedures on a patient enable an image display device to provide an operator with auxiliary information related to the surgical procedure, in addition to providing an image of the surgical site itself. The systems and methods allow an operator to selectively access and reference auxiliary information on the image display device during the performance of a surgical procedure.

Abstract: A system and method of treating target tissue in a patient's eye, which includes generating a light beam, deflecting the light beam using a scanner to form first and second treatment patterns, delivering the first treatment pattern to the target tissue to form an incision that provides access to an eye chamber of the patient's eye, and delivering the second treatment pattern to the target tissue to form a relaxation incision along or near limbus tissue or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof.

Abstract: A steerable laser probe may include a handle having a handle, a housing sleeve, a first portion of the housing sleeve having a first stiffness, a second portion of the housing sleeve having a second stiffness, an actuation control of the handle, an optic fiber disposed in an inner bore of the handle and the housing sleeve, and a shape memory wire having a pre-formed curve. An actuation of the actuation control may be configured to gradually curve the housing sleeve and the optic fiber. An actuation of the actuation control may be configured to gradually straighten the housing sleeve and the optic fiber.

Abstract: Method for determining deviations between coordinate systems of different technical systems, comprising the steps of determining a coordinate position of a reference feature of a test object in the coordinate system (u,v) of a first of the technical systems, the attachment of at least one test feature to the test object, with the test feature being attached in the coordinate system of a second of the technical systems at a coordinate position that is determined in dependence on the determined coordinate position of the reference feature, the determination of a coordinate position of at least one test feature and/or at least one feature derived from it in the coordinate system (u,v) of the first technical system, and determination of deviations between the coordinate systems of the first and second technical system, at least on the basis of: (a) the determined coordinate position of at least one test feature and/or of at least one feature derived from it in the coordinate system (u,v) of the first technical sy

Abstract: A laser-assisted method for fully or partially separating tissue such as collagen-containing tissue is provided. In one embodiment, the method pertains to a capsolurorhexis whereby the laser-assisted method is applied to the lens capsule. A light-absorbing agent is added into or onto the tissue. A light beam with a wavelength capable of being absorbed by the light absorbing agent is then directed at the tissue to cause a thermal effect at the tissue following a predetermined closed curve with the goal to avoid irregularity or potential tears in the resulting rim of the tissue.

Abstract: A steerable laser probe may include a handle, an actuation structure, an optic fiber, and a housing tube. The housing tube may include a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater than the first stiffness. The optic fiber may be disposed within the housing tube and within an inner bore of the handle. A compression of the actuation structure may be configured to gradually curve the optic fiber. A decompression of the actuation structure may be configured to gradually straighten the optic fiber.

Abstract: Systems and methods of photoaltering a region of a material using a pulsed laser beam. The method includes scanning the pulsed laser beam in a first portion of the region with a first pattern, scanning the pulsed laser beam in a second portion of the region with a second pattern, and separating a flap of the material at the region. The system includes a laser, a controller selecting at least first and second patterns, and a scanner operable in response to the controller. The first pattern has a first maximum acceleration associated with the second portion, and the second pattern has a second maximum acceleration associated with the second portion. The second maximum acceleration is less than the first maximum acceleration. The scanner scans the pulsed laser beam from the laser in the first portion with the first pattern and in the second portion with the second pattern.

Abstract: A laser surgical system for making incisions in ocular tissues during cataract surgery includes a laser system, an imaging device and a control system. The laser system includes a scanning assembly and a laser to generate a laser beam that incises ocular tissue. The imaging device acquires image data of a crystalline lens and constructs an image from the image data. The control system operates the imaging device to generate image data for the patient's crystalline lens, processes the image data to determine an anterior capsule incision scanning pattern for scanning a focal zone of the laser beam to perform an anterior capsule incision, and operates the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsule incision scanning pattern, wherein the focal zone is guided by the control system based on the image data.

Abstract: A laser surgical system for making incisions in ocular tissues during cataract surgery includes a laser system, an imaging device and a control system. The laser system includes a scanning assembly and a laser to generate a laser beam that incises ocular tissue. The imaging device acquires image data of a crystalline lens and constructs an image from the image data. The control system operates the imaging device to generate image data for the patient's crystalline lens, processes the image data to determine an anterior capsule incision scanning pattern for scanning a focal zone of the laser beam to perform an anterior capsule incision and operates the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsule incision scanning pattern, wherein the focal zone is guided by the control system based on the image data.

Abstract: A steerable laser probe may include a handle, an actuation structure of the handle, a housing tube, a flexible tube, an optic fiber, and a wire having a pre-formed curve. The flexible tube may be disposed within the housing tube wherein a distal end of the flexible tube projects out from a distal end of the housing tube. The optic fiber may be disposed within an inner bore of the handle, the housing tube, and the flexible tube. The wire may be disposed within the housing tube.

Abstract: A laser surgical system for making incisions in ocular tissues during cataract surgery includes a laser system, an imaging device and a control system. The laser system includes a scanning assembly and a laser to generate a laser beam that incises ocular tissue. The imaging device acquires image data of a crystalline lens and constructs an image from the image data. The control system operates the imaging device to generate image data for the patient's crystalline lens, processes the image data to determine an anterior capsule incision scanning pattern for scanning a focal zone of the laser beam to perform an anterior capsule incision, and operates the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsule incision scanning pattern, wherein the focal zone is guided by the control system based on the image data.

Abstract: System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

Abstract: Systems and methods for performing robotically-assisted surgical procedures on a patient enable an image display device to provide an operator with auxiliary information related to the surgical procedure, in addition to providing an image of the surgical site itself. The systems and methods allow an operator to selectively access and reference auxiliary information on the image display device during the performance of a surgical procedure.

Abstract: System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye issue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

Abstract: An ophthalmological apparatus (1) for breakdown of eye tissue includes a base station (2) with a light source (21) for generating light pulses and a support arm (3), with an application head (4) that can be placed onto an eye (6) mounted on the base station (2). The light pulses are transmitted from the base station (2) to the application head (4) through an optical transmission system (22). The application head (4) has a light projector (41) for focused projection of the light pulses for punctiform breakdown of eye tissue. The support arm (3) is of rigid design and, at one end, has a hinge (Rz) with a horizontally oriented rotation axis (rz), the hinge (Rz) being mounted in such a way that the application head (4) can be placed onto the eye (6) with a rotation (zrot) extending about the rotation axis (rz).

Abstract: A method and device for stimulating human dermal tissue retraction and collagen and elastin production is provided. One or more lasers or other electromagnetic radiation devices produce at least two output beams (split or independent beams) that can be directed to deliver electromagnetic energy to a desired subsurface depth of dermal tissue, thereby disrupting the same, without causing excessive damage to the adjacent epidermis, subcutaneous fatty tissue, or blood vessels of the skin.

Abstract: An ophthalmic laser treatment apparatus for treating a patient's eye by irradiating a treatment laser beam thereto, comprises: an irradiation unit including a treatment laser source, and a scanner for scanning an irradiation spot of the treatment beam from the laser source onto a tissue of the patient's eye in two dimensions; a memory for storing a plurality of predetermined irradiation patterns in each of which a plurality of the irradiation spots of the treatment beam are arranged in a predetermined arrangement; an irradiation pattern selecting unit including a selection switch for inputting a signal to select a desired irradiation pattern from the irradiation patterns stored in the memory; an irradiation pattern changing unit including a change switch for inputting a signal to change a part of the arrangement of the irradiation pattern in which the irradiation spots are arranged on the basis of the selected irradiation pattern by the irradiation pattern selecting unit; and a control unit for controlling dr

Abstract: A variable-applanation patient interface can include a lens support system, attachable to a distal end of an ophthalmic surgical laser system; a contact lens, supported by the lens support system and configured to make contact with an eye-surface; and an adjustable coupler, coupled to at least one of the lens support system and the contact lens, and configured to be coupled to a non-central region of the eye-surface, to accommodate the contact lens to contact a central region of the eye-surface with a central applanation, to enable a change between the central applanation and an extended applanation, and to accommodate the contact lens to contact an extended region of the eye-surface larger than the central region with the extended applanation.

Abstract: A mirror for an ophthalmic laser treatment device that is movable on an axis from a position in a treatment laser beam path to a position out of the treatment laser beam path. The mirror reflects light from a light source into the eye of a patient. The mirror is biased towards a position in the path and is moved out of the path by an actuator just long enough for the laser treatment to be applied and without noticeable interruption to viewing by a user.

Abstract: The disclosure herein provides ophthalmic surgical systems, methods, and devices. In one embodiment, a handheld medical instrument for surgical procedures comprises a body having an exterior surface shaped to be held and manipulated by a human hand; a surgical tool extending from a distal end of the body; and a pressure-sensitive button for controlling operation of the surgical tool, the pressure-sensitive button comprising an actuation surface positioned adjacent the exterior surface of the body, the pressure-sensitive button further comprising a pressure detection device, the pressure detection device configured to enable output of a signal for controlling a function of the surgical tool, the signal being proportional to a position of the actuation surface.

Abstract: A steerable laser probe may include a handle, an actuation structure of the handle, a housing tube, a wire having a pre-formed curve, and an optic fiber disposed within the housing tube and an inner bore of the handle. The housing tube may include a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater than the first stiffness. A compression of the actuation structure may curve or straighten the housing tube. A decompression of the actuation structure may curve or straighten the housing tube.

Abstract: A steerable laser probe may include a handle, an actuation mechanism of the handle, an optic fiber, and a housing tube. The housing tube may include a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater than the first stiffness. The optic fiber may be disposed within the housing tube and within an inner bore of the handle. A portion of the optic fiber may be fixed to an inner portion of the housing tube.

Abstract: The invention relates to systems and methods for measuring the angular accessibility limitations of the anterior angle of the eye, targeting one or multiple treatment zones within the anterior angle area of the eye and delivering highly focused photodisruptive laser pulses with pulse durations <50 picoseconds creating channels into various anatomical structures within the anterior angle of the eye. The invention further includes custom gonioscopy lens systems, patient interface systems and a laser delivery system to deliver highly focused laser beams to the anterior angle area of the eye.

Abstract: An ophthalmological device, comprising an eye patch, a photovoltaic, and a battery, wherein said photovoltaic is interconnected to said battery.

Abstract: Methods and systems for obtaining an ocular aberration measurement of an eye of a patient are provided. Exemplary techniques involve obtaining a first induced metric for the eye that corresponds to a first accommodation state of the eye, obtaining a second induced metric for the eye that corresponds to a second accommodation state of the eye, and determining a natural metric of the eye based on the first and second induced metrics. An induced metric may include a pupil size or a spherical aberration. Techniques can also include determining a target metric for the eye base on the natural metric, determining whether an actual metric of the eye meets the target metric, obtaining an ocular aberration measurement of the eye if the actual metric meets the target metric, and determining a treatment for the eye based on the ocular aberration measurement.

Abstract: An apparatus for ophthalmic procedures contains a source of aiming and treatment laser beams, folded mirrors and lens arrays to cause the formation of a static pupil on a delivery mirror for observation and treatment by an operator of the apparatus.

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Abstract: An ophthalmic laser treatment apparatus comprises: a laser source that emits a laser beam for treatment of an affected part of a patient's eye; an optical fiber that transmits the laser beam emitted from the laser source; and a delivery optical system that irradiates the laser beam emitted from the optical fiber to the affected part of the patient's eye, the delivery optical system including: a plurality of diffraction optical elements each being configured to shape a beam profile of the laser beam at an emission end face of the optical fiber into a beam profile having one of a uniform intensity and a lower intensity in the center than on the periphery on the affected part and also to shape the laser beam to have a different spot size on the affected part of the patient's eye; and a changing unit which selectively disposing one of the diffraction optical elements on an optical path.

Abstract: Embodiments of the present invention provide a laser surgical system with a basic set of functionality which is remotely controllable to implement an advanced set of functionality. According to one embodiment of the present invention, a basic laser surgical system may be coupled to an advanced control unit such that the basic laser surgical system may be controllable by the advanced control unit to implement a broader set of functionality. By moving less frequently used functionality to an advanced unit, the basic unit may be streamlined with regards to both cost and size, and the learning curve required to utilize the basic unit may be reduced relative to a more feature-ladened unit, allowing the basic unit to be utilized in myriad situations or procedures where an “all-in-one” unit would be less than desirable.

Abstract: A steerable laser probe may include a handle, an actuation structure of the handle, a housing tube, an optic fiber, and an optic fiber sleeve. The housing tube may have a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater that the first stiffness. The optic fiber may be disposed within an inner bore of the handle, the optic fiber sleeve, the actuation structure, and the housing tube. The optic fiber sleeve may enclose at least a portion of the optic fiber and the optic fiber sleeve may be disposed within the actuation structure and the housing tube. A compression of the actuation structure may be configured to curve the housing tube and the optic fiber.

Abstract: A steerable laser probe may include a handle having a handle distal end and a handle proximal end, an actuation structure of the handle, a flexible housing tube having a flexible housing tube distal end and a flexible housing tube proximal end, and an optic fiber disposed within an inner bore of the handle and the flexible housing tube. A compression of the actuation structure may cause the optic fiber to gradually curve. A decompression of the actuation structure may cause the optic fiber to gradually straighten.

Abstract: For processing eye tissue (8) by means of femtosecond laser pulses, an ophthalmological device (1) includes a projection optical unit (2) for the focused projection of the femtosecond laser pulses into the eye tissue (8). Disposed upstream of the projection optical unit (2) is a first beam-deflecting scanner system (3) for scanning the eye tissue (8) with the femtosecond laser pulses along a processing line (s). A second beam-deflecting scanner system (5) is disposed upstream of the first scanner system (3) and is designed for scanning the eye tissue (8) with the femtosecond laser pulses on a scanning curve (f) superimposed on the processing line (s). The second scanner system (5) has a scanner speed that is a multiple of the scanning speed of the first scanner system (3), and comprises at least one deflection mirror, a first scanning axis (51) and a second scanning axis (52).

Abstract: A system and method of estimating a distance between the distal end of an optical fiber and treated tissue, to improve treatment efficiency, is provided herein. The estimation is achieved by modulating the numerical aperture of a light beam transmitted through the fiber to receive reflections from the tissue and distinguish them from other reflections in the fiber, and further by calculating the distance by comparing reflection intensities of beams having different numerical aperture values that illuminate the tissue over a very short period, so that tissue and environment conditions do not change much. Distance estimation may be carried out by modulating the treatment beam itself, or by a light beam transmitted between pulses of a pulsed treatment beam.

Abstract: The present invention provides methods and compositions for regulating transgene expression in a subject using heat generated by electro-magnetic radiation in a target cell. The heat is generated by a thermo generator resided in the target cell upon application the electromagnetic radiation. The amount of the heat is controlled by the energy delivered by the electromagnetic radiation.

Abstract: A system and method for determining an optimal position of an eye relative to an ophthalmic device are disclosed. One embodiment of the method includes receiving data comprising an image of a surface of an eye with the eye at a first position relative to an ophthalmic device. An edge feature in the image is located, and a sharpness calculation on the edge feature is performed using a predetermined algorithm to yield a sharpness value. The eye surface is then adjusted to a second position relative to the ophthalmic device, and the previous steps are repeated until the sharpness value is maximized, which is an indication that an optimal eye position has been achieved. An embodiment of the system includes a processor and a software package executable by the processor, the software package adapted to perform the calculations as above. Means are also provided for adjusting the eye surface to a second position relative to the ophthalmic device.

Abstract: A method that includes illuminating an eye with light at a first time and a second time and generating a first image of the eye based on the light that illuminates the eye at the first time. The method includes generating a second image of the eye based on the light that illuminates the eye at the second time. The method further includes positioning a laser source relative to the eye, wherein the laser source generates a therapeutic laser beam to be directed to the eye, wherein the first time is just prior to the therapeutic laser beam being directed to the eye and the second time is prior to the first time. The method further includes correcting orientation of the laser source relative to the eye based on a correlation function that is defined for the first and second images of the eye.

Abstract: The present invention generally relates to an apparatus and processes for preventing or delaying presbyopia. More particularly, the present invention relates to processes and apparatus for ablating epithelial cells in the germinative zone or the pregerminative zone of the crystalline lens of the eye so that onset or progression of presbyopia or one or more symptoms is delayed or prevented. The present invention also relates to processes and apparatus for promoting formation of suture lines in the crystalline lens of the eye so that onset or progression of presbyopia or one or more symptoms is delayed or prevented. The present invention also relates to processes and apparatus for creating disruptions in the vitreous humor of the eye.

Abstract: A patient interface for coupling an ophthalmological application head to an eye of a patient includes a patient-sided interface structure to be coupled to the eye of a patient, and a source-sided interface structure for rigidly coupling the patient interface to the application head or an intermediate element. The source-sided interface structure comprises a first source-sided patient interface coupler and a second source-sided patient interface coupler The first source-sided patient interface coupler is designed to restrict the mobility of the patient interface relative to the application head or the intermediate element by providing a coupling with a first patient interface coupler counterpiece of the application head or the intermediate element.

Abstract: Devices to perform femtolaser ablation and phacoemulsification are physically and/or operationally combined. In some embodiments the femtolaser ablation and phacoemulsification are housed together, and in other embodiments they are housed separately, but operated through a common display screen. At least some software can be shared by the femtolaser ablation and phacoemulsification functionalities. A non-transitory computer-readable memory can provide data that can be used to operate each of at least one femtolaser ablation functionality and at least one phacoemulsification functionality.

Abstract: A method for marking coagulation sites on a retina by application of a light source including: projecting a serial spot sequence from a sequential, one-dimensional series of spots on the retina, wherein the individual spots indicate the coagulation sites; waiting for confirmation of the sequence of individual spots; after confirming, recalculating an automated sequence of steps having a further serial spot sequence and projecting them on the retina according to the first step; and subsequent repeating of the second and third steps. Also, a system for coagulating the retina, having an imaging diagnostic unit, a therapy beam for coagulating coagulation sites, a pilot beam for marking the coagulation sites by a spot sequence, a beam deflecting unit for generating the spot sequence and for positioning the therapy beam, an electronic control unit for controlling the above devices, a software interface, and an interactive interface.

Abstract: A method for producing a cut surface in a transparent material using optical radiation. A laser device separates the material using optical radiation and includes an optical unit focussing the radiation along an optical axis into an image field defining an image-field size. A focal position is adjusted transversely along the axis, producing a cut surface extending substantially parallel to the axis and, in projection along the axis, is a curve having a maximum extent. The focus is displaced by adjustment of the focal position along a trajectory curve lying in the cut surface. The cut surface has a maximum extent which is greater than the image-field size. The focal position is moved transverse to the axis along the curve. The image field is displaced transversely, and the focal position is adjusted in an oscillating fashion along the axis on the curve between an upper and lower axial focus position.

Abstract: Methods and systems for controlling selective targeting of retinal pigment epithelium (RPE) cells within a treatment region of the RPE. The methods include (a) depositing a selected amount of energy on a test region of the RPE; (b) determining an extent to which microcavitation has occurred in the test region; and (c) on the basis of the determination, either depositing the selected amount of energy on the treatment region, or depositing an increased amount of energy on the test region, and repeating steps (b) and (c).

Abstract: A steerable laser probe may include a handle, an actuation mechanism of the handle, an optic fiber, and a housing tube. The housing tube may include a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater than the first stiffness. The optic fiber may be disposed within the housing tube and within an inner bore of the handle. A portion of the optic fiber may be fixed to an inner portion of the housing tube.