Abstract: Methods of determining a desired shape for the anterior surface of the cornea in vision correction procedures.

Abstract: A method for calculating the required power of a toric implant by using both the measured pre-operative corneal astigmatism and the predicted surgically-induced post-operative astigmatism. The surgically-induced post-operative astigmatism is predicted using power vector analysis of the surgical technique employed by the surgeon. Such a method provides a more accurate method of calculating the required post-operative refractive power of the implant. The method can be implemented manually, but preferably is automated by implementation on a computer through appropriate software.

Abstract: A method and apparatus for increasing the depth of focus of the human eye is comprised of a lens body, an optic in the lens body configured to produce light interference, and a pinhole-like optical aperture substantially in the center of the optic. The optic may be configured to produce light scattering or composed of a light reflective material. Alternatively, the optic may increase the depth of focus via a combination of light interference, light scattering, light reflection and/or light absorption. The optic may also be configured as a series of concentric circles, a weave, a pattern of particles, or a pattern of curvatures. One method involves screening a patient for an ophthalmic lens using a pinhole screening device in the lens to increase the patient's depth of focus. Another method comprises surgically implanting a mask in the patient's eye to increase the depth of focus.

Abstract: The present invention provides a contact lens manufactured at least partially from an intelligent polymer, the lens having a relaxed state which, upon application of a first stimulus forms a first corrective shape and which, upon application of a second stimulus, forms a second corrective shape, wherein the corrective effect provided by the lens in the relaxed state is intermediate to the corrective visual effects provided by the first and second corrective shapes.

Abstract: An ocular implant having a body extending along a generally curved longitudinal axis, the curved longitudinal axis defining a first plane, the body having a diameter of between 0.005 inches and 0.04 inches and being adapted to be disposed within a canal of Schlemm in a human subject's eye; wherein the body has a first flexibility when bent along the first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane. Another aspect of the invention provides a method of treating a human eye, including the steps of: inserting an implant into Schlemm's canal of a human eye, the implant having a first flexibility when bent along a first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane; and supporting tissue forming Schlemm's canal with the implant.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance.

Abstract: Devices and methods for handling and depositing corneal implants onto corneal tissue. Devices and methods for packaging and storing corneal implants.

Abstract: An improved prosthesis and method for stimulating vision nerves to obtain a vision sensation that is useful for the patient that has lost vision due to age-related macular degeneration (AMD) and retinitis pigmentosa (RP) and other diseases. The present invention utilizes infrared light to cause action potentials in the retinal nerves similar to those which result from rods and cones stimulated by visible light in healthy retinas. In some embodiments, the invention provides a pathway or “image pipe” for transmitting a stimulation pattern of infrared light from an external stimulator array through the eye and focusing the stimulation pattern of infrared light on the retina, especially the fovea. Some embodiments provide improved resolution down to a group of nerves, or even the individual nerve level, with sufficient energy density so as to cause a desired action potential.

Abstract: An implantable ophthalmic device connectable to an implantable accommodating lens includes a dual-chamber sensor cell having a first and second plate where the second plate is disposed opposite the first plate. A first chamber with a first flexible membrane is disposed on an inner side of the first plate. A second chamber with a second flexible membrane is disposed on an inner side of the second plate. A space resides between the first and second chambers configured to receive a scleral spur of a ciliary muscle of a patient's eye. A connecting element is attached at a first end to the dual-chamber sensor cell. The connecting element includes a first and second channel disposed along a length of the connecting element and in communication with the first and second chamber of the dual-chamber sensor cell, respectively. The second end of the connecting element is connectable to the implantable accommodating lens.

Abstract: A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed.

Abstract: Disclosed herein is a method that comprises providing a solution containing a dye or a dye mixture, ultrasonicating the solution to reduce the average size of aggregates of the dye or dye mixture contained in the solution, and incorporating the dye or the dye mixture in the optical path of a device that transmits light.

Abstract: A lens in accordance with the present invention includes an switchable cell consisting of optical substrate with diffraction surface, elastic film in contact with the diffraction surface of the substrate, optical fluid that fills the space between the film and diffraction surface and the mean to transfer the optical fluid in and out of the space between the film and diffraction surface. The refractive index of the optical fluid matches the refractive index of the optical substrate. The switchable cell changes focus positions between refractive focus in relaxed state when the pressure at both sides of the film is the same and diffraction focus when the optical fluid is transported from the space between the film and optical substrate for the film to largely conform to the diffraction surface shape of the optical substrate.

Abstract: This disclosure describes, in one aspect, a method that generally includes combining a silica precursor and a biocompatible polymer under conditions effective for the silica precursor and the biocompatible polymer to form a gel, at least partially dehydrating the gel, and rehydrating the gel. This disclosure also describes a corneal implant prepared by any embodiment of the general method described herein.

Abstract: Devices and methods for storing and injecting a corneal tissue graft are disclosed herein. In one embodiment, an apparatus includes a tissue container and an adaptor configured to be coupled to the tissue container. The tissue container defines an interior region configured to receive a precut corneal tissue graft therein. The tissue container is also configured to be coupled to an injector assembly that can be used to move the corneal tissue graft out of the interior region of the tissue container and into an anterior chamber of a recipient's eye. The adaptor can be configured to prevent the tissue graft from migrating out of the tissue container and/or can be configured to be coupled to the injector assembly. The tissue graft can remain within the tissue container during storage, transport and during the implantation procedure until it is injected into the patient's eye.

Abstract: A photochromic composition for making optical materials comprising a polyurethane prepolymer formed by combining an isocyanate and a compound having an active hydrogen containing group, a polysilsequioxane and a photochromic compound. The photochromic composition may also include a monomer that has both an active hydrogen containing group and an unsaturated group. The polysilsesquioxane is incorporated as a copolymer and/or as a polysilsequioxane-chemically modified polyurethane.

Abstract: Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).

Abstract: Proposed is an apparatus for assistance in the implantation of a corneal prosthesis in a human eye. The apparatus comprises a laser device for providing focussed, pulsed laser radiation, and a control program for the laser device. The control program is designed, to create an incision figure in the tissue of the eye by means of the laser radiation, this incision figure allowing the corneal prosthesis to be inserted. The incision figure in this case comprises a bed incision located entirely in the depth of the corneal material and an annular incision, which, within the circumferential line of the bed incision, extends from the latter, along its entire annular circumference, as far as the corneal anterior surface. The incision figure further may comprise an auxiliary incision, which extends from a location of the eye surface outside the circumferential line of the bed incision as far the bed incision.

Abstract: A method for providing faster visual and functional recovery of patients following refractive surgery such as laser assisted in situ keratomileusis (LASIK) is disclosed. The method comprises providing a covering to the eye of a patient comprising an inner portion having an inner rigidity and at least one inner radius of curvature; and an outer portion having an outer rigidity and at least one outer radius of curvature; wherein the inner rigidity is greater than the outer rigidity.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a functionalized alkylphenol ethoxylate to reduce glistenings.

Abstract: Small diameter corneal inlays adapted to change the corneal surface curvature to provide central near vision and peripheral distance vision.

Abstract: The invention provides a transcorneal vision assistance device implantable in the eye of a patient. A preferred embodiment transcorneal microtelescope vision assistance device is implantable in the eye of a patient and includes a keratoprosthesis configured to replace a portion of the cornea of a patient and to secure the keratoprosthesis to a remaining front portion of the cornea. A microtelescope is carried by the keratoprosthesis for transcorneal mounting of the microtelescope.

Abstract: Disclosed herein are synthetic silica-based ocular devices fabricated from a composite material comprising silica and a fibrillar protein, together with methods of making and using the ocular devices.

Abstract: An ocular implant including a hydrophobic pseudo-endothelial implant and a binding agent applied thereto, the binding agent capable of bonding the implant to a posterior portion of a cornea such that the implant serves as a water barrier enabling dehydration of the cornea.

Abstract: A lens for an eye that includes a zone with a first power profile for images received by the retina on the fovea, a zone with a second power profile for images received by the peripheral retina on the nasal side and a zone with a third power profile for images received by the peripheral retina on the temporal side. The first power profile is selected to provide clear or acceptable vision and the second and third power profiles are selected to affect the peripheral image position.

Abstract: It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.

Abstract: Devices and methods for handling and depositing corneal implants onto corneal tissue. Devices and methods for packaging and storing corneal implants.

Abstract: A pre-formed intrastromal corneal insert for use in treating Keratoconus and similar dystrophies and methods of using the same. An intrastromal insert of the present invention comprises a biocompatible polymer and may be used to adjust corneal curvature, thereby correcting vision abnormalities caused by disease or other surgical procedures. The insert may be comprised of a circular or semi-circular ring shape or a portion of a ring, or “arc”, encircling the anterior cornea within the frontal circumference of the cornea. The insert may be used in multiples to form complete arcs or to form constructs of varying thicknesses. The insert of the present invention possesses a cross section that results in a low scattering level of light.

Abstract: A corneal reshaping kit may include a mold defining a concavity that is sized and shaped for receiving an outer corneal surface, such that a corneal surface pressed against the concavity will adopt a convex shape complementary to the concavity, and a biocompatible, flowable material suitable for introduction into a space within a cornea.

Abstract: An imaging lens unit is presented, comprising an imaging lens having a lens region defining an effective aperture, and a phase coder. The phase coder may be incorporated with or located close to the lens region. The phase coder defines a surface relief along the lens region formed by at least three phase patterns extending along the lens region. Each of the phase patterns differently affecting light components of one of at least three different wavelength ranges while substantially not affecting propagation of light components of other of said at least three wavelength ranges. The surface relief affects light propagation through the lens region to extend a depth of focus for at least one of said at least three wavelength ranges.

Abstract: An intraocular implant adapted to be implanted within the interior of a human eye is disclosed. The aforesaid implant is selected from a group consisting of: an intracorneal implant, an anterior chamber implant, a sulcus implant, implant in the bag, posterior chamber implant and any combination thereof. The implant comprises means selected from a group consisting of reflective surfaces and electronic device. The implant is adapted to form at least one image of at least part of the field of vision on the retina. The image is selected of a group consisting of: artificial image and reflected image, and any combination thereof. The image is formed on the retina by a predetermined indirect path selected from (z) optical reflective path and (U) electronic processing. Optionally, also a refracted image may also be created on the retina.

Abstract: Corneal implant to be introduced into the optical center (Z) of the cornea of the human eye for the purpose of correcting impaired vision, in particular presbyopia, or presbyopia in combination with hypermetropia or myopia. To propose a corneal implant which is suited for introduction into the optical center (Z) of the human eye, and which may be applied for correcting presbyopia on its own or in combination with hypermetropia or myopia, the effective thickness (d) of the corneal implant (2), measured in the direction of the optical axis (5) of the eye, must be larger than 50 ?m and the maximum width (b), measured in a plane perpendicular to the direction of thickness, must be less than 1 mm, the corneal implant (2) having no imaging function in relation to the human eye.

Abstract: A method and apparatus for increasing the depth of focus of the human eye is comprised of a lens body, an optic in the lens body configured to produce light interference, and a pinhole-like optical aperture substantially in the center of the optic. The optic may be configured to produce light scattering or composed of a light reflective material. Alternatively, the optic may increase the depth of focus via a combination of light interference, light scattering, light reflection and/or light absorption. The optic may also be configured as a series of concentric circles, a weave, a pattern of particles, or a pattern of curvatures. One method involves screening a patient for an ophthalmic lens using a pinhole screening device in the lens to increase the patient's depth of focus. Another method comprises surgically implanting a mask in the patient's eye to increase the depth of focus.

Abstract: The invention relates generally to medical devices and methods for the treatment of ocular disorders. One method provides an implant having an inlet portion with a first anchor and an outlet portion with a second anchor. The implant is implanted in tissue of an eye such the implant conducts fluid from an anterior chamber of the eye to a physiological outflow pathway of the eye. The implanting involves positioning the first anchor adjacent eye tissue, positioning the second anchor within the physiological outflow pathway, and deploying the second anchor such that the second anchor secures the implant within the physiological outflow pathway and a distal end of the second anchor is positioned further into the physiological outflow pathway than an outlet of the outlet portion.

Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer which has only one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming comonomers are disclosed.

Abstract: The invention relates to an intracorneal diffractive lens having phase inversion, said intracorneal diffractive lens including: a core (2) having a first surface and a second surface opposite the first surface; at least one first hydrogel layer (5) extending over the first surface of the core; and a second hydrogel layer (6) extending over the second surface of the core. The first hydrogel layer (5) includes, on the surface thereof turned toward the core, a plurality of concentrically or coaxially projecting annular areas (7), each annular area (7) having a continuously varying thickness toward the periphery of the lens. The first and second layers (5, 6) have a nutrient and oxygen permeability substantially identical to that of the corneal tissue, and at least one of the annular areas (7) of the first layer (5) is in contact with the second hydrogel layer (6).

Abstract: Disclosed is a method for processing porcine cornea using an aqueous NaCl solution and an aqueous trypsin/EDTA solution to decellularize enucleated porcine cornea. The porcine cornea processed by the method causes neither inflammation nor immune rejection. The porcine corneal stroma decellularized by the method can be recellularized together with host keratocytes after transplantation.

Abstract: A corneal implant adapted for implantation between layers of a cornea to focus an image on a retina of an eye includes an inlay, an outer perimeter, and a clear central region capable of refracting light to compensate for a refractive error of an eye. The inlay also has an annular opaque region comprising a plurality of holes or otherwise being adapted to transport nutrients. The annular opaque region extends from the outer circumference of the inlay to the clear central portion. The opaque region extends over a minority of the surface area of the implant. The anterior and posterior surfaces of the inlay are configured to abut adjacent layers of the cornea.

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract: An ophthalmic lens for modifying or reducing non-axisymmetric higher order aberrations includes an optic body disposed about an optical axis having a primary meridian and an orthogonal secondary meridian. The optic body comprises an anterior surface and an opposing posterior surface. The optic body includes an optic zone comprising a base shape that is configured to form an image or focus from light incident on the surfaces, either alone or when used within an optical system. The optic body also includes a higher order toric shape that is imposed on or added to one of the surfaces. The higher order toric shape also includes a first profile disposed along the primary meridian and a second profile disposed along the secondary meridian that is different in shape from the first profile. The higher order toric shape is characterized by a profile along at least one meridian of the lens that changes with increasing radius from the optical axis raised to a power that is greater than two.

Abstract: Implantation of an accommodating intraocular lens in an eye may require the accurate measurement of the size, circumference, or diameter of the capsular bag of the eye. A flexible ring or ring portion may be temporarily or permanently inserted into the capsular bag for measuring the circumference of the capsular bag, for example, after extraction of a natural lens from the capsular bag. The ring or ring portion is generally compressible to fit through a surgical incision, then expands to fill the capsular bag along an equatorial region. The ring or ring portion includes a central component that changes shape and/or angle as the ring or ring portion is compressed. The shape change is generally correlated to the size of the capsular bag and may be visually measured through the cornea, the measurement being generally independent of corneal magnification. The measurement may be used to determine or calculate information about the capsular bag such as its size, elasticity, accommodative range, and so forth.

Abstract: A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag.

Abstract: This invention describes strategies and devices for improving the visual experience while expanding the depth of field of presbyopic and pseudophakic patients. The invention describes strategies and devices for providing improved image quality and improved visual quality of patients employing simultaneous vision bifocal, trifocal or multifocal corrections or monovision. The invention describes strategies and devices for reducing the visibility of the defocused part of the retinal image generated by simultaneous vision bifocal and multifocal ophthalmic corrections and monovision. The invention describes strategies and devices that employ control of spherical aberration or other similar asphericities to reduce the visibility of defocused ghost images.

Abstract: A system comprising a hollow member is used to deliver a constrained corneal implant into a corneal pocket. The hollow member may be tapered and the system may further include an implant deformation chamber and an axial pusher to advance the implant through the hollow member.

Abstract: An ocular implant including a hydrophobic pseudo-endothelial implant and a binding agent applied thereto, the binding agent capable of bonding the implant to a posterior portion of a cornea such that the implant serves as a water barrier enabling dehydration of the cornea.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a functionalized alkyl ethoxylate to reduce glistenings.

Abstract: This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of interactive segmented block copolymers to the surface of the substrate by means of interactive functionalities of the segmented block copolymer reacting with complementary surface functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance.

Abstract: An apparatus is provided for aligning an implant with a visual axis of an eye of a patient. The apparatus has an instrument with an instrument axis and an aperture through which the patient may look along the instrument axis. The implant includes an aperture having an implant axis that can be positioned substantially collinear with the instrument axis. The implant further includes a substantially opaque annulus extending between the aperture and an outer periphery of the implant. The annulus has a nutrient transport structure for conveying nutrients between anterior and posterior surfaces of the implant.

Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights.

Abstract: Provided herein are small diameter inlays for correcting vision impairments by altering the shape of the anterior corneal surface. In an embodiment, inlays having diameters smaller than the pupil are provided for correcting presbyopia. To provide near vision, an inlay is implanted centrally in the cornea to induce an “effective” zone on the anterior corneal surface, within which diopter power is increased. Distance vision is provided by a region of the cornea peripheral to the “effect” zone. In another embodiment, small diameter inlays are provided that induce effective optical zones on the anterior corneal surface that are much larger in diameter than the inlays. The increase in the effective optical zone, due at least in part to a draping effect, allows an inlay to produce a much larger clinical effect on a patient's vision than the diameter of the inlay.