Corneal Implant Patents (Class 623/5.11)
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Patent number: 8043369Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer comprising one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming monomers are disclosed.Type: GrantFiled: June 16, 2009Date of Patent: October 25, 2011Assignee: Bausch & Lomb IncorporatedInventors: Jeffrey G. Linhardt, Ivan M. Nunez, Joseph A. McGee, Jennifer Hunt, Michele Alton, Drazen Pavlovic, Devon A. Shipp
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Patent number: 8034105Abstract: A method is provided for increasing the outflow of fluid through Schlemm's canal that is useful for treatment of glaucoma. The implant is placed in Schlemm's canal by use of a flexible delivery instrument attached to the implant. The instrument and implant are positioned within the canal, the implant is released and the distal and proximal ends of the implant are connected to apply sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability. In another embodiment a delivery instrument attached to the implant is positioned in the canal securing one of the distal or proximal ends of the implant within the canal. The implant provides sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability of the inner wall of the canal. The other of the distal or proximal ends may be secured to maintain the tensioning force on the inner wall of the canal.Type: GrantFiled: December 16, 2005Date of Patent: October 11, 2011Assignee: iScience Interventional CorporationInventors: Robert Stegmann, Stanley R. Conston, David J. Kupiecki, John McKenzie, Candice D. Pinson, Ronald K. Yamamoto
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Patent number: 8029515Abstract: A system comprising a hollow member is used to deliver a constrained corneal implant into a corneal pocket. The hollow member may be tapered and the system may further include an implant deformation chamber and an axial pusher to advance the implant through the hollow member.Type: GrantFiled: April 27, 2007Date of Patent: October 4, 2011Inventor: Yichieh Shiuey
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Publication number: 20110218623Abstract: Small diameter corneal inlays adapted to change the corneal surface curvature to provide central near vision and peripheral distance vision.Type: ApplicationFiled: September 8, 2010Publication date: September 8, 2011Inventors: Jon Dishler, Ned Schneider, Keith Holliday, Troy A. Miller, Alexander Vatz, James R. Alexander
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Patent number: 8002827Abstract: A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag.Type: GrantFiled: March 26, 2009Date of Patent: August 23, 2011Assignee: Abbott Medical Optics Inc.Inventors: Jim Deacon, Edward Garaghty
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Patent number: 7993398Abstract: Implantation of an accommodating intraocular lens in an eye may require the accurate measurement of the size, circumference, or diameter of the capsular bag of the eye. After the natural crystalline lens has been surgically removed, a flexible ring may be temporarily or permanently inserted into the capsular bag for measuring the circumference of the capsular bag. The ring is generally compressible to fit through a surgical incision, then expands to fill the capsular bag along an equatorial region. The ring has a central component that changes shape as the ring is compressed. The shape change is generally correlated to the size of the capsular bag and may be measured visually or with a camera through the cornea, the measurement being generally independent of corneal magnification.Type: GrantFiled: April 24, 2007Date of Patent: August 9, 2011Assignee: Abbott Medical Optics Inc.Inventors: Jim Deacon, Edward Geraghty, Edward Zaleski
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Publication number: 20110166650Abstract: The present invention relates to a new isolated cornea wherein the Descemet's membrane is separated from the overlying corneal stroma by an air cushion. For “DMEK” surgery a spatula (1) is provided, comprising a rounded glide (2) suitable for receiving on its upper surface (3) two overlapping separated buttons; said overlapping separated buttons comprising a lower button of support and an upper donor button to be introduced into the recipient's eye, a retaining means (4) of said overlapping separated buttons perimetrically disposed on a border (5) of said rounded glide (2) said retaining means (4) defining an aperture (6) suitable for extracting said upper button form said rounded glide (2) and a handle (7) solidly connected to said glide (2) and comprising a first portion (8) and a second portion (9), said first (8) and second (9) portions forming an a angle (10) with respect to each other.Type: ApplicationFiled: September 4, 2008Publication date: July 7, 2011Inventor: Massimo Busin
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Publication number: 20110153013Abstract: A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.Type: ApplicationFiled: March 4, 2011Publication date: June 23, 2011Applicant: CARL ZEISS SURGICAL GMBHInventors: Gerhard MOELLER, Anja SEIWERT, Michel PEREZ, Peter AMEND
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Patent number: 7960447Abstract: The present invention relates to hydrophilic dicationic siloxane prepolymers with one polymerizable vinyl moiety instead of two polymerizable vinyl moieties, resulting in contact lenses and/or biomedical devices with reduced cross-link density and modulus without detracting from other properties.Type: GrantFiled: April 13, 2006Date of Patent: June 14, 2011Assignee: Bausch & Lomb IncorporatedInventors: Derek Schorzman, Jay Kunzler
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Publication number: 20110066238Abstract: The invention relates to a model of reconstructed cornea, which may be used especially in tissue engineering, to a biomaterial that may be used for preparing a reconstructed cornea, and also to a culture device allowing better reproducibility of the cultures of the model of reconstructed cornea.Type: ApplicationFiled: February 16, 2009Publication date: March 17, 2011Applicant: BASF BEUTY CARE SOLUTIONS FRANCE S.A.SInventors: Nicolas Bechetoille, Odile Damour, Valerie Andre
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Publication number: 20110029073Abstract: Presbyopia in a patient's eye is treated by inducing spherical aberration in the central section of the pupil, while the peripheral section of the pupil is treated in a manner other than the central section of the pupil. For example, the peripheral section of the pupil may remain untreated, or high-order aberration may be controlled, and/or a second area of spherical aberration may be provided with different focus power.Type: ApplicationFiled: March 31, 2009Publication date: February 3, 2011Inventor: Junzhong Liang
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Patent number: 7842367Abstract: Opthalmic devices, particularity intraocular lenses (IOL), with improved contrast sensitivity and methods of making same. In one aspect, blue light blocking chromophores (BLBC) are diffused into, e.g. an IOL lens body to create a BLBC gradient in the lens. Orange dyes are preferred BLBCs.Type: GrantFiled: February 8, 2006Date of Patent: November 30, 2010Assignee: Key Medical Technologies, Inc.Inventor: Khalid Mentak
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Patent number: 7828844Abstract: Methods of correcting vision are described. The methods include inserting a lens into a corneal epithelial pocket or a pocket created between a corneal epithelium of an eye of a patient and Bowman's membrane of the eye. A lens is inserted into the pocket to correct vision. Certain methods include one or more steps of cooling the corneal epithelium, and applying an aqueous liquid to the eye. The lenses that are inserted into the pocket can include collagen, including recombinant collagen, synthetic polymeric materials, and combinations thereof.Type: GrantFiled: September 12, 2003Date of Patent: November 9, 2010Assignee: ForSight Labs, LLCInventors: J. Christopher Marmo, Arthur Back, Greg S. Hollrigel
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Publication number: 20100261652Abstract: There is provided in one embodiment of the disclosure a tissue adhesive composition comprising an engineered protein having repeated blocks of an elastin domain and at least one cell-binding domain and further comprising a polymer crosslinker. When the engineered protein and the polymer crosslinker are introduced onto a tissue, the engineered protein and the polymer crosslinker initiate an in situ crosslinking reaction to form an adhesive bond that is mechanically strong, transparent, biocompatible, and stimulates regrowth of one or more tissue layers over the adhesive bond. In another embodiment of the disclosure there is provided a molded corneal onlay and method of making the same.Type: ApplicationFiled: March 29, 2010Publication date: October 14, 2010Applicant: California Institute of TechnologyInventors: Muzhou Wang, Matthew S. Mattson, David A. Tirrell, Julia A. Kornfield
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Patent number: 7811267Abstract: A kit is provided, which comprises a) a collagen patch and b) an adhesive composition comprising (i) fibrin, fibrinogen or a combination thereof, and (ii) a biocompatible polymer capable of forming a viscous aqueous solution. Also provided is use of the kit for the preparation of a sealing device for use in ophthalmic surgery to replace a natural lens which has been removed, in which sealing device the collagen patch of the kit is adapted to seal an opening in a capsular bag of an eye while admitting the entrance of an injection device through the opening for injection of a lens-forming material into the capsule; and in which sealing device the adhesive composition of the kit is adapted to be applied to the collagen patch so as to enable adhesion of the collagen patch to the capsular bag. Also provided are methods for sealing an opening in a capsular bag of an eye, in which methods the kit is employed.Type: GrantFiled: May 15, 2003Date of Patent: October 12, 2010Assignee: AMO Groningen B.V.Inventors: Sverker Norrby, Rolf Bergman, Jöns Hillborn
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Publication number: 20100241060Abstract: Surgical devices and methods are described. The devices are for implanting fluidic material in a patient's eye and comprise a nozzle and a housing having a slide and a bellows. The bellows is adapted to undergo compression or decompression. The surgical procedures make use of the surgical devices and include a tissue translocation surgical procedure, a retinal implantation surgical procedure, and a corneal transplantation surgical procedure.Type: ApplicationFiled: March 18, 2009Publication date: September 23, 2010Inventors: Keith ROIZMAN, H. Michael Lambert, Patrick Michael Elliott
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Publication number: 20100215717Abstract: Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).Type: ApplicationFiled: February 25, 2010Publication date: August 26, 2010Inventors: Shay Soker, J. Koudy Williams, Patrick Laber, Margaret Greven, Keith A. Walter
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Patent number: 7776086Abstract: A corneal implant having an aspheric surface for modifying the cornea curvature and altering the corneal refractive power. The corneal implant has a lens body formed of an optically clear bio-compatible material, preferably with an index of refraction substantially similar to that of human corneal tissue (1.376). The aspheric surface is comprised of a continuous aspheric surface from the apex of the implant to beveled surface. The beveled surface, positioned near the outer diameter of the implant, is used to reduce the thickness of the aspheric surface on the periphery of the lens to the outer diameter edge. The body of the implant has a diameter between about 2.0 mm and 7.0 mm and a thickness less than about 0.150 mm.Type: GrantFiled: April 30, 2004Date of Patent: August 17, 2010Assignee: ReVision Optics, Inc.Inventor: Troy Miller
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Publication number: 20100191328Abstract: This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.Type: ApplicationFiled: February 27, 2008Publication date: July 29, 2010Applicant: TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Fiorenzo Omenetto, Jeffrey K. Marchant, Noorjahan Panjwani, Brian Lawrence
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Publication number: 20100185281Abstract: An ocular implant including a hydrophobic pseudo-endothelial implant and a binding agent applied thereto, the binding agent capable of bonding the implant to a posterior portion of a cornea such that the implant serves as a water barrier enabling dehydration of the cornea.Type: ApplicationFiled: January 18, 2009Publication date: July 22, 2010Inventor: Ofer Daphna
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Patent number: 7759408Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.Type: GrantFiled: January 27, 2006Date of Patent: July 20, 2010Assignee: Bausch & Lomb IncorporatedInventors: Derek Schorzman, Joseph C. Salamone, Jay Kunzler, Jeffrey G. Linhardt
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Patent number: 7753952Abstract: A vision prosthesis includes an optical element having a surface that is shaped to be positioned near a cornea of an eye, and a magnetic element embedded in the optical element.Type: GrantFiled: June 17, 2008Date of Patent: July 13, 2010Assignee: Massachusetts Eye & Ear InfirmaryInventor: Dimitri T. Azar
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Publication number: 20100145444Abstract: It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.Type: ApplicationFiled: March 7, 2008Publication date: June 10, 2010Applicant: JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL CARDInventors: Akio Kishida, Tsuyoshi Kimura, Hisatoshi Kobayashi, Toshiya Fujisato
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Publication number: 20100087920Abstract: Methods for improving vision in a person diagnosed with presbyopia include placing a corneal onlay lens having a lens body diameter less than 5 mm in contact with an eye of the person. The corneal onlay lens has at least one refractive region having a refractive power to correct vision effects caused by the presbyopia. If the person is a presbyopic emmetrope, the method may include a step of placing only one corneal onlay lens in the person to treat presbyopia or improve the vision of the person. Additional corneal onlay lenses and methods of making such corneal onlay lenses are also described.Type: ApplicationFiled: October 7, 2008Publication date: April 8, 2010Applicant: FORSIGHT LABS, LLCInventor: J. Christopher Marmo
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Publication number: 20100069915Abstract: A system comprising a hollow member is used to deliver a constrained corneal implant into a corneal pocket. The hollow member may be tapered and the system may further include an implant deformation chamber and an axial pusher to advance the implant through the hollow member.Type: ApplicationFiled: March 17, 2009Publication date: March 18, 2010Inventor: YICHIEH SHIUEY
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Publication number: 20100036488Abstract: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.Type: ApplicationFiled: April 6, 2009Publication date: February 11, 2010Applicant: ForSight Labs, LLCInventors: Eugene de Juan, JR., Cary J. Reich, Stephen Boyd, Yair Alster, David Sierra, Hanson S. Gifford, Jose D. Alejandro, Richard L. Lindstrom, K. Angela Macfariane, Douglas Sutton, John Anthony
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Publication number: 20090326650Abstract: Method and system for modifying a refractive profile associated with an eye having a recipient cornea. The method includes obtaining a corneal tissue inlay from a donor cornea, forming a recipient bed in the recipient cornea, and positioning the corneal tissue inlay into the recipient bed to correct the refractive profile of the eye with the refractive profile of the corneal tissue. The system includes a laser assembly outputting a pulsed laser beam, and a controller coupled to the laser assembly. The controller directs the laser assembly to incise a corneal tissue inlay from a donor cornea, form a recipient bed in the recipient cornea having a contour matching the contour of the inlay, register the inlay with the recipient bed, determine a position of the inlay, and determine a position change for the inlay based on the position of the inlay to align the refractive profile of the inlay with the refractive profile of the eye.Type: ApplicationFiled: June 29, 2009Publication date: December 31, 2009Applicant: AMO Development, LLCInventors: Leander Zickler, Scott J. Catlin, Andrew Y. Pang
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Publication number: 20090306773Abstract: Implants configured for corneal implantation are disclosed that have a light transmitting portion and a light-blocking portion disposed about the periphery of the implant. The implant can be an elongate member, such as a split or continuous ring, that can be implanted in the cornea to alter the refractive properties of the cornea by altering the curvature of the anterior surface of the cornea, thereby providing corrective refraction. The light-blocking portion can reduce edge effects, which may be visible or distracting to the patient.Type: ApplicationFiled: June 4, 2008Publication date: December 10, 2009Applicant: AcuFocus, Inc.Inventors: Thomas Silversrini, Bruce A. Christie
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Patent number: 7622512Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymeric compositions comprise polymerized cationic hydrophilic siloxanyl monomers.Type: GrantFiled: January 27, 2006Date of Patent: November 24, 2009Assignee: Bausch & Lomb IncorporatedInventors: Derek Schorzman, Joseph C. Salamone, Daniel Ammon, Jay Kunzler, Jeffrey G. Linhardt
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Publication number: 20090281209Abstract: High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise a single aryl hydrophobic monomer as a device forming monomer. In addition, the copolymers comprise a non-polymerizable block copolymer surfactant. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures.Type: ApplicationFiled: May 5, 2009Publication date: November 12, 2009Applicant: Alcon, Inc.Inventors: Chance Lehman, Charles Freeman
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Publication number: 20090270982Abstract: Devices and methods for storing and injecting a corneal tissue graft are disclosed herein. In one embodiment, an apparatus includes a tissue container and an adaptor configured to be coupled to the tissue container. The tissue container defines an interior region configured to receive a precut corneal tissue graft therein. The tissue container is also configured to be coupled to an injector assembly that can be used to move the corneal tissue graft out of the interior region of the tissue container and into an anterior chamber of a recipient's eye. The adaptor can be configured to prevent the tissue graft from migrating out of the tissue container and/or can be configured to be coupled to the injector assembly. The tissue graft can remain within the tissue container during storage, transport and during the implantation procedure until it is injected into the patient's eye.Type: ApplicationFiled: April 23, 2009Publication date: October 29, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Aurora A. Torres, David J. Schanzlin, Thomas A. Trozera
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Patent number: 7601766Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain carboxylic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymeric compositions comprise polymerized carboxylic hydrophilic siloxanyl monomers.Type: GrantFiled: June 30, 2006Date of Patent: October 13, 2009Assignee: Bausch & Lomb IncorporatedInventors: Derek Schorzman, Jay Kunzler, Joseph Salamone
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Publication number: 20090240327Abstract: Corneal implant to be introduced into the optical centre (Z) of the cornea of the human eye for the purpose of correcting impaired vision, in particular presbyopia, or presbyopia in combination with hypermetropia or myopia. To propose a corneal implant which is suited for introduction into the optical centre (Z) of the human eye, and which may be applied for correcting presbyopia on its own or in combination with hypermetropia or myopia, the effective thickness (d) of the corneal implant (2), measured in the direction of the optical axis (5) of the eye, must be larger than 50 ?m and the maximum width (b), measured in a plane perpendicular to the direction of thickness, must be less than 1 mm, the corneal implant (2) having no imaging function in relation to the human eye.Type: ApplicationFiled: May 23, 2007Publication date: September 24, 2009Inventor: Albert Daxer
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Publication number: 20090198325Abstract: Methods of designing corneal implants, such as inlays, to compensate for a corneal response, such as epithelial remodeling of the epithelial layer, to the presence of the implant. Additionally, methods of performing alternative corneal vision correction procedures to compensate for an epithelial response to the procedure. Methods of compensating for a corneal response when performing a vision correction procedure to create a center near region of the cornea for near vision while providing distance vision peripheral to the central near zone.Type: ApplicationFiled: April 3, 2009Publication date: August 6, 2009Inventors: Keith Holliday, Alan Lang
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Publication number: 20090168012Abstract: This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of interactive segmented block copolymers to the surface of the substrate by means of interactive functionalities of the segmented block copolymer reacting with complementary surface functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.Type: ApplicationFiled: December 15, 2008Publication date: July 2, 2009Inventors: Jeffrey G. Linhardt, Devon A. Shipp, Jay F. Kunzler, David Paul Vanderbilt
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Publication number: 20090048670Abstract: “Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea.Type: ApplicationFiled: August 29, 2008Publication date: February 19, 2009Applicant: SCIENTIFIC OPTICS, INC.Inventors: Jonathan Grierson, David Lieberman
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Publication number: 20090036980Abstract: The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye. Also disclosed are ophthalmic lenses as obtained by the methods which are capable reducing aberrations of the eye.Type: ApplicationFiled: July 17, 2008Publication date: February 5, 2009Applicant: AMO GRONINGEN BVInventors: Sverker Norrby, Pablo Artal, Patricia Ann Piers, Marrie Van Der Mooren
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Patent number: 7476398Abstract: A membrane for corneal implant or keratoprosthesis comprising a biological polymer and a polyacrylamide is described. The mixture of both polymers produces a hydrogel that becomes a transparent film or membrane upon drying. The resulting device and tissue engineered implants are useful for biomedical applications of the cornea, such as tissue repair and transplantation.Type: GrantFiled: June 27, 2003Date of Patent: January 13, 2009Assignee: Universite LavalInventors: Charles J. Doillon, May Griffith, Fengfu Li, Shigeto Shimmura
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Patent number: 7476248Abstract: A method for calculating the required cylindrical power of a toric implant by using both the measured pre-operative corneal/ocular astigmatism and the predicted surgically-induced astigmatism. The post-operative corneal/ocular astigmatism is predicted using power vector analysis of the surgical technique employed by the surgeon. Such a method provides a more accurate method of calculating the required spherocylindrical refractive power of the implant. The method can be implemented manually, but preferably is automated by implementation on a computer through appropriate software.Type: GrantFiled: April 6, 2004Date of Patent: January 13, 2009Assignee: Alcon, Inc.Inventors: Blake Harris, James Hoffman, Xin Hong, Xiaoxiao Zhang, Warren E. Hill
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Publication number: 20080249621Abstract: A vision prosthesis includes an optical element having a surface that is shaped to be positioned near a cornea of an eye, and a magnetic element embedded in the optical element.Type: ApplicationFiled: June 17, 2008Publication date: October 9, 2008Applicant: Massachusetts Eye & Ear InfirmaryInventor: Dimitri T. Azar
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Publication number: 20080243138Abstract: Provided therein are apparatuses, systems and methods for storing and retrieving a corneal implant and for delivering the corneal implant in or on the cornea. In an embodiment, a insertion system comprises an inserter for delivering a corneal implant to a desired location in or on the cornea. The inserter has a holding space at its distal end for holding a corneal implant therein. A solution may substantially fill the holding space with the corneal implant to keep the implant hydrated and to hold the implant in the holding space by the surface tension of the solution. The corneal implant may be preloaded in the holding space of the inserter and stored in a storage container filled with storage fluid, e.g., saline, until use. To deliver the corneal implant, the inserter is positioned at the desired location, and the corneal implant released from the holding space of the inserter.Type: ApplicationFiled: March 28, 2007Publication date: October 2, 2008Inventors: Jon Dishler, Ned Schneider, Alan Ngoc Le
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Publication number: 20080221674Abstract: A corneal inlay protects ocular structures from harmful wavelengths of light while maintaining acceptable color cosmetics, color perception, overall light transmission, photopic vision, scotopic vision, color vision, and/or cirdadian rhythms. The corneal inlay can also include a pinhole effect to increase depth of focus. In some embodiments, the corneal inlay can also correct refractive errors including, but not limited to, higher order aberration, lower order aberration, myopia, hyperopia, astigmatism, and/or presbyopia.Type: ApplicationFiled: February 26, 2008Publication date: September 11, 2008Applicant: High Performance Optics, Inc.Inventors: Ronald D. Blum, Andrew W. Ishak, Peter Haaland, Michael B. Packard, D. James Schumer
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Patent number: 7402175Abstract: A vision prosthesis includes an optical element having a surface that is shaped to be positioned near a cornea of an eye, and a magnetic element embedded in the optical element.Type: GrantFiled: May 17, 2004Date of Patent: July 22, 2008Assignee: Massachusetts Eye & Ear InfirmaryInventor: Dimitri T. Azar
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Publication number: 20080154360Abstract: A local deformation of the cornea of an eye can be compensated by a set comprising at least two implant members for insertion into at least one receptacle inserted into the cornea, wherein at least two implant members are arranged in differing planes located one above the other. Undesirable repercussions and side effects of the intervention in the eye can be detected as early as the simulation takes place and suitable receptacles and the like can be accordingly selected in order to minimise such repercussions and side effects and, at the same time, to provide optimum compensation for the deformation of the cornea in order to compensate for the deformation.Type: ApplicationFiled: February 23, 2006Publication date: June 26, 2008Inventors: Mark Tomalla, Gebhard Tomalla
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Publication number: 20080124276Abstract: Methods of producing synthetic corneas are disclosed which are differentiated from retinal stem cells (rSC) derived from parthenogenetically activated human oocytes, including that such synthetic corneas are produced in the absence of a 3-D scaffold. Isolated synthetic corneas, produced by the disclosed methods, are also described.Type: ApplicationFiled: October 19, 2006Publication date: May 29, 2008Applicant: LIFELINE CELL TECHNOLOGYInventors: Jeremy Hammond, Judy Kelleher-Andersson
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Patent number: 7354980Abstract: This invention relates to novel copolymers preferably for intraocular lenses (“IOL”), contact lens, and other ophthalmic and optical applications. This invention, in one aspect, relates to copolymer compositions comprising limited amounts of a monomer having a naphthyl moiety or naphthyl functionalities, naphthalene, or a naphthyl group.Type: GrantFiled: March 14, 2005Date of Patent: April 8, 2008Assignee: Key Medical Technologies, Inc.Inventor: Khalid Mentak
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Patent number: 7323010Abstract: Biomaterial including tissues basically obtained from an animal cornea, in particular, from a fish cornea. A cardiac valve (10) which may envisage at least one cusp (15) made with an organic tissue obtained from this particular biomaterial.Type: GrantFiled: July 10, 2001Date of Patent: January 29, 2008Inventors: Alessandro Verona, Roberto Erminio Parravicini
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Publication number: 20070255402Abstract: A method for convenient, controlled wound closure of an eye, the skin, internal organs and other soft tissue which comprises administering to the wound a sterile, body compatible photopolymerizable acrylate or methacrylate adhesive, and exposing the applied adhesive to light.Type: ApplicationFiled: May 1, 2007Publication date: November 1, 2007Inventors: Jacob J. Moore, David H. Pashley, Balamurali K. Ambati
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Patent number: 7287852Abstract: Circular and annular lens zones are disclosed which, at a given lens area, exhibit a depth of focus of a lens of considerably smaller area. The large depth of focus is achieved by imparting the lens zones a refractive power profile. An assembly of such large depth of focus lens zones represents a lens of large diameter which lens, in polychromatic light, exhibits essentially the same depth of focus as the lens zones from which it is composed.Type: GrantFiled: June 29, 2004Date of Patent: October 30, 2007Inventor: Werner J. Fiala
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Publication number: 20070203577Abstract: Provided herein are small diameter inlays for correcting vision impairments by altering the shape of the anterior corneal surface. In an embodiment, inlays having diameters smaller than the pupil are provided for correcting presbyopia. To provide near vision, an inlay is implanted centrally in the cornea to induce an “effective” zone on the anterior corneal surface, within which diopter power is increased. Distance vision is provided by a region of the cornea peripheral to the “effect” zone. In another embodiment, small diameter inlays are provided that induce effective optical zones on the anterior corneal surface that are much larger in diameter than the inlays. The increase in the effective optical zone, due at least in part to a draping effect, allows an inlay to produce a much larger clinical effect on a patient's vision than the diameter of the inlay.Type: ApplicationFiled: October 30, 2006Publication date: August 30, 2007Inventors: Jon Dishler, Troy A. Miller, Alexander Vatz, James R. Alexander