Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: Fluid-driven accommodating intraocular lenses comprising deformable optic portions.

Abstract: An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

Abstract: The system is able to correct the spherical and cylindrical power as well as other aberrations of the optical pathway of both eyes of a person eliminating the need for multiple heavy glass lenses and mirrors. For correcting the refractive errors, the above described system is equipped with a diachroic mirror interposed in front of the system, to divert part of the light reflecting from the pupil to a Shack-Hartman wave front sensor.

Abstract: A lens for correcting human vision, for example an IOL, contact lens or corneal inlay or onlay, that carries and interior phase or layer comprising a pattern of individual transparent adaptive displacement structures. In the exemplary embodiments, the displacement structures are actuated by shape change polymer that adjusts a shape or other parameter in response to applied energy that in turn displaces a fluid media within the lens that actuates a flexible lens surface. The adaptive optic means of the invention can be used to create highly localized surface corrections in the lens to correct higher order aberrations—which types of surfaces cannot be fabricated into and IOL and then implanted. The system of displacement structures also can provide spherical corrections in the lens.

Abstract: The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.

Abstract: An accommodating intraocular lens (IOL) device adapted for implantation in the lens capsule of a subject's eye. The IOL device includes an anterior refractive optical element and a membrane coupled to the refractive optical element. The anterior refractive optical element and the membrane define an enclosed cavity configured to contain a fluid. At least a portion of the membrane is configured to contact a posterior area of the lens capsule adjoining the vitreous body of the subject's eye. The fluid contained in the enclosed cavity exerts a deforming or displacing force on the anterior refractive optical element in response to an anterior force exerted on the membrane by the vitreous body. The IOL device may further include a haptic system to position the anterior refractive optical element and also to engage the zonules and ciliary muscles to provide additional means for accommodation.

Abstract: A lens in accordance with the present invention includes an accommodating cell having two chambers with at least one chamber filled with optical fluid with the refractive index matching the refractive index of the accommodating element separating them. The accommodating element has a diffractive surface with surface relief structure that maintains its period but changes its height due a pressure difference between the chambers to redirect most of light that passes through the lens between different foci of far and near vision. The invention also includes a sensor cell that directly interacts with the ciliary muscle contraction and relaxation to create changes in pressure between the accommodating cell chambers that results in changing surface relief structure height and the lens accommodation.

Abstract: An object is to provide an artificial lens for use in an artificial eye device for cataract surgery practice. The artificial lens includes an artificial nucleus corresponding to a human eye lens nucleus and an artificial cortex corresponding to a human eye lens cortex. The artificial nucleus is formed of an agar gel of agar concentration 1.0 wt % to 5.0 wt %. The artificial cortex is formed of an agar gel of agar concentration 0.5 wt % to 1.5 wt % which is lower than the agar concentration of an agar gel forming the artificial nucleus. In another embodiment, an artificial lens includes an artificial nucleus corresponding to a human eye lens nucleus and an artificial cortex corresponding to a human eye lens cortex. The artificial nucleus is formed of cheese or a cheese-like substance, and the artificial cortex is formed of pulp fiber.

Abstract: An accommodating intraocular lens includes an optic portion a haptic portion and a backstop. The optic portion of the lens includes an actuator that deflects a lens element to alter the optical power of the lens responsive to forces applied to the haptic portion of the lens by contraction of the ciliary muscles. Forces applied to the haptic portion may result in fluid displacements from or to the haptic portion from the actuator. The backstop provides support to the haptic so that bulk translation of the haptic is prevented in response to the forces applied by the capsular sac.

Abstract: An accommodating intraocular lens (AIOL) assembly (10) including an optics assembly (12) including an inflatable member (14), and characterised by an extra-capsular-bag interface structure (16) for interfacing with ocular structure of an eye external to a capsular bag for implanting the AIOL (10) outside the capsular bag, the extra-capsular-bag interface structure (16) including a less-rigid portion (18) and a more-rigid portion (20) that define a volume therebetween which is at least partially filled with a fluid (22) and which is in fluid communication with the inflatable member (14) via at least one conduit (24), and wherein the less-rigid portion (18) is responsive to movement of the ocular structure to apply a pumping force on the fluid (22) to cause the fluid (22) to flow via the at least one conduit (24) to the inflatable member (14) so as to change the optical power of the optics assembly (12).

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.

Abstract: An accommodating intraocular lens (AIOL) (10) characterised by a first member (1) and a second member (3) arranged to correspond to anterior and posterior portions of a capsular bag, having an anterior-posterior axis passing centrally through the first and second members (1, 3), the first and second members (1, 3) being connected by one or more link members (2), a lens structure (4) including an inflatable lens (21), and a reservoir (23) of filling fluid (12) in fluid communication with the inflatable lens (21) through one or more channels (22), wherein axial movement of one of the first and second members (1, 3) along the anterior-posterior axis applies a pumping force to cause the filling fluid (12) to flow between the reservoir (23) and the inflatable lens (21).

Abstract: Systems and their methods of use for testing intraocular lenses outside of the lens capsule. In some embodiments the systems measure an accommodative response based on a force applied to the intraocular lens.

Abstract: The present invention relates to an ocular, variable-focus lens, and in particular, to an ocular, fluid-focussed, accommodating lens having first and second fluids which are in contact over a meniscus of changeable shape, for the restoration or improvement of vision in a patient.

Abstract: A lens for correcting human vision, for example an IOL, contact lens or corneal inlay or onlay, that carries and interior phase or layer comprising a pattern of individual transparent adaptive displacement structures. In the exemplary embodiments, the displacement structures are actuated by shape change polymer that adjusts a shape or other parameter in response to applied energy that in turn displaces a fluid media within the lens that actuates a flexible lens surface. The adaptive optic means of the invention can be used to create highly localized surface corrections in the lens to correct higher order aberrations-which types of surfaces cannot be fabricated into and IOL and then implanted. The system of displacement structures also can provide spherical corrections in the lens.

Abstract: In accordance with the present invention, a multifocal intraocular lens provides greater or lesser refraction in relation to the position of the head and eyes of a user. A multifocal intraocular lens body for insertion into a fluid-filled enucleated natural lens capsule of an eye is provided wherein the lens body encompasses the optical axis of the eye and provides different greater or lesser refraction depending upon the position of the eye.

Abstract: The present invention relates to an ocular, variable-focus lens, and in particular, to an ocular, fluid-focussed, accommodating lens having first and second fluids which are in contact over a meniscus of changeable shape, for the restoration or improvement of vision in a patient.

Abstract: A vision prosthesis includes an intra-ocular lens system having a variable focal length; and a controller that causes a change in the focal length thereof.

Abstract: The invention concerns an intraocular lens device which is used in particular for treatment of diseases of the central retina (macula) with retinal areas which are still healthy. The main principle of the invention at hand is that a lens device is provided for the redirection of the focal point from an area with impaired retinal function to a functioning area which comprises at least one convex lens element and several wedge-shaped recesses. Surprisingly it was found that a considerable reduction of the thickness of the lens device is thus achievable when several wedge-shaped recesses are provided.

Abstract: The invention relates to an accommodative lens implant controlled by the ciliary muscle, consisting of at least one or more lenses made of preferably biocompatible material and disposed on a common optical axis, the at least one lens being a component of a flexible, closed implant body that is transparent in the region of the actual lens, is engaged at its outer periphery with the ciliary muscle, and has a main axis that coincides with the visual axis, and in addition at least part of the implant body with the lens or lenses comprises a fluid filling, such that the axial position of the lens or the lens system can be altered by activation of the ciliary muscle, the implant body being inserted in the sulcus of the posterior chamber of the eye or attached to the ciliary muscle.

Abstract: An intraocular lens comprises an optical element adapted to be implanted within the capsular bag of a human eye. The optical element includes one or more internal layers formed by one or more planes that are moveable relative to one another in order to effect the power of the optical element.

Abstract: Fluid-driven accommodating intraocular lenses comprising deformable optic portions.

Abstract: Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Abstract: A novel multiphase optic lens contains an elastic chamber including a fluid or gel to transfer an eye positioning to a lens shape with a refractive power and visual axis matching an eye's targeting. The elasticity of an anterior wall of the elastic chamber is higher than that of the remainder of the wall of the elastic chamber, particularly in a near reading center at an inferior area toward the nose. A near response is achieved when the anterior wall is pushed anteriorly by the fluid or gel to form a protrusion when a user is looking downward and toward the nose, and vice versa for far response. A balance is achieved when the chamber is substantially perpendicular to horizon when a user is looking forward. This multiphase lens may be made in situ by laser. The method is useful for intraocular lens, nose/ear-free eyewear, and macular protection.

Abstract: An intraocular device including a prism and shift amplifier is provided. Also provided is a system containing the intraocular device, and a method for improving vision of a person with central vision loss. The method involves implanting the intraocular device in the person so that the prism and shift amplifier cumulatively shift a retinal image away from the fovea of an eye to a functional retinal portion of the eye. Also provided is a method for correcting a binocular misalignment of a person using the intraocular device.

Abstract: A fluid lens assembly including a front rigid lens, a semi-flexible membrane that is adapted to be expanded from a minimum inflation level to a maximum inflation level, and a fluid layer therebetween. The front lens of the fluid lens assembly is configured to have a negative optical power. In an embodiment, the fluid lens assembly may be configured to have an overall negative optical power when the membrane is expanded to the maximum inflation level. In an embodiment, the fluid lens assembly can be configured to have an overall negative optical power when the membrane is expanded between the minimum inflation level and the maximum inflation level.

Abstract: An accommodating intraocular lens, for use in an eye, is made from flexible, optionally elastic, bio-compatible lens body material surrounding a s closed and sealed lens cavity which is filled with bio-compatible optical liquid, optionally a gel. The optical liquid has a refractive index sufficiently high to, in cooperation with the ciliary muscle, focus light, incident on the eye, on the retina, and to provide accommodation. The curvature of the front surface of the lens is deformable, by the pressure expressed by the ciliary body during the to accommodative effort, thus to change the radius of curvature of the anterior body member and/or the posterior body member, thus providing smooth focusing, including from far distance in the relaxed state to near distance of less than 50 centimeters in the accommodative state.

Abstract: An accommodative intra-ocular lens deformable between the unaccommodating and accommodating configurations upon the relaxation and contraction of the ciliary muscle. The lens anterior and posterior portions are substantially sealingly joined together about their peripheral edges and define a lens internal volume filled with a substantially incompressible lens internal fluid. Causing a variable internal fluid pressure exerted on the lens inner surfaces. The lens is configured such that radius of curvature of both the central and peripheral sections of the lens anterior portion will decrease upon an increase in internal fluid pressure and increase upon a decrease in internal fluid pressure.

Abstract: An intraocular lens having a light-transmitting optic (32, 94a, 94b, 142, 148, 216) comprised of a synthetic light-refractive material (40, 102) operably coupled with a flexible optic positioning member (34, 62, 74, 84, 100, 150, 210) to refract light onto the retina in order to correct refractive errors in the eye (10). The refractive material has an index of refraction of from about 1.36 to 1.5 or higher. The optic positioning member (34, 62, 74, 84, 100, 150, 210) is constructed of a flexible synthetic resin material such as polymethylmethacrylate and permits focusing upon objects located near to and far from the viewer. The optic (32, 94a, 94b, 142, 148, 216) of the present invention possess greater refractive capability than optics conventionally used in IOL construction, and permits retinal receipt of the image being viewed in order to correct refractive errors.

Abstract: A deformable intracapsular implant device for shaping an enucleated lens capsule sac for use in cataract procedures and refractive lensectomy procedures. In one embodiment, the intraocular implant devices rely on thin film shape memory alloys and combine with the post-phaco capsular sac to provide a biomimetic complex that can mimic the energy-absorbing and energy-releasing characteristics of a young accommodative lens capsule. In another embodiment, the capsular shaping body is combined with an adaptive optic. The peripheral capsular shaping body carries at least one fluid-filled interior chamber that communicates with a space in a adaptive optic portion that has a deformable lens surface. The flexing of the peripheral shaping body in response to zonular tensioning and de-tensioning provides an inventive adaptive optics mechanism wherein fluid media flows between the respective chambers “adapts” the optic to increase and decrease the power thereof.

Abstract: An accommodating intraocular lens, for use in an eye, is made from flexible, optionally elastic, bio-compatible lens body material surrounding a closed and sealed lens cavity which is filled with bio-compatible optical liquid, optionally a gel. The optical liquid has a refractive index sufficiently high to, in cooperation with the ciliary muscle, focus light, incident on the eye, on the retina, and to provide accommodation. The curvature of the front surface of the lens is deformable, by the pressure expressed by the ciliary body during the accommodative effort, thus to change the radius of curvature of the anterior body member and/or the posterior body member, thus providing smooth focusing, including from far distance in the relaxed state to near distance of less than 50 centimeters in the accommodative state.

Abstract: This invention relates to intraocular lenses. More particularly, this invention relates to intraocular lenses that have the ability to alter the light refractive power in response to changes in the tension of the ciliary muscle or ciliary body of the eye or any other accommodative forces. Lenses of this invention are generally referred to as interfacial, i.e., lens properties being defined as the interface of two liquids having different refractive indices, refractive accommodating lenses (IRAL).

Abstract: Fluids incorporated into intraocular lenses and their methods of use. In some embodiments the fluids are silicone oils, and in some embodiments they are used in accommodating intraocular lenses.

Abstract: An exemplary embodiment provides a biocompatible polymer composition suitable for making intraocular lenses, especially posterior chamber phakic lenses, that includes a hydrogel having an equilibrium water content of less than about 55 wt. %. The hydrogel has a refractive index greater than about 1.41 and a sodium ion flux between about 16 to about 20 ?eq-mm/hr/cm2.

Abstract: An accommodating intraocular lens comprising an optic made from solid silicone and liquid silicone. The optic has a central anterior area or membrane that can vary in radius and thus charge power.

Abstract: An accommodating intraocular lens comprising an optic made from solid silicone and liquid silicone. The optic has a central anterior area or membrane that can vary in radius and thus change power.

Abstract: The present invention relates to a fluidic intraocular lens inserted into a capsular bag of an eye to replace a crystalline lens. The fluidic intraocular lens may be shaped by elastic membranes bonded to a support ring. The space inside the device may be filled with optically transparent fluid or gel having an index of refraction greater than the index of vitreous humor. The device may be such designed so that the focusing power of the lens can be changed by the deformation of the capsular bag, which may be subsequently controlled by a ciliary muscle.

Abstract: An optical component comprises a transparent network of cells juxtaposed and separated by walls parallel to a surface of the component, each cell being hermetically sealed and comprising at least one substance with an optical property, and all or part of the surface of said component comprises walls less than 100 nm thick. The optical component is thus pixelized by a cell network, the cells being separated by walls which may themselves be pixelized. Such an optical component is particularly useful for making optical elements such as ophthalmic lenses.

Abstract: An intraocular lens of novel structure exhibiting an excellent focus adjusting power. A hollow capsule structure is filled with a transparent liquid-like or gel-like filler (32). A front wall of the capsule structure is composed of a flexible lens front film (16), and a rear wall of the capsule structure is composed of an optical lens (18) having a diameter larger than that of the flexible lens front film (16). Under a state inserted into and attached to a capsula lentis, pressure variation of a corpus vitreum acts on the optical lens (18) to enable focal refraction power to be adjusted by utilizing swelling deformation of the lens front film (16).

Abstract: This invention relates to intraocular lenses. More particularly, this invention relates to intraocular lenses that have the ability to alter the light refractive power in response to changes in the tension of the ciliary muscle or ciliary body of the eye or any other accommodative forces. Lenses of this invention are generally referred to as interfacial, i.e., lens properties being defined as the interface of two liquids having different refractive indices, refractive accommodating lenses (IRAL).

Abstract: An intraocular lens (IOL) that provides for optical power adjustment following its implantation, for example, for use in treating cataract patients. The lens body has first and second surface portions that bound at least one interior chamber or space that extends from the central optic portion to the lens periphery. The interior chamber or space has a microporous body that is intermediate inner and outer portions of the space. In one embodiment, the microporous body is capable of cooperating with an external Rf or light source to expose a charge to a charge-carrying fluid within the interior chamber. By this system, fluid flows are induced to alter the optical parameters of the lens.

Abstract: An accommodating intraocular lens is provided in which a deflectable lens element is anchored to a substrate along its optical axis to define a fluid filled space. Fluid-filled haptics disposed in fluid communication with the space vary the fluid volume in the space responsive to forces applied by the ciliary muscles, thereby causing the periphery of the lens element to deflect relative to the substrate and changing the optical power of the intraocular lens.

Abstract: An accommodating intraocular lens (AIOL) including a biasing mechanism for elastically deforming an elastically deformable shape memory disk-like optical element for affording the AIOL a natural positive diopter strength for near vision. The AIOL is intended to be implanted in a human eye such that relaxation of its ciliary body causes its capsular diaphragm to apply an accommodation force for overcoming the biasing mechanism to reduce the AIOL's natural positive diopter strength for distance vision.

Abstract: A prosthesis is provided, which includes anterior and posterior lenses spaced from one another and aligned along an optical axis, and an optic body supporting the lenses in spaced relation to one another to establish a chamber between the lenses. Optically transmissive primary and secondary fluids are contained in the chamber. Orienting the optical axis in a horizontal orientation for far vision positions the optical axis through the primary fluid. Orienting the optical axis for near vision at a range of effective downward angles relative to the horizontal orientation positions the optical axis to extend through the primary fluid and the secondary fluid. The prosthesis may further include an internal plate between the lenses, which may be offset at an oblique angle relative to perpendicular to the optical axis. Related methods are also provided.

Abstract: An intraocular lens (IOL) that provides for optical power adjustment following its implantation, for example, for use in treating cataract patients. The lens body has first and second surface portions that bound at least one interior chamber or space that extends from the central optic portion to the lens periphery. The interior chamber or space has a microporous body that is intermediate inner and outer portions of the space. In one embodiment, the microporous body is capable of cooperating with an external Rf or light source to expose a charge to a charge-carrying fluid within the interior chamber. By this system, fluid flows are induced to alter the optical parameters of the lens.

Abstract: Blue light blocking chromophore (BLBC) ophthalmic devices are disclosed. In an embodiment, BLBC is relatively concentrated in the device center gradually decreasing to the device edge to create a BLBC gradient.

Abstract: Accommodating intraocular lenses and methods of use which account for changes to a capsular bag post-implantation as well as a mismatch is size between the accommodating intraocular lens and capsule.

Abstract: An accommodating intraocular lens system for implantation in a capsular bag of an eye includes an optic component comprising first and second light-transmitting lens elements that define a fluid-filled deformation chamber located between the first and second lens elements. The first and/or second lens elements have an elastic membrane adapted to deform in response to a change in pressure. The elastic membrane includes a first portion having a first deformation response and a second portion having a different second deformation response. The system also includes a refractive fluid filling the deformation chamber and at least one haptic member coupled to the optic component. The haptic member is configured for changing a hydrostatic pressure in the deformation chamber in response to muscle movement in the eye in order to deform the elastic membrane of the first and/or second lens elements, thereby changing the shape and the refractive characteristics of the optic component.