Abstract: The present disclosure concerns a curvature-changing, accommodative intraocular lens (IOL) for implantation in the capsular bag of a patient's eye. The IOL includes a fluid optic body having a cavity for containing an optical fluid, the cavity at least partially defined by a sidewall extending around the cavity and defining a diameter of the cavity and a deformable optical membrane intersecting the sidewall around a circumference of the sidewall and spanning the diameter of the cavity. The IOL further includes a second optic body spaced a distance apart from the fluid optic body and a plurality of struts extending from the sidewall and coupling the fluid optic body to the second optic body. The struts are configured such that axial compression of the capsular bag causes the struts to deform the sidewall in a manner that increases the diameter of the cavity, modifying a curvature of the deformable optical membrane.

Abstract: The invention concerns an implant that comprises an anterior part and a posterior part extending along a longitudinal axis and having respectively an anterior (A) and a posterior pole (E) both located on axis. The anterior and posterior parts extend each radially relative to axis, on either side thereof, the anterior and posterior parts having each two portions located on both sides of axis respectively when viewed in a sagittal plane. Each portion of the anterior part has a radial extension that increases from anterior pole (A) to a point (B, B?) where the anterior part ends and the posterior part begins, each portion of the posterior part having a radial extension decreasing from point (B, B?) to the posterior pole (E). The outer outline of each portion of the anterior part forms a curve having a radius of curvature that is greater at anterior pole (A) than at point (B, B?).

Abstract: A method for optical sensing includes providing a mirror comprising a central reflective region surrounded by a peripheral glare-suppressing region. A beam of light from a laser light source is directed to reflect from the central region so as to pass through an output optic along an axis toward a target scene. The light returned from the target scene through the output optic is focused onto an optical sensor, via collection optics having a collection aperture surrounding the mirror.

Abstract: This disclosure provides ophthalmic implants such as sulcus implants which can comprise one or more drug delivery devices. Further provided herein are methods of using the drug delivery ophthalmic devices described herein for implantation into a subject's eye, e.g., into an eye's ciliary sulcus or capsular bag.

Abstract: An intraocular lens (IOL) configured to support a first optic for functioning as a single lens IOL and configured to support a second optic for functioning as a dual optic IOL. The base includes a first optic for providing a base power. A recess in an anterior rim of the base is configured for positioning a radial extension of a second optic. The geometry of the recess is configured to securely couple to the radial extension to prevent rotation of the second optic relative to the base and prevent tilting of the second optic relative to an optic axis.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: A method improves depth of focus in a first eye only by adding a higher order aberration (HOA) to the first eye by adding a monofocal optical device to the first eye. The method may also correct a spherical aberration in a second eye by inserting a monofocal aspheric IOL. The HOA added to the first eye may be selected from the group consisting of spherical, trefoil and coma. Additionally, the monofocal optical device inserted into the first eye may comprise a monofocal aspheric IOL that adds spherical aberration to the first eye. The optical device inserted into the first eye may comprise a 20 D monofocal aspheric IOL that adds 0.4 ?m of spherical aberration to the first eye at 6 mm entrance pupil and adds 0.1 ?m of spherical aberration to the first eye at 4 mm entrance pupil.

Abstract: An ophthalmic device comprises an ultrasonic transducer, an accommodation actuator, and a controller. When the ophthalmic device is mounted in or on an eye of a user, the ultrasonic transducer is positioned to direct ultrasonic signals towards ciliary processes in the eye and the accommodation actuator is positioned to focus light entering the eye. The controller is coupled to the ultrasonic transducer and the accommodation actuator. The controller includes logic that when executed by the controller causes the ophthalmic device to perform operations including emitting the ultrasonic signals from the ultrasonic transducer towards the ciliary processes, receiving reflected ultrasonic signals from the ciliary processes with the ultrasonic transducer, calculating a time of flight between emitting the ultrasonic signals and receiving the reflected ultrasonic signals, and adjusting an optical power of the accommodation actuator based on the time of flight.

Abstract: An intraocular lens system comprising a single lens comprising two optical surfaces selected to maintain image quality at the foveal centre whilst reducing image aberration at preferred retinal locus locations outside of the fovea region.

Abstract: A virtual aperture integrated into an intraocular lens is disclosed. Optical rays which intersect the virtual aperture are widely scattered across the retina causing the light to be virtually prevented from reaching detectable levels on the retina. The use of the virtual aperture helps remove monochromatic and chromatic aberrations yielding high-definition retinal images. For a given definition of acceptable vision, the depth of field is increased over a larger diameter optical zone. In addition, thinner intraocular lenses can be produced since the optical zone can have a smaller diameter. This in turn allows smaller corneal incisions and easier implantation surgery.

Abstract: A system includes a controller with at least one processor and at least one non-transitory, tangible memory on which instructions are recorded for executing a method for obtaining a profile of a lens capsule of an eye. The profile is represented by respective central surfaces and respective equatorial surfaces separated at respective transition points. The controller is configured to obtain imaging data for a portion of the lens capsule visible through a pupil of the eye. The imaging data is transformed to an adjusted frame of reference and fitted to the respective central surfaces in a predefined central region of the lens capsule. The profile is obtained based on a set of fitting parameters for the respective central and equatorial surfaces. The respective central surfaces and respective equatorial surfaces may be represented as elliptical cones and skewed parabolas, respectively.

Abstract: An intraocular optic assembly can include a first lens, a first plurality of stanchions, a second lens, and a second plurality of stanchions. A central optic axis can extend through centers of the first and second lenses. The first plurality of stanchions can each extend a first distance between a first base end and a first distal end. The first lens can be connected with the first distal ends. The second plurality of stanchions can each extend a second distance between a second base end and a second distal end. The second lens can be connected with the second distal ends. Compression at the peripheries of the stanchions induces movement of the lenses apart from one other.

Abstract: An intraocular lens, wherein an outer periphery of an optic portion has a peripheral surface, and a radially inner portion of a peripheral portion of the IOL has an inner surface, wherein the peripheral surface is directly adjacent to the inner surface, and wherein the peripheral surface does not directly extend (coupled to or integrally formed therewith) from the inner surface, and wherein the peripheral surface and the inner surface are configured so that the peripheral portion is stabilized in at least one of, and optionally both of, the proximal and distal directions relative to the optic portion.

Abstract: An ophthalmic implant configured for peri-operative, intra-operative, or post-operative assembly and disassembly. Drug delivery devices may be implanted with an intraocular lens, and later removed and replaced with new drug delivery devices.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with one or more folds of the bellows extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between the inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes when the eye accommodates.

Abstract: An ophthalmic assembly for implantation in an anterior chamber of an eye of a patient to provide accommodation of the vision to said patient comprises a variable-focus lens and an actuator for modifying the focal length of the variable-focus lens. The ophthalmic assembly comprises an autofocus system configured to determine a distance parameter of an object that the patient's eye is looking at; a signal processing unit arranged to convert said distance parameter into a focal length value of the variable-focus lens; and an actuator control unit configured to control the actuator as a function of the focal length value received from said signal processing unit. A method for accommodating the vision of a patient using an opthamalic assembly is also disclosed.

Abstract: An accommodative intraocular lens capable of effectively exerting a focus adjustment function includes an optical portion and a plurality of support portions arranged around the optical portion. The support portion includes an anterior support portion and a posterior support portion, and the anterior support portion presses an anterior capsule and the posterior support portion presses a posterior capsule by the elastic force of the support portion. When the lens capsule is in a distance vision state or in a near vision state, as the pressing force of the anterior capsule against the anterior support portion increases or decreases, the anterior support portion deflects backward or returns forward while maintaining the radial position of the base end portion, so that the tip end portion of the anterior support portion moves backward or forward greatly while maintaining the radial position, and the optical portion moves backward or forward accordingly.

Abstract: An intraocular lens (IOL) for implantation within a capsular bag of a patient's eye comprises an optical structure and a haptic structure. The optical structure comprises a planar member, a plano convex member, and a fluid optical element defined between the planar member and the plano convex member. The fluid optical element has an optical power. The haptic structure couples the planar member and the plano convex member together at a peripheral portion of the optical structure. The haptic structure comprises a fluid reservoir in fluid communication with the fluid optical element and a peripheral structure for interfacing to the lens capsule. Shape changes of the lens capsule cause one or more of volume or shape changes to the fluid optical element in correspondence to deformations in the planar member to modify the optical power of the fluid optical element.

Abstract: A two-part accommodating intraocular lens (IOL) device for implantation in a capsular bag of a patient's eye. The IOL device includes a primary lens assembly and a power changing lens. The primary lens assembly includes a fixed lens and a peripherally disposed centration member. The centration member has a circumferential distal edge and a first coupling surface adjacent the circumferential distal edge. The power changing lens has an enclosed, fluid- or gel-filled lens cavity and haptic system disposed peripherally of the lens cavity. The haptic system has a peripheral engaging edge configured to contact the capsular bag and a second coupling surface. The first and second coupling surfaces are in sliding contact with one another to permit movement of the power changing lens relative to the primary lens assembly and also to maintain a spaced relationship between the fixed lens and the lens cavity during radial compression of the power changing lens.

Abstract: An intraocular lens (IOL) having an optical axis extending in an anterior-posterior direction and an equator extending in a plane substantially perpendicular to the optical axis is described. The IOL includes: an elastic anterior face located anterior to the equator; a posterior face located posterior to the equator, wherein the anterior face, the posterior face, or both comprises a poly(dimethylsiloxane) elastomer having a durometer between about 20 Shore A to about 50 Shore A; and a chamber located between the anterior face and the posterior face comprising a silicone oil comprising polysiloxanes comprising diphenyl siloxane and dimethyl siloxane units, the silicone oil having a maximum viscosity of about 800 cSt at 25° C.

Abstract: An accommodating intraocular lens implant includes an anterior floating lens unit, a posterior lens unit, an anterior rim complex disposed such that the anterior floating lens unit is movable toward and away from the anterior rim complex. A plurality of levers are in jointed connection with: the anterior floating lens unit at respective first longitudinal sites along the levers, the anterior rim complex at respective second longitudinal sites along the levers, and the posterior lens unit at respective third longitudinal sites along the levers. The respective second longitudinal sites are longitudinally between the respective first and the respective third longitudinal sites. The levers are arranged (a) such that the third longitudinal sites serve as respective fulcrums for the plurality of levers, and (b) to move the anterior floating lens unit toward and away from the anterior rim complex, in the anterior-posterior direction. Other embodiments are also described.

Abstract: An intraocular lens system comprising a single lens comprising two optical surfaces selected to maintain image quality at the foveal centre whilst reducing image aberration at preferred retinal locus locations outside of the fovea region.

Abstract: The invention provides an improved rotationally stabilized contact lens design and method of designing such a lens which minimizes stabilization time of the lens while maximizing the lens on-eye comfort. The lens and the method of designing the lens further improves upon an earlier method which utilizes and combines non-circularity and thickness differential aspects which results in equivalent or minimized stabilization time, ease of insertion and manufacturability as well as maximum comfort that is improved over that of what either aspect can achieve independently. This further improvement of stiffness profile is achieved by optimizing and selectively addressing thickness differential both diametrically and circumferentially in a non-round lens design.

Abstract: An ophthalmic device includes an optic including an optic axis and a periphery and a closed-loop ring haptic structure coupled with the optic. The closed loop haptic structure includes a first ring structure having a first characteristic length, a second ring structure having a second characteristic length, and a plurality of connectors coupling the first ring structure and the second ring structure. The first ring structure is positioned adjacent to the periphery of the optic and is coupled to the entire periphery of the optic, and the first characteristic length is less than the second characteristic length.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: Antennas and antenna systems may be designed and configured for incorporation into mechanical devices, including medical devices, such as ophthalmic devices, including contact lenses. These antennas and antenna systems may be utilized to transmit data from the mechanical device to a receiver, to receive data from a transmitter, and/or to inductively charge an electromechanical cell or the like incorporated into the mechanical device.

Abstract: An accommodating intraocular lens (IOL) device adapted for implantation in the lens capsule of a subject's eye. The IOL device includes an anterior refractive optical element and a membrane coupled to the refractive optical element. The anterior refractive optical element and the membrane define an enclosed cavity configured to contain a fluid. At least a portion of the membrane is configured to contact a posterior area of the lens capsule adjoining the vitreous body of the subject's eye. The fluid contained in the enclosed cavity exerts a deforming or displacing force on the anterior refractive optical element in response to an anterior force exerted on the membrane by the vitreous body. The IOL device may further include a haptic system to position the anterior refractive optical element and also to engage the zonules and ciliary muscles to provide additional means for accommodation.

Abstract: An intraocular lens includes an annular housing coupled to a first window to form a lensing cavity. Disposed within the lensing cavity is two immiscible liquids, including a first liquid and a second liquid which form a meniscus at an immiscibility interface between the first liquid and the second liquid within the lensing cavity. The intraocular lens includes a flexible reservoir to store a variable portion of the first liquid. The flexible reservoir is disposed about at least a portion of a periphery of the annular housing. The intraocular lens also includes at least one channel linking the flexible reservoir to the lensing cavity to permit a transfer of the first liquid between the flexible reservoir and the lensing cavity. The transfer of the first liquid changes a curvature of the meniscus to adjust optical power of the intraocular lens.

Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, via a device implanted in a mammal, sensing a ciliary muscle movement and/or force and/or converting the ciliary muscle movement and/or force to a signal and/or a predetermined form of power.

Abstract: A method and system provide an ophthalmic device including an optic and a haptic. The optic includes at least one optical material having a first Young's modulus. The haptic is coupled with the optic. The haptic includes at least a second Young's modulus greater than the first Young's modulus and less than 1.8 GPa. Thus, the haptic is stiffer than the optic, but more flexible than a material such as polymethyl metacrylate (PMMA).

Abstract: An accommodating intraocular lens implant is provided that includes (a) a bowl-shaped posterior component and (b) an anterior component, which includes an anterior floating lens unit, which includes an anterior lens; a circumferential rim; and levers, which connect the anterior floating lens unit to the circumferential rim, such that the anterior floating lens unit is movable toward and away from the circumferential ring in an anterior-posterior direction. The bowl-shaped posterior component and the anterior component are distinct from each other and not permanently fixed to each other, and are shaped so as to be assemblable together in situ in a human eye such that the circumferential rim contacts an interface region of an inner surface of the bowl-shaped posterior component, and the levers are pivotable about the interface region during motion of the anterior floating lens unit toward and away from the circumferential ring in the anterior-posterior direction.

Abstract: A reprogrammable intraocular adaptive lens prosthesis apparatus is provided. The apparatus includes a tunable liquid crystal lens (TLCL) encapsulated in the intraocular prosthesis with control electronics and a power source or in the intraocular prosthesis with a control signal receiver while an external control electronics package transmits the control signal. The TLCL is driven in response to a stimulus signal to provide accommodation. The TLCL corrects other visual shortcomings of the natural eye. The intraocular prosthesis has a remote programmable TLCL controller configured to recalibrate the TLCL to compensate for dynamic adaptation of the eye over time.

Abstract: An accommodative hydraulic intraocular lens system (AHIOL) has a cylindrical actuator contained within which is a hydraulic lens assembly. The hydraulic lens assembly has a transparent elastically reconfigurable membrane coupled to a fixed focus lens by a bellows and a refractive hydraulic fluid contained in the space defined by the membrane, the bellows and the lens, and is maintained at the upper range of its diopter power by the elastic properties of the bellows, springs, or both.

Abstract: An accommodating intraocular lens implant is provided that includes a bowl-shaped posterior lens unit, which comprises a posterior lens, and has an inner surface; an anterior floating lens unit, which comprises an anterior lens; and a plurality of levers, which (a) are in jointed connection with the anterior floating lens unit and the posterior lens unit, and (b) are arranged to move the anterior floating lens unit toward and away from the posterior lens unit, in an anterior-posterior direction. The lens implant is shaped such that the inner surface limits posterior motion of the anterior floating lens unit.

Abstract: Devices, systems, and methods for treating and/or determining appropriate prescriptions for one or both eyes of a patient are particularly well-suited for addressing presbyopia, often in combination with concurrent treatments of other vision defects. High-order spherical aberration may be imposed in one or both of a patient's eyes, often as a controlled amount of negative spherical aberration extending across a pupil. A desired presbyopia-mitigating quantity of high-order spherical aberration may be defined by one or more spherical Zernike coefficients, which may be combined with Zernike coefficients generated from a wavefront aberrometer. The resulting prescription can be imposed using refractive surgical techniques such as laser eye surgery, using intraocular lenses and other implanted structures, using contact lenses, using temporary or permanent corneal reshaping techniques, and/or the like.

Abstract: A two-part accommodating intraocular lens (IOL) device for implantation in a capsular bag of a patient's eye. The IOL device includes a primary lens assembly and a power changing lens. The primary lens assembly includes a fixed lens and a peripherally disposed centration member. The centration member has a circumferential distal edge and a first coupling surface adjacent the circumferential distal edge. The power changing lens has an enclosed, fluid- or gel-filled lens cavity and haptic system disposed peripherally of the lens cavity. The haptic system has a peripheral engaging edge configured to contact the capsular bag and a second coupling surface. The first and second coupling surfaces are in sliding contact with one another to permit movement of the power changing lens relative to the primary lens assembly and also to maintain a spaced relationship between the fixed lens and the lens cavity during radial compression of the power changing lens.

Abstract: An accommodating intraocular lens for providing a range of accommodative vision contains an optic and a haptic. The optic is disposed about an optical axis and includes an anterior surface and a posterior surface defining a clear aperture of the optic. The haptic is at least partially disposed inside the optic and includes an inner structure, an outer structure, and a plurality of arms disposed between and connecting the inner structure and the outer structure. The inner structure is circumferentially disposed about the optical axis, while the outer structure is circumferentially disposed about the inner structure and has an outer face. Each arm has proximal portion adjacent the inner structure and a distal portion adjacent the outer structure that is bifurcated in a radial direction from the proximal portion. The intraocular lens also has an outer surface defined by outer surfaces of the plurality of arms and an outer surface of the outer structure.

Abstract: A haptic for fixation to, and manufacture in conjunction with, an intraocular lens to be implanted in the natural lens capsule of the human eye is disclosed. The haptic secures the lens in an appropriate position within the natural capsule so as to provide optimal visual acuity through the aphakic lens. The haptic is designed to position the lens neutrally, anteriorly or posteriorly within the lens envelope. The haptic has an anterior retention ring and a posterior retention ring.

Abstract: A haptic supporting an intraocular lens (IOL) in the eye permits radial tension from ciliary muscle relaxation rather than contraction to alter the lens power. The IOL is supported by the overlying tissue in the eye such as iris root, sclera and ciliary process, so that anterior and posterior forces on IOL are balanced, and buckling or displacement of lens in the eye or haptic is reduced or prevented. The haptic is of a thickness so as to increase stiffness and to reduce or prevent IOL buckling or displacement.

Abstract: Accommodating intraocular lenses containing a flowable media and their methods of accommodation.

Abstract: Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include a deformable inner portion and a deformable peripheral portion. When disposed over the optical region of an eye, the inner portion is configured so that engagement of the posterior surface against the eye deforms the posterior surface so that the posterior surface has a shape diverging form the refractive shape of the epithelium when viewing with the eye through the ophthalmic lens. The rigidity of the inner portion is greater than the rigidity of the peripheral portion and the ophthalmic lenses are configured to allow movement relative to the eye upon blinking of the eye and to be substantially centered on the optical region of the cornea following the blinking of the eye. Methods of correcting refractive errors of an eye such as astigmatism or spherical aberration using the ophthalmic lenses are also disclosed.

Abstract: A Double Accommodating Intraocular Lens (DAIOL), which not only axially moves its flexible optic to accommodate, but also peripherally compresses or decompresses the optic to change its convexity or power, thus, double accommodating simultaneously upon contraction or expansion of the ciliary muscles and subsequently the lens capsule. The DAIOL includes a deployable semi-rigid or elastic haptic assembly and a flexible single optic. The DAIOL is further composed of three or four ring haptics and three or four deployable resilient lazy tongs, attached to a single elastically flexible plate encompassing a flexible optic. Accordingly, the radial compression of the capsular bag by the contraction of the ciliary muscles axially moves and radially compresses the flexible optic in the lens and vice versa upon radial expansion of the capsular bag, backward axial movement, and decompression of the optic, due to the resilient lazy tongs action, for double accommodation.

Abstract: A novel lens for variable focus has two optical elements which simultaneously move in a lateral and an axial direction. The lens also includes variable corrective optics to correct for undesired variable optical aberrations. The lens can be used as an accommodating lens for implantation in the capsular bag. The lens can be driven by either the surfaces of the capsular bag as well as the rim of the capsular bag.

Abstract: A prosthetic capsular device configured to be inserted in an eye includes a housing structure and a ring structure. The housing structure includes a first side, a second side opposite the first side, a third side, a fourth side opposite the third side, a posterior side including a refractive surface, an anterior side opposite the posterior side, and a longitudinal axis. The first side, the second side, the third side, the fourth side, the posterior side, and the anterior side at least partially define a cavity configured to contain an intraocular device (e.g., an IOL). The anterior side includes an opening. The ring structure includes a ring structure portion extending radially outward from proximate one of an end of the first side and an end of the second side.

Abstract: An implantable intraocular lens and methods of manufacturing them provide a target degree of optical accommodation. In various embodiments, the lens includes at least one internal optic, an outer shell for enclosing at least a portion of the internal optic, and a fluid at least partially filling the outer shell.

Abstract: Disclosed herein is an implantable capsule expander device for insertion within a lens capsule of an eye of a patient. The device comprises an arcuate center portion including first and second rims and having a first height, an outermost peripheral portion including a second height that is less than the first height, and a receiving portion formed between the first and second rims. The center portion and the outermost peripheral portion are configured to stabilize the capsule expander device within the lens capsule and to expand the lens capsule. The receiving portion is sized to receive an artificial intraocular lens.

Abstract: A polymeric material with a molecular response time that makes it suitable for use near fragile body tissues. The polymeric material is useful for both low modulus and high modulus applications thereby simplifying the multi-part polymeric article manufacturing process and creating better integrated multi-part polymeric articles. Cross-linked polymers with different moduli may be obtained utilizing the same or similar starting materials but modifying the amount of catalyst, the amount of cross-linking agent, and/or the amount of methyl vinyl cyclics.

Abstract: An accommodating intraocular lens comprising a lens optic coupled to at least one haptic and a torsion bar positioned between the lens optic and the at least one haptic such that the torsion bar facilitates accommodation by deforming in response to a vitreous pressure change.

Abstract: An intraocular lens comprising a lens optic coupled to at least one haptic and at least one deformable connecting bar positioned between the lens optic and the at least one haptic.

Abstract: An intraocular lens designed to separate and prevent fibrosis of the anterior capsular rim with the posterior capsule where it surrounds the optic.