Abstract: A multifocal IOL including at least one diffractive surface including a plurality of discrete, adjacent, diffractive, concentric rings, having a radial phase profile cross-section with a near-symmetrical diffractive surface topography, and an odd number, greater than three, of diffractive orders and an asymmetrical distribution of energy flux over the diffractive orders.

Abstract: The present invention refers to an intraocular lens provided with specific diffractive profile, in which each step height is individually defined, with no fixed pattern. The intraocular lens provides a better control of the luminous efficiency of each focal point, guaranteeing more flexibility and customization, being adaptable to the optical quality that the patient needs.

Abstract: An example reinforcement ring for intraocular lenses may include at least include a support structure, first and second optical windows disposed on opposing sides of the support structure, and a reinforcement ring included in the apparatus to strengthen the support structure and the first and second optical windows. In some examples, the reinforcement ring is formed from a shape memory alloy, such as Nitinol.

Abstract: A multifocal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffractive orders corresponding a range of vision between near and distance vision. The constructive interference produces a near focus, a distance focus corresponding to the base power of the ophthalmic lens, and an intermediate focus between the near focus and the distance focus.

Abstract: A multifocal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffractive orders corresponding a range of vision between near and distance vision. The constructive interference produces a near focus, a distance focus corresponding to the base power of the ophthalmic lens, and an intermediate focus between the near focus and the distance focus. A diffraction efficiency of at least one of the diffractive orders is suppressed to less than ten percent.

Abstract: An intraocular lens includes a lens capsule expanding device and an optical portion. The lens capsule expanding device includes a front supporting portion to make contact with an inner surface of an anterior capsule. A rear supporting portion provided on a rear side of the front supporting portion makes contact with an inner surface of a posterior capsule while facing the front supporting portion. A connecting portion connects the front supporting portion and the rear supporting portion so as to have biasing force in a direction of separating the front supporting portion and the rear supporting portion from each other. Due to the biasing force, the front supporting portion presses the inner surface of the anterior capsule and the rear supporting portion presses the inner surface of the posterior capsule. The optical portion changes the curvature of a central portion according to movement of the connecting portion.

Abstract: A foldable intraocular lens for providing vision contains an optic body that includes an optical zone and a peripheral zone entirely surrounding the optical zone. The optic body has an anterior face, a substantially opposing posterior face, an optic edge, and an optical axis. The anterior face comprises a central face, a peripheral face, and a recessed annular face therebetween that is disposed posterior to the peripheral face. The intraocular lens further comprises at least one haptic that is integrally formed with the peripheral zone. The haptic comprises a distal posterior face, a proximal posterior face, and a step edge disposed at a boundary therebetween. The haptic further comprises a side edge disposed between the optic edge and the step edge. The proximal posterior face and the posterior face of the optic body form a continuous surface. An edge corner is formed by the intersection of the continuous surface with the optic edge, the side edge, and the step edge.

Abstract: An intraocular lens delivery system has an injector body, a plunger, a nozzle portion, and a heater. The plunger is slidably movable within the injector body. The nozzle portion is located on a distal end of the injector body and has a hollow interior adapted for receiving the intraocular lens. The heater is integrated with the intraocular lens delivery system and is adapted to heat the intraocular lens.

Abstract: The present specification discloses Ranpirnase and Amphinase, compositions comprising Ranpirnase and/or Amphinase, and methods and uses to treat a viral conjunctivitis, an epidemic keratoconjunctivitis, and/or a pharyngoconjunctival fever, reduce or suppress a level of virus or viral titer, reduce or suppress viral replication, reduce or suppress protein synthesis, reduce or suppress a level of a tRNA, reduce or suppress a level of an inflammation inducing molecule and/or an inflammation inducing prostaglandin, stimulate or enhance a peroxisome proliferator-activated receptor (PPAR) pathway signal, promote the resolving phenotypic change of M1 to M2, modulate Th1 and Th2 cytokines, and/or reduce or suppress a NF?B pathway signal using Ranpirnase, Amphinase or compositions comprising Ranpirnase and/or Amphinase.

Abstract: A prosthetic capsular device configured to be inserted in an eye includes a housing structure and a ring structure. The housing structure includes a first side, a second side opposite the first side, a third side, a fourth side opposite the third side, a posterior side including a refractive surface, an anterior side opposite the posterior side, and a longitudinal axis. The first side, the second side, the third side, the fourth side, the posterior side, and the anterior side at least partially define a cavity configured to contain an intraocular device (e.g., an IOL). The anterior side includes an opening. The ring structure includes a ring structure portion extending radially outward from proximate one of an end of the first side and an end of the second side.

Abstract: A description has been provided herein of an intrastromal segment especially designed for use as a prosthesis inside the corneal tunnel of patients suffering from keratoconus. The segment consists of a lengthened body of variable dimensions in the form of an arc with noticeably rounded ends, devoid of any communicating orifice, and endowed with a transverse section that may be triangular, trapezoidal, hexagonal or oval, with at least three marks connecting to the narrowest side for which two ends aid the safe handling of the segment and the mid-section mark serves as a positional reference point. The segment will be connected to a disposable guide track along which it moves and from which it is pushed into the implantation position.

Abstract: An intraocular lens is disclosed with an optic that changes shape in response to forces exerted by the zonules of the eye. A haptic with an inner and outer ring couples the optic to the capsular bag of the eye. The haptic stresses the optic when the intraocular lens is in a natural state such that the internal stress is present throughout the accommodation range in order to prevent ripples and/or waves in the optic.

Abstract: An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.

Abstract: An ophthalmic lens for providing enhanced vision includes a finished optic comprising a base optic and a membrane. The base optic has an anterior surface and an opposing posterior surface, at least one of the surfaces having a first value of a surface quality parameter. The base optic also includes a membrane including an inner surface and an outer surface, the inner surface covering one or more of the surfaces of the base optic. The outer surface has a second value of the surface quality parameter, wherein the second value is greater than the first value.

Abstract: Accommodative intraocular lens comprising an optic part (1), which in turn comprises at least one incurving notch (3) and a peripheral edge of the optic (2); a haptic part (8), which in turn comprises at least one central branch (9), one lateral branch (10) and one angular branch of the haptic (11); an incomplete incurving ring (6) that in turn comprises at least one angled branch of the ring (17); an incurving tab (5); and means for sliding and/or stopping and/or amplifying the moving parts. The new accommodative intraocular lens accommodates in near vision by a posteroanterior displacement of the optic, changes in its curvature and changes in its thickness. The design of the incomplete incurving ring allows keeping the capsular bag open and tense to allow a greater displacement of the optic, and the incurving tabs (5) provide a greater accommodation power by curving the optic and increasing its thickness.

Abstract: The present invention relates to a prosthetic capsular bag and method for inserting the same. The prosthetic capsular bag helps to maintain the volume of the natural capsular bag, thereby stabilizing the effective lens position of an IOL so that refractive outcomes may be improved with cataract surgery. The prosthetic capsular bag further provides an integrated refractive surface, providing a means for experimentally determining an effective lens position prior to inserting an IOL.

Abstract: Disclosed is an intraocular lens supporter having a control ability. One embodiment of the present invention provides an intraocular lens supporter that is inserted into a capsular sac, including a first face coming in contact with an inner surface of the capsular sac in at least one point as a structural body that is extended along an equatorial region of the capsular sac; and a second face arranged opposite to the first face, wherein, in a section where the structural body is cut along a virtual plane in a visual axis direction (Y direction) of an eye lens, the first face is provided at a length as much as ¾ to 3 times of a length (d5, d10) of a region where an zonule of Zinn is coupled to an outer surface of the capsular sac.

Abstract: An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

Abstract: An intraocular lens having a light-transmitting optic (32, 94a, 94b, 142, 216) comprised of a synthetic light-refractive material (40, 102) operably coupled with a flexible optic positioning member (34, 62, 74, 84, 100, 210) to refract light onto the retina in order to correct refractive errors in the eye (10). The refractive material has an index of refraction of from about 1.36 to 1.5 or higher. The optic positioning member (34, 62, 74, 84, 100, 210) is constructed of a flexible synthetic resin material such as polymethylmethacrylate and permits focusing upon objects located near to and far from the viewer. The optic (32, 94a, 94b, 142, 216) of the present invention possess greater refractive capability than optics conventionally used in IOL construction, and permits retinal receipt of the image being viewed in order to correct refractive errors.

Abstract: The invention provides for an inflatable intra ocular lens/lens retainer or a system of inflatable intra ocular lens/lens retainers, which are fitted into an aphakic eye, to substantially occupy the space previously held by the crystalline lens to retain and secure the position of delicate intra ocular structures of the eye. The inflatable lens/lens retainer may also be used suspend optical interfaces along the visual axis of the eye. The inflatable intra ocular lens/lens retainer may be pressed against residual elements of the lens capsule to re-establish accommodation. In the absence of a lens capsule, the inflatable intra ocular lens/lens retainer may be compressed directly by the ciliary muscle to alter the refractive state of the eye.

Abstract: A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.

Abstract: An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

Abstract: The embodiments herein provide a pupil centered and fovea focused optics assembly comprising a ring platform provided inside a capsular bag of a mammalian eye to support an intraocular lens. The optical center of the intraocular lens is decentered with respect to the geometric center of the intraocular lens to align the optical centre of the lens with a visual axis of a pupil of the mammalian eye to improve the visual quality and to prevent an aberration. A plane of the intraocular lens is turned and tilted through a preset angle to point an optic axis of the intraocular lens to the Fovea.

Abstract: The present invention provides copolymers made up of alkoxyalkyl methacrylate and/or alkoxyalkyl acrylate monomers in combination with one or more additional hydrophobic monomers. The copolymers may be used in the manufacture of intraocular lenses, including both the optic and haptic portions of the lenses. The present invention also provide methods for making intraocular lenses from the copolymers.

Abstract: An intraocular lens for insertion into the capsular bag of an eye contains an optic, an outer periphery, and an outer support structure. The optic has a periphery and centered about an optical axis. The outer periphery is disposed about the optic and configured to engage an equatorial region of the capsular bag of an eye. The outer support structure is disposed along the periphery and spaced from the optic with voids outer support structure and the optic. The intraocular lens further comprises a first intermediate member and a weakened region disposed along the outer periphery between the outer support structure and the first intermediate member. The first intermediate member operably couples the optic and the outer support structure. The weakened region is attached to, and configured to provide relative motion between, the outer support structure and the first intermediate member in response to the ciliary muscle of the eye.

Abstract: A haptic is provided for use in an accommodating intraocular lens. The haptic has multiple filaments, each connected to the edge of the optic at one end. Each filament has a shape that conforms to an equatorial region of the capsular bag. The haptic couples the forces exerted by the capsular bag of the eye during accommodation radially to the edge of the optic, produce a diametric expansion or compression of the optic. This diametric motion distorts the optic, producing a change in any or all of the anterior radius, the posterior radius, and the thickness. These changes affect the power of the lens and/or location of the image. The haptic may optionally have a thin membrane joining the filaments at the optic end, and may optionally have a connecting ring that joins the filaments at the end opposite that of the optic.

Abstract: An intraocular lens for providing accommodative vision to a subject includes a frame disposed about an optical axis, a first optical element, a second optical element, and a connecting element operably coupling the frame to the optical elements. The frame comprises an anterior frame element and a posterior frame element. The connecting element is configured to convert a first displacement between the frame elements in a direction that is substantially parallel to the optical axis into a second displacement between the optical elements that is substantially perpendicular to the optical axis. The second displacement may be translational and/or rotation. In some embodiments, the optical elements are two varifocal lenses.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and hinged portions longitudinally connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and a weakened portion connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: An injectable intraocular implant including an optics portion and a resilient, flexible haptics portion mounted coaxially with the optics portion and a method for inserting the implant into the eye.

Abstract: There is provided a soft intraocular lens, comprising: an optical lens section 10 made of a foldable soft material; and a support arm section 20 formed so as to protrude outward from an outer peripheral edge of the optical lens section 10 for holding the optical lens section 10 in an eye, wherein a tip end part 22 of the support arm section 20 is made of a different kind of material which is harder than a soft material of other portion of the soft intraocular lens 1, and adhesiveness of the tip end part 22 of the support arm section 20 is set to be lower than the adhesiveness of other portion of the soft intraocular lens 1.

Abstract: The present invention discloses a multi-component intraocular lens implanted in an optical system of a human eye, including one or more foldable removable components, each component being foldable. One component acts as a base lens, including a flange with a slot. Another component acts is an optical assembly that may include a top lens joined to or integrated with a mid lens. The top lens, the mid lens or the optical assembly may include at least one projection that engages the slot of the base lens. The top and mid lenses are manufactured from a material having adhesive properties, wherein the top and mid lenses adhere to each other free of any material or substance being present therebetween.

Abstract: A method of manufacturing an aphakic intraocular lens that is capable of ensuring every multi-focusing effect more securely, while reducing the impact of aperture changes and lens eccentricity. At least two reliefs whose first order diffracted lights give respective focal distances different from one another are set to overlap with each other in at least a part of an area in a radial direction of the lens, and with respect to every grating pitches of one relief having a maximum grating pitch among the reliefs set up in overlap, grating pitches of another relief are overlapped periodically in order to obtain a relief pattern, so that the resulting relief pattern is formed on a lens surface.

Abstract: The present invention provides copolymers made up of alkoxyalkyl methacrylate and/or alkoxyalkyl acrylate monomers in combination with one or more additional hydrophobic monomers. The copolymers may be used in the manufacture of intraocular lenses, including both the optic and haptic portions of the lenses. The present invention also provide methods for making intraocular lenses from the copolymers.

Abstract: A method of anchoring an accommodating intraocular lens assembly in the posterior chamber of an eye includes the steps of, (1) introducing the first haptic portion, which includes a first anchor portion projecting therefrom, into the posterior chamber of the eye until the first anchor portion is anchored in the scleral wall at a desired location; and (2) moving the second haptic portion, which comprises a second anchor portion projecting therefrom, until the second anchor portion is anchored in the scleral wall on the opposite side of the lens from the first anchor portion and the lens structure is in contact with the collapsed natural lens, whereby the collapsed natural lens capsule will be prestressed and deform the lens body relative to and substantially independently of the haptics element in relation to the force the capsular unit applies directly or indirectly to the lens body along the optical axis.

Abstract: The present invention is generally directed to accommodative intraocular lenses (IOLs) that exhibit a dynamic spherical aberration as a function of accommodative power. By way of example, in one aspect, the present invention provides an intraocular lens (IOL) having an anterior optical element, a posterior optical element, and a mechanism for coupling the anterior and posterior elements so as to allow axial movement of those elements relative to one another for providing accommodation when the lens is implanted in a patient's eye. Each of the anterior and the posterior elements includes at least one aspherical surface, where the asphericities of the surfaces are adapted to provide a combined spherical aberration that varies with accommodation.

Abstract: An intraocular clip including first and second hook members extending generally coplanarly in opposite directions from a spine, the spine being formed with an attachment member attachable to ocular structure.

Abstract: Several methods for preventing, minimizing, or delaying the incidence of posterior capsule opacification are provided. A first method involves chemically activating the surface of an implantable ocular device, such as an intraocular lens or a capsular tension ring, by grafting a chemical moiety onto the surface of the device, covalently attaching a non-cytotoxic inhibitor compound to the chemical moiety to produce an inhibitor implantable ocular device, and implanting this inhibitor implantable ocular device into the capsular bag of an eye of a patient during extracapsular cataract surgery. Appropriate inhibitor compounds include RGD mimetics, RGD peptides, and flavonoids. A second method involves surface modifying the exterior surface of a capsular tension ring by covalently attaching a mitotic inhibitor, preferably a conjugate of methotrexate and a bovine serum albumin, and implanting this inhibitor tension ring into the capsular bag of an eye of a patient during extracapsular cataract surgery.

Abstract: An intraocular lens having a light-transmitting optic (32, 94a, 94b, 142, 216) comprised of a synthetic light-refractive material (40, 102) operably coupled with a flexible optic positioning member (34, 62, 74, 84, 100, 210) to refract light onto the retina in order to correct refractive errors in the eye (10). The refractive material has an index of refraction of from about 1.36 to 1.5 or higher. The optic positioning member (34, 62, 74, 84, 100, 210) is constructed of a flexible synthetic resin material such as polymethylmethacrylate and permits focusing upon objects located near to and far from the viewer. The optic (32, 94a, 94b, 142, 216) of the present invention possess greater refractive capability than optics conventionally used in IOL construction, and permits retinal receipt of the image being viewed in order to correct refractive errors.

Abstract: An intraocular lens for providing accommodative vision to a subject includes a frame disposed about an optical axis, a first optical element, a second optical element, and a connecting element operably coupling the frame to the optical elements. The frame comprises an anterior frame element and a posterior frame element. The connecting element is configured to convert a first displacement between the frame elements in a direction that is substantially parallel to the optical axis into a second displacement between the optical elements that is substantially perpendicular to the optical axis. The second displacement may be translational and/or rotation. In some embodiments, the optical elements are two varifocal lenses.

Abstract: Intraocular devices for use in and attached to the natural lens capsule of an eye are provided. The lens capsule may be maintained in a configuration to avoid post-operative changes that are deleterious to vision. Single or dual optic systems are provided, which may be accommodating. Combinations of devices to obtain dual optic systems are disclosed.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and a weakened portion connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: A posterior chamber phakic lens made from an elastomeric, foldable, highly biocompatible and permeable material. The lens has a generally circular optic and a plurality of integrally formed, filament-like haptics. The haptics project posteriorly from the optic and contain a raised feature or ridge that is sandwiched between the posterior iris and the zonules when implanted in an eye. Such a construction has a low vaulting force under compression, is size insensitive, provides for a stable lens once implanted in the eye, helps to avoid pupillary blockage and allows for improved aqueous flow around the natural lens.

Abstract: A curable resin composition for intraocular lens is provided, the curable resin composition including: (a) a first monomer selected from compounds represented by formula (I); (b) a polyfunctional second monomer; and (c) a radical polymerization initiator: wherein R1 represents a hydrogen atom or an alkyl group; X1 represents an oxygen atom or a sulfur atom; when X1 represents a sulfur atom, X2 represents CR2 where R2 represents a hydrogen atom or an alkyl group; when X1 represents an oxygen atom, X2 represents C?O; R3 to R5 each represents a hydrogen atom, an alkyl group, an aryl group, a hetero ring group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an alkoxycarbonyl group, an aryloxycarbonyl group, an acyloxy group, an arylcarbonyloxy group, an acylamino group, a sulfonylamino group, an amino group, an acyl group or a halogen atom; and n represents 0 or 1.

Abstract: Intraocular lenses (IOLs) and related methods. One embodiment provides an IOL which includes a lens optic and a pair of haptics. The haptics can be coupled to the lens optic and can cause compression of the lens optic when the IOL is fixated in an eye. The lens optic can have a compressed geometry, an uncompressed geometry including an aberration, and a desired geometry. The compressed geometry can be the desired geometry. The aberration can be astigmatism, coma, or spherical aberration. For instance, the aberration can be astigmatism of about 0.17 D at the spectacle plane and of about 0.25 D at the intraocular lens plane. Moreover, the haptics can define a first axis between the haptics; the lens optic can define a second axis perpendicular to the first axis; and the uncompressed geometry can differ from the compressed geometry in the vicinity of the second axis.

Abstract: An accommodating intraocular lens comprising a flexible body and flexible optic, and a flexible skirt connecting the optic to the body. The body may have extending loop haptics.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and hinged portions longitudinally connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: An intraocular lens of the present invention has a substantially circular or elliptical optical lens portion made of a soft material, and an arm-shaped support arm portion attached to outer peripheral edges of this optical lens portion, and out of the peripheral edges of the optical lens portion that are contiguous to both sides in a width direction of a root of the support arm portion, at least one outer peripheral edge has a portion recessed inward from the convex curve. Thus, there is provided a soft intraocular lens that can be inserted into an eye from a further smaller incision, without damaging an optical function as much as possible.

Abstract: According to an embodiment of the present invention, an implant device may be provided. The implant may be adapted to manipulate the position of an eyeball associated with a patient, whereby the device comprises an insertion device including a first and a second portion. The first portion may include a first thickness and may be adapted to elevate the position of the eyeball. The second portion may include a second thickness and/or a second position relative the first portion for moving the position of the eyeball in a forward direction.

Abstract: An improved multifocal design for an ocular implant is provided. This ocular implant can include an accommodating intraocular lens (IOL) and a number of haptics. The accommodating IOL includes a liquid suspended between two optically transparent plates or membranes to form a pressure lens that passes optical energy. The haptics mechanically couple to the IOL in order to position and secure the IOL within the eye. The IOL achieves accommodation by using the eye's ciliary muscles to vary the surface curvature of the liquid. The liquid may have a high surface tension and be surrounded by phobic liquid. Pressure from the ciliary muscles causes fluid to be added from or withdrawn to a reservoir. Increasing/decreasing the internal pressure of the liquid changes the angle (curvature) of the surface thus changing the optical properties of the lens. When the pressure is released the liquid returns to the reservoir. The whole system may be sealed off from the interior of the eye by a membrane/transparent lens.