Abstract: The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (MS) and/or liquid chromatography (LC) functionalities.

Abstract: A calibration method that enables calibration easily in a short time in a measurement of hemoglobin A1c by use of a separation analysis is provided. In a measurement of a hemoglobin A1c amount by use of a separation analysis, a one-point calibration using a single calibration standard is performed to obtain calibration data to be used for correcting a measured value.

Abstract: One method for estimating the extracorporeal blood volume in a portion of a physical sample includes: comparing a portion of an image of the sample with a template image of known extracorporeal blood volume indicator; tagging the portion of the image of the sample with a blood volume indicator according to the template image that is matched to the portion of the image of the sample; and estimating the extracorporeal blood volume in at least a portion of the physical sample, associated with the portion of the image of the sample, according to the blood volume indicator.

Abstract: A gas monitoring system is disclosed. The gas monitoring system may have a first electrode in fluid communication with a first gas and a second gas, and a second electrode spaced apart from the first electrode to contain the second gas between the first and second electrodes. The gas monitoring system may also have a pulse generator configured to apply a series of voltage pulses to the first and second electrodes and create a plasma in the second gas. Each voltage pulse in the series of voltage pulses may have an incrementally higher voltage amplitude than a preceding voltage pulse in the series of voltage pulses. The gas monitoring system may further have a detection controller in communication with the pulse generator. The detection controller may be configured to detect breakdown of the second gas during application of one of the series of voltage pulses, and based on a voltage amplitude of the one of the series of voltage pulses, determine a parameter of the first gas.

Abstract: A protective container for holding a reusable control part of a transcutaneous sensor system for detecting at least one analyte in a bodily fluid is disclosed. The control part includes at least one coupling, which has at least one sensor coupling for connection to at least one transcutaneous sensor. The protective container has at least one container housing. The control part can be held in the container housing. The container housing is adapted to shield the control part from environmental influences. The container housing also has at least one connector which can be connected to the coupling and seals the latter in a media-tight fashion.

Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

Abstract: Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values.

Abstract: Embodiments herein provide processing of sensor signals (e.g., signals representative of a level of an analyte in a body). An electronics assembly may include a sensor contact configured to receive a sensor signal from a sensor assembly, an integrator circuit configured to provide an integrator output signal representative of the sensor signal integrated from a first time to a second time, and a reset circuit configured to reset the integrator output signal in response to a reset signal. The electronics assembly may also include a processor circuit configured to determine a value of the integrator output signal and to provide the reset signal to the reset circuit when an integration interval has elapsed from the first time. The integration interval may be based at least in part on the integrator output signal.

Abstract: A method for assaying one or more immunosuppressant drug analytes in a sample derived from whole blood comprises: (a) passing the sample dissolved in a mobile phase through a length of 30 mm or less of a stationary phase of a reversed-phase chromatographic column; (b) eluting the separated analytes from the reversed-phase chromatographic column; (c) ionizing molecules of the eluted separated analytes by a heated electrospray ionization source of a mass spectrometer so as to generate a plurality of precursor ion species; (d) isolating, for each analyte, a respective one of the precursor ion species; (e) fragmenting ions of each of the isolated precursor ion species in a fragmentation cell of the mass spectrometer so as to generate a plurality of product ions therefrom; and (f) detecting, for each analyte, the presence and quantity of a respective one of the product ion species using a detector of the mass spectrometer.

Abstract: An improved calibration process for a medical testing machine. The machine automatically recognizes that a package of calibration material has been inserted into it, and performs a calibration sequence to ascertain a calibration parameter to be used in performing future tests with the medical testing machine. The calibration package may include machine-readable indicators that the package is to be used for calibration, and of a calibration setpoint of a calibration material in the package. A calibration material may be stored in a lyophilized state in the package, and the medical testing machine may automatically reconstitute the lyophilized material.

Abstract: A rationality diagnosis method and a rationality diagnosis apparatus for a sensor inside a tank are provided. The rationality diagnosis method and the rationality diagnosis apparatus can accurately and easily perform a diagnosis to determine whether rationality of all sensors is maintained. The rationality diagnosis method for the sensor inside the tank performs a rationality diagnosis of a concentration sensor, a liquid level sensor and a temperature sensor that are provided inside the tank that stores liquid. The rationality diagnosis method is characterized by diagnosing whether the rationality is lost in one of the concentration sensor, the liquid level sensor and the temperature sensor by determining whether there exists any contradiction between respective sensor values of the concentration sensor, the liquid level sensor and the temperature sensor.

Abstract: A measurement device includes mechanical support elements (101-104) for supporting a sample well, other mechanical support elements (105-109) for supporting a measurement head (112) suitable for optical measurements, and a control system (111) configured to control the measurement head to carry out at least two optical measurements from at least two different measurement locations inside the sample well, where each measurement location is a center point of a capture range from which radiation is captured in the respective optical measurement. The final measurement result is formed from the results of the at least two optical measurements in accordance with a pre-determined rule. The use of the at least two optical measurements from different measurement locations reduces measurement variation in situations where the sample well (153) contains a piece (158) of sample carrier.

Abstract: A method for calibrating and/or adjusting a sensor, especially an electrochemical, electrophysical or optical sensor, wherein the sensor has an evaluating electronics, which is embodied in such a manner, that a signal produced by the sensor is essentially non-changeable by a subsequent transmission. The sensor is calibrated and/or adjusted at a site other than a later measuring location or a later measuring environment or the like.

Abstract: A calibration device according to embodiments of the disclosure is capable of being used with a non-invasive sensor. Certain embodiments of the calibration device simulate a human pulse by varying the volume of blood being measured by the optical sensor. Further, embodiments of the calibration device allow the generation of calibration curves or data for measured parameters over larger ranges of measured values compared to patient-based calibration.

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal purity analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to characterize one or more non-physiological anomalies of a representation of the blood glucose level of the patient by the at least one sensor signal. A reliability of the at least one sensor signal to represent the blood glucose level of the patient may be assessed based at least partly on the at least one metric. Other example embodiments are disclosed herein.

Abstract: An apparatus for insufflating a body cavity with an insufflation gas comprising an insufflation device for delivering the insufflation gas to the body cavity. To detect possibly critical states in the body cavity, the apparatus is designed to withdraw a measuring gas from the body cavity. A measuring device having a gas sensor serves for measuring an additional substance contained in the measuring gas in addition to the insufflation gas and for outputting a measuring signal as a function of the additional substance.

Abstract: A method for operating a measuring device comprising the following steps: providing a first sample of the liquid; ascertaining an updated calibration function by means of a standard addition method, wherein the first sample is supplemented at least once with a standard solution, which has a known concentration of the measured ion; determining a measured value of concentration of the measured ion in the first sample; providing a second sample of the liquid; ascertaining a measured value of concentration of the measured ion in the second sample as a reference measured ion concentration (cref) by means of a reference method; and determining a difference (cdisturb) between the apparent measured ion concentration (capparent) and the reference measured ion concentration (cref) and deriving a correction value (ckorr) therefrom for future measured values of concentration of the measured ion in the liquid, as ascertained with the measuring device.

Abstract: The invention relates to different designs of a microelectronic device comprising an array of heating elements (HE) with local driving units (CU2) and optionally with an array of sensor elements (SE) adjacent to a sample chamber (SC). By applying appropriate currents to the heating elements (HE), the sample chamber can be heated according to a desired temperature profile. The local driving units comprise means for compensating variations of their individual characteristics.

Abstract: The present invention relates to a calibratable sensor unit for a reaction vessel, such as for example a fermenter (48), in particular a disposable fermenter, comprising at least one sensor device (14) to be calibrated and at least one compartment (26, 28, 30) containing a calibrating agent, the at least one sensor device and the at least one compartment (26, 28, 30) being accommodated movably relative to one another in a housing (12) that is connected to or can be connected to the reaction vessel (48), wherein the calibrating unit (10) is arranged to calibrate the at least one sensor device (14) by contact with the calibrating agent before chemical and/or physical parameters of a measurement substance are measured with the at least one sensor device (14). According to the invention it is proposed that the sensor device (10) is configured in such a way that the relative movement between the at least one sensor device (14) and the at least one compartment (26, 28, 30) can be carried out irreversibly.

Abstract: A biosensor with an underfill recognition system assesses whether to analyze a sample for one or more analytes in response to the volume of the sample. The underfill recognition system applies polling and test excitation signals to the sample. The polling signals generate one or more polling output signals, which maybe used to detect when a sample is present and to determine whether the sample has sufficient volume for analysis. The test excitation signal generates one or more test output signals, which may be used to determine one or more analyte concentrations in the sample.

Abstract: A detection and identification system includes a sensor unit (100) having a sensor array that detects and identifies at least one chemical included in an air flow. The system also includes a pump (120) that drives the air flow through the detection and identification system, in which the pump receives the air flow that has passed out of the sensor unit. The system further includes an adsorption unit (130) that dries and cleans the air flow within the detection and identification system, to obtain a substantially dry and clean air flow, in which the adsorption unit receives the air flow that has passed out of the pump. The system also includes at least one valve (140) that receives the substantially dry and clean air flow that has passed through the adsorption unit. The valve provides the substantially dry and clean air flow to the sensor unit in a close-loop circulation operation to thereby clean a sensor array.

Abstract: The invention provides compositions and methods for chromatographic analysis and system quality control. Compositions can include a reference material that comprises a standardized formulation of two or more compounds that can be used for benchmarking and troubleshooting the chromatographic system (e.g., which is not simply a standard solution for a particular analyte of interest).

Abstract: An apparatus, system, and method for determining the osmolarity of a fluid. The apparatus includes at least one micro-fluidic circuit and at least one electrical circuit disposed in communication with the micro-fluidic circuit for determining a property of a fluid contained within the at least one micro-fluidic circuit.

Abstract: Embodiments provide a method and related systems that take into account the difference between a measured glucose value and the calibration level and the amount of elapsed time since the prior calibration. As one or both of these determined differences increases, the desirability of an additional calibration also increases. The methodology described herein thus analyzes the combination of change in glucose level as well as the time since the prior calibration. If the combination exceeds a predetermined value, the system recommends, but does not require, that the subject user perform an additional calibration.

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.

Abstract: A rationality diagnostic device for an alcohol concentration sensor includes a capacitance-type remaining fuel amount sensor as a remaining fuel amount sensor disposed in a fuel tank. The capacitance-type remaining fuel amount sensor has such output characteristics that its output value is determined by the amount of fuel remaining in the fuel tank and the alcohol concentration of the fuel. The rationality diagnostic device corrects the output value of the remaining fuel amount sensor in accordance with the output value of the alcohol concentration sensor to eliminate an alcohol-concentration-dependent component from the output value of the remaining fuel amount sensor. The rationality diagnostic device then verifies the accuracy of the corrected output value of the remaining fuel amount sensor to judge whether the rationality of the alcohol concentration sensor is maintained.

Abstract: A reaction chamber enables a reaction between received elemental mercury gas and an oxidizing agent gas. The reaction chamber includes a porous (or permeable) medium through which to pass the elemental mercury gas and the oxidizing agent gas. Passing of the elemental mercury gas and the oxidizing agent gas through the porous medium supports a number of useful functions. For example, the porous medium enhances mixing of the elemental mercury gas with the oxidizing agent gas to enhance a reaction. Also, the porous medium increases an amount of surface area in a reaction chamber on which reactions (e.g., heterogeneous surface reactions) can take place between the elemental mercury gas and the oxidizing agent gas to form oxidized mercury gas. Accordingly, the reaction chamber configured to include a porous medium enhances a conversion of elemental mercury gas into oxidized mercury gas.

Abstract: A method for verifying the plausibility of a measuring device for determining a quality of an aqueous urea solution in a reservoir of an SCR catalyst system comprises determining whether a filling of the reservoir has taken place, determining the quality of the aqueous urea solution in the reservoir and detecting whether an error of the measuring device is present or whether the reservoir was filled with an aqueous urea solution, the quality of which deviates from a default value consisting of a filling status of the reservoir and the quality of the aqueous urea solution in said reservoir.

Abstract: The invention relates to a method of determining an unknown property or information of a reservoir fluid. The method includes measuring a set of responses of a measuring instrument to the fluid and measuring one or more physical or chemical properties of the fluid. The method further includes determining the unknown property or information of the fluid based on the relationship between the instrument responses and the measured properties of the fluid using equation-of-state (EOS) model.

Abstract: An automotive urea solution monitoring device is deployed in conjunction with the urea tank of a selective catalytic reduction vehicle. An RF signal of a constant frequency may be generated across a resonant circuit, which may be comprised of an inductor and a PCB trace capacitor, or the like. Electromagnetic radiation is propagated into the automotive urea solution in the urea tank. The conductivity and dielectric properties of the liquid change the impedance of the discrete/trace capacitor and or the discrete/trace inductor. These changes are proportional to ammonia content, temperature, and/or level of the automotive urea solution in the urea tank and are preferably detected by a microcontroller, or the like, and then transmitted to a selective catalytic reduction vehicle engine management system, or the like.

Abstract: A method and apparatus for measuring dissolved residue concentrations and particulate residue particle concentrations and size distribution in liquids, particularly colloidal suspensions. The method involves separating dissolved and particulate residues in liquids for subsequent analysis of the residue species. The method includes the steps of forming an aerosol from the liquid sample to be analyzed, evaporating the droplets in the aerosol to dryness, detecting and sizing the particles, and determining the liquid volumetric inspection rate. An apparatus for separating dissolved and particulate residues in liquids for determination of the concentrations of the two residue species as well as the size distribution of the particulate species is also disclosed. The apparatus includes a droplet former, a dryer communicatively connected to the droplet former, and a detector communicatively connected to the evaporator for detecting and sizing particles.

Abstract: An integral regulator and gauge for a vacuum device consists of a circular regulator having the vacuum gauge inside thereof such that the regulator and gauge rotate about a common radial axis. An opening defined in a boss extending from the bottom of the regulator engages a sloped shoulder defined on the inside surface of a circular port in which the regulator is disposed, varying the size of an opening which allows air to bleed into the vacuum chamber to regulate the strength of the vacuum.

Abstract: Methods of calibrating a fluid analyzer for use in a wellbore are described. An example method of generating calibration data for a fluid analyzer for use in a downhole tool involves lowering a downhole tool including a fluid analyzer to a location in a wellbore, measuring, via the fluid analyzer, a characteristic value of a calibration fluid or a vacuum while the fluid analyzer is at the location, obtaining an expected characteristic value for the calibration fluid or the vacuum at the location, and comparing the measured characteristic value to the expected characteristic value to generate a calibration value for the fluid.

Abstract: A quencher for a flow cell battery is described. The quencher utilizes a quench solution formed from FeCl2 in a dilute HCl solution in order to quench chlorine emissions from the flow cell battery. A quench sensor is further described. The quench sensor monitors the concentration level of FeCl2 in the quench solution and may also monitor the level of the quench solution in the quencher.

Abstract: A fluid cartridge, comprising a channel layer within which at least one circumferentially sealed fluid channel is formed, the channel layer comprising a substrate and an elastic layer fixedly arranged on the substrate, wherein the substrate has a rigidity being greater than that of the elastic layer, and wherein the at least one fluid channel is defined on at least one side thereof by the elastic layer.

Abstract: Disclosed herein is a device comprising a biosensor having disposed upon it a coating; the coating comprising a polymer matrix; where the polymer matrix is operative to facilitate the inwards and outwards diffusion of analytes and byproducts to and from the sensing element of the biosensor; and a sacrificial moiety; the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.

Abstract: Methods and systems for calibrating a chemical sensing system are disclosed. Detection of a substance using a first chemical sensor in a chemical sensing system may be initiated at a first time. The first chemical sensor may output a first sensor value. Detection of the substance using a second chemical sensor in a chemical sensing system may be initiated at a second time that differs from the first time by a delta value. The second chemical sensor may output a second sensor value. The chemical sensing system may be calibrated based on the first and second sensor values at the second time and the first and second sensor values at a current time.

Abstract: A method and system for improving sensor accuracy of diesel emissions is disclosed. The method and system change the sensor reading as a function of sensor age to provide a more accurate measure of the diesel emissions. By estimating the degree of sensor error and then providing a gain correction factor as a function of sensor age, a more accurate measure of the diesel emissions is provided.

Abstract: A system having reduced gas interference that includes a fluid chamber and a resonant sensor device in fluid communication with a fluid in the fluid chamber. The system includes a fluid control device adapted to change at least one of the fluid flow or pressure within the fluid chamber to achieve substantial wetting of surfaces in proximity to the resonant sensor device. Fluid surfaces of the system can include a material to increase the wettability (e.g., hydrophilicity) of the fluid surfaces.

Abstract: A method of calibrating a gas analysis apparatus that measures the moisture concentration in a gas using a radiating unit includes a moisture concentration measurement value calibrated based on the relationship between the intensity of an absorption spectrum of moisture of a concentration to be measured and the intensity of an absorption spectrum of an other component gas that can be measured by the radiating unit, for which the relationship to the intensity of the absorption spectrum of moisture of the measured prescribed concentration is known, and based on the intensity of an absorption spectrum obtained by measuring the other component gas.

Abstract: A multi-sensor as disclosed herein can include a substrate and at least three sensing elements disposed on the substrate. Each sensing element includes two electrodes separated by a distance and a nanowire mat adjacent to and in contact with the electrodes. The nanowire mats include nanowires which define a percolation network. The density of the nanowires in the nanowire mat of one sensing element is different than the density of the nanowires in the nanowire mat of either of the other at least two sensing elements.

Abstract: A sample analysis device is provided for determining samples in a sample matrix with several sample volumes. The device includes: a receiving device with a receiving facility for a sample matrix comprising a plurality of sample volumes; a first measuring device configured to determine samples in the sample matrix, by means of wet measuring; a second measuring device, configured to determine further samples in the sample matrix, which further samples differ from the samples, or in another sample matrix, by means of dry measuring; and a transfer device, which is coupled to the receiving device and is configured to transfer the receiving device between a loading position and a plurality of measuring positions in such a manner that the receiving facility can be transferred to various measuring positions that are either associated with the first or with the second measuring device.

Abstract: A calibration device according to embodiments of the disclosure is capable of being used with a non-invasive sensor. Certain embodiments of the calibration device simulate a human pulse by varying the volume of blood being measured by the optical sensor. Further, embodiments of the calibration device allow the generation of calibration curves or data for measured parameters over larger ranges of measured values compared to patient-based calibration.

Abstract: The present invention includes analyte measurement systems, analyte measurement meters, analyte testing devices, cartridges thereof and integrated circuits for use therewith, and further includes methods related to the use of the integrated circuits and, in certain embodiments, to the counting or tracking of parameters related to the cartridges and analyte test devices.

Abstract: The present invention relates to a method for predicting the concentration or the mass of hemoglobin or an approximation thereof, respectively, in a body fluid and/or an extracorporeal sample thereof of a patient at a later, second point of time, the patient having theoretically or in reality been administered a certain dose of an erythropoiesis stimulating agent at an earlier, first point of time. It relates further to a method for determining the dose of an erythropoiesis stimulating agent to be administered to a patient, to a method for determining whether a patient is affected by circumstances leading to the loss of hemoglobin, to corresponding devices and to an erythropoiesis stimulating medicament for use in the treatment of anemia.

Abstract: An apparatus for determining the proportion of gases in a gas mixture, has a measurement chamber having a chamber defining structure, a gas inlet and a gas outlet, an ultrasound source and an ultrasound detector mounted such that the ultrasound source is capable of transmitting ultrasound through the chamber to the ultrasound detector; a temperature sensor mounted such that the sensor is capable of sensing the temperature in the chamber. The chamber defining structure is adapted to amplify thermal exchange with a gas content in the chamber so as to suppress a temperature change in the chamber.

Abstract: A method for the calibration of a device for measuring the total organic carbon content (TOC) of an aqueous solution by measuring resistivity. The method includes the following steps, in the presence of a reference TOC analyzer: (a) producing a calibration point by a measurement carried out on ultrapure water by the device and the analyzer; (b) producing a plurality of calibration points, each calibration point corresponding to a measurement of the resistivity of a solution having a given content of photo-oxidizable compound, by the device and the analyzer, in order to establish a correlation between the values measured by the device and the analyzer; and (c) calibrating the device by at least one algorithm, based on the measurements carried out in the previous step.

Abstract: The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.

Abstract: An apparatus for measuring a water content in a multiphase fluid flow stream is provided. The apparatus includes a measurement section configured to obtain a series of electrical measurements of the multiphase fluid flow stream over a first predetermined time interval, and determine a minimum electrical measurement Fmin_baseline from the series of electrical measurements. The measurement section also is configured to calculate a running average of the frequency (Fmin_gas_pattern) from the series of electrical measurements indicative of a change in a gas flow pattern of the multiphase fluid flow stream over a second predetermined time interval. The measurement section further is configured to calculate a corrected electrical measurement F_calc_WC for determining the water content in the multiphase fluid flow stream by subtracting the running average of the frequency. Fmin_gas_pattern from the minimum electrical measurement Fmin_baseline.

Abstract: An object of the present invention is to accurately diagnose an abnormality of a fuel property detection apparatus that detects a fuel property based on a capacitance between electrodes. The abnormality detection apparatus for a fuel property detection apparatus of the present invention detects an abnormality of a fuel property detection apparatus that detects a fuel property based on a measurement value of a capacitance between a pair of electrodes installed on a fuel supply channel of an internal combustion engine that can use a fuel that includes a predetermined fuel component that has a characteristic such that a permittivity thereof changes according to a frequency of an electric field.