Abstract: Methods of auto-calibrating a meter are disclosed. In one aspect, the method can include determining a set of calibration information applicable to a sensor and storing the calibration information onto a tag element associated with a sensor dispenser. The tag element can be placed into communication with a reader element that is associated with a meter and which is configured to receive the calibration information so as to allow the meter to use the calibration information in a calibration procedure. Various aspects of a system for auto-calibrating a meter are also disclosed.

Abstract: Methods and devices for providing calibration in analyte monitoring systems are provided.

Abstract: The invention provides a calibrating method for use in a method of determining the quantity of an analyte labeled with an accelerator mass spectrometry (AMS) isotope in a test sample. The samples can include, for example, urine, faeces, plasma or blood. The analyte can be, for example, a drug or metabolite of a drug.

Abstract: The present invention pertains to new methods and apparatuses for the determination of pH of a fluid. Applicants have discovered that ultrasonic spectrophonometry (the study and measurement of acoustic spectra) can be used to distinguish conformational changes of albumin and red blood cells in response to pH. In accordance with the present invention, there is provided a method of determining the pH of a fluid based on a pH-dependent conformation of at least one fluid constituent comprising subjecting the fluid to an ultrasonic pulse; detecting ultrasonic spectral data of the fluid constituent resulting from the ultrasonic pulse; wherein the spectral data varies with pH; and then calculating pH from the spectral data.

Abstract: A device includes a sensor array and a processor is automatically calibrated. The sensor array collects data from a pattern using at least one of a capacitive measurement and a radio frequency measurement. The pattern is included on a calibration storage device. The processor receives the data from the sensor array and calibrates the device in accordance with the data.

Abstract: The present invention relates to optical sensor arrangements, especially sensors of the type that can be used in motor vehicles and which can detect hydrogen in a gaseous measured medium.

Abstract: Systems and methods are provided for monitoring a solid-liquid interface during a casting process. The systems and methods enable determination of the location of a solid-liquid interface during the casting process.

Abstract: A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.

Abstract: A rationality diagnosis method and a rationality diagnosis apparatus for a sensor inside a tank are provided. The rationality diagnosis method and the rationality diagnosis apparatus can accurately and easily perform a diagnosis to determine whether rationality of all sensors is maintained. The rationality diagnosis method for the sensor inside the tank performs a rationality diagnosis of a concentration sensor, a liquid level sensor and a temperature sensor that are provided inside the tank that stores liquid. The rationality diagnosis method is characterized by diagnosing whether the rationality is lost in one of the concentration sensor, the liquid level sensor and the temperature sensor by determining whether there exists any contradiction between respective sensor values of the concentration sensor, the liquid level sensor and the temperature sensor.

Abstract: A system of measuring oxygen levels based on the intensity of a sensor material. Through use of intensity-based measurement techniques and improved light rejection, less excitation light and system gain are required as compared to certain conventional lifetime/phase shift techniques. One embodiment applies an intensity-based measuring system for taking measurements, and on an intermittent basis, using a lifetime/phase shift-type sensor in order to automatically calibrate the intensity-based measuring system in situ. A single sensing membrane may be provided while still allowing the system to be used in both the lifetime/phase-shift mode and the intensity mode. The system of the present invention may also include use of a variable thickness sensor for an oxygen sensing system, such as a portable handheld sensor and/or a sensor or controller at a fixed location.

Abstract: A test system comprises a sensor container and a testing device. The sensor container has a base and a lid. The container encloses a plurality of test sensors therein. The container includes a calibration label attached thereto. The label includes electrical contacts located thereon that encode calibration information onto the calibration label. The testing device has a sensor-container opening formed thereon. The sensor-container opening has an auto-calibration feature located therein. The auto-calibration feature is external to the testing device. The auto-calibration feature includes calibration elements to communicate with the electrical contacts on the calibration label. The testing device determines the calibration information encoded on the calibration label in response to the calibration elements engaging the electrical contacts. A portion of the sensor container remains external to the meter while the encoded calibration information is being determined.

Abstract: Embodiments provide a method and related systems that take into account the difference between a measured glucose value and the calibration level and the amount of elapsed time since the prior calibration. As one or both of these determined differences increases, the desirability of an additional calibration also increases. The methodology described herein thus analyzes the combination of change in glucose level as well as the time since the prior calibration. If the combination exceeds a predetermined value, the system recommends, but does not require, that the subject user perform an additional calibration.

Abstract: Systems and methods are described for measuring pH of low alkalinity samples. The present invention provides a sensor array comprising a plurality of pH indicators, each indicator having a different indicator concentration. A calibration function is generated by applying the sensor array to a sample solution having a known pH such that pH responses from each indicator are simultaneously recorded versus indicator concentration for each indicator. Once calibrated, the sensor array is applied to low alkalinity samples having unknown pH. Results from each pH indicator are then compared to the calibration function, and fitting functions are extrapolated to obtain the actual pH of the low alkalinity sample.

Abstract: Embodiments provide expanded ability to communicate calibration information to diagnostic systems for determining a characteristic of a test sample. An example system for determining a characteristic of a test sample includes: a test sensor for receiving a test sample; a sensor meter responsive to the test sensor, the sensor meter determining a characteristic of the test sample received on the test sensor; and a calibration element including electrical contacts readable by the sensor meter. The electrical contacts are configurable in one of a plurality of patterns that communicates, to the sensor meter, information relating to the determination of the characteristic of the test sample. The plurality of patterns include two or more of the electrical contacts that are electrically isolated from any other electrical contacts. The sensor meter determines at least partially the information from the electrical contacts by determining a combination of values corresponding to the isolated electrical contacts.

Abstract: A system and method for detecting the presence of submicron sized particles in a sample taken from the environment. More particularly, the system may be used to detect and identify bacteria by detecting the presence of bacterial pili which have been separated from bacterial cells in the sample. The system includes means for collecting a sample from the environment, separating pili from bacteria in the sample, and purifying and concentrating the submicron sized pili in the sample based on the size of the pili. The purified and concentrated pili are detected with an apparatus which includes an electrospray assembly having an electrospray capillary, a differential mobility analyzer which receives output from the capillary, and a condensation particle counting device for counting the number of pili sized particles that pass through the differential mobility analyzer.

Abstract: A method and apparatus for measuring the presence or absence of reaction between a first and second material of interest by measuring osmotic pressure changes in a reaction cell. The reaction cell is capable of measuring the small changes in pressure that occur due to osmotic pressure shifts during a catalytic or binding reaction at species concentrations down to approximately 10?7 M.

Abstract: Embodiments of the invention contemplate an apparatus that determines gas sorption properties of a large number of material samples simultaneously, by sequentially measuring the pressure in a plurality of sample chambers until all chambers have reached equilibrium pressure. In most applications, it is most useful to quantify the sorption capacity of a material under specific conditions, i.e., at a certain temperature and pressure. Because sorption capacity is determined by bringing a material sample to an equilibrium state with a dosing gas, detailed kinetic data related to the sorption properties of a material are not absolutely necessary. Therefore, complete pressure-time curves are not typically necessary, and only the equilibrium pressure of a material sample for a given quantity of dosing gas is required.

Abstract: The present invention describes a replaceable breath alcohol sensor module that can be replaced with a new pre-calibrated breath alcohol sensor module or re-calibrated. The breath alcohol sensor module requiring calibration can be removed from the body of a Breath Alcohol Testing Device (commonly called “breathalyser” or “breathalyzer”). The breath alcohol sensor module can be separately calibrated for accurate calculation of “percent blood alcohol concentration” (% BAC) based on breath air samples and then re-installed into the breath alcohol tester or the old breath alcohol sensor module can be replaced with a new pre-calibrated breath alcohol sensor module. The present invention improves upon and/or replacing the current method of re-calibration at a breathalyzer service center.

Abstract: A method and apparatus for validating the flow calibration factor of a Coriolis flowmeter. In accordance with a first embodiment, an improved material density is obtained by measuring material density when the temperature of the material is equal to a predetermined reference temperature. In accordance with a second embodiment, a preprogrammed data base stores density/temperature relationships. Improved density information is obtained by measuring the density and temperature of the material, applying the measured density/temperature information from the data base, and obtaining density information compensated for a predetermined reference temperature. The improved density information obtained for both embodiments is unaffected by temperature changes and is used to validate the flow calibration factor. The flow calibration factor compensation for pressure changes and changes in material composition is obtained in a similar manner.

Abstract: A system of measuring pH of a solution having a calibration device to counteract time-drift effect. The calibration device of the system adjusts a compensation voltage to zero a measuring voltage of a first sensor and only respond to time-drift voltage of the first sensor. The calibration device has a differential operation amplifier receiving measuring voltages from the first sensor and a second sensor of the system to eliminate the time-drift voltages of the first and second sensors, thereby achieving calibration of the time-drift effects.

Abstract: The present invention provides a novel procedure of preparing samples for analysis by way of mass spectrometry, preferably LC-MS/MS. Accordingly, functionalized magnetic particles with a hydrophobic surface were used for extracting low molecular weight compounds from complex liquid biological samples such as plasma, serum, whole blood or hemolyzed blood. The method of the invention includes (a) contacting the sample with an amount of functionalized magnetic particles with a hydrophobic surface, (b) incubating the sample and the particles, thereby adsorbing the compound to the hydrophobic surface, (c) separating the particles by applying a magnetic field and removing the liquid, (d) optionally washing the particles, (e) eluting the compound from the particles.

Abstract: A reference leak (10) includes a first substrate (20), a second substrate (40) disposed and bonded on the first substrate, and predetermined numbers of leak channels (14) defined in at least one of the first and second substrates. Oblique walls of the leak channels are formed by crystal planes of the at least one of the first and second substrates, the oblique walls thereby being aligned according to such crystal planes. A method for making a reference leak is also provided.

Abstract: A sensor head for a dry powder agent according to an exemplary aspect of the present disclosure includes a housing defined along an axis along which light is communicated, the housing defines a multiple of apertures transverse to the axis and in communication with a measurement volume along the axis. Each of the multiple of apertures defines a longitudinal length along the axis which is less than a lateral length defined around the axis. A minor is within the housing to reflect the light through the measurement volume.

Abstract: A method of calibrating a metabolic analyzer incorporating an oxygen analyzer and a NDIR carbon dioxide analyzer in the field that does not require the use of gas cylinders containing gases of known concentration is described. In calibrating the CO2 detector, at the time of factory setup, the detector output for a gas of a known concentration is measured and stored in the memory of the metabolic analyzer's microprocessor, as is the detector output voltage when the IR source is dimmed by a known percentage. Subsequently, in the field, CO2 levels in ambient air and cell pressure are measured at two different flow rates through the sample chamber and the IR source is again dimmed by the same percentage as had been used at the time of factory setup. Based upon the resulting readings, both the zeroing and span adjustment factors can be computed.

Abstract: A calibration method for a flow cytometer with a multichannel detector module. During calibration, the fluorescence intensity data values for the different detector channels are used to calculate normalization factors needed to adjust subsequent data collected by each of the channels. By using a multichannel detector module, the results from the different flow cells can be reliably compared, so that multiple stages of flow cells can be arranged in series along a common flow path, for example to measure the same sample at defined time intervals.

Abstract: A method for calibrating machines suitable to effect an analysis of a blood sample by measuring the erythrocyte sedimentation rate (ESR) and/or aggregation of the red corpuscles, wherein the measurement is effected by exploiting the optical density kinetics obtained from the measurement of the variation in the optical density of the blood sample in an interval of time, to include measuring in which, by the same machine with which the measurement of the optical density is effected on the blood sample, a measurement is effected of the optical density of two latexes, or turbidimetric samples. Each of the two latexes has a known optical density that is reproducible, measurable and different from each other. The method also calibrates in which the difference is calculated between the values of optical density of the latexes as obtained from the measurement performed by the machine and the known values of optical density, to determine at least one correction factor usable to calibrate machine.

Abstract: A system and method for determining the asphaltene content of a downhole oil sample are provided. In one example, the method includes obtaining a hydrocarbon sample from a hydrocarbon formation of a reservoir at a given depth using a downhole tool. A liquid phase of the hydrocarbon sample is isolated within the downhole tool and the liquid phase is subjected to downhole analysis within the downhole tool to create a chromatography sample. The downhole analysis is based at least partially on size exclusion chromatography. A first property of the chromatography sample is measured to obtain a measured value, and a second property of the chromatography sample is estimated based on the measured value and known calibration curves.

Abstract: A selective gas sensor is for determining the presence of a test gas, for example, helium includes an evacuated housing, sealed by a selectively gas-permeable membrane. The membrane is part of a sight glass, whereby the glass pane is provided with a hole, sealed by the membrane made from a silicon material. The frame of the membrane wall is connected to the housing by means of a high-vacuum soft-metal seal. The housing can also form one of the electrodes of the gas pressure sensor.

Abstract: The present invention provides quantitation of seven classes of compounds (saturates, 1-4+ ring aromatics, sulfides, and polars) present in petroleum streams boiling from 550-1050° F. Operating the present invention in the preparative mode will allow us to load and collect multi-milligram amounts of material. In the present invention, all seven fractions are produced in a single run, whereas the most commonly used preparative liquid chromatographic separations requires two or more large scale separations to generate similar fractions. The present invention uses 100 times less solvent. The present invention protocol provides a quicker and cheaper alternative to most commonly used preparative liquid chromatographic separations and is flexible enough to target many refining and chemicals problems.

Abstract: An apparatus for determining the proportion of gases in a gas mixture, has a measurement chamber having a chamber defining structure, a gas inlet and a gas outlet, an ultrasound source and an ultrasound detector mounted such that the ultrasound source is capable of transmitting ultrasound through the chamber to the ultrasound detector; a temperature sensor mounted such that the sensor is capable of sensing the temperature in the chamber. The chamber defining structure is adapted to amplify thermal exchange with a gas content in the chamber so as to suppress a temperature change in the chamber.

Abstract: The present invention relates to the calibration of devices using a secondary binding agent or reference material. In one embodiment, the present invention provides a method of calibrating a nanosensor by providing a nanosensor comprising an analyte binder attached to a reference binder, extracting a calibration curve from binding a reference material to the reference binder, and calibrating the nanosensor by using the calibration curve to correct for device variation.

Abstract: A capacitive sensor in its simplest form has three identical plated spatial electrodes, which are positioned equally spaced apart, in order, alignment and parallel with each other. The first and third electrodes are the outer electrodes and connected in parallel by a first lead wire serving as a first electrical pole to be a group of the integrated electrodes. The second electrode is the middle electrode and connected by a second lead wire serving as a second electrical pole. The sensor is applied by an alternating current (AC) excitation by an AC device. The present invention method includes application of referencing and sensing capacitive sensors to obtain a measured temperature compensated electrical property of the oil to thereby obtain a measured remaining usage so as to a predicted one for the oil.

Abstract: The present disclosure relates generally to devices that may be used to calibrate a reader. Such devices may comprise an electrical memory chip, a calibration device comprising an optical check, and an interface that allows interaction with the reader.

Abstract: The subject matter disclosed herein relates to systems, methods and/or devices for calibrating sensor data to be used in estimating a blood glucose concentration. A relationship between sensor measurements and reference readings may be used to estimate a relationship between sensor measurements and blood glucose concentration. Such sensor measurements may be weighted according to a decreasing function of uncertainty associated with sensor values.

Abstract: A reaction chamber enables a reaction between received elemental mercury gas and an oxidizing agent gas. The reaction chamber includes a porous (or permeable) medium through which to pass the elemental mercury gas and the oxidizing agent gas. Passing of the elemental mercury gas and the oxidizing agent gas through the porous medium supports a number of useful functions. For example, the porous medium enhances mixing of the elemental mercury gas with the oxidizing agent gas to enhance a reaction. Also, the porous medium increases an amount of surface area in a reaction chamber on which reactions (e.g., heterogeneous surface reactions) can take place between the elemental mercury gas and the oxidizing agent gas to form oxidized mercury gas. Accordingly, the reaction chamber configured to include a porous medium enhances a conversion of elemental mercury gas into oxidized mercury gas.

Abstract: The present invention provides a detector for a chromatograph capable of obtaining the accurate retention time, even if there is a frequency deviation of the clock signal for determining the timing of data sampling, by conforming the progress of the detector internal time accompanied with the repetition of the sampling to that of real time. In the detector, consecutive data sampling intervals are defined to be a time adjustment period, and in one time adjustment period, each of the sampling intervals whose number is given as the interpolation value M is elongated by a predetermined number of clock counts compared to each of the other sampling intervals. If the clock signal has a positive frequency deviation, the apparatus internal time determined by the clock signal progresses faster than real time.

Abstract: An error specifying method of specifying an error of an analyzer. The method specifies an error related to removal of a high-concentration reagent. The method includes a low-concentration reagent measuring step of performing an analysis process, which causes a composition to emit light, on a low-concentration reagent and measuring an amount of light emitted in order to acquire performance of the low-concentration reagent; a high-concentration reagent measuring step of performing the analysis process on the high-concentration reagent and measuring an amount of light emitted in order to acquire performance of the high-concentration reagent; and a reagent evaluating step of evaluating the performance of the low-concentration reagent and the performance of the high-concentration reagent based on the measurement results in the low-concentration reagent measuring step and the high-concentration reagent measuring step.

Abstract: A multi-sensing device is provided which includes a first sensor for sensing a temperature of the fluid flowing through the filter element, a second sensor for sensing a pressure generated by the fluid flowing through the filter element; and an indicator for indicating a condition of the filter system, and a microcontroller operatively coupled to the first and second sensors.

Abstract: The invention relates to a method for measuring the permeability to gases of the wall of a hollow body (6) made of polymeric material, characterized: in that it comprises a first conditioning step during which a flushing gas flushes said hollow body (6), and a second measuring step during which a measurement gas is introduced into said hollow body (6); in that the flow of flushing gas is greater than the flow of the measurement gas, and; the flushing gas is sent into the hollow body (6) without mixing with the measurement gas.

Abstract: A moisture detection sensor is used in a building structure to detect moisture penetration. The sensor is a flat adhesive tape of a substrate of dielectric, hydrophobic material. Three or four elongate, parallel, conductors are secured to the top surface and a protective layer of non-hygroscopic, water pervious material is secured over two of the conductors so that they are exposed to surface moisture. One or two of the conductors are covered by an insulating layer to prevent moisture access. Pairs of moisture probes along the length of the tape penetrate the insulating layer, the respective conductors and the substrate and to extend into a building component to which the substrate has been adhered. A diode guide arrangement allows a monitoring unit to monitor the exposed conductors for surface moisture and the penetrated conductors for moisture in the component by reversing polarity of the voltage across the conductors.

Abstract: Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided

Abstract: A corpuscle/plasma separating part is disposed at the lower end of the substrate, and a sensor part connected to the corpuscle/plasma separating part is disposed at the upper end of the substrate, with a calibration solution reservoir being disposed on the lower side of the sensor part, and a calibration solution waste reservoir being disposed on the upper side of the sensor part. A first centrifugal axis is located upper to the corpuscle fraction storing part and lower to the plasma fraction storing part of the corpuscle/plasma separating part, while a second centrifugal axis is located within or close to the sensor part. Conveyance and discharge of the calibration solution can be carried out by performing centrifugation around the first centrifugal axis which is distant from the sensor part at a low speed of rotation, so that the centrifugal force exerted on the sensors would be small.

Abstract: A system for testing and calibrating gas sensors with gas stored in a strip of packets. The strip may be fed into a chamber having a defined volume of air. A packet may be punctured with a mechanism to release one or more gases into the volume of air to result in an air-gas mixture. New air may be moved into the chamber to push the mixture out of the chamber to a sensor for testing and/or calibration. Then another packet may be punctured to release one or more gases into the volume of new air in the chamber for another air-gas mixture. This mixture may be moved out of the chamber, in the same manner as the previous mixture, to another sensor for testing and/or calibration. This procedure may be repeated with additional packets on the strip.

Abstract: The present invention comprises a method for calibrating a droplet dispensing apparatus using acoustic energy to dispense a plurality of droplet sets of a liquid from a source container into a plurality of target containers, with each droplet set being comprised of one or more individual droplets of the liquid, and with a liquid level of the liquid in the source container being measured before each of the droplet sets are dispensed. The average droplet volume for the individual droplets in each of the droplet sets is then calculated by detecting the presence of an indicator, such as a fluorescent chemical. Once the average droplet volume has been calculated, it is determined if the average droplet volume for each droplet set is acceptable or not acceptable. Where the average droplet volume is determined to be not acceptable, an existing droplet dispensing parameter is changed to a new droplet dispensing parameter that will cause the average droplet volume for that droplet set to change.

Abstract: Methods for calibrating blood content sensors used independently or in conjunction with medical instruments such as traditional or capsule type endoscopes.

Abstract: A method and apparatus for calibrating a sensor used to sense the concentration of vaporized hydrogen peroxide (VHP). A concentration of liquid hydrogen peroxide in an aqueous solution is determined and correlated with a corresponding concentration of vaporized hydrogen peroxide indicative of an “actual” vaporized hydrogen peroxide concentration. An error value is determined by comparing the “actual” vaporized hydrogen peroxide concentration to a “measured” vaporized hydrogen peroxide concentration, indicated by the sensor being calibrated. The error value is used to properly calibrate the sensor.

Abstract: An auto-calibration circuit or label is adapted to be used with an instrument. The instrument is adapted to determine information related to an analyte of a fluid sample. The auto-calibration circuit or label comprises a plurality of electrical connections, first and second common connections, and first and second auxiliary common connections. The electrical connections convey auto-calibration information corresponding to a test sensor. The auto-calibration information is adapted to be utilized by the instrument to auto-calibrate for the test sensor. The electrical connections include first contact areas. The second common connection is separate and distinct from the first common connection. The first auxiliary common connection is separate and distinct from the first and second common connections. The second auxiliary common connection is separate and distinct from the first and second common connections. The first and second auxiliary common connections are located on opposing sides of the contact areas.

Abstract: A distributed analysis system may include at least one analysis instrument for generating sample data from a sample at a local site. A storage device may hold a library of calibration models at a site remote from the local site). A data processor, which may be integral with or separate from the analysis instrument, may determine a trait of the sample using a calibration model selected from the library and the sample data. The data processor may be located at the local site and may be connectable to the storage device via a telecommunications link. The data processor may temporarily retain the selected calibration model received via the telecommunications link.

Abstract: A hydrogen gas sensor and/or switch fabricated from arrays nanowires composed of metal or metal alloys that have stable metal hydride phases. The sensor and/or switch response times make it quite suitable for measuring the concentration of hydrogen in a flowing gas stream. The sensor and/or switch preferably operates by measuring the resistance of several metal nanowires arrayed in parallel in the presence of hydrogen gas. The nanowires preferably comprise gaps or break junctions that can function as a switch that closes in the presence of hydrogen gas. Consequently, the conductivity of the nanowires of the sensor and/or switch increases in the presence of hydrogen.

Abstract: Generally, this invention relates to the development of field monitoring methodology for new substances and sensing chemical warfare agents (CWAs) and terrorist substances. It also relates to a portable test kit which may be utilized to measure concentrations of halogenated volatile organic compounds (VOCs) in the field. Specifically it relates to systems for reliably field sensing the potential presence of such items while also distinguishing them from other elements potentially present. It also relates to overall systems and processes for sensing, reacting, and responding to an indicated presence of such substance, including modifications of existing halogenated sensors and arrayed sensing systems and methods.