Layer Containing Protein Patents (Class 977/757)
  • Method of producing nanopatterned articles, and articles produced thereby
    Patent number: 9018649
    Abstract: A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: April 28, 2015
    Inventors: Thomas P. Russell, Soojin Park, Ting Xu
  • Membrane precursors and membranes formed therefrom
    Patent number: 8772041
    Abstract: Disclosed are biomimetic membrane precursors and membranes formed therefrom. Also disclosed are methods of making biomimetic membrane precursors and membranes formed therefrom. Methods of using, including methods of storing and handling biomimetic membrane precursors and membranes formed therefrom, are also disclosed.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: July 8, 2014
    Assignee: The Regents of the University of California
    Inventors: Jacob J. Schmidt, Tae-Joon Jeon, Jason L. Poulos
  • Method of producing nanopatterned articles, and articles produced thereby
    Patent number: 8581272
    Abstract: A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film. The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: November 12, 2013
    Assignees: The University of Massachusetts, The Regents of the University of California
    Inventors: Thomas P. Russell, Soojin Park, Ting Xu
  • NANOSCALE BOUND BILAYERS, METHODS OF USE AND PRODUCTION
    Publication number: 20110059159
    Abstract: Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly obtaining a NABB not associated with membrane proteins. Immunogenic compositions comprising NABBs with native conformational epitopes are also provided along with their methods of use.
    Type: Application
    Filed: January 30, 2009
    Publication date: March 10, 2011
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Thomas P. Sakmar, Thomas Huber, Sourabh Banerjee
  • Targeted drug delivery of pain and addiction therapies using opioid receptor-mediated internalization
    Patent number: 7776819
    Abstract: Drug delivery is targeted to new opioid receptors using receptor-mediated internalization. Dermorphin was successfully conjugated to DSPE-PEG3400 without affecting the affinity to its receptor. The synthesized conjugate was inserted into preformed sterically stabilized liposomes to obtain dermorphin-grafted SSL. DSPE-PEG34Qo-dermorphin and dermorphin-SSL retained their affinity and selectivity for MOR. Moreover, dermorphin-SSL and encapsulated probes were taken up by CHO-hMOR cells, but not by naive CHO cells or very closely related CHO-hDOR cells. Dermorphin-SSL can be used to deliver drugs to the intracellular component of intended cells with high fidelity. Therefore, dermorphin-SSL is useful to carry pharmaceutical agents to achieve region-specific delivery of analgesics and/or to attenuate side effects associated with opioids.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: August 17, 2010
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Zaijie Jim Wang