Abstract: A medical device lead includes an insulative lead body, outer and inner conductive coils, and a flexible core assembly. The outer conductive coil extends through the lead body and is coupled to a first electrode at a distal end of the outer conductive coil. The inner conductive coil extends coaxially with the outer conductive coil, is coupled to a second electrode at a distal end of the inner conductive coil, and includes a central lumen. The flexible core assembly is disposed in the central lumen and is comprised of a material that has a saturation magnetization of at least about 1.5 T and a relative permeability of greater than one. The flexible core assembly includes a positioning interface configured for manipulation of the flexible core assembly such that the flexible core assembly translates through the central lumen during insertion and extraction of the flexible core assembly.

Abstract: The invention relates to nanoparticles of noble metals, having a controlled microstructure which leads to the appearance of ferromagnetic behaviour in said nanoparticles, thereby enabling the use of very small magnets (<5 nm) in a range in which standard ferromagnetic metals behave as superparamagnetic entitles (disappearance of hysteresis cycle). The inventive nanoparticles can be used, for example, to reduce the dimensions in magnetic recordings, as well as in biomedicine as tools for biomolecule recognition, nuclear magnetic resonance imaging, drug-release control or hypothermia treatments.

Abstract: This invention provides novel tools for surgery on single cells. In certain embodiments the tools comprise a microcapillary having at and/or near the tip a metal coating or a plurality of nanoparticles that can be heated by application of electromagnetic energy. In certain embodiments substrates are provided that facilitate the introduction of agents into cells. The substrates typically comprise a surface bearing a film or particles or nanoparticles that can be heated by application of electromagnetic energy.

Abstract: Methods and devices for selectively removing from a subject a target cell, pathogen, or virus expressing a binding partner on its surface are presented. In one embodiment, the device contains an excorporeal circuit, which includes, at least, a magnetic filter comprising a magnet and a removable, magnetizable substrate capable of capturing magnetic nanomaterials; and a pump in fluid communication with the magnetic filter, wherein the pump moves fluid through the excorporeal circuit. The magnet is capable of generating a magnetic field sufficient to capture magnetic nanomaterials in the magnetic field. In a preferred embodiment, the target cells are cancer cells and/or cells infected with pathogenic agents. The devices may be designed for extracorporeal or in vivo uses. Functionalized superparamagnetic nanoparticles are either mixed ex vivo with a biological fluid from the patient or injected into the patient.

Abstract: In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so &s to focus the polymer solution and/or suspension. The polymer solution and/or suspension stream forms microbeads in the fluid bath. Some of the focusing fluid is drawn from the fluid bath, so as to concentrate the microbeads in die fluid bath. The system includes a flow focusing apparatus and a liquid-containing cell. The focusing apparatus includes polymer and focusing nozzles. The cell contains the fluid bath and has an outlet port, through which the focusing fluid is drawn from the fluid bath.

Abstract: Compositions, systems and methods for using a nanoparticle composite to act as a valve within a microfluidic conduit to regulate fluid flow therethrough are provided. The nanoparticle composite includes a core having magnetic particles and Au particles and includes a hydrogel coating surrounding the core. The size of the nanoparticle composite is controlled by causing the hydrogel coating to lose water or absorb water, thus decreasing or increasing the size of the nanoparticle composite within the microfluidic conduit.

Abstract: Novel water soluble paramagnetic organic nanoparticles are formed by a novel method where an organic solution of an organic compound is injected into water under agitation that is maintained for a desired period of time for nanoparticle growth followed by termination of the growth by the addition of an aqueous surfactant solution. The size of the nanoparticles depends on the time between injection and addition of the surfactant solution. In embodiments of the invention, the water soluble paramagnetic organic nanoparticles can be DPPH nanoparticles, DPPH nanoparticles doped with DPPH-H, or core/shell nanoparticles where a DPPH core is covered by a DPPH-H shell.

Abstract: A method of forming at least one electronic device on a substrate comprising creating a depository and an attached capillary; providing a liquid containing particles in the range 1 nanometer to 1 millimeter for deposit into the depository; the liquid flowing into the at least one capillary by capillary action; evaporating the liquid such that the particles form an agglomerate beginning at the end of the at least one capillary with a substantially uniform distribution of the particles within the agglomerate; whereby the agglomerate is used to form a part of the at least one electronic device. An microelectronic integrated circuit device comprising a substrate; a depository coupled to said substrate formed by at least one wall, a capillary channel coupled to said depository adapted to be filled with liquid comprising nanoparticles by capillary action, whereby as the liquid evaporates, an agglomerate forms in the capillary channel having a substantially uniform distribution of the particles.

Abstract: A magnetic nanotube includes bacterial magnetic nanocrystals contacted onto a nanotube which absorbs the nanocrystals. The nanocrystals are contacted on at least one surface of the nanotube. A method of fabricating a magnetic nanotube includes synthesizing the bacterial magnetic nanocrystals, which have an outer layer of proteins. A nanotube provided is capable of absorbing the nanocrystals and contacting the nanotube with the nanocrystals. The nanotube is preferably a peptide bolaamphiphile. A nanotube solution and a nanocrystal solution including a buffer and a concentration of nanocrystals are mixed. The concentration of nanocrystals is optimized, resulting in a nanocrystal to nanotube ratio for which bacterial magnetic nanocrystals are immobilized on at least one surface of the nanotubes. The ratio controls whether the nanocrystals bind only to the interior or to the exterior surfaces of the nanotubes. Uses include cell manipulation and separation, biological assay, enzyme recovery, and biosensors.

Abstract: The disclosure provides elongated nanostructures useful for biological imaging and measurement. More particularly the disclosure provides nanoworms having an increased bioavailability compared to nanospheres.

Abstract: Negatively charged luminescent CdSe—ZnS quantum dots (QDs) were successfully incorporated into novel luminescent glyconanospheres averaging around 190 nm in diameter through electrostatic interactions with carboxymethyldextran (CM-dextran) and polylysine. The glyconanospheres preferably contain as well carboxyl-modified iron oxide nanocrystals. In addition to electrostatic attraction between the negatively charged dextran, the negatively charged CdSe—ZnS QDs (and negatively charged iron oxide nanocrystals, if present), and the positively charged polylysine, covalent amide bonds were introduced to cross link the QDs (and negatively charged iron oxide nanocrystals, if present) with the polysaccharide matrix to further stabilize the glyconanospheres. The dextran residues on the surface of the nanospheres show high affinity toward the glucose binding protein-Concanavalin A (Con A).

Abstract: The present invention is related to a method for forming a structure that contains alternating first and second ferromagnetic layers of different material compositions. A substrate containing a supporting matrix with at least one open pore and a conductive base layer is first formed. Electroplating of the substrate is then carried out in an electroplating solution that contains at least one ferromagnetic metal element and one or more additional, different metal elements. A pulsed current with alternating high and low potentials is applied to the conductive base layer of the substrate structure to thereby form alternating ferromagnetic layers of different material compositions in the open pore of the supporting matrix.

Abstract: A method of positioning a sample at a desired location relative to a magnetic sensor, for measurement of magnetic characteristics of the sample. A sample mounting substrate is provided, and an amphifunctional molecule is bound to the sample mounting substrate at the desired location. The amphifunctional molecule has a portion for binding to the sample mounting substrate, and a portion for capturing the sample. The sample is then provided for capture by the amphifunctional molecule.

Abstract: The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium. Water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths.

Abstract: Low power magnetoelectronic device structures and methods therefore are provided. The magnetoelectronic device structure (100, 150, 450, 451) comprises a programming line (104, 154, 156, 454, 456), a magnetoelectronic device (102, 152, 452) magnetically coupled to the programming line (104, 154, 156, 454, 456), and an enhanced permeability dielectric (EPD) material (106, 108, 110, 158, 160, 162, 458, 460, 462) disposed adjacent the magnetoelectronic device. The EPD material (106, 108, 110, 158, 160, 162, 458, 460, 462) comprises multiple composite layers (408) of magnetic nano-particles (406) embedded in a dielectric matrix (409). The composition of the composite layers is chosen to provide a predetermined permeability profile. A method for making a magnetoelectronic device structure is also provided. The method comprises fabricating the magnetoelectronic device (102, 152, 452) and depositing the programming line (104, 154, 156, 454, 456).

Abstract: Low power magnetoelectronic device structures and methods for making the same are provided. One magnetoelectronic device structure (100) comprises a programming line (104), a magnetoelectronic device (102) magnetically coupled to the programming line, and an enhanced permeability dielectric material (106) disposed adjacent the magnetoelectronic device. The enhanced permeability dielectric material has a permeability no less than approximately 1.5. A method for making a magnetoelectronic device structure is also provided. The method comprises fabricating a magnetoelectronic device (102) and depositing a conducting line (104). A layer of enhanced permeability dielectric material (106) having a permeability no less than approximately 1.5 is formed, wherein after the step of fabricating a magnetoelectronic device and the step of depositing a conducting line, the layer of enhanced permeability dielectric material is situated adjacent the magnetoelectronic device.

Abstract: Magnetic nanostructures comprised of an assembly of magnetic nanorods held together by dipole forces in a dendritic pattern and their method of manufacture. The dendritic magnetic nanostructures are prepared at room temperature by applying a magnetic field to a reverse micelle system wherein at least one salt of a magnetic metal is being precipitated within the core of the reverse micelle.

Abstract: The present invention provides a surgical manipulator which capable of manipulating a surgical or medical tool in up to six degrees of freedom. The manipulator has a relatively lightweight, compact design as a result of the use of high force to mass ratio actuators. The manipulator includes a mounting fixture which permits the manipulator to be fixed relative to a portion of a body of a patient.

Abstract: An active optical filter transmits or blocks light according to whether or not a magnetic field is applied, and functions as an optical filter transmitting light having a predetermined wavelength when light is transmitted according to a magnetic field. The active optical filter includes: an optical filter layer for transmitting or blocking light according to whether or not a magnetic field is applied; and a magnetic field applying unit surrounding the optical filter layer for applying a magnetic field to the optical filter layer. The optical filter layer has a multi-layer thin layer structure which is formed of two kinds of thin layers having different respective refractive indices and sequentially and periodically stacked on a substrate.

Abstract: Electromechanical systems utilizing suspended conducting nanometer-scale beams are provided and may be used in applications, such as, motors, generators, pumps, fans, compressors, propulsion systems, transmitters, receivers, heat engines, heat pumps, magnetic field sensors, kinetic energy storage devices and accelerometers. Such nanometer-scale beams may be provided as, for example, single molecules, single crystal filaments, or nanotubes. When suspended by both ends, these nanometer-scale beams may be caused to rotate about their line of suspension, similar to the motion of a jumprope (or a rotating whip), via electromagnetic or electrostatic forces. This motion may be used, for example, to accelerate molecules of a working substance in a preferred direction, generate electricity from the motion of a working substance molecules, or generate electromagnetic signals. Means of transmitting and controlling currents through these beams are also described.

Abstract: A method of heat energy transfer, hi one embodiment, the method comprises the steps of establishing a temperature gradient along a first direction in a heat reservoir with a medium and having a first end portion and an opposite, second end portion defining a length, L, therebetween, wherein the first direction is from the first end portion to the second end portion, such that the first end portion has a first temperature, Ti1; and the second end portion has a second temperature, Ti<Tj1; and applying an electromagnetic field in the heat reservoir to establish an electromagnetic field gradient along a second direction to generate a driving force to transfer heat energy from the second end portion to the first end portion.

Abstract: An electric motor comprises a first member having one or more magnetic, electric or electro-magnetic components, a second member having one or more magnetic, electric or electro-magnetic components, and a fluid containing ferromagnetic particles located in between the first member and the second member.

Abstract: A circuit for providing an A.C. signal including a number N of nanomagnetic oscillators, N being an integer greater than or equal to 2, each nanomagnetic oscillator providing a periodic signal; a unit for providing a control signal that can take N values, each periodic signal being associated with one of the values of the control signal; and a multiplexer receiving the N periodic signals and the control signal and providing the A.C. signal equal to one of the periodic signals according to the value of the control signal.

Abstract: The present invention discloses a lipiodol-ferrofluid, and a process for preparation thereof, wherein the lipiodol-ferrofluid includes the ferrofluid including a magnetic component, ?-Fe2O3 or Fe3O4; and the lipiodol.

Abstract: A nitrogenated carbon electrode suitable for use in a chalcogenide device and method of making the same are described. The electrode comprises nitrogenated carbon and is in electrical communication with a chalcogenide material. The nitrogenated carbon material may be produced by combining nitrogen and vaporized carbon in a physical vapor deposition process.

Abstract: An exemplary spin-polarized electron source includes a cathode, and a one-dimensional nanostructure made of a compound (e.g., group III-V) semiconductor with local polarized gap states. The one-dimensional nanostructure includes a first end portion electrically connected with the cathode and a second end portion located/directed away from the cathode. The second end portion of the one-dimensional nanostructure functions as a polarized electron emission tip and is configured (i.e., structured and arranged) for emitting a spin-polarized electron current/beam under an effect of selectably one of a magnetic field induction and a circularly polarized light beam excitation when a predetermined negative bias voltage is applied to the cathode. Furthermore, a spin-polarized scanning tunneling microscope incorporating such a spin-polarized electron source is also provided.

Abstract: An apparatus includes a thermally insulating substrate, an energy absorbing layer on the thermally insulating substrate, and a flash annealed magnetic layer on the energy absorbing layer. The flash annealed magnetic layer may be configured for data storage. A method includes providing a thermally insulating substrate, depositing an energy absorbing layer on the thermally insulating substrate, depositing a magnetic layer on the energy absorbing layer, and flash annealing the magnetic layer.

Abstract: Embodiments of the present invention provide methods for coating nanoparticles with polymeric coatings and nanoparticles that are coated with polymeric coatings. The polymeric coatings typically comprise two or more layers wherein the first layer has a charge that is opposite to that of the second layer. In further embodiments, the nanoparticles that can act as labels or reporters are coated with polymeric coatings. Optionally, these reporter or label nanoparticles may be Raman-active, such that they provide a distinctive Raman signature upon excitation with electromagnetic radiation.

Abstract: A magnetic nanoparticle (22), a magnetic nanomaterial (30), assembly (30), and a method for synthsising a magnetic nanoparticle, relating to thermodynamically stable and air stable ferromagnetic nanoparticles of adjustable aspect ratio made upon decomposition of organometallic precursors in solution in the presence of a reaction gas and a mixture of organic ligands. The magnetic nanomaterial comprises magnetic nanoparticles of homogeneous size, shape, and magnetic orientation that comprises a magnetic core (24, 34) ferromagnetic at room temperature and/or operating temperatures, and a non-magnetic matrix (26, 36) encapsulating the magnetic core. This magnetic nanomaterial could be used in high frequency integrated circuit applications, such as used in wireless portable electronic devices, to enchance magnetic field confinement and improve passive component performance at MHz and GHz frequency in a variety of passive and active devices, such as transformers, on-chip signal isolation, inductors, and the like.

Abstract: The present invention provides methods and systems for nanowire alignment and deposition. Energizing (e.g., an alternating current electric field) is used to align and associate nanowires with electrodes. By modulating the energizing, the nanowires are coupled to the electrodes such that they remain in place during subsequent wash and drying steps. The invention also provides methods for transferring nanowires from one substrate to another in order to prepare various device substrates. The present invention also provides methods for monitoring and controlling the number of nanowires deposited at a particular electrode pair, as well as methods for manipulating nanowires in solution.

Abstract: The present invention is concerned with the adsorption of chiral molecules at surfaces or interfaces, with the arrangement and properties of adsorbed chiral molecules, and with devices and methods based thereupon. In particular, an apparatus allows the influence of the magnetic environment of the adsorbed chiral molecules by means of a magnetic field. The new observed orientation of the adsorbed chiral molecules caused by the chiro-magnetic effect, and the possible applications, are disclosed too.

Abstract: Electromechanical systems utilizing suspended conducting nanometer-scale beams are provided and may be used in applications, such as, motors, generators, pumps, fans, compressors, propulsion systems, transmitters, receivers, heat engines, heat pumps, magnetic field sensors, kinetic energy storage devices and accelerometers. Such nanometer-scale beams may be provided as, for example, single molecules, single crystal filaments, or nanotubes. When suspended by both ends, these nanometer-scale beams may be caused to rotate about their line of suspension, similar to the motion of a jumprope (or a rotating whip), via electromagnetic or electrostatic forces. This motion may be used, for example, to accelerate molecules of a working substance in a preferred direction, generate electricity from the motion of a working substance molecules, or generate electromagnetic signals. Means of transmitting and controlling currents through these beams are also described.

Abstract: The present application is directed to the preparation and use of a class of nanoparticles called Quantum Confined Atoms or QCA's. A QCA is a particle of material comprising a plurality of host atoms in a nanoparticle of a size of less than 10 nm with a single atom of a dopant (or activator) confined within. The QCA's have unique luminescent and optical properties and thus can act as a very efficient nanophosphor which generate polarized light and can operate as a laser and a nanomagnet. An anti-agglomeration coating surrounding the nanoparticles can prevent clumping and loss of the enhanced properties.