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  • Human hypoxanthine-(guanine) phosphoribosyl transferase-2
    Publication number: 20020081695
    Abstract: A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
    Type: Application
    Filed: July 12, 2001
    Publication date: June 27, 2002
    Applicant: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Craig A. Rosen, Mark D. Adams
  • Soluble interleukin-1 receptor accessory molecule
    Patent number: 7390880
    Abstract: The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are futher provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: June 24, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Henrik S. Olsen, Craig A. Rosen
  • Soluble interleukin-1 receptor accessory molecule
    Patent number: 6974682
    Abstract: The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: December 13, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Henrik S. Olsen, Craig A. Rosen
  • Human hypoxanthine- (guanine) phosphoribosyl transferase-2
    Patent number: 6653446
    Abstract: A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: November 25, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Craig A. Rosen, Mark D. Adams
  • Interferon stimulating protein and uses thereof
    Patent number: 6001806
    Abstract: This invention relates to the use of the baculovirus glycoprotein, Interferon Stimulating Protein (ISP) (also known as gp67, gp64 EFP, or gp64), or the gene sequence encoding ISP, to stimulate production of interferon, such as for immunotherapy, anti-viral, anti-cancer, anti-bacterial, or anti-parasitic therapy. This invention also relates to novel mutant forms of ISP that show enhanced biological (i.e., anti-viral) activity, increased stability, higher yield or better solubility.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: December 14, 1999
    Assignees: Humn Genome Sciences, Inc., Washington University
    Inventors: David M. Hilbert, Daniel P. Bednarik, Bernadetta Nardelli, Marianne Murphy, David Parmelee, Ann Gronowski, Robert Schreiber
  • Human hypoxanthine-(guanine) phosphoribosyl transferase-2
    Patent number: 6849436
    Abstract: A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: February 1, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Daniel P. Bednarik, Craig A. Rosen, Mark D. Adams
  • Oil and moisture absorbent material and food package
    Publication number: 20040156957
    Abstract: A oil and moisture absorbent material suitable for use in food packages and a food package made of such material. The material comprises an oil and moisture absorbent layer covered by an oil and moisture repellent substance that has a multiplicity of perforations or which is applied in a pattern so that oil and moisture can pass through. Alternatively, the oil and moisture absorbent layer may be covered by an oil and moisture permeable substance. The oil and moisture absorbent layer may have indentations and additives that improve its oil and moisture absorbency. The oil and moisture absorbent layer may be made of a paperboard that is manufactured using a reduced level of calendering and having a reduced amount of sizing applied.
    Type: Application
    Filed: February 12, 2003
    Publication date: August 12, 2004
    Inventors: Sandeep Kulkarni, Ladislav Bednarik, Keith S. Shih, Richard Previty, I. Daniel Sand, Vivek Rohatgi, Richard A. Tedford, John Tonelli
  • Device and assembly for coupling an external optical component to a portable electronic device
    Patent number: 9294659
    Abstract: An assembly for coupling an external optical component to a portable electronic device is disclosed. The assembly includes a portable electronic device case having two sidewalls extending from a rear wall, a camera opening extending through the rear wall, a rear groove on an outer surface of the rear wall, and a side groove on a sidewall. Also included is an optical component coupling configured to removably couple to the portable electronic device case. The optical component coupling includes a face plate, a side plate, a rear tongue positioned to engage with the rear groove, a side tongue positioned to engage with the side groove, an optical component mount positioned to align with the camera opening. The optical component comprises one of a spectrometer, a magnifying optical component, a light filter, a telescope, a night vision optical component, a spotting scope, and a bore scope.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: March 22, 2016
    Assignee: The Quadrillion Group, LLC
    Inventors: Jason Garrett Bednarik, Emily Marie Hovater, Fred Lance Hovater
  • Velocity limiter shear for BWR control rods
    Patent number: 4747995
    Abstract: An apparatus for the simultaneous shearing of two sides of the boiling water nuclear reactor control rod. The rotation of the rods at 90 degree rotation and the shearing of the second two sides underwater in a nuclear waste storage pool.In a previous application by A. H. Krieg, Ser. No. 692,849, we have seen the crushing of a BWR control rod for the purpose of reducing nuclear radioactive waste. The control rod however has an end referred to as the velocity limiter end, which is round and bulbous. This end can not be crushed practically, due to its mass. The purpose of this invention is to shear or cut-off the velocity limiter from the rest of the control rod thus having the remaining cruciform crushable. Between the velocity limiter and the rest of the control rod are 2 "D" shaped holes, hereafter refered to as the "D" holes. At this point the control rod is solid and does not contain hollow fins or boron rods.
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: May 31, 1988
    Assignee: Widder Corporation
    Inventors: Alan Bednarik, Bonnie Whalen
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