Search Patents
  • Patent number: 9296993
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: March 29, 2016
    Assignee: Codexis, Inc.
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
  • Patent number: 9487760
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: November 8, 2016
    Assignee: Codexis, Inc.
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
  • Publication number: 20060264036
    Abstract: In a multilevel microelectronic integrated circuit, air comprises permanent line level dielectric and ultra low-K materials are via level dielectric. The air is supplied to line level subsequent to removal of sacrificial material by clean thermal decomposition and assisted diffusion of byproducts through porosities in the IC structure. Optionally, air is also included within porosities in the via level dielectric. By incorporating air to the extent produced in the invention, intralevel and interlevel dielectric values are minimized.
    Type: Application
    Filed: July 24, 2006
    Publication date: November 23, 2006
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Shyng-Tsong Chen, Stefanie Chiras, Matthew Colburn, Tomothy Dalton, Jeffrey Hedrick, Elbert Huang, Kaushik Kumar, Michael Lane, Kelly Malone, Chandrasekhar Narayan, Satyanarayana Nitta, Sampath Purushothaman, Robert Rosenberg, Christy Tyberg, Roy Yu
  • Patent number: 6314324
    Abstract: An apparatus and method in which the portions of the labyrinth associated with the labyrinthine sense and/or the nerves associated therewith are stimulated to perform at least one of the following functions: augment or control a patient's respiratory function, open the patient's airway, induce sleep, and/or counteract vertigo. In one embodiment, the vestibular stimulating system of the present invention includes 1) a stimulation element that performs the actual stimulation of the tissue, 2) a sensor to detect a physiological condition of the patient, and 3) a power/control unit that receives the signals provided by the sensor and causes stimulation energy to be provided to the stimulation element at an appropriate timing, level, pattern, and/or frequency to achieve the desired function. However, the present invention also contemplates eliminating the sensor in favor of applying a predetermined pattern of stimulation to the patient.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: November 6, 2001
    Assignee: Respironics, Inc.
    Inventors: Stefanie Lattner, Douglas M. Mechlenburg
  • Patent number: 6748275
    Abstract: An apparatus and method in which the portions of the labyrinth associated with the labyrinthine sense and/or the nerves associated therewith are stimulated to perform at least one of the following functions: augment or control a patient's respiratory function, open the patient's airway, induce sleep, and/or counteract vertigo. In one embodiment, the vestibular stimulating system of the present invention includes 1) a stimulation element that performs the actual stimulation of the tissue, 2) a sensor to detect a physiological condition of the patient, and 3) a power/control unit that receives the signals provided by the sensor and causes stimulation energy to be provided to the stimulation element at an appropriate timing, level, pattern, and/or frequency to achieve the desired function. However, the present invention also contemplates eliminating the sensor in favor of applying a predetermined pattern of stimulation to the patient.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: June 8, 2004
    Assignee: Respironics, Inc.
    Inventors: Stefanie Lattner, Douglas M. Mechlenburg
  • Patent number: 8341107
    Abstract: Embodiments of the present invention address deficiencies of the art in respect to expert modeling in a KM system and provide method, system and computer program product for organically ranked knowledge and categorization for a KM system. In one embodiment of the invention, a method for organically ranked knowledge and categorization in a KM system can be provided. The method can include bookmarking answer content for a first end user of the knowledge management system, suggesting a set of categories previously associated with the answer content by other end users of the knowledge management system, and categorizing the bookmarked answer content with a category selected from the set of categories.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: December 25, 2012
    Inventors: Robert L. Arseneault, Vani T. Chiganmy, Robert Cohen, David P. Cokely, Enzo Guadagnoli, David M. Heath, Stefanie L. Moses, Sergio A. Rubio, Hector C. Torres
  • Patent number: 6254135
    Abstract: An album construction for holding and displaying printed folded cards comprising (a) a rectangular support having a center portion and two outer portions, said center portion being longitudinally shorter than the two outer portions and thereby forming two bounded slots at each end of the center portion; (b) an elastic cord having both ends attached to said rectangular support and being of sufficient length to encircle or wrap the center portion of the rectangular support at least twice and thereby produce a series of at least two taut elastic strands located immediately adjacent to each other whereby the fold of the printed cards may be held between one of the taut elastic cord materials and the rectangular support; and (c) an album cover having a central spine and two outer covers, said rectangular support affixed to the spine.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: July 3, 2001
    Assignee: Girard Design LLC
    Inventor: Stefanie L. Girard
  • Patent number: 8078565
    Abstract: Embodiments of the present invention address deficiencies of the art in respect to expert modeling in a KM system and provide method, system and computer program product for organically ranked knowledge and categorization for a KM system. In one embodiment of the invention, a method for organically ranked knowledge and categorization in a KM system can be provided. The method can include bookmarking answer content for a first end user of the knowledge management system, suggesting a set of categories previously associated with the answer content by other end users of the knowledge management system, and categorizing the bookmarked answer content with a category selected from the set of categories.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: December 13, 2011
    Assignee: Kana Software, Inc.
    Inventors: Robert L. Arseneault, Vani T. Chiganmy, Robert L. Cohen, David P. Cokely, Enzo Guadagnoli, David M. Heath, Stefanie L. Moses, Sergio A. Rubio, Hector C. Torres
  • Patent number: 8871016
    Abstract: The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The present invention further provides a process for preparing a cellulose hydrogel comprising: (i) contacting cellulose with a solvent to activate the cellulose; (ii) optionally removing the solvent from the activated cellulose; (iii) substantially dissolving the activated cellulose to form a solution; (iv) allowing the solution to gel; and optionally (v) drying the gel and rehydrating the gel. The cellulose hydrogel can have many uses, including uses as contact lenses.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: October 28, 2014
    Assignee: The Johns Hopkins University
    Inventors: Morgana M. Trexler, Jenna L. Graham, Jennifer L. Breidenich, Jeffrey P. Maranchi, Julia B. Patrone, Marcia W. Patchan, Jennifer H. Elisseeff, Xiomara Calderon-Colon
  • Patent number: 7084479
    Abstract: In a multilevel microelectronic integrated circuit, air comprises permanent line level dielectric and ultra low-K materials are via level dielectric. The air is supplied to line level subsequent to removal of sacrificial material by clean thermal decomposition and assisted diffusion of byproducts through porosities in the IC structure. Optionally, air is also included within porosities in the via level dielectric. By incorporating air to the extent produced in the invention, intralevel and interlevel dielectric values are minimized.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: August 1, 2006
    Assignee: International Business Machines Corporation
    Inventors: Shyng-Tsong Chen, Stefanie Ruth Chiras, Matthew Earl Colburn, Timothy Joseph Dalton, Jeffrey Curtis Hedrick, Elbert Emin Huang, Kaushik Arun Kumar, Michael Wayne Lane, Kelly Malone, Chandrasekhar Narayan, Satyanarayana Venkata Nitta, Sampath Purushothaman, Robert Rosenburg, Christy Sensenich Tyberg, Roy RongQing Yu
  • Patent number: 7867937
    Abstract: Catalysts for experimentation are produced having a controlled matrix pore structure. The manufacturing process utilizes tape casting in the drying procedure in which a catalyst slurry is cast on a substrate and dried at a temperature of between about 50° C. to 200° C. for a period of time of about 0.1 to 1.0 hour. The dried catalyst particles can be removed from the substrate by several techniques, including scraping, burning, and deforming the substrate material. The resulting catalytic particles can be produced in an amount of about ca. 3 g to 300 g from slurries with volumes between 5 cc to 500 cc, which are suitable for small scale FCC reactors and for high throughput experimentation.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: January 11, 2011
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: William A. Wachter, Jeffrey T. Elks, Brenda A. Raich, Theodore E. Datz, Mary T. Van Nostrand, Gordon F. Stuntz, David O. Marler, Nicholas Rollman
  • Patent number: 9175153
    Abstract: The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high oxygen permeability, high biocompatibility, high tensile strength and desirable thermal stability. The present invention further provides a process for preparing a cellulose hydrogel comprising (i) a step of activating cellulose, in which the activating step comprises contacting the cellulose with a solvent to activate the cellulose for a time duration from about 2 hours to about 30 hours; (ii) substantially dissolving the activated cellulose to form a solution; and (iii) gelling the solution to form a gel, in which the gelling step comprises allowing the solution to gel in an environment comprising a relative humidity from about 30% to about 80% at 35° C.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: November 3, 2015
    Assignee: The Johns Hopkins University
    Inventors: Morgana M. Trexler, Jenna L. Graham, Jennifer L. Breidenich, Jeffrey P. Maranchi, Julia B. Patrone, Marcia W. Patchan, Jennifer H. Elisseeff, Xiomara Calderon-Colon
  • Patent number: 9441080
    Abstract: The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high oxygen permeability, high biocompatibility, high tensile strength and desirable thermal stability. The present invention further provides a process for preparing a cellulose hydrogel comprising (i) a step of activating cellulose, in which the activating step comprises contacting the cellulose with a solvent to activate the cellulose for a time duration from about 2 hours to about 30 hours; (ii) substantially dissolving the activated cellulose to form a solution; and (iii) gelling the solution to form a gel, in which the gelling step comprises allowing the solution to gel in an environment comprising a relative humidity from about 30% to about 80% at 35° C.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: September 13, 2016
    Assignee: The Johns Hopkins University
    Inventors: Morgana M. Trexler, Jeffrey P. Maranchi, Jennifer L. Breidenich, Xiomara Calderon-Colon, Julia B. Patrone, Jennifer H. Elisseeff, Marcia W. Patchan, Jenna L. Graham, Oliver D. Schein
  • Patent number: 8273181
    Abstract: The present invention provides a process for obtaining a product stream comprising one or more sulfate salts of potassium, sodium or ammonium from a sugar stream resulting from [processing a lignocellulosic feedstock, said sugar stream which includes calcium sulfate and one or more of these sulfate salts. The process comprises (i) treating the sugar stream to remove calcium, thereby producing a sugar stream containing substantially no calcium, and obtaining a salt stream comprising a calcium salt; (ii) choosing a feed stream that is either (a) a clarified salt stream derived from the salt stream of step (i) after removal of calcium therefrom; or (b) the sugar stream containing substantially no calcium that is produced in step (i); (iii) introducing the feed stream chosen in step (ii) to an ion exchange bed; and (iv) regenerating the ion exchange resin bed of step (iii) with sulfuric acid to produce the product stream.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: September 25, 2012
    Assignee: Iogen Energy Corporation
    Inventors: Brian E. Foody, Jeffrey S. Tolan
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