Abstract: A macrolactam disaccharide isolated from an antimicrobial complex 530 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. indica ATCC 53714.

Abstract: A movable display assembly for use with a fixed display wall includes a stationary base positioned horizontally in front of and at the lower end of the fixed display wall; a pair of spaced apart parallel tracks extending parallel to the fixed display wall and mounted on the stationary base; a trolley movably mounted on the tracks, each trolley including a plurality of rollers which ride within the tracks and thereby movably support the trolley therealong; an inverted substantially U-shaped rack formed from a tubular member for supporting a plurality of articles thereon, the rack including a lower end fixedly supported on the trolley and an upper free end, with a transparent pegboard supported by the rack for supporting the plurality of articles thereon.

Abstract: Processes for preparing bicyclic compounds useful as anti-allergic, anti-inflammatory and/or cytoprotective agents are described, together with a process for preparing intermediates thereof.

Abstract: Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.

Abstract: A method of treating gynecomastia in noncastrated patients being treated with an antiandrogen for androgen-dependent diseases such as benign prostatic hypertrophy, who are in need of such treating comprising administering to such patients therapeutically effective amounts of an antiandrogen, e.g., flutamide, in association with an antiestrogen, e.g., Tamoxifen, or an aromatase inhibitor such as 4-hydroxyadrostenedione is disclosed.

Abstract: A dispenser for dispensing metered amounts of a viscous material includes a rigid tube which defines a compartment for the material, a discharge passage at one end of the tube, a push button activated and reciprocatingly movable rod which moves back and forth between two positions in the tube, and a sealing plunger which moves step-wise on the rod, from the push button end to the discharge end. Each activation of the push button expels a metered amount of the viscous material. The plunger is formed of a short inner tube section which makes sealing contact with the rod, an outer tube section which is in sealing contact with the interior surface of the tube and a radially extending, ring-shaped, rib which connects the two sealing tubes to one another. In a preferred embodiment, the radial cross-section of the plunger exhibits and H-shape. A metallic gripper is secured to the plunger and has a free end which is inclined toward the rod.

Abstract: The invention features a novel hybrid interferon species that comprises a chain of 161 and/or 162 amino acids. The hybrid is novel not only for its new structure, but also because the hybrid comprises a shortened or truncated segment of alpha interferon, and hence, an entirely new interferon species which is not occurring in nature.

Abstract: Novel compounds and compositions which inhibit SRS-A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarction resulting from heart attack are disclosed.Useful intermediates for preparing said compounds are also disclosed.

Abstract: Azetidinones represented by the formula ##STR1## are prepared by a multistep process from L-(-)-theonine via an epoxyamide.

Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain aryl-substituted naphthyridines and pyrido-pyrazines.

Abstract: Novel compounds including 1-aryl-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofurans such as 1-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofuran, and 1-aryl-1-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dihydroisobenzofurans are disclosed. The corresponding benzo[c]thiophenes, isochromans, and isothiochromans and antifungal pharmaceutical compositions containing same, and methods of using said pharmaceutical compositions to elicit an antifungal response in warm blooded animals having a susceptible antifungal infection are also disclosed.

Abstract: Novel and useful silylenol intermediates for preparing penem and carbapenem antibacterials and a process for making selected intermediates are disclosed.

Abstract: A multi-step stereospecific process for preparing (3S,4R,5R)-1-(allyloxycarbonyl)-methyl-3-(1-hydroxyethyl)-4-beta-naphthoxy thi ocarbonylthio-2-azetidinone, stereoisomers thereof or hydroxy protected analogs thereof from anhydropenicillin. The azetidinones are intermediates useful for producing penems which are a known group or antibacterial compounds. The process involves protecting the hydroxy group of anhydropenicillin with a readily removable hydroxy protecting group, then reacting the resulting compound by treatment with oxygen and cuprous chloride in methanol, followed by reaction with ozone to produce a hydroxy protected dithiobis azetidinone and convert the methylidene groups originally in the 2-position of anhydropenicillin and in the bis-compound, to a (methoxycarbonyl)-carbonyl group. The resulting compound is converted to the unprotected dithiobis compound by reaction with ammonium hydroxide, then allyliodoacetate followed by an acid.

Abstract: A lipstick composition comprising a gloss-enhancing amount i.e. about 0.5 to about 8 weight percent of isohexadecane in a conventional lipstick formulation is disclosed.

Abstract: A hand-held fluid container and dispenser with a fluid reservoir, an applicator tube with two ends, one of which is unattached (free) and the second end of which is in communication with the reservoir and mounted on the body so as to be movable between a rest position in which the unattached end of the tube is adjacent to the body and a range of dispensing positions in which the unattached end of the tube projects from the body, a button actuated by finger pressure to cause fluid to flow from the reservoir through the applicator tube so it can be dispensed, and a cap which holds the applicator tube in the rest position through engagement with the unattached end thereof, the cap being displaceable relative to the applicator tube to permit movement of the applicator tube to the dispensing positions. Preferably the cap means is displaceable longitudinally of the applicator tube.

Abstract: Liquid makeup compositions containing an oil-absorbing effective amount of distarch phosphate in an alcohol-free e.g. ethanol-free-liquid makeup formulation which may be anhydrous, an oil-in-water emulsion or a water-in-oil emulsion.

Abstract: A shaped container having therein a water-soluble dyeing composition and a method of dyeing eggs using the shaped containers and a kit containing various shaped containers having therein different water-soluble dyeing compositions.

Abstract: The disclosed invention is compounds represented by the formulaZ--X--Q--Y--W, IZ--X--Q--Y--W'--Y--Q--X--Z IIand pharmaceutically acceptable acid addition salts and quarternary amine salts thereof, whereinZ is phenyl, naphthyl or adamantyl; substituted phenyl wherein the substituents are one or more of halogen, lower alkoxy, phenoxy, nitrile, nitro, phenylsulfonyl, methylsulfonyl, isoxazol-2-yl, lower alkanoyl, benzoyl, lower alkoxycarbonyl, lower alkyl, loweralkylthio, phenyl, phenylaminothiocarbonyl, or lower alkylaminothiocarbonyl; 5 or 6 membered unsubstituted or substituted heterocyclic ring containing at least one nitrogen and one carbon in the ring, wherein the substituents are one or more of carboxyl, hydroxymethyl, loweralkyl, loweralkylcarbonyl or aryl lower alkyl; or tertiary butyl;X and Y are each independently a bond, -O-, ##STR1## Q is a divalent substituted or unsubstituted straight or branched chain lower alkanediyl, -lower alkanedinyl- cycloalkanediyl- lower alkanediyl-, lower alkendiyl, lower

Abstract: There are disclosed novel di- and tri-O-acetyl-23-O-demycinosyl-4"-O-iso-valeryltylosins and the pharmaceutically acceptable salts thereof, which have improved activity as antibacterials and provide higher blood levels than other tylosin derived compounds. These compounds have the following structural formula ##STR1## wherein R is acetyl or hydrogen and z is for example O or ##STR2##Processes for selectively deacylating the 2' and 4"-positions of 3,2',4",4'"-tetra-O-acyltylosin or 2',4",4'"-tri-O-acyltylosin and for the selective acylation of 2',4"-di-O-acyltylosin and 2',4",4'"-tri-O-acyltylosin are also disclosed.