Patents Represented by Attorney A. S. Rosen

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  • 2-(heterocycloalkylthio)penems
    Patent number: 4690922
    Abstract: This invention relates to 2-(heterocycloalkylthio)penems wherein the nitrogen of the heterocyclic ring is connected to the alkyl group, and to their use as antibacterial agents.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: September 1, 1987
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Viyyoor M. Girijavallabhan, Patrick A. Pinto, Richard W. Versace
  • Retractable mascara applicator
    Patent number: 4687364
    Abstract: A mascara device comprising a container with a mascara reservoir, a retractable mascara brush on a shaft therein and a spring to move the brush longitudinally (axially) between a position inside the reservoir and a position outside the reservoir.
    Type: Grant
    Filed: July 17, 1985
    Date of Patent: August 18, 1987
    Assignee: Plough, Inc.
    Inventor: Ted I. Kingsford
  • 6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids
    Patent number: 4683226
    Abstract: 6-substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids and cogeners having useful antibacterial activity are disclosed. The compounds are prepared in a reaction sequence starting with a 4-acyloxy-2-azetidinone.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: July 28, 1987
    Assignee: Schering Corporation
    Inventor: Stuart W. McCombie
  • Shoe inlay
    Patent number: 4677766
    Abstract: A full shoe inlay for athletic shoes constructed of resilient material having a depression for the 1st metatarsal head, a raised portion for the 2nd, 3rd, and 4th metatarsal heads, a full arch support, and an eccentric heel seat. The heel seat is built up more on the inside than on the outside. The inlay prevents or lessens a number of common athletic-related injuries.
    Type: Grant
    Filed: July 28, 1982
    Date of Patent: July 7, 1987
    Assignee: Scholl, Inc.
    Inventor: Charles J. Gudas
  • Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
    Patent number: 4677214
    Abstract: A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: June 30, 1987
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, Stuart W. McCombie
  • Sensor circuit
    Patent number: 4667518
    Abstract: A high density miniature sensor circuit useful for measuring pressure changes in a fluid in a closed chamber, comprising a high density of resistor segments gapped about 0.002 inches and conductors as contact pads which conductors are permanently affixed to a ceramic substrate is disclosed.
    Type: Grant
    Filed: March 18, 1986
    Date of Patent: May 26, 1987
    Assignee: Iden Industries, Inc.
    Inventor: Lee J. Iden
  • Method for modulating the immune response
    Patent number: 4666922
    Abstract: There is disclosed a method for immunomodulation employing as active agents certain substituted 1,8-naphthyridines and 1,5,8-azanaphthyridines.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: May 19, 1987
    Assignee: Schering Corporation
    Inventors: Sidney R. Smith, Marvin I. Siegel
  • Combination therapy for treatment of female breast cancer
    Patent number: 4666885
    Abstract: A method of treatment of breast cancer in susceptible animals whose ovarian hormonal secretions are blocked by surgical or chemical means, e.g., by use of an LH-RH agonist, e.g., [D-Trp.sup.6, des-Gly-NH.sub.2.sup.10 ]LH-RH ethylamide with a therapy comprising administering an antiandrogen, e.g., flutamide and an optionally, an inhibitor of adrenal sex steroid biosynthesis e.g., aminoglutethimide, pharmaceutical compositions useful for such treatment and two, four and five component pharmaceutical kits containing such compositions are disclosed.
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: May 19, 1987
    Inventor: Fernand Labrie
  • Dyed eggs
    Patent number: 4664925
    Abstract: A means and compositions for pretreating whole intact eggs in a boiling solution at about pH 3.2-3.6 with a buffer, preferably cream of tarter, prior to dyeing and coating with a flavor fragrance.A kit for consumer use in treating, dyeing and adding a flavor fragrance is also disclosed.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: May 12, 1987
    Assignee: Plough, Inc.
    Inventor: James E. McShane
  • Skin cooling method
    Patent number: 4661476
    Abstract: There is disclosed a method of cooling overheated skin by applying to the surface thereof a composition comprising on a weight basis about 0.5% to 1.5% hydrolyzed starch-acrylonitrile copolymer sodium salt and water and optional lubricants, dyes, moisturizers, preservatives, and the like.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: April 28, 1987
    Assignee: Plough, Inc.
    Inventors: James W. Lane, Davendra D. Parikshak, Carl Kaplan
  • Method of treatment of prostate cancer
    Patent number: 4659695
    Abstract: A method of treatment of prostate cancer in susceptible male animals including humans whose testicular hormonal secretions are blocked by surgical or chemical means, e.g., by use of an LH-RH agonist, e.g., [D-Trp.sup.6, des-Gly-NH.sub.2.sup.10 ]LH-RH ethylamide which comprises administering an antiandrogen, e.g., flutamide in association with at least one inhibitor of sex steroid biosynthesis, e.g., aminoglutethimide and/or ketoconazole. Pharmaceutical compositions useful for such treatment and three, four and five component kits containing such compositions are also disclosed.
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: April 21, 1987
    Inventor: Fernand Labrie
  • Preparation of (-)-5-(beta)-1-hydroxy-2-((beta)-1-methyl-3-phenylpropyl)aminoethyl) salicylamide
    Patent number: 4658060
    Abstract: There is disclosed a multistep process for producing (-)-5-[(R)-1-hydroxy-2-((R)-1-methyl-3-phenyl-propyl)aminoethyl]salicylami de in high yields which does not require chromatography.The process is stereoselective for the desired products starting with the reaction of D-(+)-alpha-methylbenzylamine with benzylacetone followed by reduction of the resulting Schiff's base to form an amine as an R,R: R,S diastereomeric mixture, resolution of the mixture to obtain the R,R stereoisomer as a salt, conversion to a free base, reaction of the R,R free base with an O-protected alpha-bromo-3-carbamoyl-acetophenone to produce the corresponding R,R-ketobenzamide, reduction to produce a mixture of S,R,R;R,R,R hydroxybenzamide, removal of the protecting groups, resolution of the deprotected product and then conversion to the free R,R-amine.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: April 14, 1987
    Assignee: Schering Corporation
    Inventors: Elijah J. Gold, Esther Babad, Lydia Peer, Wei K. Chang
  • Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents
    Patent number: 4652564
    Abstract: Substituted spiro pyridine derivatives are anti-allergic and anti-inflammatory agents. They are also useful for the treatment of peptic ulcers.Methods for their preparation and use are disclosed.
    Type: Grant
    Filed: December 14, 1983
    Date of Patent: March 24, 1987
    Assignee: Schering Corporation
    Inventor: David J. Blythin
  • Shoe insole
    Patent number: 4642912
    Abstract: A shoe insole having superior cushioning and comfort, good resistance to buckling, and excellent retention of cushioning properties after wear. The insole consists of three layers:(a) a bottom layer having compressive strength of at least 0.3 kg/cm.sup.2 at 40% strain,(b) an intermediate layer having less compressive strength at 40% strain than the bottom layer, and(c) a top layer constructed of fabric. The three layers are laminated together and shaped to fit inside of an article of footwear.
    Type: Grant
    Filed: May 2, 1984
    Date of Patent: February 17, 1987
    Assignee: Scholl, Inc.
    Inventors: Gary C. Wildman, Frank Wirth, Vijay Surpuriya
  • Means of aiding in the prevention of sudden infant death syndrome
    Patent number: 4639455
    Abstract: A means of aiding in the prevention of Sudden Infant Death Syndrome (SIDS) is disclosed. The means comprises administering a pharmaceutically effective amount of the drug 6-methylene-6-desoxy-N-cylopryplymethyl-14-hydroxydihydronormorphone to an infant determined to be susceptible to SIDS. The drug is preferably administered bi-daily via the GI tract. The drug attaches to the nerve receptor sites responsible for the actuation of respiration thus blocking the attachment of endogenous endorphins which, if present in high levels, prevents such actuation resulting in apnea and SIDS. A suppository containing the drug for use in carrying out the method is also disclosed.
    Type: Grant
    Filed: October 2, 1984
    Date of Patent: January 27, 1987
    Assignee: Key Pharmaceuticals, Inc.
    Inventor: Luana Moore
  • Interferon-cyclaradine combination
    Patent number: 4636383
    Abstract: Treatment of viral infections with combinations of cyclaradine and interferon and compositions and kits used therein are disclosed.
    Type: Grant
    Filed: August 29, 1984
    Date of Patent: January 13, 1987
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, George H. Miller, Jerome Schwartz, Michael R. Ostrander
  • Athletic shoe insole
    Patent number: D288621
    Type: Grant
    Filed: May 4, 1984
    Date of Patent: March 10, 1987
    Assignee: Scholl, Inc.
    Inventors: Vijay Surpuriya, Charles J. Gudas
  • Eye makeup applicator
    Patent number: D290173
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: June 2, 1987
    Assignee: Plough, Inc.
    Inventors: Albert K. Taylor, Robert L. Baumgartner
  • Sandal
    Patent number: D290900
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: July 21, 1987
    Assignee: Scholl, Inc.
    Inventors: Michael M. Schornstein, Malcolm G. Blissett
  • AZA penem compounds
    Patent number: RE32465
    Abstract: Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, followed by reaction of the thereby formed 1-imido-4-substituted-azetidine-2-one with a trialkyl phosphite.Also described are novel penems useful as antibacterials which are prepared by the described process.
    Type: Grant
    Filed: May 29, 1985
    Date of Patent: July 28, 1987
    Assignee: Schering Corporation
    Inventors: Adriano Afonso, Frank Hon