Patents Represented by Attorney, Agent or Law Firm Alan L. Scrivner
  • Patent number: 6747061
    Abstract: N-substituted dithiocarbamate esters, pharmaceutical compositions containing them, and methods of treating hyperproliferative disorders such as cancer by administering the N-substituted dithiocarbamate esters.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: June 8, 2004
    Assignee: AtheroGenics, Inc.
    Inventors: Russell M. Medford, Uday Saxena, Lee K. Hoong, Patricia K. Somers
  • Patent number: 6670398
    Abstract: The use of compounds of the formula and pharmaceutically acceptable salts thereof, alone or in combination for the treatment of transplant rejection, wherein the substituents are further defined in the application.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: December 30, 2003
    Assignee: AtheroGenics, Inc.
    Inventors: David B. Edwards, Patricia K. Somers, Mitchell Glass
  • Patent number: 6485718
    Abstract: The present invention relates to site-specific conjugation of synthetic particles to proteins.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: November 26, 2002
    Assignee: Pharmacia Corporation
    Inventors: Rajani V. Parthasarathy, Stephen C. Lee
  • Patent number: 6242612
    Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: June 5, 2001
    Assignee: G. D. Searle & Co.
    Inventors: Matthew J. Graneto, Michael L. Vazquez, Susan J. Hartmann, Suzanne Metz, John J. Talley, David L. Brown, Richard M. Weier, Michael A. Stealey, Xiangdong Xu
  • Patent number: 6207708
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: March 27, 2001
    Assignee: G. D. Searle & Company
    Inventors: Rolando E. Gapud, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Barnett S. Pitzele, Suzanne S. Metz, R. Keith Webber, Foe S. Tjoeng, Robert E. Manning, Mihaly V. Toth
  • Patent number: 6169089
    Abstract: The current invention discloses aminotetrazole derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: January 2, 2001
    Assignee: G. D. Searle & Company
    Inventors: E. Ann Hallinan, Donald W. Hansen, Jr., Sofya Tsymbalov
  • Patent number: 6143892
    Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: November 7, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Matthew J. Graneto, Michael L. Vazquez, Susan J. Hartmann, Suzanne Metz, John J. Talley, David L. Brown, Richard M. Weier, Michael A. Stealey, Xiaodong C. Xu
  • Patent number: 6143790
    Abstract: There is disclosed a novel amino glycol derivatives of L-N.sup.6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: November 7, 2000
    Assignee: G.D. Searle & Co.
    Inventors: E. Ann Hallinan, Foe S. Tjoeng, Kam F. Fok, Timothy J. Hagen, Mihaly V. Toth, Sofya Tsymbalov, Barnett S. Pitzele
  • Patent number: 6136829
    Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: October 24, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Ariia A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Patent number: 6087496
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R.sup.1, R.sup.2, Ar.sup.1 and HetAr.sup.2 are as described in the specification.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: July 11, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Ashok Anantanarayan, Michael Clare, Lifeng Geng, Gunnar J. Hanson, Richard A. Partis, Michael A. Stealey, Richard M. Weier
  • Patent number: 6071906
    Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: June 6, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Patent number: 6046211
    Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: April 4, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Patent number: 6043261
    Abstract: The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: March 28, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
  • Patent number: 6011028
    Abstract: The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: January 4, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann. Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
  • Patent number: 5985862
    Abstract: The present invention discloses novel pharmaceutical compositions having steroid nitrate ester(ONO.sub.2) derivatives, and to their use treating undesired smooth muscle contractions and inflammatory diseases.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: November 16, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec
  • Patent number: 5981511
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 9, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Rolando E. Gapud, Timothy J. Hagen, Ann E. Hallinan, Donald W. Hansen, Jr., Robert E. Manning, Suzanne Metz, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, R. Keith Webber
  • Patent number: 5981556
    Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: November 9, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Patent number: 5958958
    Abstract: 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: September 28, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Patent number: 5945408
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: August 31, 1999
    Assignee: G.D. Searle & Co.
    Inventors: R. Keith Webber, Foe S. Tjoeng, Robert E. Manning
  • Patent number: 5932576
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: August 3, 1999
    Assignee: G. D. Searle & Company
    Inventors: Ashok Anantanarayan, Michael Clare, Lifeng Geng, Gunnar J. Hanson, Richard A. Partis, Michael A. Stealey, Richard M. Weier