Abstract: The current invention discloses azepine derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
November 25, 1997
Date of Patent:
March 16, 1999
Assignee:
G. D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., E. Ann Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivede, Foe S. Tjoeng, Barnett S. Pitzele
Abstract: Aminotetrazole derivatives of the formula (I) wherein the variables are as defined in the disclosure are useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
April 30, 1997
Date of Patent:
December 29, 1998
Assignee:
G. D. Searle & Co.
Inventors:
Ann E. Hallinan, Donald W. Hansen, Jr., Sofya Tsymbalov
Abstract: The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
December 29, 1998
Assignee:
G. D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
Abstract: The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.
Type:
Grant
Filed:
May 2, 1996
Date of Patent:
November 17, 1998
Assignee:
G. D. Searle & Co.
Inventors:
Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec