Patents Represented by Attorney Albert H. Graddis
  • Patent number: 4472495
    Abstract: The color-intensity of exposed and developed Kodachrome color film in the form of color transparencies or continuous strip such as movie film can be reduced by treating selected areas or all of the emulsion side of said color film with an aqueous solution of a dichromate salt acidified with an inorganic mineral acid or formic acid. Any undesirable alteration in color tone is minimized by including a soluble salt of nickel or cobalt in said aqueous solution. The reduction in color-intensity is a function of time and/or acid concentration.
    Type: Grant
    Filed: January 20, 1983
    Date of Patent: September 18, 1984
    Inventor: Edward Degginger
  • Patent number: 4357311
    Abstract: A method is disclosed for preparing an activated microporous substrate to which antibody may be covalently bonded through trichloro-triazine to yield an activated substrate which is very useful for many immunochemical reactions utilizing a flow-through procedure.
    Type: Grant
    Filed: October 3, 1980
    Date of Patent: November 2, 1982
    Assignee: Warner-Lambert Company
    Inventor: Ernest G. Schutt
  • Patent number: 4327745
    Abstract: An arterial blood sampling syringe consisting of a barrel and a plunger assembly in which the plunger is hollow and provided at its distal end with two annular rings which cooperate with the hollow plunger and each other to maintain a sealing ring and gas-pervious but liquid impervious membrane in position at the end of the plunger. The plunger position in the barrel may be preset to receive any desired blood sample volume. Further blood flow is halted when the barrel of the syringe fills to the volume desired.
    Type: Grant
    Filed: September 2, 1980
    Date of Patent: May 4, 1982
    Assignee: The Deseret Company
    Inventor: George W. Ford, Jr.
  • Patent number: 4325908
    Abstract: Theophylline concentrations in body fluids can be determined by a color reaction. The theophylline is converted to theophyllidine by reaction with an alkali such as sodium or potassium hydroxide at an elevated temperature and, after neutralization of the alkali with an organic acid, the theophyllidine formed is coupled with a chromogen to yield a color whose depth is proportional to the theophylline concentration in the body fluid being tested. The improved procedure utilizes a solid alkali for the heating step and a non-corrosive acid for the neutralization. An improved chromogen yields a bright, relatively stable purple color.
    Type: Grant
    Filed: February 20, 1980
    Date of Patent: April 20, 1982
    Assignee: Warner-Lambert Company
    Inventors: Bernard M. Scheinthal, Lester Chafetz
  • Patent number: 4275075
    Abstract: The present invention relates to prostaglandin analogues of the general formula: ##STR1## [wherein A represents a grouping of the formula: ##STR2## X represents trans-vinylene or ethylene and Y represents cis-vinylene or ethylene, R represents a group of the formula --COOR.sup.4, in which R.sup.4 represents hydrogen or straight- or branched-chain alkyl of 1 to 12 carbon atoms, or a group of the formula --CH.sub.2 OR.sup.5, in which R.sup.5 represents hydrogen or alkylcarbonyl of 2 to 5 carbon atoms and R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent hydrogen, straight- or branched-chain alkyl of 1 to 12 carbon atoms, or an aryl group unsubstituted or substituted by one, two or three substituents selected from alkyl, alkoxy, alkylthio, monoalkylamino and dialkylamino groups and halogen atoms, the alkyl groups or moieties of the said groups containing from 1 to 5 carbon atoms in a straight- or branched-chain, with the proviso that at least one of the symbols R.sup.1, R.sup.
    Type: Grant
    Filed: June 14, 1978
    Date of Patent: June 23, 1981
    Assignee: ONO Pharmaceutical Co. Ltd.
    Inventors: Masayasu Kurono, Hisao Nakai, Shigeru Sakuyama
  • Patent number: 4247555
    Abstract: Certain 4,9-dihydro-9-oxo-N-1H-tetrazol-5-yl-pyrazolo[5,1-b]quinazoline-2-carboxam ides are disclosed. These compounds prevent the allergic response in mammals.
    Type: Grant
    Filed: January 11, 1980
    Date of Patent: January 27, 1981
    Assignee: Warner-Lambert Company
    Inventors: Jagadish C. Sircar, Thomas Capiris
  • Patent number: 4242239
    Abstract: A heavy bodied reversible hydrocolloid dental impression material is disclosed. This material comprises agar-agar as the main component in which there is added a small amount of locust bean gum, potassium or zinc sulfate, a borate and nonionic poly(ethyleneoxide)homopolymer. This dental impression material is effective, for example, for bonding to an alginate material.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: December 30, 1980
    Assignee: Warner-Lambert
    Inventors: Henry A. Kessler, Richard A. McEvoy
  • Patent number: 4231933
    Abstract: The present invention is concerned with novel 3-hydroxy-pyrrolin-2-one derivatives and with the preparation thereof.
    Type: Grant
    Filed: December 7, 1978
    Date of Patent: November 4, 1980
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred F. Herrmann, Gustav Hechtfischer
  • Patent number: 4230707
    Abstract: Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: October 28, 1980
    Assignee: Warner-Lambert Company
    Inventors: Francis J. Tinney, David T. Connor, Wiaczeslaw A. Cetenko, Joseph J. Kerbleski, Roderick J. Sorenson
  • Patent number: 4229457
    Abstract: New 3-(3-methoxyphenoxy)-2-pyridinecarbonitriles, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. Other known 3-(3-substituted phenoxy)-2-pyridinecarbonitriles are disclosed having the same utility. The compounds can be produced by dehydrating the appropriately substituted oxime or displacing an alkoxy group to give the desired carbonitrile.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: October 21, 1980
    Assignee: Warner-Lambert Company
    Inventor: Donald E. Butler
  • Patent number: 4228179
    Abstract: The present invention is concerned with new N-substituted spirolactams and their preparation.
    Type: Grant
    Filed: July 13, 1978
    Date of Patent: October 14, 1980
    Assignee: Warner-Lambert Company
    Inventors: Johannes Hartenstein, Gerhard Satzinger, Manfred Herrmann, Wolfgang Heldt
  • Patent number: 4226599
    Abstract: A tableted form of fibrous triethylaminoethyl cellulose suitable for the removal of heparin from heparin-containing blood plasma. The tablet is composed of granular microcrystalline cellulose and fibrous triethylaminoethyl cellulose in a ratio of from about 5.4:1 to about 10:1. The triethylaminoethyl cellulose tablet, which is formulated to provide from about 5 to about 26 mg. of triethylaminoethyl cellulose per milliliter of plasma sample, is added to a heparin-containing blood plasma sample, the sample is agitated or allowed to stand for a time sufficient to permit adsorption of substantially all heparin present. The sample is then centrifuged and the remaining heparin-free plasma can be subjected to coagulation testing in order to determine the true clotting time.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: October 7, 1980
    Assignee: Warner-Lambert Company
    Inventors: James R. Butler, James E. Turner, Frank W. Goodhart
  • Patent number: 4225722
    Abstract: This invention relates to Compounds of formula II: ##STR1## wherein Y is formyl, carboxylic acid, acrylic acid, cyano or tetrazolo; X is hydrogen, lower alkanoyl or lower alkyl, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthamatic reactions.
    Type: Grant
    Filed: October 13, 1977
    Date of Patent: September 30, 1980
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Patricia A. Young, Maximilian Von Strandtmann
  • Patent number: 4218456
    Abstract: Tetrahydropyridylbutyrophenones of the following formula I: ##STR1## wherein x is hydrogen, halogen such as fluorine, chlorine, bromine or iodine, trifluoromethyl, alkoxy, thioalkoxy, nitro, cyano, amino, lower alkyl of 1 to 6 carbons, aryl or substituted aryl; and y is hydrogen or halogen; and the non-toxic, pharmaceutically acceptable acid addition salts thereof. The compounds of the invention having the formula I are useful in the treatment of psychotic disorders such as schizophrenia.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: August 19, 1980
    Assignee: Warner-Lambert Company
    Inventors: Lawrence D. Wise, Patrick F. Flynn, Glenn C. Morrison
  • Patent number: 4218455
    Abstract: Tetrahydropyridylbutyrophenones of the following formula IX: ##STR1## wherein x is hydrogen, halogen such as fluorine, chlorine, bromine or iodine, trifluoromethyl, alkoxy, nitro, cyano, amino, lower alkyl of 1 to 6 carbons, aryl or substituted aryl; y is hydrogen or halogen; and n is 0, 1 or 2; and the non-toxic, pharmaceutically acceptable acid addition salts thereof. Tetrahydropyridylbutanols having the formula X: ##STR2## wherein x and y are as defined above, as well as their non-toxic, pharmaceutically acceptable acid addition salts, are also disclosed. The compounds of the invention having the formulas IX and X are useful as antipsychotics.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: August 19, 1980
    Assignee: Warner-Lambert Company
    Inventors: Lawrence D. Wise, Patrick F. Flynn, Glenn C. Morrison
  • Patent number: 4215142
    Abstract: Prostaglandin E.sub.1 analogues of the general formula: ##STR1## [wherein Y represents ethylene or trans-vinylene, Z represents ethylene or trans-vinylene, R.sup.1 represents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 12 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group containing from 1 to 6 carbon atoms, a phenyl group unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group, alkyl group containing from 1 to 4 carbon atoms or phenyl group, a --C.sub.m H.sub.2m COOR.sup.5 group (wherein m represents an integer of from 1 to 12 and R.sup.5 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms), a --C.sub.n H.sub.2n OR.sup.6 group (wherein R.sup.6 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and n represents an integer of from 2 to 12), or a ##STR2## group (wherein R.sup.7 and R.
    Type: Grant
    Filed: September 8, 1978
    Date of Patent: July 29, 1980
    Assignee: Ono Pharmaceutical Co. Ltd.
    Inventors: Masaki Hayashi, Katsuichi Shimoji, Yoshinobu Arai
  • Patent number: D256995
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: September 23, 1980
    Assignee: Warner-Lambert Company
    Inventor: Ernest F. Kiraly
  • Patent number: D256996
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: September 23, 1980
    Assignee: Warner-Lambert Company
    Inventor: Ernest F. Kiraly
  • Patent number: D256997
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: September 23, 1980
    Assignee: Warner-Lambert Company
    Inventor: Vincent C. Motta
  • Patent number: D256998
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: September 23, 1980
    Assignee: Warner-Lambert Company
    Inventor: Vincent C. Motta