Abstract: A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1.

Abstract: A data transfer application for concurrent transfer of data streams based on two or more transport layer protocols via a single one-way data link. The present invention provides a great degree of routing flexibility by providing seamless network connectivity under a plurality of transport layer protocols, such as TCP and UDP, between multiple source and destination platforms over a single one-way data link.

Abstract: A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient's tumor; (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and 20 of the PIK3CA gene or which show loss of PTEN protein expression will be considered not likely to benefit from EGFR targeting therapies.

Abstract: A computer-implemented method includes the steps of accessing, using one or more processors, data relating to visitors who have visited one or more websites, determining, using one or more processors, geographic areas corresponding to locations of the visitors, receiving, using one or more processors, one or more signals indicating a first request to provide at least a portion of data to be provided on a webpage, determining, using one or more processors, a geographic area from where the request originates; generating, using one or more processors, a subset of the data that pertains to the requested data based on: relevancy of the requested data to the geographic area from where the request originates, and relevancy of the requested data to the visitors that are located in or near the geographic area from where the request originates; and providing, using one or more processors, the subset of the data; and providing, using one or more processors, data that indicates whether or not the visitors found each item

Abstract: The invention relates to a digital motion picture camera including at least one optoelectronic sensor device for the recording of motion pictures. The sensor device has, in an areal arrangement, a plurality of sensor elements for the generation of a respective received signal in dependence on a light exposure. The camera further has a control device for the controlling of the read-out of the received signals of the sensor elements as well as a digitizing device for the digitizing of the received signals. The camera moreover has an optical viewfinder for the visual observation of the motion pictures to be recorded and a beam deflection device which is interposed in front of the sensor device and by which the reception beam path can be split at least into one recording beam path for the sensor device and one viewfinder beam path for the optical viewfinder.

Abstract: This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic screens for disorders and conditions involving regulation of fat storage in tissue, assays for identifying agents that can regulate fat storage in tissue through modulating the levels of FIT1 and/or FIT2, and genetically altered mammals in which expression of FIT1 and/or FIT2 is altered in one or more tissue.

Abstract: A door and board lifting device comprising a foot operated lever and locking means wherein said locking means is operative to releasably secure the lever in a substantially fixed position.

Abstract: An absorbent article is provided that includes a top sheet and a back sheet joined to form side seam regions. An absorbent core is disposed between the top sheet and the back sheet; and laterally oriented elastics are disposed between the top sheet and the back sheet. The elastics include a first elastic region disposed adjacent to the front end and a second elastic region disposed adjacent the first elastic region. The second elastic region includes one or more elastic elements that extend between the side seam regions. The elastic elements have internal cuts adjacent the side seams in a configuration that relieves elastic tension adjacent the side seams regions.

Abstract: In the ex vivo stimulation method of dendritic cells, the stimulation occurs with the lysate of tumor spheres (TS) of the solid tumors.

Abstract: The invention is a device for characterizing the particle size distribution of powders, comprising a supply member, a discharge member, a weighing member, a continuous vibration member, a screening member and, optionally, a control member, said device being characterized in that the screening member is a member that rotates about a horizontal axis and has at least four positions corresponding to two screens of different mesh size, one release space and one anti-shock plate. Another subject of the invention is the use of such a device for characterization of the particle size distribution of powders and especially their in-line characterization, that is to say characterization during their manufacturing process.

Abstract: An absorbent article has an inside surface that faces a wearer's body when the absorbent article is worn, and an outside surface opposite the inside surface. The absorbent article includes a liquid pervious topsheet and a backsheet, at least a portion of the backsheet being liquid impervious. A front waist portion includes a first side front panel and a second side front panel. A back waist portion includes a first side back panel and a second side back panel. A crotch portion longitudinally extends between the front waist portion and the back waist portion. An absorbent assembly is disposed between the topsheet and the backsheet. A first fastening component is disposed at the first side front panel and a second fastening component is disposed at the second side front panel for respective attachment to the first side back panel and the second side back panel to fasten the absorbent article around the waist of the wearer.

Abstract: A squirting toy is comprised of a cylindrical housing and a piston that slides within to force water into or out of the housing via a hole therein. The housing is encased within a shell creating a water impervious volume sufficient for the toy to float in water. The shell is soft, so that the gun is not a safety hazard when left floating in a swimming pool. Handles associated with one or both actuating portions of the squirting toy are provided for gripping and operating the squirting toy more effectively.

Abstract: Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B-CLL). Vectors comprising those genes and cells comprising those vectors are also provided, as are isolated and purified antibodies encoded by the antibody genes. Anti-idiotype antibodies, peptides, and aptamers that bind to the antigen-binding region of an antibody encoded by the antibody genes are additionally provided, as are multimeric molecules comprising multiple binding sites that bind to the antigen-binding region of an antibody encoded by the antibody genes.

Abstract: A device and method for improving the performance of an electro-acoustic transducer. An acoustic test signal is generated through the electro-acoustic transducer. The acoustic test signal is measured at multiple points on an ambient surface around the electro-acoustic transducer to create measured acoustic data. Based on the measured acoustic data, an acoustic power frequency response of the electro-acoustic transducer is calculated. A correction impulse response for the electro-acoustic transducer is determined based on the acoustic power frequency response. A correction filter applies the correction impulse response to a sound signal input to generate a sound signal output for playback through the electro-acoustic transducer.