Abstract: Provided are oligopeptide antigens to AI4-like T cells, and mouse proteins comprising those antigens. The oligopeptide antigens comprise the amino acid sequence XX(I/D/F/L)ENY(I/L)(E/W/Y)(L/M) or VMLENYTHL. Additionally provided are methods for treating a mammal having or at risk for type 1 diabetes using these antigens, or compounds which reduce or eliminate expression of these antigens. Kits comprising these antigens, and methods for determining whether a mammal is at risk for or has type 1 diabetes are also provided.

Abstract: Provided are methods of determining whether a compound is an inhibitor of an S100 protein. The methods utilize a biosensor that comprises the S100 protein that has a covalently bound fluorescent dye at an amino acid residue of the S100 protein that becomes less exposed to the aqueous solution upon activation of the S100 protein, where the fluorescent dye has decreased fluorescence when exposed to the aqueous solution than when protected from exposure to the aqueous solution. Also provided are methods of treating a subject having metastatic cancer.

Abstract: Provided are methods of inhibiting prostaglandin transporter (PGT) activity in mammals. Also provided are methods of determining whether a test compound is an inhibitor of a prostaglandin transporter. Additionally provided are compounds that inhibit prostaglandin transporter activity, and pharmaceutical compositions of those compounds. Methods of inhibiting COX-2 in a mammal are also provided. Additionally, methods of treating pain or inflammation in a mammal are provided.

Abstract: A method for manufacturing fastener ears for absorbent articles and other garments includes the step of cutting a wave-shaped pattern along the longitudinal axis of an elongated strip of material. The wave-shaped cutting pattern is substantially centered along the strip and divides the strip into a first web and a second web. Each web has a series of ear shapes, with each ear shape having a wave crest portion. Each wave crest portion has a first edge with a convex curvature. The method also includes the step of cutting each of the ear shapes out of its respective web to form a plurality of fastener ears. A fastener ear formed by such method is also contemplated.

Abstract: A disposable absorbent article such as, e.g., a T-shaped diaper comprising two portions, a lateral portion (backwaist) having two lateral segments or wings for wrapping around the waist of a wearer of the diaper, and a second vertical portion or insert which is adapted to be passed under the crotch of the wearer and folded thereover. A uniquely designed tape tab located at the outer lateral end of one wing assures more perfect and comfortable fit. Tape tabs are also provided at the distal ends of vertical portion for engagement onto landing zones disposed on the surface of each wing. These tape tabs may have the same general construction as the tape tab on the diaper wing. The dimensions of the diaper and several of its components and the relative locations of these components are important factors which contribute to improved fitness and functions of the diaper.

Abstract: A squirting toy is comprised of a cylindrical housing and a piston that slides within to force water into or out of the housing via a hole therein. The housing is encased within a polyethylene closed cell foam shell. The shell is non-absorbing, so that the foam remains buoyant and keeps the gun afloat indefinitely when left in water. The foam is soft, so that the gun is not a safety hazard when left floating in a swimming pool.

Abstract: A bar clamp including a first bar member and a second bar member with the second bar member telescoping out from the first bar member. A securing mechanism, such as a pin in the first member, releasably secures the members together at a preferred telescoping position. The second bar member has a jaw member that can be advanced or retracted by means of a linear actuator and the first bar member has a jaw member that can be adjusted by positioning the cam-action locking mechanism in one of the notches disposed along the length of the first bar member. As a result of the telescoping relationship of the bar members, workpieces of varying sizes may be clamped between the jaw members without the need of multiple bar clamps of varying lengths.