Abstract: Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand upon illumination of the compound with light. Also provided are cells transfected with a gene of interest and a gene encoding a receptor, the gene of interest operably linked to a genetic element capable of being induced by the receptor when bound to a ligand, and the receptor not naturally present in the species of the cell. The cells also comprise a caged ligand of the receptor. Additionally provided are methods of inducing a gene of interest in the above cells. Also provided are methods of repressing a gene of interest in a cell using caged ligands of receptors. Methods are additionally provided for inducing elimination of a target sequence in a cell of a species, using a caged ligand and a recombinase.

Abstract: The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid residue, wherein the replacement residues together cause a reduction in catalytic rate (kcat) of the enzyme and an increase in substrate-binding affinity (Kd) of the enzyme. The present invention further provides methods for identifying a substrate of a PTP. Also provided are kits for identifying a substrate of a PTP. Additionally, the present invention provides methods for identifying an agent that alters interaction between a PTP and a substrate of the PTP. The invention also provides methods for reducing the activity of a substrate of a PTP.

Abstract: The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutically effective amount of a PEGylated albumin.

Abstract: Network interface circuitry for a secure one-way data transfer from a sender's computer (“Send Node”) to a receiver's computer (“Receive Node”) over a data link, such as an optical fiber or shielded twisted pair copper wire communication cable, comprising send-only network interface circuitry for transmitting data from the Send Node to the data link, and receive-only network interface circuitry for receiving the data from the data link and transmitting the received data to the Receive Node, wherein the send-only network interface circuitry is configured not to receive any data from the data link, and the receive-only network interface circuitry is configured not to send any data to the data link. The network interface circuitry may use various interface means such as PCI interface, USB connection, FireWire connection, or serial port connection for coupling to the Send Node and the Receive Node.

Abstract: The present invention relates to a process for the purification of water by adding surface-reacted natural calcium carbonate or an aqueous suspension comprising surface-reacted calcium carbonate and having a pH greater than 6.0 measured at 20° C., to the medium, wherein the surface-reacted calcium carbonate is a reaction product of natural calcium carbonate with carbon dioxide and one or more acids and the use of the surface-reacted natural calcium carbonate for this process.

Abstract: An embodiment of the present invention is an illuminated stop sign for allowing pedestrians to control traffic. The system comprises a fixed support assembly; a pedestrian activated mechanism; a timer set for a predetermined period of time when the pedestrian activated mechanism is activated; and an octagonal display nonremovably mounted to the fixed support assembly comprising a backlight within the display and a display surface comprising a word “STOP” visible when the backlight is illuminated and substantially not visible when the backlight is not illuminated, the backlight being illuminated until the predetermined period of time is expired.

Abstract: The present invention relates to a method and system for evaluating at least one abnormality in one or more medical images of a subject comprising: (a) determining the location of each abnormality from pre-defined selection, (b) determining the pattern of each abnormality from pre-defined selection, (c) accessing a multidimensional database comprising data of patterns, locations, and conditions associated therewith, in which the database comprises data of each of patterns, locations, and conditions is comprised in separate dimension(s), and characteristic information for patterns, locations, and conditions is organized in the database into discrete categories, (d) extracting from the multidimensional database a list of conditions corresponding to the imaging data determined in steps (a) and (b), (e) providing an evaluation of abnormality using list obtained in step (d). The invention also relates to a database, computer program, system for navigating the database, a method for entering data into a database.

Abstract: An electronic motion picture camera for recording a sequence of images includes a sensor device having a two-dimensional arrangement of sensor elements that generate electrical signals in dependence on an exposure to light. A first group of the sensor elements forms a recording region of the sensor device and generates recording signals, and a second group of the sensor elements forms a monitoring region of the sensor device and generates monitoring signals, wherein the monitoring region surrounds the recording region. A memory device stores the recording signals, but not the monitoring signals. A display device displays the recording signals, the monitoring signals and a frame signal representing a border between the recording region and the monitoring region of the sensor device, and the border between the recording region and the monitoring region is kept fixed during the recording of the sequence of images.

Abstract: The present invention relates to the removal of endocrine disrupting compounds from an aqueous medium by adding surface-reacted natural calcium carbonate or an aqueous suspension comprising surface-reacted calcium carbonate and having a pH greater than 6.0 measured at 20° C., to the medium, wherein the surface-reacted calcium carbonate is a reaction product of natural calcium carbonate with carbon dioxide and one or more acids, the use of the surface-reacted natural calcium carbonate for the removal of endocrine disrupting compounds, as well as to a combination of a surface-reacted natural calcium carbonate and activated carbon for the removal of endocrine disrupting compounds.

Abstract: The present invention relates to an interactive board game comprising a playing surface having a series of tabs, wherein each opened tab reveals clues or directions to the next tab to be opened. In one embodiment, the board game comprises individual cells containing a prize, such as a chocolate, located under each tab, which are accessible upon opening the tabs.

Abstract: An absorbent pad including: a main body having a first longitudinal edge and a second longitudinal edge, including: a liquid pervious topsheet; a liquid impervious backsheet; an absorbent layer disposed between the topsheet and the backsheet; a central adhesive element disposed on the backsheet and extending along a longitudinal centerline of the absorbent pad; and an elastic element disposed along each of the first and second longitudinal edges of the main body and attached to at least one of the topsheet and the backsheet; a first wing element extending from the backsheet and laterally beyond the first longitudinal edge of the main body; and a second wing element extending from the backsheet and laterally beyond the second longitudinal edge of the main body, the first and second wing elements being releasably attachable to an undergarment.

Abstract: A computer-implemented method of prioritizing a predefined set of electronic data sources includes the steps of electronically determining data sources in which at least one of one or more source fields is the same as a query data item of a query statement, electronically and dynamically ranking the data sources in which at least one of the one or more source fields is the same as the query data item based on at least the ability of the data sources to provide data at one or more query dimensions of the query statement and the extent of aggregation necessary to provide the data, and electronically identifying one or more of the data sources having the highest rank as preferred data sources for locating the data value.

Abstract: A collapsible projection screen system mountable on or at a moveable carriage (10), the system comprising a flexible projection screen (16) moveable between a collapsed position and an erect position in which the screen (16) is supported by a support arrangement (14, 15), and a screen tensioning mechanism (64, 40, 56) operable on the screen (16) in the erect position to provide a generally flat screen surface. In another embodiment there is disclosed a mounting assembly for a flexible projection screen in a collapsible projection screen system having a roller, a mechanism for applying tension across and between a leading edge and a trailing edge of the screen in the erect position, the mechanism comprising a braking device and a drive apparatus.