Patents Represented by Attorney, Agent or Law Firm Arnold White & Durkee
  • Patent number: 6579893
    Abstract: The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel discovery that Troglitazone inhibits steroidogenesis in granulosa cell cultures. This activity is believed to result from the ability of thiazolidinedione derivatives to act as a ligand for the orphan steroid receptor peroxisome proliferator-activated receptor gamma (PPAR&ggr;). Troglitazone and related compounds can therefore be used to prevent excessive uterine bleeding during. Further enhanced translocation of this orphan nuclear receptor into the nucleus of cells will block transcription in rapidly proliferating cancer cells that express PPAR&ggr; resulting in loss of cell viability.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: June 17, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventors: Randall J. Urban, Allan Green
  • Patent number: 6303850
    Abstract: According to the invention, there is provided an inbred corn plant designated 09DSS1. This invention thus relates to the plants, seeds and tissue cultures of the inbred corn plant O9DSS1, and to methods for producing a corn plant produced by crossing the inbred corn plant O9DSS1 with itself or with another corn plant, such as another inbred. This invention further relates to corn seeds and plants produced by crossing the inbred plant O9DSS1 with another corn plant, such as another inbred, and to crosses with related species. This invention further relates to the inbred and hybrid genetic complements of the inbred corn plant O9DSS1, and also to the RFLP and genetic isozyme typing profiles of inbred corn plant O9DSS1.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: October 16, 2001
    Assignee: Dekalb Genetics Corporation
    Inventor: Roderick D. Lee
  • Patent number: 6255539
    Abstract: Inert gas additive is utilized in the catalytic oxidation of benzene with nitrous oxide to produce phenol in order to prevent excessive exothermic temperature increases and to render gaseous mixtures throughout the process non-flammable.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: July 3, 2001
    Assignee: Solutia Inc.
    Inventors: Anthony K. Uriarte, Christopher R. Buechler, Jerry R. Ebner, Michael J. Gross, William D. McGhee, Jayne E. Morris, Erik D. Sall
  • Patent number: 6235971
    Abstract: Introducing sucrose phosphorylase activity into plants by transformation with a gene for the enzyme increases the rate of sucrose hydrolysis, leading to increased starch, oil, and/protein levels. Sucrose phosphorylase genes from Streptococcus mutans and Leuconostoc mesenteroides have been found particularly advantageous for use in the present invention. Surprisingly, in potatoes transformed to express these genes in tubers, reduced bruise discoloration susceptibility and increased uniformity of starch deposition throughout the tuber are achieved.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: May 22, 2001
    Assignee: Monsanto Company
    Inventors: Gerard Francis Barry, Jan Willem deWeerd, Ganesh Murthy Kishore, Marcia Lee Weldon
  • Patent number: 6228807
    Abstract: This invention relates to dry, water soluble, agriculturally acceptable herbicidal compositions, to a herbicidal method of use thereof and and to a process for preparing such compositions. This invention also relates to dry, water soluble and/or water dispersible, agriculturally acceptable herbicidal compositions containing two or more herbicides, a herbicidal method of use thereof and to a process for preparing such compositions.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: May 8, 2001
    Assignee: Monsanto Company
    Inventors: Masuo Kuchikata, Erhard J. Prill, Ronald O. Richardson, Tatsuo Sato, John M. Surgant, Daniel R. Wright
  • Patent number: 6212824
    Abstract: Methods for classifying plants by remote sensing and image analysis technology are presented. These methods are useful for evaluating plants and for selecting plants for a plant breeding program which has as its goal to selectively alter phenotype. The methods combine the newer techniques of remote sensing technology to obtain indirect correlates of the traits of interest, with classical pedigree breeding strategies. Thermal and infrared reflectance measures of plant canopies are examples of energy values measured by remote sensing, used to indirectly predict the selected traits.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: April 10, 2001
    Assignee: Dekalb Genetics Corporation
    Inventors: Peter M. Orr, David C. Warner, James V. O'Brien, G. Richard Johnson
  • Patent number: 6204375
    Abstract: This specification relates to the field of molecular biology and provides a novel method and reagent for preserving and protecting the ribonucleic acid (RNA) content of tissue samples from degradation prior to RNA isolation. This preservation may be accomplished without ultra-low temperature storage or disruption of the tissue.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: March 20, 2001
    Assignee: Ambion, Inc.
    Inventor: Eric S. Lader
  • Patent number: 6194176
    Abstract: The present invention a provides methods for production of heterologous polypeptides using a variety recombinantly engineered secretory cell lines. The common feature of these cell lines is the absence of expression of at least one endogenous polypeptide. The host cell machinery normally used to produce the endogenous polypeptide is then usurped for the purpose of making the heterologous polypeptide. Also described are methods engineering cells for high level expression, methods of large scale protein production, and methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: February 27, 2001
    Assignees: Board of Regents, The University of Texas System, Betagene, Inc.
    Inventors: Christopher B. Newgard, Philippe Halban, Karl D. Normington, Samuel A. Clark, Anice E. Thigpen, Christian Quaade, Fred Kruse
  • Patent number: 6190902
    Abstract: A method for producing recombinant peptides and proteins having a diminished retention of N-formyl-methionine by coexpressing a peptide deformylase enzyme is disclosed. Also disclosed are substantially deformylated protein compositions and transformed bacterial cells and DNA vectors useful for acheiving such deformylation.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: February 20, 2001
    Assignee: Monsanto Company
    Inventor: Gregg Bogosian
  • Patent number: 6183984
    Abstract: The present disclosure provides a detailed characterization of the sequences and factors controlling expression of a human gene expressed specifically in keratinocytes. Using 5′ upstream sequence of the human K14 keratin gene coupled to one of two reporter genes, sequences necessary and sufficient for expression of K14 have been examined in both cultured human keratinocytes and in mitotically active basal keratinocytes of transgenic mouse epidermis. The existence of distal and proximal elements located 5′ from the transcription initiation site of the hK14 gene is demonstrated, which when combined with a TATA box element, appear to act in concert to drive keratinocyte-specific expression. The proximal element was also examined.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: February 6, 2001
    Assignee: Arch Development Corporation
    Inventor: Elaine V. Fuchs
  • Patent number: 6184938
    Abstract: Composite ghost cancellation reference (GCR) signals that make available both a chirp and a PN sequence during the same vertical-blanking-interval (VBI) scan line in each successive field facilitate more rapid and efficient calculations of ghost cancellation and of equalization, on a continuing basis. A television receiver for use with such composite GCR signals includes circuitry for separating the chirp and PN sequence portions of the GCR signals from the remainder of the composite video signal, a ghost cancellation filter and an equalization filter connected in cascade to respond to the composite video signal and provided each with adjustable filtering weights, and a computer. Random-access memory addressed during writing snatches the vertical-blanking-interval scan lines selected to include GCR signals. Sets of four successive ones of the selected scan lines are then additively and subtractively combined to separate the chirp portions of the GCR signals from a remainder of the composite video signal.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: February 6, 2001
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Chandrakant Bhailalbhai Patel, Jian Yang
  • Patent number: 6180768
    Abstract: The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes sequences. More particularly, the present invention relates to new HCV type 7 sequences, new HCV type 9 sequences, new HCV type 10 and new HCV type 11 sequences. Also, the present invention relates to new HCV type 1 sequences of subtypes 1d, 1e, 1f and 1g; new HCV type 2 sequences of subtypes 2e, 2f, 2g, 2h, 2i, 2k and 2l; new HCV type 3 sequences of subtype 3g, new HCV type 4 sequences of subtypes 4k, 4l and 4m; a process for preparing them, and their use for diagnosis, prophylaxis and therapy. More particularly, the present invention provides new type-specific sequences of the Core, the E1 and NS5 regions of new HCV types 7, 9, 10 and 11, as well as of new variants (subtypes) of HCV types 1, 2, 3 and 4.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: January 30, 2001
    Assignee: Innogenetics N.V.
    Inventors: Geert Maertens, Lieven Stuyver
  • Patent number: 6176755
    Abstract: The present disclosure involves a toy vehicle and method of construction therefor involving the use of plastic bottles. Toy vehicles constructed according to the present invention are advantageous in that they educate children as to the importance of recycling at the same time they are being entertained by constructing and/or playing with the toy vehicles. Toy vehicles according to the present invention are constructed by coupling any of a plurality of simulated vehicular elements to a plastic bottle to produce any of a variety of simulated vehicles, including but not limited automobiles, motorcycles, sailboats, space ships, trains, etc.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: January 23, 2001
    Assignee: Dakota Science Center
    Inventors: Karen A. Bye, Lisa M. Nagle, Mark S. Neary, Jennifer M. Oliva
  • Patent number: 6172004
    Abstract: Compositions of exogenous chemicals, particularly phloem-mobile exogenous chemicals, are provided for treatment of plants, wherein the composition comprises the exogenous chemical and an enhancing agent consisting of an anthraquinone or substituted anthraquinone. Specific compositions contain herbicides, particularly N-phosphonomethylglycine and herbicidal derivatives thereof, i.e., glyphosate. The compositions exhibit enhanced effectiveness compared to compositions in which the enhancing agent is not present. Also provided are processes for applying an exogenous chemical with an anthraquinone or substituted anthraquinone enhancing agent to achieve enhanced biological effectiveness.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: January 9, 2001
    Assignee: Monsanto Company
    Inventors: Ronald J. Brinker, Jane L. Gillespie, Peter J. Raymond, Joseph J. Sandbrink, James M. Warner, Al S. Wideman, Daniel R. Wright
  • Patent number: 6169231
    Abstract: According to the invention, there is provided an inbred corn plant designated RQAB7. This invention thus relates to the plants, seeds and tissue cultures of the inbred corn plant RQAB7, and to methods for producing a corn plant produced by crossing the inbred plant RQAB7 with itself or with another corn plant, such as another inbred. This invention further relates to corn seeds and plants produced by crossing the inbred plant RQAB7 with another corn plant, such as another inbred, and to crosses with related species. This invention further relates to the inbred and hybrid genetic complements of the inbred corn plant RQAB7, and also to the RFLP and genetic isozyme typing profiles of inbred corn plant RQAB7.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: January 2, 2001
    Assignee: Dekalb Genetics Corporation
    Inventor: James R. Larkins
  • Patent number: 6169230
    Abstract: According to the invention, there is provided an inbred corn plant designated 29MIF12. This invention thus relates to the plants, seeds and tissue cultures of the inbred corn plant 29MIF12, and to methods for producing a corn plant produced by crossing the inbred plant 29MIF12 with itself or with another corn plant, such as another inbred. This invention further relates to corn seeds and plants produced by crossing the inbred plant 29MIF12 with another corn plant, such as another inbred, and to crosses with related species. This invention further relates to the inbred and hybrid genetic complements of the inbred corn plant 29MIF12, and also to the RFLP and genetic isozyme typing profiles of inbred corn plant 29MIF12.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: January 2, 2001
    Assignee: Dekalb Genetics Corporation
    Inventor: Daniel F. Palmer
  • Patent number: 6160026
    Abstract: The invention is a process for producing hydrocarbons from hydrogen and carbon monoxide by reacting hydrogen and carbon monoxide in the presence of a particulate solid catalyst and a substantially inert liquid medium. This reaction takes place in a reactor vessel adapted for the reaction of gases in the presence of a substantially inert liquid medium and a bed of solid particulate catalyst. The hydrogen gas and carbon monoxide gas are introduced at a plurality of locations within the reactor vessel. Bubbles of gas flow upward through the bed of solid catalyst particles and substantially inert liquid medium at sufficient velocity to expand the bed to a volume greater than its static volume. This velocity creates a turbulent reaction zone wherein liquid, gas, and solid catalyst are present and are in a state of motion.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: December 12, 2000
    Assignee: Texaco Inc.
    Inventors: Pei-Sing Dai, deceased, Jeffrey B. Harrison, Govanon Nongbri, Lalit Shah, Kamlesh B. Vakil
  • Patent number: 6157537
    Abstract: A data processing apparatus having a liquid heat-dissipating system includes a central processing unit (CPU), a housing to receive the CPU, and a heat conductive member. The housing has a top wall and a top opening in the wall immediately above the CPU. The heat conductive member is mounted on the wall to cover the opening and to transfer heat produced by the CPU from an inside of the housing to an outside of the housing, and has a receiving cavity adapted for receiving a cooling liquid.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: December 5, 2000
    Assignee: GETAC Corporation
    Inventor: Ted Cheng
  • Patent number: H1936
    Abstract: An aqueous, coatable, thermally condensable composition is disclosed. The coating is based on dispersions of vinyl acetate polymers in water. Uniquely, the coating can be advantageously used for both nylon and polyester yarns. The coated yarns exhibit performance equivalent to or better than coated yarns based on traditional compositions.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: January 2, 2001
    Assignee: Solutia, Inc.
    Inventors: Tingdong Lin, Jing-Peir Yu, P. Robert Peoples
  • Patent number: H2029
    Abstract: A safety apparatus has been found for recovering an airborne hydrogen fluoride release in a hydrocarbon alkylation process. The safety apparatus comprising containment baffles and hydrogen fluoride detectors. Hydrogen fluoride detectors activate water flood means which discharge into the containment baffles. The water flood containing essentially all of the hydrogen fluoride release is recovered for disposal. Recoveries of 90 wt % have been demonstrated.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: June 4, 2002
    Assignee: Texaco Inc.
    Inventors: Kenneth Roy Comey, III, Gerald Verdell Nelson, Lee Kessie Gilmer