Patents Represented by Attorney Arthur R. Whale

Find this attorney in the Justia Lawyer Directory

  • Quiuolizine and indolizine enzyme inhibitors
    Patent number: 4508901
    Abstract: Angiotensin I converting enzyme inhibitors A-58365 factors A, B, and C are produced by culturing Streptomyces chromofuscus NRRL 15098 under submerged aerobic fermentation conditions and are isolated and purified from the acidic filtered fermentation broth via chromatography, in particular HPLC. The factors are useful hypotensive agents.
    Type: Grant
    Filed: August 19, 1982
    Date of Patent: April 2, 1985
    Assignee: Eli Lilly and Company
    Inventors: Jon S. Mynderse, Sean C. O'Connor
  • 1-Benzoyl-3-(arylpyridyl)urea compounds
    Patent number: 4508722
    Abstract: The present invention is directed to 1-benzoyl-3-(arylpyridyl)urea compounds useful as insecticides.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: April 2, 1985
    Assignee: Eli Lilly and Company
    Inventor: John L. Miesel
  • 2-Mercaptopyrimidohexahydroquinolines and related compounds
    Patent number: 4507478
    Abstract: Trans-(.+-.) or trans-(-)-2,4-permissibly-substituted-6-alkyl or allyl octahydropyrimido[4,5-g]quinolines and related compounds, ultraviolet light absorbers.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: March 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Cynthia L. Nichols, Edmund C. Kornfeld, John M. Schaus
  • Stabilizing and selecting recombinant DNA host cells
    Patent number: 4506013
    Abstract: A method for stabilizing and selecting host cells containing recombinant DNA which expresses a functional polypeptide and the novel organisms and cloning vectors for the practice thereof. The invention further provides a simple, convenient, and inexpensive method to lyse host cells for purification of intracellular products.
    Type: Grant
    Filed: June 18, 1981
    Date of Patent: March 19, 1985
    Assignee: Eli Lilly and Company
    Inventors: Charles L. Hershberger, Anna K. Radue, Paul R. Rosteck, Jr.
  • Glycopeptide derivatives
    Patent number: 4504467
    Abstract: Method of preparing compounds of formula 1: ##STR1## by oxidative deamination of a glycopeptide antibiotic of formula 2: ##STR2## the antibiotic being selected from A35512 factors A, B, C, E and H, A35512B pseudoaglycone, actaplanin factors A, B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.2a, C.sub.3, D.sub.1, D.sub.2, E.sub.1, G, K, L, M, N and O, actaplanin pseudoaglycone, A41030 factors A, B, C, D, E, F and G, A47934, ristocetin A and ristocetin A pseudoaglycone, novel compounds and compositions and methods of increasing feed-utilization efficiency in animals are provided.
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: March 12, 1985
    Assignee: Eli Lilly and Company
    Inventors: R. Michael Molloy, Manuel Debono
  • Multifunctional, cloning vectors for use in Streptomyces, Bacillus, and E. coli
    Patent number: 4503155
    Abstract: The present invention discloses multifunctional recombinant DNA cloning vectors for use in Streptomyces, Bacillus, and E. coli. The invention further discloses transformants of the aforementioned vectors.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: March 5, 1985
    Assignee: Eli Lilly and Company
    Inventors: James R. Miller, Jeffrey T. Fayerman, Steven Kovacevic, Nancy E. Beerman
  • 7-(2-(Substituted cinnolinoyl)amino)acetamido)-1-oxa-beta-lactams
    Patent number: 4503052
    Abstract: 1-Oxa-beta-lactam antibiotics of the formula ##STR1## are broad spectrum antibiotics especially useful in the treatment of infections attributable to the gram-negative microorganisms such as Pseudomonas or are intermediates to such antibiotics.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: March 5, 1985
    Assignee: Eli Lilly and Company
    Inventor: William H. W. Lunn
  • Oxidation process
    Patent number: 4502988
    Abstract: Penicillin and cephalosporin sulfides and sulfoxides are readily converted to sulfones in the presence of ruthenium tetroxide.
    Type: Grant
    Filed: August 8, 1983
    Date of Patent: March 5, 1985
    Assignee: Eli Lilly and Company
    Inventor: Lowell D. Hatfield
  • N,N-disubstituted carboxamide derivatives, and fungicidal use thereof
    Patent number: 4501746
    Abstract: Novel N,N-disubstituted carboxamide derivatives useful as herbicides, fungicides and aquatic plant growth regulators.
    Type: Grant
    Filed: September 15, 1982
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventor: Eriks V. Krumkalns
  • Cephalosporin antibiotics
    Patent number: 4501741
    Abstract: 7.beta.-[2-Amino-2-(benzothien-4,5,6, and 7-yl)acetylamino]-3-substituted-3-cepham-4-carboxylic acids and 7.beta.-[2-amino-2-(2,3-dihydrobenzothien-4,5,6, and 7 yl)acetylamino]-3H- or 3-substituted-3-cephem-4-carboxylic acids (1), e.g. 7.beta.-[2-amino-2-(benzothien-4-yl)acetylamino]-3-methyl-3-cephem-4-carbo xylic acid, are orally effective antibiotics. Also provided are benzothienyl oximino compounds, the corresponding 2,3-dihydro compounds (2) useful as intermediates to (1) and as antibiotics, as well as 7.beta.-(2,2-dialkyl-5-oxo-4-benzothienyl-1-imidazolidinyl)-3H-(3-substitu ted)-3-cephem-4-carboxylic acids and the corresponding 2,3-dihydro compounds (3) useful as antibiotics, and prepared with (1) by condensation with ketones. Pharmaceutical formulations of antibiotic compounds (1), (2), and (3) are provided.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Bernard J. Graves, Stjepan Kukolja
  • Nitrosamine inhibition
    Patent number: 4501608
    Abstract: The present invention is directed to the inhibition of nitrosamines in dinitroaniline herbicides by the incorporation of an addition compound of an alkali metal or ammonium bisulfite with an aldehyde or ketone.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventor: William N. Cannon
  • Thieno and furopyridinium-substituted cephalosporins
    Patent number: 4501739
    Abstract: Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and in the 3-position with a thienopyridinium methyl group or a furopyridinium methyl group are broad spectrum antibiotics highly effective in combating bacterial infections of gram-negative and gram-positive microorganisms. The cephalosporins are best prepared by reacting a silylated 7-[2-(heterocyclic)-2-oximinoacetylamino-3-iodomethyl-3-cephem-4-carboxyli c acid with the thienopyridine or the furopyridine. Pharmaceutical formulations comprising a compound of the invention and a method for treating bacterial infections comprising their use are also provided.
    Type: Grant
    Filed: December 15, 1982
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: William H. W. Lunn, Robert T. Vasileff
  • Trans-( .+-.)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quino lines
    Patent number: 4501890
    Abstract: Trans-(.+-.)-2-Amino or substituted amino-4-permissibly-substituted 6-lower alkyl or allyl-5,5a,-6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-)-stereoisomers and salts thereof, useful in treating anxiety, Parkinson's Syndrome, sexual dysfunction, depression, hypertension and elevated prolactin levels, and intermediates useful for the synthesis thereof.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Cynthia L. Nichols, Edmund C. Kornfeld
  • Process for preparing 2-acetylthiomethyl-5-guanidinopentanoic acid
    Patent number: 4501703
    Abstract: A process is described for preparing 2-acetylthiomethyl-5-quanidinopentanoic acid by treating 2-acetylthiomethyl-5-aminopentanoic acid with 1-quanyl-3,5-dimethylpyrazole in a medium comprising a hydroxylated solvent.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Russell L. Barton, Stephen L. Briggs, Gary A. Koppel
  • Synthesis of alkylidene intermediates
    Patent number: 4501921
    Abstract: A stereo-selective preparation of novel sulfonated o-phenylenediamines carrying a trans-.alpha.-alkylidenebenzyl group at the 5-position, which are intermediates in the synthesis of antiviral benzimidazoles.
    Type: Grant
    Filed: November 18, 1982
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Charles W. Ryan, Bruce A. Slomski
  • Oxazolyl and thiazolyl amides as herbicides
    Patent number: 4500343
    Abstract: 1-Heterocyclic-2-pyrrolidinone analogs, and intermediates thereof, as aquatic and terrestrial herbicides and aquatic algicides. The compounds and intermediates can also be used together with one or more herbicides to provide useful terrestrial herbicidal combinations.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: February 19, 1985
    Assignee: Eli Lilly and Company
    Inventor: Kenneth W. Burow, Jr.
  • Hydroxyaminotetralincarboxamides
    Patent number: 4500545
    Abstract: o-Hydroxy tetralin carboxamides, substituted with an amino group in the aliphatic ring, are dopamine agonists.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: February 19, 1985
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmund C. Kornfeld, Robert D. Titus
  • 2,4,5-Triaryl pyrimidines and a method of treating pain, fever, thrombosis, inflammation and arthritis
    Patent number: 4500533
    Abstract: This invention provides for certain novel 2,4,5-triaryl pyrimidine derivatives, their pharmaceutical formulations, and a method of treating pain, fever, thrombosis, inflammation, and arthritis.
    Type: Grant
    Filed: June 22, 1983
    Date of Patent: February 19, 1985
    Assignee: Eli Lilly and Company
    Inventor: Ken Matsumoto
  • Preparation of 4-fluoroazetidinones using FClO.sub.3
    Patent number: 4500456
    Abstract: 4-Fluoroazetidinone antibacterial agents are provided by a process comprising the reaction of an azetidinone-4-sulfinic acid, or a salt thereof, with perchloryl fluoride (FClO.sub.3) at -80.degree. C. to -25.degree. C., e.g., p-nitrobenzyl 3-methyl-2-(2-oxo-4-sulfino-3-phenoxyacetamido-1-azetidinyl-3-butenoate is reacted with FClO.sub.3 to provide corresponding 4-fluoroazetidinone. The latter is isomerized with a tertiary amine to corresponding 2-butenoate which a carboxy group deprotection provides an antibacterial compound.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: February 19, 1985
    Assignee: Eli Lilly and Company
    Inventors: Wayne A. Spitzer, Theodore Goodson, Jr.
  • N-Acyl glycopeptide derivatives
    Patent number: 4497802
    Abstract: N-Acyl-glycopeptide antibiotics having the formula ##STR1## and their salts are useful new antibiotics. The N-acyl actaplanin derivatives also increase feed-utilization efficiency and promote growth in animals and improve milk production in lactating ruminants.
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: February 5, 1985
    Assignee: Eli Lilly and Company
    Inventor: Manuel Debono