Abstract: Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus.

Abstract: A security system for detecting physical intrusion in a monitored area including a plurality of radio units arranged in a network around the monitored area to determine received signal strength and pass variations thereof through the radio units to a base station.

Abstract: Fluid regulators provide a fluid to a cannula for use by a person. Fluid conservers also a fluid to a cannula for use by a person. A fluid conserver may be operational in a continuous flow mode of operation and an intermittent flow mode of operation. The selection of either the continuous flow mode of operation and the intermittent flow mode of operation may be based on a position of a flow selector. A home fill device may operate with a fluid conserver and may include an oxygen concentrator which provides a source of fluid.

Abstract: A multi-supply power supply circuit has a first power supply regulating circuit that produces a first power supply voltage; and a second power supply regulating circuit that receives the first power supply voltage from the first power supply regulating circuit as an enable input signal and is operative to produce a second and different power supply voltage. In one embodiment, the first power supply voltage may reach a steady state condition prior to the second power supply voltage reaching a steady state condition. In one example, the multi-supply power supply circuit includes a plurality of cascaded low drop out power supply regulating circuits.

Abstract: An insulin pump configuration programming approach is disclosed that permits setting parameters of pump configuration files to invalid values. An operator may continue with the programming workflow after setting the invalid value. The configuration file including the invalid value may be saved to a memory location of a computing device, but cannot be saved to the pump. Invalid item icons are presented when a parameter is set to an invalid value, and instructions for correcting the invalidity condition are provided when an invalid item icon is hovered over using a pointing device.

Abstract: An all-terrain vehicle that permits adjustment of rider supports to ergonomically accommodate both a single rider and multiple riders.

Abstract: A routing layer for a semiconductor die is disclosed. The routing layer includes pads for attaching solder bumps; bond-pads bonded to bump-pads of a die having an integrated circuit, and traces interconnecting bond-pads to pads. The routing layer is formed on a layer of dielectric material. The routing layer includes conductive traces at least partially surrounding some pads so as to absorb stress from solder bumps attached to the pads. Parts of the traces that surround pads protect parts of the underlying dielectric material proximate the solder bumps, from the stress.

Abstract: A method and apparatus for manufacturing a catalytic converter is described where the catalytic converter is comprised of an outer tube member having a monolith substrate internally compressed therein with a wrapped mat material surrounding the monolith substrate and intermediate the outer tube. One or more monolith members can be applied within the outer tube and heat shields may also be applied internal to the outer tube and adjacent to the monolith substrate. The assembly of the catalytic converter includes measuring the sequence of compression of the mat material to the monolith substrate in order to understand the possible force characteristics that can be applied during the assembly thereof. The mat material is therefore compressed within the outer tube by way of compression jaws, by compression rollers, by spinning and/or by a shrinker including compression members. The compression of the mat material can be in single or multiple steps.

Abstract: A method and apparatus for providing mutual authentication between a user and a sending unit, (i.e. target resource) in one embodiment, includes determining, for a user that has been assigned an article, such as a card or other suitable article that has indicia thereon, desired sender authentication information that corresponds to actual sender authentication information that is embodied on the article. The sender authentication information can be located on the article by using the location information provided by the sending unit in a challenge. The method includes determining for the user, corresponding article identification information, such as a serial number that has been assigned to the article, or a shared secret, and sending a challenge for the user wherein the challenge includes at least location information, to allow the user to identify desired sender authentication information located on the article, and sending the article identification information.

Abstract: A vehicle is shown such as a snowmobile, where a frame includes a tunnel and a front frame portion comprised of cast halves. A suspension system is comprised of upper and lower control arms connected to the front frame portion. Some of the frame components are adhesively fixed together. A powertrain is supported by the frame, and is comprised of an engine and a clutch. The clutch includes a clutch guard supporting an oil container. The engine has an exhaust system which extends through the front frame portion. The snowmobile also has a rear snow deflector.

Abstract: This publication discloses a method for manufacturing a circuit-board structure.1. The structure comprises a conductor pattern (3) and at least one component (6), which is surrounded by an insulating-material layer (10), attached to it by means of a contact bump (5). According to the invention, the contact bumps (5) are made on the surface of the conductor pattern (3), before the component (6) is attached to the conductor pattern (3) by means of the contact bump (5). After attaching, the component (6) is surrounded with an insulating-material layer (10).

Abstract: A connector holder suitable for use in a communications signal distribution system, comprising first and second parts between which an optical connector element may be secured, and which have means for locating the holder in one of a number of different positions and/or orientations on a base or other support of an optical fibre termination unit, whereby to permit a selected one of a number of different connector elements to be held between the two parts of the connector holder, and means for holding the two parts together with a connector element between them.

Abstract: An air distribution support surface product includes a vapor permeable material such as a sheet of breathable material, a fluid resistant material, such as a sheet of waterproof material and an intermediate fluid passing material interposed between the vapor permeable material and the fluid resistant material to form a plurality of chambers. One of the chambers serves as a type of fluid retention chamber and another chamber serves as a type of fluid loss chamber. A fluid intake opening may be provided to allow fluid, such as air, to inflate the chambers. In one example, both of the chambers share the intermediate fluid passing material. As such, the fluid retention chamber is formed by the fluid resistant material and the intermediate fluid passing material. The fluid loss chamber is formed by the vapor permeable material and the intermediate fluid passing material.

Abstract: A graphics multi-media integrated circuit (GMIC) is connected to a host processor over two serial links: a half duplex bi-directional serial link which accords to a protocol defined for a display serial interface, and a uni-directional serial link which accords to a compatible protocol defined for a camera serial interface. The GMIC receives packets according to the protocol from the host over the half duplex bi-directional serial link and processes these packets. The GMIC sends packets according to the protocol to the host over the uni-directional serial link. A packet from the host can request a processing operation by the GMIC or can initiate a memory operation at the memory of the GMIC. The GMIC can also send packets to the host to initiate a memory operation at the memory of the host.

Abstract: The embodiments herein relate to an electrode having a porous coating including a fiber mesh, a multi-layer coating, and an outer coating, and a method of making the same. The various electrode coating embodiments include pores in the coating that prevent access by protein or cells while allowing for ion and/or liquid access.

Abstract: In a plug-and-socket connector with a locking means having an unlocking ring, it is proposed according to the invention that the first connector element be provided in its end section with an external circumambient groove, in which the unlocking ring is rotatably guided, which ring has pockets distributed across its periphery for the catch projections of catch hooks fixed in the second connector element. The second connector element has a window-like cut-out through which the unlocking ring is accessible and can be turned in the locked state.