Abstract: The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of treatment using the said composition. More precisely, the subject of the present invention is a pesticide composition based on propamocarb-fosetylate, an insecticide active substance and optionally a further fungicide active substance.
Type:
Grant
Filed:
December 21, 2007
Date of Patent:
August 7, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Koen Van Den Eynde, Marc Andrieux, Heike Hungenberg, Wolfgang Thielert, Anne Suty-Heinze
Abstract: The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.
Type:
Grant
Filed:
July 16, 2007
Date of Patent:
July 24, 2012
Assignee:
4SC Discovery GmbH
Inventors:
Alexander B. Maurer, Sascha Hoevelmann, Elke Martin, Bernd Hentsch, Michael Gassen, Juergen Kraus, Rolf Krauss, Adam-Spencer Vincek
Abstract: The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the present invention relates to 49 novel peptide sequences derived from HLA class II molecules of human tumor cell lines which can be used in vaccine compositions for eliciting anti-tumor immune responses.
Abstract: The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the present invention relates to 49 novel peptide sequences derived from HLA class II molecules of human tumor cell lines which can be used in vaccine compositions for eliciting anti-tumor immune responses.
Abstract: A process for the manufacture of plated strips comprising at least two layers of different metals or alloys. The process allows subsequent separation of different cropped layers resulting from shearing the plated strips. The process comprises preparing plates corresponding to each of the plating layers, superimposing and assembly of these plates to form a composite plate, hot and possibly cold rolling of this composite plate to obtain a plated strip, and shearing of cropping areas during or after rolling. In one embodiment, prior to superimposing the different plates, an anti-sticking agent is applied to the cropping areas of at least one of the surfaces of the plates which will be in contact with each other.
Type:
Grant
Filed:
June 1, 2004
Date of Patent:
July 3, 2012
Assignee:
Constellium France
Inventors:
Sandrine Dulac, Christian Barthelemy, Sylvain Henry, Armand Gabriel
Abstract: The present invention relates to a method for the production of polarization holograms, an apparatus for the production of polarization holograms and the use of the polarization holograms according to the invention as data stores, security features or diffractive optical elements for performing conventional optical functions.
Type:
Grant
Filed:
January 31, 2007
Date of Patent:
June 26, 2012
Assignee:
Bayer Innovation GmbH
Inventors:
Jean-Michel Asfour, Stephan Schneider, Dietmar Eberhard, Wolfgang Riedel, Dominik Giel, Stephan Völkening, Hardy Jüngermann
Abstract: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.
Type:
Grant
Filed:
August 29, 2008
Date of Patent:
June 12, 2012
Assignee:
DSM IP Assets B.V.
Inventors:
Timothy Hitchman, Christopher L. G. Dayton, Katie A. Kline, Jonathan Lyon, Mark Wall, Nelson R. Barton
Abstract: The present invention relates to biomedical foam articles for the wound sector which are formed by spraying a polymeric dispersion onto a wound. The polymeric dispersion being sprayed onto a wound surface forms a three-dimensional body which conforms to the spatial shape of the wound and which, as well as covering the wound surface, ensures a complete and accurately fitted packing of the wound in the depth dimension as well as the other dimensions. The biomedical foam articles of the present invention are particularly useful for treating chronic wounds.
Type:
Grant
Filed:
April 5, 2007
Date of Patent:
June 12, 2012
Assignees:
Bayer Innovation GmbH, Bayer Materialscience AG
Inventors:
Melita Dietze, Burkhard Fugmann, Michael Mager, Thorsten Rische, Michael Heckes, Daniel Rudhardt, Rolf Gertzmann
Abstract: 2-(3-Alkylthiobenzoyl)cyclohexanediones of the formula (I) are described as herbicides. In this formula (I), X, Y, R1 to R8 represent radicals such as hydrogen, organic radicals such as alkyl and alkoxy.
Type:
Grant
Filed:
July 27, 2010
Date of Patent:
June 5, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Hartmut Ahrens, Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Stefan Lehr, Dieter Feucht
Abstract: Unsaturated polyester resin compositions with improved weathering characteristics are presented. Further, the manufacture of these unsaturated polyester resin compositions and their potential applications are presented.
Type:
Grant
Filed:
July 27, 2006
Date of Patent:
May 29, 2012
Assignee:
AOC, LLC
Inventors:
John E. McAlvin, Daniel A. Oakley, James S. Tedesco, Thomas J. Folda, Paul Taylor Hutson, Kamana Kigweba, Diana Klein, Thomas Steinhausler, David Treadwell, John Wilson, David J. Zwissler
Abstract: Natamycin is separated and recovered from a fermentation broth containing biomass and natamycin by adjusting the pH of a natamycin-containing suspension first to dissolve the natamycin in a solvent then adjusting the pH again to precipitate the dissolved natamycin which is used as an antifungal used to protect products susceptible to fungal spoilage.
Type:
Grant
Filed:
September 29, 2006
Date of Patent:
May 29, 2012
Assignee:
DSM IP Assets B.V.
Inventors:
Ferdinand Theodorus Jozef Van Rijn, Willem Johannes Wildeboer
Abstract: The invention describes phenyl-substituted pyridazinones of the formula (I) as herbicides and insecticides. In this formula (I), A, B, G, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen, nitro and cyano.
Type:
Grant
Filed:
December 15, 2009
Date of Patent:
May 29, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Stefan Lehr, Thomas Schenke, Christopher Hugh Rosinger, Reiner Fischer, Isolde Häuser-Hahn, Dieter Feucht, Jan Dittgen, Pierre Cristau, Oliver Gaertzen, Stefan Herrmann, Olga Malsam, Eva-Maria Franken
Abstract: 4-(3-Aminobenzoyl)-5-cyclopropylisoxazoles of the formula (I) are described as herbicides. In this formula (I), A, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
Type:
Grant
Filed:
March 19, 2009
Date of Patent:
May 29, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Heinz Kehne, Andreas Almsick, Hartmut Ahrens, Dieter Feucht, Ines Heinemann, Jan Dittgen, Martin Jeffrey Hills, Stefan Lehr, Christopher Hugh Rosinger
Abstract: A novel (?)-enantiomer of 2-[2-(1-chloro-cyclopropyl)-3-(2-chloro-phenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione of the formula a process for preparing this novel active compound and its use as microbicide in crop protection and in the protection of materials.
Type:
Grant
Filed:
October 31, 2007
Date of Patent:
May 29, 2012
Assignee:
Bayer Aktiengesellschaft
Inventors:
Rolf Grosser, Manfred Jautelat, Astrid Mauler-Machnik, Stefan Dutzmann, Gerd Hanβler, Klaus Stenzel
Abstract: A description is given of 3-amino-2-nitro-substituted benzoyl derivatives of the formula (I) as herbicides. In this formula (I), X, R1, R2, R3, R4, R5, R6, R7 and R8 are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
Type:
Grant
Filed:
September 22, 2010
Date of Patent:
May 29, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Dieter Feucht
Abstract: Novel avermectin derivatives of the formula (I) in which —C22R1-A-C23R2, R3, R4 and R5 have the meanings given in the description, processes for preparing these compounds and their use for controlling animal pests, and also novel intermediates and their preparation.
Type:
Grant
Filed:
August 8, 2007
Date of Patent:
May 22, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Peter Jeschke, Gunter Karig, Robert Velten, Reiner Fischer, Olga Malsam, Ulrich Görgens, Christian Arnold, Erich Sanwald, Achim Harder, Andreas Turberg
Abstract: Disclosed are thermoresponsive microparticle composite hydrogels comprising poly(N-isopropyl acrylamide) and polyacrylamide, and methods regarding their manufacture and their use. The present invention provides in one aspect a thermoresponsive microparticle hydrogel, wherein the matrix morphology is controllably and selectively altered by incorporation of thermoresponsive nano/micro-particles. The particles are preferably poly(N-isopropyl acrylamide) particles. The present invention also provides methods of making and using such hydrogels.
Type:
Grant
Filed:
November 21, 2008
Date of Patent:
May 15, 2012
Assignee:
Tennessee Technological University
Inventors:
Jeffery W. Thompson, Holly Stretz, Pedro E. Arce
Abstract: What is described are 4-(3-aminobenzoyl)-1,3-dimethylpyrazoles of the general formula (I) and their use as herbicides. In this general formula (I), R1 and R2 are radicals such as hydrogen and organic radicals, such as alkyl, alkenyl and alkynyl. Y is hydrogen or a protective group, such as tosyl.
Type:
Grant
Filed:
April 10, 2008
Date of Patent:
May 15, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Ines Heinemann, Andreas van Almsick, Lothar Willms, Monika Schmitt, Jan Dittgen, Martin Hills, Heinz Kehne, Christopher Rosinger, Dieter Feucht