Abstract: The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a replicative vector carrying at least two marker genes.

Abstract: A dry joint wall panel attachment system is provided. The system uses interlocking components to attach aluminum (or other) wall panels to an exterior wall. The system is held together non-adhesively.

Abstract: The invention relates to novel 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) in which X, Y, A, B, Q1, Q2 and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) and, secondly, at least one crop plant compatibility-improving compound.

Abstract: The present invention relates to thiadiazolyloxyphenylamidines of the general formula (I), to a process for the preparation thereof, to the use of the amidines according to the invention in combating undesirable microorganisms and to a composition for this purpose comprising the thiadiazolyloxyphenylamidines according to the invention. The invention furthermore relates to a method for combating undesirable microorganisms by application of the compounds according to the invention to the microorganisms and/or to the habitat thereof.

Abstract: The present invention relates to antagonists of the human bitter-taste receptors hTAS2R38. The invention also relates to methods for identifying further molecules that suppress hTAS2R38 mediated bitter taste transduction or bitter taste response and uses thereof.

Abstract: The present invention relates to a herbicide combination comprising components (A) and (B) where (A) denotes one or more compounds or salts thereof from the group described by the general formula (I): in which R1 is halogen, preferably fluorine or chlorine, R2 is hydrogen and R3 is hydroxyl or R2 and R3 together with the carbon atom to which they are attached are a carbonyl group C?O and R4 is hydrogen or methyl; and (B) denotes one or more herbicides from the group of the pyrimidines consisting of: (B1-1) ancymidol, (B1-2) flurprimidol, (B1-3) pyrimisulfan, (B2-1) bispyribac-sodium, (B2-2) pyribenzoxim, (B2-3) pyriminobac-methyl, (B2-4) pyribambenz-isopropyl, (B2-5) pyribambenz-propyl, (B3-1) pyriftalid, (B3-2) pyrithiobac-sodium, (B4-1) benzfendizone, (B4-2) bromacil, (B4-3) butafenacil, (B4-4) lenacil, (B4-5) terbacil, (B4-6) SYN-523, (B4-7) saflufenacil.

Abstract: The present invention relates to compositions for controlling plant pests containing the compound of the formula (I) in a mixture with specified fungicidally active compounds.

Abstract: A device for the removal of small arachnids and insects from clothing and skin is provided. The device comprises a body having a first end and a second end. The device also includes an elongated stem, also having a first end and a second end. The first end of the stem is connected to the second end of the body. The device also comprises a tubular tape cartridge having: a supporting base member that is received on and freely rotates around the elongated stem, and a tape roll wound around the base member. The tape roll comprises a series of tape sections. The tape cartridge is dimensioned to be removably received over the elongated stem. The device also comprises a cap that removably covers the stem and tape cartridge. A method for removing small arachnids and insects from clothing and skin is also provided.

Abstract: The present invention relates to isothiazolyloxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms, and also to a composition for this purpose which comprises the isothiazolyloxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or in their habitat.

Abstract: The novel active compound combinations comprising a carboxamide of the general formula (I) (group 1) in which A, R1 and R2 are as defined in the description, and the active compound groups (2) and (3) listed in the description have very good fungicidal properties.

Abstract: The present invention relates to dispersions comprising A) one or more herbicidal active substances from the group of the HPPD inhibitors, B) one or more oils, C) one or more surface-active substances, D) diammonium oxalate, diammonium hydrogen phosphate or ammonium dihydrogen phosphate, E) one or more rheological additives, F) optionally one or more agrochemical active substances other than A), such as herbicides, insecticides, fungicides, safeners or growth regulators, G) optionally formulation auxiliaries from the group consisting of antifoams, evaporation inhibitors, perfumes, colorants, antifreeze agents and preservatives. The dispersions are suitable for use in the field of plant protection.

Abstract: A firearm enabling and disabling electronic system comprising a base unit (1) and a safety device (4) adapted to be incorporated into a firearm (7). Each of the base unit (1) and the safety device (4) has a transmitter and/or receiver (2, 5) adapted to exchange and process wireless command signals with each other. The safety device (4) has an actuating circuit (6) which is controlled by the transmitter and/or receiver (5) of the safety device (4) and is adapted to actuate a locking mechanism (8), wherein in the locking mechanism is operable to prevent a firearm from firing.

Abstract: This invention is directed to stabilizing additives that contain at least one platinum complex, with the complex including a carbene group. The stabilizing additives make it possible to improve the resistance to decomposition of silicone elastomers under high temperatures. The additive can be used in a polyorganosiloxane composition intended for the production of a silicone elastomer with either crosslinks at high temperature under the action of organic peroxides or crosslinks at ambient temperature or with heat by polyaddition reactions in the presence of a metal catalyst.

Abstract: A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whether the recognition sequence of said methyltransferase has been modified with the cofactor or a derivative thereof, wherein modification of the recognition sequence of said methyltransferase is indicative of an absence of methylation at said recognition sequence. Also disclosed is a cofactor specific for S-adenosyl-L-methionine-dependent methyltransferases, wherein said cofactor is an N-adenosylaziridine derivative with a reporter group attached to the 6 or 7 position of the adenine ring or attached to the aziridine ring. A complex of the cofactor and a methyltransferase a composition comprising the cofactor or the complex and the use of the cofactor or the complex for detecting sequence-specific methylation in DNA molecules are also disclosed.

Abstract: The invention relates to continuous flow systems, in particular thermocyclers for the automated and continuous cycling of fluid between a plurality of temperature zones in the amplification of nucleic acids. The invention also relates to an improved sample port for introducing a volume of a liquid sample into a continuous flow system.

Abstract: The present invention relates to novel 3-biphenyl-substituted, 3-substituted 4-keto-lactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y and Z are as defined in the disclosure, to processes for their preparation, and to their use as pesticides and/or microbicides and/or herbicides.

Abstract: This invention relates to novel intermediates used in the preparation of iodopyrazolylcarboxanilides of the formula (I) in which R1, R2, R3, R4, R5, R6 and Z are as defined in the disclosure, and to the preparation of such intermediates.

Abstract: A holographic storage system for reading a hologram stored on a holographic storage medium. The system comprises: storage medium holding means; a spatial light modulator (SLM) for encoding a reference beam with a code pattern; a detector; and a servo control unit for determining a misalignment of the reference beam and the storage medium from the detected image and for acting upon the SLM to shift the code pattern. A method of reading a hologram stored on a holographic storage medium comprising: a) encoding a reference beam with a code pattern created by a spatial light modulator (SLM); b) detecting an image of the reconstructed hologram; c) determining a misalignment of the reference beam and the storage medium from the detected image; and d) shifting the code pattern on the SLM based at least in part on the misalignment.

Abstract: The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.