Abstract: The present invention relates to a composition and method of producing noggregating, filterable dispersion of liposome encapsulated agent or therapeutic of interest, specifically hemoglobin. A key step in the method of the present invention is the addition of a passivating protein prior to hydration of the liposomes with the agent of interest. The resulting dispersion is composed of unilamellar vesicles having a diameter of less than or equal to 0.2 microns.
Type:
Grant
Filed:
September 30, 1997
Date of Patent:
March 7, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
Victoria Kwasiborski, Richard O. Cliff, Alan S. Rudolph
Abstract: A receiver, especially useful for MMIC semiconductor communications circuits, in which plural mixers replace LRC filter networks to produce notched bandwidth filters. In a preferred embodiment, the input signal and a the output of a variable oscillator are mixed to produce a beat frequency. As an operator changes the desired frequency notch of the receiver, the output frequency of variable oscillator similarly changes to ensure that the beat frequency is the same regardless of desired frequency. Circuity downstream may be thus fixed, eliminating the need for large variable capacitors, which MMIC technology cannot fabricate in desirably small sizes.
Type:
Grant
Filed:
May 31, 1996
Date of Patent:
February 22, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: An organoboron polymer having a backbone with a repeating of at least one kynyl group, at least one silyl group, at least one boranyl group, optionally at least one siloxyl group, and optionally an aryldisilyl group. The boron containing units in and the silicon containing units can be arranged in either random occurrences between each other or in the form of interdispersed block-type structures of each unit. The hybrid polymer is useful for making high temperature, oxidatively stable thermosetting plastics and for microelectronic applications via crosslinking to three-dimensional inorganic-organic hybrid polymers.
Type:
Grant
Filed:
July 26, 1996
Date of Patent:
February 15, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: A core/clad glass optical fiber is made by melting a core glass rod and a adding glass rod in separate crucibles which are not concentric with respect to each other and the respective core and cladding glass melts passed out of contact with each other to a glass melt contacting zone proximate a fiber drawing orifice in which the cladding glass surrounds the core glass and a core/clad glass fiber is drawn. This process enables the clad glass fiber to be drawn directly from core and cladding glass rods without the need for a preform or forming a melt from glass chards or chunks, thereby reducing the cost of producing the fiber and also producing a glass clad optical fiber of high purity and excellent concentricity. Chalcogenide glass fibers having a concentricity of 100% have been made.
Type:
Grant
Filed:
February 24, 1999
Date of Patent:
February 8, 2000
Assignee:
The United States of America as Represented by the Secretary of the Navy
Inventors:
Jasbinder S. Sanghera, Pablo Pureza, Ishwar D. Aggarwal, Reza Mossadegh
Abstract: The process for making a porous mass containing dense aggregates or granu includes the steps of mixing powder with more than 10% by weight of a binder to form agglomerated powder, heating the agglomerated powder to remove the binder and to grow crystallites in the powder to an average diameter exceeding 5 microns to form a porous mass containing the dense aggregates, and cooling the porous mass. The porous mass is broken up, if it is cohesive, into the aggregates containing the crystallites and the aggregates can be used to make an article, such as a transducer. The transducer is essentially a thick film and its thickness is that of the ceramic aggregates of granules. The electrodes connect to the top and to the bottom of the aggragates. As a result, the transducer material operates in the 1-3 mode.
Type:
Grant
Filed:
January 23, 1997
Date of Patent:
February 8, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: This invention is a one-dimensional elementary motion detector that measu the linear optical flow in a small subsection of the visual field. This sensor measures motion by tracking the movement of a feature across the visual field and measuring the time required to move from one location to the next. First a one-dimensional image is sampled from the visual field using a linear photoreceptor array. Feature detectors, such as edge detectors, are created with simple circuitry that performs simple computations on photoreceptor outputs. The detection of the feature's location is performed using a winner-take-all (WTA) mechanism on feature detector outputs. Motion detection is the performed by monitoring the location of the high WTA output in time to detect transitions corresponding to motion. The correspondence problem is solved by ignoring transitions to and from the end lines of the WTA output bus. Speed measurement is performed by measuring the time between WTA output transitions.
Type:
Grant
Filed:
August 27, 1998
Date of Patent:
February 1, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: A Mach-Zehnder interferometer has electrodes configured to act as a microe transmission line. The optical waveguide arms have a reflective coating on their distal ends so that light is reflected back through the arms. The microwave transmission line is open-ended in a vicinity of the reflective coating so that microwave energy is reflected at the open end. Thus, the interferometer supports a traveling wave in a reflective configuration, and the distance over which interaction takes place can be effectively doubled.
Type:
Grant
Filed:
November 7, 1997
Date of Patent:
January 18, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: A telluride glass with glass transition temperature above 150.degree. C., fference between the crystallization temperature and the glass transition temperature of above 200.degree. C., and extended transmission in the infrared region of radiation of up to 20 microns having, on mol basis, 20-60% tellurium, 10-50% arsenic, 4-35% germanium, 0.5-15% gallium, up to 15% iodine, and up to 30% selenium. All or part of the gallium can be replaced with indium and the glass can contain up to 5%, based on the weight of the glass components, of a rare earth ion to render the glass fluorescent. Optical fibers drawn from these glasses have shown mid infrared fluorescence and may have as a bright source of IR light.
Type:
Grant
Filed:
December 24, 1997
Date of Patent:
January 18, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
Barry B. Harbison, Jasbinder S. Sanghera, L. Brandon Shaw, Ishwar D. Aggarwal
Abstract: A spectral filter is made in the form of a wafer of nanochannel glass having an array of substantially uniform parallel hollow channels of from about 0.1 microns to about 10 microns that are coated with a reflective material.
Type:
Grant
Filed:
April 8, 1997
Date of Patent:
January 11, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: Lipid microtubules having a controlled bilayer structure and high aspect io are formed in a methanol/ethanol/water solvent system. The lipid microtubules may then be catalyzed (e.g., with a palladium/tin catalyst) in an acidified catalytic bath having no more than about 30 g of catalytic salts. These catalyzed microtubules are then metallized using a diluted plating bath with replenishment of the plating bath as needed to obtain the desired metallization thickness.
Type:
Grant
Filed:
May 18, 1998
Date of Patent:
January 11, 2000
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
Ronald R. Price, Joel M. Schnur, Paul E. Schoen, Dan Zabetakis, Mark Spector
Abstract: Stabilized zirconia containing sintered particles of alumina and zirconia tetragonal phase at temperatures below about 1150.degree. C. is prepared by mixing alumina particles of less than 30 nanometers with zirconia particles of less than 30 nanometers in presence of a liquid to form a suspension, drying the suspension at a temperature up to about 600.degree. C. to remove the liquid and products thereof to form a dried suspension composed of agglomerated alumina and zirconia particles, sintering the dried suspension to fuse the particles, and cooling the sintered dried suspension to an ambient temperature to produce free-standing bodies or coatings on substrates.
Type:
Grant
Filed:
January 30, 1997
Date of Patent:
December 28, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
Virgil Provenzano, Ronald L. Holtz, David Lewis
Abstract: The advanced vertical array beamformer signal processor accomplishes acoustic beamforming of an underwater vertical array used in shallow water utilizing matched beam processing to suppress generated noise and/or ship radiated noise thereby increasing the detectability of a submerged source emitting only a low noise signal. The processor exploits the difference of the signal arrival angle of both active and passive signals with that of the wind generated noise and ship radiated noise which is prominent in downward refractive sound speed profiles. After filtering the undesired noise, the processor uses the depth of the source as a clue for detection; the processor is an energy detector focused on the returns of a deep source.
Type:
Grant
Filed:
August 13, 1998
Date of Patent:
December 28, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: Bulk crystalline materials are annealed by introducing into them mechanical energy of sufficient intensity to create a large amplitude sound wave. The mechanical energy may be introduced into the material, for example, by laser ablation. Where the bulk crystalline material is a doped semiconductor, the process also electrically activates the material.
Type:
Grant
Filed:
June 26, 1996
Date of Patent:
December 14, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
Charles Keith Manka, Jacob Grun, Billy Charles Covington, David William Donnelly
Abstract: An immobilized substrate surface is chemically modified by manipulating an nzyme which is immobilized to a solid surface. Modifications include (1) chemical dissection of a substrate surface such as by chemical hydrolysis, (2) chemical synthesis on a substrate surface, and (3) chemical patterning of a substrate surface. The enzyme may be coupled to colloidal beads or particles, locally flat solid surfaces including planar, textured planar, cylindrical and spherical surfaces or arbitrary predefined shapes, or scanning probe microscope probes. In the patterning applications, colloidal particles containing the enzyme can be confined to desired regions of the substrate surface by various techniques which control the movement of the particles. The particles can be confined to tunnels or channels in a patterned polymer mold on top of the substrate surface. The enzyme can also be immobilized onto the surface of a raised pattern and this patterned surface can then be placed in contact with the immobilized substrate.
Type:
Grant
Filed:
April 8, 1997
Date of Patent:
December 14, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: This invention is a demultuplexer consisting on a sequential division of the data stream in a series of Sagnac interferometer amplitude modulators (SIAMs), wherein each modulator in the series is driven by a single microwave frequency derived directly from a radio frequency (RF) data rate clock, with the RF phase properly adjusted to extract a channel of interest.
Type:
Grant
Filed:
February 20, 1998
Date of Patent:
December 7, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Inventors:
Michael L. Dennis, Irl N. Duling, III, William K. Burns
Abstract: A sample support member for atomic force microscopy of intermolecular interactions includes a sample support base having a plurality of protrusions, each protrusion having an apical substrate region or tip that has been chemically modified by the immobilization thereon of a sample compound or of a linking compound that is capable of binding a sample compound. A reference compound support member has a surface region having at least one reference compound immobilized thereon.The relative position and orientation of the reference compound support member and the substrate support member are controlled to select a particular protrusion and to cause an interaction between a reference compound immobilized on the surface region of the free end of the cantilever and the sample compound immobilized on the apical substrate area of the selected protrusion. A physical parameter associated with the interaction between the reference compound and the sample compound can be measured.
Type:
Grant
Filed:
May 8, 1998
Date of Patent:
November 30, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: A two-dimensional imager for measuring the electric-field amplitude and phase distribution across an extended spatial region for millimeter and microwave electro-magnetic waves. The imager consists of a small active area within a generally passive structure which measures the electric (E)-field amplitude and phase information and impresses this information onto an optical beam. The E-field information is measured by converting the optical signal into and electrical signal and demodulating the E-field information from the electrical signal by processing electronics where the electrical signal is conditioned, stored and the data displayed.
Type:
Grant
Filed:
September 30, 1997
Date of Patent:
November 23, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: Phosphors having a doped core are surrounded by a shell material. Additionally, these nanocrystalline phosphors, or larger phosphors formed by conventional or other processes may be surrounded by a shell that prevents or significantly reduces non-radiative recombination at the surface of the original phosphor.
Type:
Grant
Filed:
November 18, 1997
Date of Patent:
November 16, 1999
Inventors:
Henry F. Gray, Jianping Yang, David S. Y. Hsu, Banhalli R. Ratna
Abstract: Organometallic linear polymers containing metallocene, inorganic units (such as silicon and boron), and acetylenic units which display superb processability, and which are readily converted to a thermoset through the acetylenic groups, yielding high temperature thermosetting polymers and ceramics that exhibit outstanding long-term thermal (high char yield) and magnetic properties and synthesis of these.
Type:
Grant
Filed:
March 14, 1997
Date of Patent:
November 16, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: A precursor composition includes (1) at least one crosslinking compound resented by the formula: ##STR1## wherein: u and x are independently selected positive integers, v and w are independently selected integers greater than or equal to zero, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of alkyl, aryl, alkylaryl, haloalkyl, haloaryl and mixtures thereof, A and E are independently selected from the group consisting of O, an aliphatic bridge, an aryl bridge and mixtures thereof; and R.sup.9 and R.sup.10 are unsubstituted or substituted vinyl or ethynyl groups, (2) at least one organosilicon compound containing at least two silicon hydride moieties per molecule, and (3) a hydrosilation catalyst. A cross-linked polymer is formed by reacting the crosslinking compound of formula I with the organosilicon compound via a hydrosilation reaction. A thermoset polymer is formed by thermally curing the crosslinked polymer.
Type:
Grant
Filed:
February 27, 1998
Date of Patent:
November 9, 1999
Assignee:
The United States of America as represented by the Secretary of the Navy