Patents Represented by Attorney Bertram Bradley
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Patent number: 5356878Abstract: Highly purified antihemophilic factor is produced by a process comprising a PEG precipitation step, a gel filtration step and a virus inactivation step. Al(OH).sub.3 adsorption and PEG precipitation carried out at room temperature allow processing to proceed directly to a gel filtration step.Type: GrantFiled: January 4, 1993Date of Patent: October 18, 1994Assignee: Miles Inc.Inventors: William J. Brockway, Richard L. Seng
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Patent number: 5177191Abstract: Highly purified antihemophilic factor can be produced from a cryoprecipitate by a process comprising a PEG precipitation step, a viral inactivation step and a gel filtration step, all steps being carried out at room temperature.Type: GrantFiled: September 24, 1990Date of Patent: January 5, 1993Assignee: Miles, Inc.Inventors: William J. Brockway, Richard L. Seng
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Patent number: 4983722Abstract: Protein A is selectively isolated from an antibody--Protein A mixture by exposing the mixture to an anion exchange material under conditions sufficient to adsorb both components and then sequentially eluting the antibodies and protein A under conditions of increasing ionic strength. Resulting antibody preparations have less than about 15 ng of Protein A per mg of antibody.Type: GrantFiled: June 8, 1988Date of Patent: January 8, 1991Assignee: Miles Inc.Inventors: James W. Bloom, Melvin F. Wong, Gautam Mitra
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Patent number: 4981951Abstract: A method of purifying a recombinant protein from a solution, such as tissue culture fluid, containing gylcoproteins. The affinity of lectins for specific glycoproteins is assessed and used to select a particular lectin specific for the contaminating glycoprotein(s). A sugar buffer such as alpha methyl mannoside prevents binding of the recombinant protein. The preferred lectin is lentil lectin, for use in separating recombinant Factor VIII from tissue culture fluid contaminated with rodent protein from the cell line used to produce the recombinant Factor VIII.Type: GrantFiled: April 14, 1988Date of Patent: January 1, 1991Assignee: Miles Inc.Inventor: Grace C. Tsay
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Patent number: 4294249Abstract: An injection site is disclosed comprising a self-sealing, puncturable member of resilient material and a housing wherein the puncturable member is compressibly confined by a swage-molded edge on the top of the housing. The injection site may be attached to an injection-receiving receptacle such as a medicament injection device as used in an assembly for intravenous administration.Type: GrantFiled: October 18, 1979Date of Patent: October 13, 1981Assignee: Cutter Laboratories, Inc.Inventors: Neil J. Sheehan, Melvin H. Norman
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Patent number: 4280497Abstract: A plastic bag containing a platelet concentrate is disclosed wherein the viability of platelets remains at a high level even after storage at 22.degree. C. for up to five days. The bag in which the platelet concentrate is stored comprises walls of polyvinyl chloride film containing tri 2-ethylhexyl trimellitate as plasticizer together with epoxidized vegetable oils for heat stabilization of the film. The film may also contain metal soaps in preferred formulations.Type: GrantFiled: October 9, 1979Date of Patent: July 28, 1981Assignee: Cutter Laboratories, Inc.Inventors: Willis L. Warner, Edward J. Nelson
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Patent number: 4207988Abstract: Improvements in inner and outer closures for containers are disclosed. The outer closure is characterized by a cap member having a top wall, a side wall and a base adapted for sealing to the neck of a container. Two score lines extend across the top wall with finger gripping means attached at the apex where the two score lines meet. One score line extends down the side wall to connect with a third score line near the base which extends completely around the cap. The other score line extends down the side wall to an intermediate position and diverges away and terminates a short distance from the one score line. By pulling on the finger gripping means, the entire cap member above the third score line is removed in one piece. The inner closure comprises a plastic member sealed at its periphery to the mouth of the neck and includes a vertically aligned spike-entry port and an additive port which is oriented at an angle away from the entry port.Type: GrantFiled: May 18, 1979Date of Patent: June 17, 1980Assignee: Cutter Laboratories, Inc.Inventors: Myron R. Prouty, Colin J. Nichols, Norman A. Brown, Stephen P. Sutter
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Patent number: 4204604Abstract: An improvement in a closure system for containers in which a cap member sealed at its base to an annular flange about the neck of the container is removeable by a cutting ring. The cap includes an upwardly projecting brim at the base separated from the side wall of the cap to provide an annular groove. The groove has at least one tapered recess. The cutting ring which can be positioned around the side wall of the cap has at least one depending tab with an inwardly directed sharpened projection. Normally, the tab rests in the recess of the groove. Upon rotation of the cutting ring, the tab is forced inwardly causing the sharpened projection to sever the side wall of the closure.Type: GrantFiled: April 30, 1979Date of Patent: May 27, 1980Assignee: Cutter Laboratories, Inc.Inventors: Marius J. Morin, Colin J. Nichols, Myron R. Prouty
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Patent number: 4195632Abstract: An improvement in a fluid flow valve is disclosed. The valve comprises a combination of flexible tubing joined to a tubular member having a membrane closing off the passageway in the tubular member. A pointed spike having at least three radially projecting ribs extending longitudinally is located within the tubing adjacent the membrane and is movable by external manipulation of the tubing whereby the spike ruptures the membrane and creates a passageway permitting fluid to flow freely through the tubular member and adjoining tubing.Type: GrantFiled: May 3, 1978Date of Patent: April 1, 1980Assignee: Cutter Laboratories, Inc.Inventors: Wendell R. Parker, Mark H. Silverman, Willis L. Warner
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Patent number: 4187558Abstract: Surgically implantable skeletal ligament having secured thereto at least one deformable collar having a velour-like outer surface adapted to invite tissue ingrowth. In use, the collar portion of the ligament is positioned within a surgically prepared passageway in a bone to protect the ligament from bone abrasion and to assist in ligament attachment by accepting tissue ingrowth into the velour-like surface.Type: GrantFiled: October 25, 1977Date of Patent: February 12, 1980Assignee: Cutter Laboratories, Inc.Inventors: Burton L. Dahlen, James A. Stubstad
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Patent number: 4186192Abstract: Composition comprising an aqueous solution of immune serum globulin and maltose, the amount of maltose being sufficient to inhibit "shedding" of the globulin with time.Type: GrantFiled: December 18, 1978Date of Patent: January 29, 1980Assignee: Cutter Laboratories, Inc.Inventors: John L. Lundblad, Willis L. Warner, Peter M. Fernandes
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Patent number: 4141379Abstract: An improved check valve is disclosed for use in a system for sequentially delivering primary and secondary solutions through a common conduit. The check valve comprises a hollow housing with an inlet and an outlet connected to an enlarged intermediate portion. Sealed at its periphery in the enlarged portion is a flexible diaphragm characterized by having foraminous means in at least its outer portion and imperforate means in its central portion. The imperforate means is spaced from a valve seat surrounding the passage at the inner end of the inlet so that when the primary solution flows from the inlet to the outlet, it will pass freely around the imperforate means and through the foraminous means. When an increase in pressure, even though slight, is exerted against the diaphragm caused by flow of the secondary solution in the direction of the outlet to the inlet, the diaphragm moves towards the inlet causing the imperforate means to seal against the valve seat and stop the flow of the primary solution.Type: GrantFiled: May 16, 1977Date of Patent: February 27, 1979Assignee: Cutter Laboratories, Inc.Inventor: Reinhold R. Manske
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Patent number: 4141975Abstract: Semi-solid preparation useful as a boticide and anthelmintic in horses and comprising an effective amount of trichlorfon dispersed in a mineral oil.Type: GrantFiled: November 3, 1977Date of Patent: February 27, 1979Assignee: Cutter Laboratories, Inc.Inventors: John C. Gay, William P. Marsland
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Patent number: 4138105Abstract: The device comprises a closed container with a breathing tube and a means for variably adjusting the size of an aperture into the container. A transparent inclined tube is mounted on the container and houses a moveable air flow indicating member. The tube has a passage at the top leading into the container and a vent at the bottom of the tube allows air to enter to move the flow indicating member up the inclined tube. Air drawn from the container by inspiring through the breathing tube is replaced in part by air entering through the variable aperture means and by the air entering through the vent. By adjusting the size of the variable aperture, one can determine inspiratory capacity as correlated with the amount of air necessary to move the flow indicating member to the top of the tube or to an intermediate position in the tube.Type: GrantFiled: February 28, 1977Date of Patent: February 6, 1979Assignee: Cutter Laboratories, Inc.Inventors: Darrell M. Hunger, Lee E. McGill, Raymond D. VON Alven
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Patent number: 4112068Abstract: A finite cell strain is derived from canine fetal lung tissue, the cells of which are fibroblast-like, diploid, and are free of reverse transcriptase and C-type particles. With a nutrient medium the cells provide a cell culture system useful in the cultivation of a number of viruses from which vaccines may be prepared.Type: GrantFiled: August 29, 1977Date of Patent: September 5, 1978Assignee: Cutter Laboratories, Inc.Inventor: Victor J. Cabasso
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Patent number: 4078563Abstract: An improved disc valve in a container for dispensing liquids is disclosed. The disc valve comprises at least two upstanding posts adjacent an outlet passage in the bottom of the container and a floatable disc member with apertures near its periphery through which the posts extend. The posts further have disc-retaining stops at their upper ends. The posts position the disc and the relationship between the size of the apertures and the thickness of the posts assures the disc will seat over the outlet passage to prevent the passage of air when all the liquid has been dispensed.Type: GrantFiled: June 10, 1976Date of Patent: March 14, 1978Assignee: Cutter Laboratories, Inc.Inventor: Robert D. Tuseth
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Patent number: 4043997Abstract: A method for the isolation of albumin which allows the selective adsorption and substantially quantitative elution of albumin from mixtures containing the same. The method comprises contacting a solution which contains albumin with a member of a series of dye-insoluble support compounds in which the insoluble support is a polyhydroxy polymer coupled to a dye by means of a reactive pyrimidine. The albumin which is selectively adsorbed can be readily eluted resulting in essentially a quantitative recovery of pure albumin.Type: GrantFiled: May 28, 1976Date of Patent: August 23, 1977Assignee: Cutter Laboratories, Inc.Inventor: Duane D. Schroeder
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Patent number: 4027577Abstract: A process and apparatus adapted to automate the conversion of a continuous sheet of flexible plastic film into ported bags. The apparatus includes means for maintaining the film sheet in proper alignment during the various processing steps and functions in a manner which reduces environmental particulate contamination of the bags to a minimum.Type: GrantFiled: July 25, 1975Date of Patent: June 7, 1977Assignee: Cutter Laboratories, Inc.Inventors: John A. Thompson, Robert V. Torres
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Patent number: 4025070Abstract: The device is a disposable compact unit comprising a transparent column with an aperture at its base, an air float within the column and with the column mounted on a closed container. A conduit joins the top of the column to an opening into the container. The container is also equipped with a breathing tube and a variable aperture means for varying the size of another opening into the container. By inhaling through the breathing tube, a patient can judge his capacity for alveolar expansion by the height to which the air float rises. Adjustment to any patient's capacity can be easily made by changing the opening in the variable aperture means.Type: GrantFiled: April 19, 1976Date of Patent: May 24, 1977Assignee: Cutter Laboratories, Inc.Inventors: Lee E. McGill, Raymond D. Von Alven
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Patent number: D260427Type: GrantFiled: March 26, 1979Date of Patent: August 25, 1981Assignee: Cutter Laboratories, Inc.Inventors: Lee E. McGill, Susan J. Watkins