Patents Represented by Attorney, Agent or Law Firm Bozicevic, Field, & Francis
  • Patent number: 8349575
    Abstract: The present invention provides a method and composition for raising an immune response in an animal. The method comprising administering to the animal a composition comprising a carrier and an antigen bound to a targeting moiety. The targeting moiety binds to at least one receptor that is upregulated on lymphocytes that home to MAdCAM+ mucosal lymphoid tissues.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: January 8, 2013
    Assignee: The Council of the Queensland Institute of Medical Research (QIMR)
    Inventors: Brent Steven McKenzie, Jefferey Stephen Boyle, Andrew Mark Lew
  • Patent number: 8348921
    Abstract: Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: January 8, 2013
    Assignee: The Regents of the University of California
    Inventors: Antoni Ivorra, Boris Rubinsky
  • Patent number: 8350097
    Abstract: A (?)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or pro drug thereof, is useful as an anesthetic.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: January 8, 2013
    Assignee: Signature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Patent number: 8349910
    Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: January 8, 2013
    Assignee: The Regents of the University of California
    Inventors: Isaac S. Carrico, Brian L. Carlson, Peng Wu, Carolyn Ruth Bertozzi
  • Patent number: 8349348
    Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a proteinaceous substrate and a crosslinking agent, such as a stabilized aldehyde crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: January 8, 2013
    Assignee: Matrix Medical, LLC
    Inventors: Kemal Schankereli, Ronald Dieck
  • Patent number: 8348091
    Abstract: Provided are plate designs that enable a user to hold a plate in one hand, together with a drinking cup in the same hand. The subject designs find use in various situations in which a user desires to hold a plate and a drinking cup simultaneously. The subject designs also find use in various situations in which a user desires to hold a plate securely, in the presence or absence of a drinking cup.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 8, 2013
    Inventor: John Zox
  • Patent number: 8343441
    Abstract: Aspects of the invention include methods and devices for manufacturing and testing microfluidic chips having at least one capillary for through-flow of a fluid.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: January 1, 2013
    Assignee: Micronit Microfluidics B.V.
    Inventors: Ronny van 't Oever, Marko Theodoor Blom
  • Patent number: 8342031
    Abstract: Provided are capacitive strain sensors. In certain embodiments, the capacitive strain sensor can continuously and accurately measure strain in corrosive ambient conditions and may operate up to 370° C. or more in air. The sensor includes a differential capacitor that includes a bending beam structure. In some instances, the sensor is configured to increase the effect of strain in a substrate along a sensing axis while attenuating the effect of cross-axis strain. Also provided are methods of making the capacitive strain sensors, e.g., using Micro-Electro-Mechanical System (MEMS) fabrication techniques, and methods of using the capacitive strain sensors.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: January 1, 2013
    Assignee: The Regents of the University of California
    Inventors: Babak Jamshidi, Albert P. Pisano
  • Patent number: 8343130
    Abstract: A needleless injector has a syringe body having an opening at one end, a piston housed within the syringe body for urging a liquid within the syringe body through the opening and a ram for driving the piston. A shock absorbing component is provided for reducing an initial transfer of force from the ram to the piston. The initial rate of pressure increase on the liquid is reduced, thereby controlling the rate of collapse of gas bubbles in the liquid.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: January 1, 2013
    Assignee: Zogenix, Inc.
    Inventor: Terry Green
  • Patent number: 8343723
    Abstract: The present inventors succeeded in cloning the CDT genes of C. coli and C. fetus, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by comparing the CDTs of C. jejuni and C. fetus. Furthermore, the inventors demonstrated that these primers were applicable to multiplex PCR that simultaneously allows for the rapid and convenient determination of the presence of Campylobacter CDT and identification of species, and that they can also be used in PCR-RFLP-based typing.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: January 1, 2013
    Assignee: Fuso Pharmaceutical Industries, Ltd.
    Inventors: Shinji Yamasaki, Masahiro Asakura
  • Patent number: 8338776
    Abstract: Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A device parcels a light source into many points of light transmitted through a microlens optical array and an Offner relay to an objective, where particles may be trapped. Preferably the individual points of light are individually controllable through a light controlling device. Optical properties of the particles may be determined by interrogation with light focused through the optical array. The particles may be manipulated by immobilizing or releasing specific particles, separating types of particles, etc.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: December 25, 2012
    Assignee: Tufts University
    Inventors: David R. Walt, Alexei R. Faustov
  • Patent number: 8337883
    Abstract: Disclosed are bupivacaine transdermal delivery systems, and related methods.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: December 25, 2012
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Sung Yun Kwon, Xiaoping Song, James E. Brown
  • Patent number: 8338176
    Abstract: Provided is a method for the derivation of neural stem cells (NSCs) from embryonic stem cells (ESCs) and the use of the NSCs for treatment of various neural disorders. The NSCs that are derived from the ESCs are tissue-specific multipotent NSCs with a stable growth rate, unlimited self-renewal capacity, and a predictable differentiation profile. Being both non-tumorigenic and engraftable, the NSCs of the present invention have utility in repopulation stroke-damaged tissue. The NSCs of the present invention may be differentiated to produce tyrosine-hydroxylase expressing neurons, which may be used as a source of dopaminergic neurons for subjects suffering from a condition characterized by dopaminergic dysfunction, such as Parkinson's disease.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: December 25, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Marcel M. Daadi, Gary K. Steinberg
  • Patent number: 8337583
    Abstract: Soil amendment/foliar nutrient compositions and methods for their manufacture and use are provided. The compositions are aqueous compositions that include a carbon skeleton energy component (CSE); a macronutrient; a vitamin cofactor; a complexing agent; and at least one of exotic micronutrient component and an ionophore component.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: December 25, 2012
    Inventor: Thomas T. Yamashita
  • Patent number: 8337692
    Abstract: A method for determining the presence or amount of a metal-labelled analyte (12) in a sample is described. The method comprises the steps of adding a release agent (20) to the metal labelled analyte (12) to release the metal label (18) from the analyte (12), the release agent (20) forming a charged stable species (22) with the metal label (18), applying a potential to bring the charged stable species (22) to an electrode (22), dissolving the charged stable species (22) under a positive potential to form metal ions (26), and carrying out a quantitative determination procedure such as anodic stripping voltammetry to determine the presence or amount of the metal-labelled analyte (12).
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: December 25, 2012
    Assignee: The Secretary of State for Innovation, Universities and Skills of Her Majesty's Britannic Government
    Inventors: Robert Andrew Porter, Mateusz Szymanski
  • Patent number: 8337805
    Abstract: The present invention provides a method for preparing magnetite nanoparticles from low-grade iron ore and magnetite nanoparticles prepared by the same. According to the method of the present invention, in which iron ore leachate is obtained by adding low-grade iron ore powder to an acidic solution, Si and Mg that inhibit the formation of magnetite nanoparticles present in the leachate are selectively removed, iron hydroxide (Fe(OH)3) is allowed to be precipitated from a supernatant containing Fe2+ ions and Fe3+ ions, a mixed iron solution containing Fe2+ ions and Fe3+ ions is prepared using the iron hydroxide (Fe(OH)3), and the mixed iron solution is added to an alkaline solution to react, thereby preparing magnetite nanoparticles.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 25, 2012
    Assignee: Korea Institute of Geoscience and Mineral Resources
    Inventors: Yong Jae Suh, Myung Eun Ju, Dae Sup Kil, Hee Dong Jang
  • Patent number: D673007
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: December 25, 2012
    Inventor: John Zox
  • Patent number: D673577
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: January 1, 2013
    Assignee: Proteus Digital Health, Inc.
    Inventors: Danielle Schulze Cojuangco, Todd Nathan Rinker, Arna Diana Ionescu
  • Patent number: D673578
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: January 1, 2013
    Assignee: Proteus Digital Health, Inc.
    Inventors: Danielle Schulze Cojuangco, Todd Nathan Rinker, Arna Diana Ionescu
  • Patent number: D673964
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: January 8, 2013
    Assignee: Proteus Digital Health, Inc.
    Inventors: Danielle Schulze Cojuangco, Todd Nathan Rinker, Arna Diana Ionescu