Patents Represented by Attorney, Agent or Law Firm Bozicevic, Field, & Francis
  • Targeted cross-linked nanoparticles and their use in vivo gene delivery
    Patent number: 8163305
    Abstract: The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: April 24, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark D. Bednarski, Samira Guccione, King Chuen Li
  • Recombinant bicistronic flaviviruses and methods of use thereof
    Patent number: 8163548
    Abstract: The present invention provides recombinant bicistronic flaviviruses, particularly live attenuated recombinant bicistronic flavivirus, which comprise, in order from 5? to 3?, a viral 5?UTR, an ORF encoding all viral proteins, an internal ribosome entry site, an exogenous nucleotide sequence that encodes an exogenous polypeptide, and a viral 3?UTR. Infection of a host cell with a recombinant flavivirus provides for expression of the exogenous nucleic acid in a host cell. Such recombinant flavivirus are useful for delivering a protein to a mammalian host; and for eliciting an immune response to the exogenous polypeptide.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: April 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Raul Andino-Pavlovsky, Andres McAllister-Moreno
  • System and method for sharing content based on positional tagging
    Patent number: 8166383
    Abstract: Systems and methods for sharing digital content based on positional tagging on a digital platform. For example, in one embodiment, the systems and methods generally include: (a) providing a first user with an interface to tag content on a first digital platform; (b) creating a positional identifier that identifies the location of the tagged content on the first digital platform; and (c) posting, on a second digital platform, a link to the first digital platform. When a second user on the second digital platform activates the link on the second digital platform, the second user is directed to the first digital platform. The systems and methods thereafter include: (d) identifying when a second user has accessed the first digital platform via the link on the second digital platform; and (e) highlighting the tagged content on the first digital platform.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: April 24, 2012
    Assignee: Luminate, Inc.
    Inventors: James R. Everingham, Will H. Scullin
  • Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof
    Patent number: 8163980
    Abstract: The present invention provides isolated nucleic acids comprising nucleotide sequences encoding isoprenoid modifying enzymes, as well as recombinant vectors comprising the nucleic acids. The present invention further provides genetically modified host cells comprising a subject nucleic acid or recombinant vector. The present invention further provides a transgenic plant comprising a subject nucleic acid. The present invention further provides methods of producing an isoprenoid compound, the method generally involving culturing a subject genetically modified host cell under conditions that permit synthesis of an isoprenoid compound modifying enzyme encoded by a subject nucleic acid.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: April 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Dae-Kyun Ro, Karyn Newman, Eric M. Paradise, Jay D. Keasling, Mario Ouellet, Rachel Eachus, Kimberly Ho, Timothy Ham
  • Gels with predetermined conductivity used in electroporation of tissue
    Patent number: 8162918
    Abstract: Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: April 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Antoni Ivorra, Boris Rubinsky
  • Prodrugs of active agents
    Patent number: 8163701
    Abstract: Disclosed herein are prodrugs of active agents which contain at least one amine, phenol, carboxylic acid, or thiol functionality. Also disclosed herein are methods of making prodrugs of active agents, pharmaceutical compositions of prodrugs of active agents and methods of using prodrugs of active agents and pharmaceutical compositions.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: April 24, 2012
    Assignee: Signature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Pseudotyped retroviral vectors and methods of use thereof
    Patent number: 8163893
    Abstract: The present invention provides nucleic acids encoding recombinant envelope proteins; and packaging cells comprising the nucleic acids, which packaging cells provide for encapsidation of recombinant retroviral vectors. The present invention provides producer cells that produce pseudotyped recombinant retroviral vectors. The present invention further provides methods of purifying pseudotyped recombinant retroviral vectors; and purified pseudotyped recombinant retroviral vectors. The present invention further provides methods of delivering a gene product to an individual. The methods generally involve introducing a subject recombinant retroviral vector into an individual.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: April 24, 2012
    Assignee: The Regents of the University of Caifornia
    Inventors: David V. Schaffer, Julie H. Yu
  • Small volume in vitro analyte sensor and methods of making
    Patent number: 8163164
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: April 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Biosensor having improved hematocrit and oxygen biases
    Patent number: 8163160
    Abstract: The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: April 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Nigel J. Forrow, Shridhara Alva Karinka
  • Mediator stabilized reagent compositions for use in biosensor electrodes
    Patent number: 8163146
    Abstract: The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: April 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Nigel J. Forrow
  • Nicotine receptor agonists in stem cell and progenitor cell recruitment
    Patent number: 8163780
    Abstract: The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: April 24, 2012
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: John Cooke, Frances Lauri Johnson, Anjali Pathak, James Jang, Philip Tsao, Christopher Heeschen
  • Method and apparatus for rapidly counting and identifying biological particles in a flow stream
    Patent number: 8159670
    Abstract: A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: April 17, 2012
    Assignee: Abbott Laboratories
    Inventors: Giacomo Vacca, Richard G. Kendall, Norman R. Goldblatt, Michael W. Yee, Mahesh R. Junnarkar
  • Analyte monitoring devices
    Patent number: 8158081
    Abstract: Covers for covering an opening in an analyte meter, and meters that include the same are provided.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: April 17, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Steve Scott, Yi Wang
  • Methods for treatment of insulin-like growth factor-1 deficiency
    Patent number: 8158582
    Abstract: The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having an endocrine disorder characterized by partial endogenous growth hormone activity or signaling. The invention provides a method comprising administering to a patient suffering from an endocrine disorder characterized by partial endogenous growth hormone activity or signaling an amount of insulin-like growth factor-1 (IGF-1) effective to improve metabolism in the patient, where the patient receives IGF-1 in a single daily administration.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: April 17, 2012
    Assignee: Tercica, Inc.
    Inventors: Ross G. Clark, Gillian Clark, legal representative
  • Methods of generating protein variants
    Patent number: 8158383
    Abstract: The present invention provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypeptide. The present invention further provides nucleic acids encoding enzyme variants, as well as vectors and host cells comprising the nucleic acids. The present invention further provides variant enzymes; methods of producing the variant enzymes; and methods of producing compounds using the enzymes.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: April 17, 2012
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, Yasuo Yoshikuni, Jeffrey Allen Dietrich, Farnaz F. Nowroozi, Patricia C. Babbitt
  • Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent
    Patent number: 8160670
    Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: April 17, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
  • Gene expression markers for colorectal cancer prognosis
    Patent number: 8153378
    Abstract: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: April 10, 2012
    Assignees: Genomic Health, Inc., NSABP Foundations, Inc.
    Inventors: Wayne Cowens, Joffre B. Baker, Kim Clark, James Hackett, Drew Watson, Soonmyung Paik
  • Means and methods for diagnosing and/or treating a subject at risk of developing heart failure
    Patent number: 8153376
    Abstract: The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of said subject; (b) comparing the level of said biological marker to a standard level of the same biological marker; and (C) determining whether the level of the marker is indicative of a risk for developing heart failure, wherein the biological marker is Krüppel Like Factor 15 (KLF-15) and/or lysosomal integral membrane protein-2 (LIMP-2) and/or fragments and/or variants thereof, and/or wherein the biological marker is a gene coding for KLF15 and/or LIMP-2, and/or fragments and/or variants thereof.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: April 10, 2012
    Assignee: Universiteit Maastricht
    Inventors: Yigal M. Pinto, Esther E. Creemers, Joost L. Leenders
  • Methods for phenotyping of leukemias
    Patent number: 8153388
    Abstract: Isolated populations of leukemic stem cells are provided. The cells are useful for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery of factors or molecules that can affect them. Detection of leukemic stem cells is useful in predicting disease progression, relapse, and development of drug resistance. Proliferation of LSC may be inhibited through interfering with activation of the ?-catenin pathway. Methods are provided for the clinical staging of pre-leukemia and leukemias by differential analysis of hematologic samples for the distribution of one or more hematopoietic stem or progenitor cell subsets.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: April 10, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Catriona Helen M. Jamieson, Laurie Ailles, Irving L. Weissman
  • Reference electrodes having an extended lifetime for use in long term amperometric sensors
    Patent number: 8155722
    Abstract: The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: April 10, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Zenghe Liu, Tianmei Ouyang