Patents Represented by Attorney, Agent or Law Firm Bozicevic, Field, & Francis
  • Analyte monitoring device and methods of use
    Patent number: 8226558
    Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: July 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Keith A. Friedman, Fredric C. Colman
  • Methods and compositions for genomic modification
    Patent number: 8227249
    Abstract: The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting construct comprises, for example, (i) a first recombination site and a polynucleotide sequence of interest, and (ii) a site-specific recombinase, which are introduced into the cell. The genome of the cell comprises a second recombination site. Recombination between the first and second recombination sites is facilitated by the site-specific recombinase. The invention describes compositions, vectors, and methods of use thereof, for the generation of transgenic cells, tissues, plants, and animals. The compositions, vectors, and methods of the present invention are also useful in gene therapy techniques.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: July 24, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Michele P. Calos
  • Analyte monitoring device and methods of use
    Patent number: 8226557
    Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: July 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Keith A. Friedman, Fredric C. Colman
  • Small volume in vitro sensor and methods of making
    Patent number: 8226815
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 24, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Small volume in vitro sensor and methods of making
    Patent number: 8221685
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 17, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Monoclonal antibodies against extracellular loops of C5aR
    Patent number: 8221757
    Abstract: The present invention relates to antibodies which bind to C5aR and which are useful in diagnostic and therapeutic methods. The antibodies of the present invention are reactive with an extracellular loop of C5aR other than the N-terminal domain and are capable of substantially reducing or inhibiting the binding of C5a to C5aR and functional consequences of neutrophil chemoattractant receptor activation.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: July 17, 2012
    Assignee: G2 Therapies Ltd
    Inventor: Charles Reay MacKay
  • Biosensor electrode mediators for regeneration of cofactors
    Patent number: 8221612
    Abstract: The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: July 17, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Nigel J. Forrow, Gurdial S. Sanghera, Jared L. Watkin, Stephan Walters
  • Sulfatases and methods of use thereof
    Patent number: 8216580
    Abstract: Novel sulfatases and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting tumor-induced angiogenesis and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of a subject sulfatase.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 10, 2012
    Assignee: The Regents of the University of California
    Inventors: Roman Nawroth, Steven D. Rosen
  • Controlled release of phenolic opioids
    Patent number: 8217005
    Abstract: A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: July 10, 2012
    Assignee: Signature Therapeutics, Inc.
    Inventors: Thomas E. Jenkins, Aleksandr Kolesnikov
  • Article and method for applying a coupling agent for a non-invasive optical probe
    Patent number: 8219168
    Abstract: This invention provides an article of manufacture and method for controlling the application of a coupling agent, such as a silicone oil or mineral oil, on a surface of a tissue prior to contacting the tissue with an apparatus for non-invasive optical measurement of the concentration of an analyte. The article ensures that a specific quantity of the coupling agent is deposited in a uniform layer over the entire target area of the tissue, thereby enhancing both the optical signal and the repeatability of thermal and optical coupling with the components of the apparatus. The article comprises a backing and a layer of coupling agent on at least one major surface of the backing.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: July 10, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Michael G. Lowery
  • In situ combustion in gas over bitumen formations
    Patent number: 8215387
    Abstract: The invention provides methods for natural gas and oil recovery, which include the use of air injection and in situ combustion in natural gas reservoirs to facilitate production of natural gas and heavy oil in gas over bitumen formations.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: July 10, 2012
    Assignee: Encana Corporation
    Inventors: Larry Weiers, Ben Nzekwu
  • Lancet removal tool
    Patent number: 8216263
    Abstract: A lancet removal tool 26 comprises an elongate hollow body 28 having an opening 32 at one end. The opening 32 is bounded by resilient fingers 36 which can flex to expand the opening 32 to engage the body 16 of the lancet 14. Withdrawal of the tool 26 after engagement with the lancet body 16 causes the lancet 14 to be removed from the lancet device. Subsequently, the lancet 14 can be moved from the opening 32 into the interior of the tool 26. The tool 26 and the removal procedure enables lancets 14 to be removed without risk of injury or infection from contact with the contaminated needle 18 of the lancet 14.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: July 10, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Farzad M. Shahrokni, Andrew Huckstep, Oliver Paul Jones, Paul Sen Yang
  • Embossed cell analyte sensor and methods of manufacture
    Patent number: 8211632
    Abstract: An analyte measurement system is provided having sensors with embossed test chamber channels. In one embodiment, the sensors are elongate test strips for in vitro testing, each test strip having a substrate, at least one electrode, an embossed channel in the electrode, and lidding tape covering at least a portion of the embossed channel. Methods of manufacture are also disclosed for filling the sensor channels with reagent, and for trimming the ends of the sensors to eliminate the need for a calibration code during use of the sensors with a meter.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: July 3, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adrian Petyt, Simon A. Hector
  • Biosensors and methods of making
    Patent number: 8211280
    Abstract: Devices and methods for determining the concentration of an analyte in a sample of liquid are provided.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: July 3, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Adrian Petyt, Simon Andrew Hector
  • Small molecule inhibition of PDZ-domain interaction
    Patent number: 8211934
    Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula (I) or (III). The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl), inhibiting Wnt signaling.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: July 3, 2012
    Assignee: The Regents of the University of California
    Inventors: Rodney Kiplin Guy, Naoaki Fujii, Liang You, David M. Jablons
  • Small volume in vitro analyte sensor and methods of making
    Patent number: 8211363
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 3, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • TNF?-neutralizing antibodies
    Patent number: 8211433
    Abstract: The invention provides monoclonal antibodies that neutralize TNF? activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from those rabbit monoclonal antibodies. In certain embodiments, the monoclonal antibodies may be humanized. Methods of using the subject antibodies to inhibit TNF? activity, methods of treatment using those antibodies and kits containing the same are also provided. The invention finds use in a variety of research and medical applications.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: July 3, 2012
    Assignee: Epitomics, Inc.
    Inventors: Fernando Jose Rebelo Do Couto, Kristin Beth Hendricks, Stacey Ellen Wallace
  • Gripper for objects
    Patent number: 8210587
    Abstract: The invention relates to a device for engaging objects, such as heat exchangers of varying sizes. The device includes at least one gripper provided with at least a first and a second gripper arm, at least one of which is movable with respect to the other gripper arm for enclosing an object therebetween; and a driving mechanism connected to at least one of the first and second gripper arms for closing or opening the gripper as needed, wherein at least one of the first and second gripper arms includes a first and a second gripper arm part that are pivotally coupled together, and an adjusting mechanism provided between the first and second gripper arm parts, the adjusting mechanism being arranged for adjusting the angle between the gripper arm parts in dependence on the diameter of the object to be engaged prior to engaging the object.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: July 3, 2012
    Assignee: Peinemann Equipment B.V.
    Inventor: Leendert Cornelis Mizelmoe
  • Sensors
    Patent number: D663223
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: July 10, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Yi Wang
  • Analyte meter
    Patent number: D663420
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: July 10, 2012
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Matthew P. Presta, Ronaldo F. Carreon, Williams J. Evans