Abstract: The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.

Abstract: A method is provided of recycling and cleaning up oil-based waste drilling mud and cuttings contaminated with oil-based waste drilling mud. A facility for performing the method is also provided. The method includes removing the coarse solids from the mud, breaking the emulsion, separating the hydrophobic phase from the water phase and the solid phase, vaporizing all residual oil and water from the solids, and burning off the vaporized oil. The method produces a solid “soil” product that is free from oil contamination, an oil product that is fit for reuse, and clean air emissions. A thermal desorber can be used to efficiently vaporize the oil at low temperature. Optionally the water fraction of the mud can be vaporized, solutes and salts can be captured as evaporite and then be mixed with the soil product. The method has the unique advantage of producing no persistent hazardous waste.

Abstract: A printing and dispensing bonusing system for gaming devices has been developed. The system includes a gaming device with a main processor unit containing that generates event signals according to the gaming logic, a signal transmission device that detects the event signals, and a peripheral device processor that receives the event signals from the signal transmission device. The peripheral device processing unit is isolated from the main processor unit and cannot influence the generation of the event signals.

Abstract: A method of providing an undisplayed outcome of an electronic device has been developed. First a wager is received from a player and an electronic outcome is generated. The outcome is not displayed to the player. A cashless payout is generated for the electronic outcome. The outcome is displayed according to the cashless payout.

Abstract: The present disclosure is directed to methods for treatment and prevention of disease states characterized by a decreased 14-3-3 polypeptide expression or activity. In one embodiment, the present disclosure provides methods for the treatment and/or prevention of Parkinson's disease, neurodegeneration and/or diseases characterized, at least in part, by neurodegeneration, by increasing a 14-3-3 polypeptide activity.

Abstract: A variable ratio power divider (VRPD) used for adjusting a calibration signal for a dual polarization radar system has been developed. The VRPD includes an input line that receives a calibration signal and splits the calibration signal into two separate test signals that have a 0° phase shift between them. The VRPD also includes a horizontal polarization output port for a horizontal calibration signal and a vertical polarization output port for a vertical calibration signal. A waveguide switch receives one of the test signals. If the waveguide switch is operating in a first position, it passes the test signal through a variable 0°-180° phase shifter. This evenly divides the power of the test signals between the horizontal and vertical output ports. If the waveguide switch is operating in a second position, it causes the test signal to bypass the phase shifter so that the entire power of the both test signals is directed entirely to either the horizontal phase output port or the vertical phase output port.

Abstract: The present system and method detects and predicts potential tornadic activity. In one aspect, the invention predicts potential tornadic activity based on radar data. In another aspect, the invention predicts potential tornadic activity based on an integrated and composite product based on model forecast data and radar data by generating a composite tornado potential index using weighted values of the model forecast data and the radar data.

Abstract: The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A?O, C, NH, or S; B?O, C, NH, or S; and R2 is selected from the group consisting of —CO—(CH2)n—CH3; —CO—(CH2)n—CHO; and —CO—(CH2)n—COOH, with n=3-7, with the proviso that in general formula (I), R1 is selected from the group consisting of —CH2—(CH2)n—X; and —CO—(CH2)n—X with n=5-11, wherein X is a fluorophore; and in general formula (II), R1 is selected from the group consisting of —CH?CH—(CH2)n—CH3 with n=9-15; —(CH2)n—CH3 with n=11-17; and —CO—(CH2)n—CH3 with n=10—16; and R3 is selected from the group consisting of —CO—(CH2)n—X; and —SO2—(CH2)n—X, with n=0-5, wherein X is a fluorophore.

Abstract: The present disclosure describes novel standardized citrate replacement fluid solutions and a standardized dialysate solution for use with CRRT methods. The standardized citrate replacement fluid solutions and standardized dialysate solutions do not require modification based on the clinical status of the individual patients. The use of the standardized solutions described herein offers significant advantages over the prior art solutions used in CRRT. The present disclosure describes superior metabolic and electrolyte control and significantly increased dialyzer patency in: (a) 24 intensive care unit (ICU) patients with ARF using a 0.67% trisodium citrate replacement fluid solution, and (b) 32 ICU patients with ARF using a 0.5% trisodium citrate replacement fluid solution. Both groups were treated with Bicarbonate-25 dialysate and achieved effluent rates of 35 mL/kg/hr.

Abstract: A tire that is capable of moving a vehicle in both longitudinal and lateral directions has been developed. The tire is mounted on a circular hub with a center opening and a concave groove around the outer edge. The groove contains an electromagnetic drive mechanism that provides lateral drive to the tire. An axle that provides longitudinal drive to the tire is attached to the center opening. The tire further includes a surface layer that is in contact the groove of the hub, a belt layer comprising a that is connected to the interior of the surface layer and a bladder located in the interior of the belt layer that provides structural support to the tire so that the tire stays within the groove of the hub when the tire is moving laterally. The tire also includes a pair of rigid roller rings made of incrementally spaced roller bearings. Longitudinal movement of the tire is generated by rotating the axle and lateral movement of the tire is generated by the electromagnetic drive mechanism.

Abstract: A supplemental bonusing system for an electronic gaming device has been developed. The system includes a gaming device with a processor that generates an outcome for the gambling device and a bonus system that generates payout that is supplemental to the payout of the gaming device. The supplemental payout is generated is response to gaming events in the gaming device.

Abstract: A method is provided of recycling and decontaminating oil-based waste drilling mud and cuttings contaminated with oil-based waste drilling mud. A facility for performing the method is also provided. The method includes removing the coarse solids from the mud, breaking the emulsion, and separating the hydrophobic phase from the water phase and the solid phase. The solids may then be treated by either or both of two approaches. One approach involves vaporizing all residual oil and water from the solids, and burning off the vaporized oil. Another approach involves at least partially vaporizing the residual oil from the solids and recondensing the oil. The method produces a solid “soil” product that is free from oil contamination (or is sufficiently decontaminated to allow reuse), an oil product that is fit for reuse, and clean air emissions. A thermal desorber or a soil dryer can be used to efficiently vaporize the oil at low temperature.

Abstract: A mechanism for securing screen modules to support frames, said mechanism comprising a plurality of legs for insertion into said support frame, said legs comprising a raised portion that presses against a compatible raised portion of at least one other leg inserted adjacently within the support frame, causing separation of said legs into a restraining relationship with said support frame.

Abstract: A system and methods for targeting mobile content to a mobile device based on the context of where and how a user discovers the content. Instead of advertising content during commercial breaks of a television program, the invention contextually targets the mobile content to specific program content (e.g., music video) as it is being broadcast in the form of a screen pop-up containing text messaging instructions to obtain the mobile content concurrently with, or following the broadcast of the specific program content. Such “contextual targeting” leads to a significantly higher frequency and profitability of conversions and downloads. Similarly, the invention contextually integrates mobile content into a user's online experience using a web-enabled device in which the contextual content can be integrated with a search engine or a contextual link can be placed on web pages that are served to the user.

Abstract: Disclosed is a novel method for diagnosis or differential diagnosis of disease agents and secondary disease agents. The method disclosed uses a novel amplification strategy termed TemPCR to allow sensitive and specific amplification of target sequences from any disease agents and/or secondary disease agent whose nucleic acid sequence is known. The TemPCR method utilizes at least one set of target enrichment primers specific for the disease agent or secondary disease agent to be detected (present at a low concentration) and at least one pair of shared target amplification primers (present at high concentrations). At least one pair of said target enrichment primers comprises a binding sequence for the target amplification primers. Therefore, the use of the TemPCR method allows multiplex amplification reactions to be carried out without the need for empirical optimization of the multiplex amplification parameters.

Abstract: A system for providing environmental condition information to remote users includes a computer system that obtains environmental data from a variety of sources and converts them into data that indicate presence of an environmental condition (including the strength, severity and form of a weather event), a distribution network in communication with the computer system, and one or more remote systems, which further comprise a receiver configured to receive distribution network signals and down convert them, and a remote computer system. The remote computer system is configured to receive the down-converted signals from the receiver and uses the data transmitted in the messages to determine whether the environmental conditions are geo-graphically relevant to the remote system based upon the geographic position of the remote system. The remote systems include a display systems which provide visual or aural alerts relating to weather phenomena, road conditions, road status or traffic.