Abstract: The molecular mechanisms of peroxisome biogenesis have begun to emerge: in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS 1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor, Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.

Abstract: In the case of a musical instrument, in particular a cajón, with a basic element, the side faces of which are configured as striking faces, provision is made for a striking face to be convexly and ergonomically curved.

Abstract: The invention relates to a toy vehicle for collecting and conveying garbage, paper or the like, having a collection container with charging hole, and distinguished by a collecting and emptying arrangement for a garbage can, paper can or the like.

Abstract: A multi-link telescopic cover includes a cover assembly having a plurality of shield plates fitted in sequence to be extended and telescoped along a telescopic orientation and a link assembly having a set of parallel first linkages, a set of parallel second linkages and four short linkages. The first linkages and the second linkages are crosswise and are tilted relative to the telescopic orientation of the cover assembly. A number of the first linkages is identical to that of the second linkage, and a number of the shield plates less the number of the first linkages is two. Each of the first linkages and the second linkages are connected to three of the continuous shield plates respectively and the short linkages are connected to the first and second shield plates from opposite ends of the cover assembly.

Abstract: An apparatus for formation of a course of fibrous materials on a perforated forming wire mesh with an underlying suction box and an overlying fiber distribution box, in which a pair of rotating, perforated drum cylinders are provided for the delivery of a stream of air-fluidised fiber, which is then flung out down on to the wire mesh by the drawing-down of air by the suction box from the upper end of the distribution box, cover plates (18) is arranged at a distance below the upper level of the drum cylinders, which plates substantially shield-off the free flow of air down through the vertical spaces between the drums themselves and between the drums and the adjacent side walls of the distribution box.

Abstract: An electric socket includes an insulating main member, two check securing devices, and a release device. The insulating main member has apertures thereon and electrodes behind the apertures. The check securing device is provided in the insulating main member having a suspended flexible section sloping toward a bottom end of the aperture. When a plug has prongs inserted into the apertures, the prongs will bend the flexible section of the check securing device inwards. An interference condition will be occurred between the prong and the flexible section when the plug is pulled out. The release device is provided on the insulating main member for manipulation. The release device has a arm pressing the flexible section of the check securing device bending inwards when it is pressed for releasing the interference condition between the prong and the flexible section.

Abstract: The invention relates to a cell culture insert (1) comprising a beaker-shaped insert wall (11), a base (9) consisting of a membrane filter, projecting support arms (3, 4) that are distributed around the periphery of the top and lateral spacers (7, 8) for a vertical and horizontal orientation in a well (2) containing a liquid culture medium (N) in a cell culture plate. According to the invention, the spacers (7, 8) are distributed around the periphery of the cell culture insert (1) and have different radial lengths in such a way that a large feed opening (5) and several smaller openings (5A) are formed.

Abstract: A phyto-composition is described for the treatment of joint diseases that comprises: a) from 0.01% to 26% in weight of an extract of Curcuma longa (turmeric); b) from 30% to 80% in weight of an extract of Harpagophytum procumbens, (devil's claws); c) from 0.01% to 25% in weight of an extract of Filipendula ulmaria (meadowsweet); and d) from 7% to 35% in weight of oil of Oenothera biennis (onagra). Said phyto-composition being used in combination with a pharmaceutically acceptable vehicle in order to obtain a pharmaceutical composition useful in the treatment of joint diseases, particularly, rheumatoid arthritis and osteoarthritis.

Abstract: A module and kit for coupling at least one telephone service signal to at least one telephone device over a wiring. The network includes: a wiring having at least two conductors for carrying multiple time-domain multiplexed digitized voice channels; an exchange side device coupled to the wiring and operative to couple at least one telephone service signal to at least one digitized voice channel; and at least one subscriber side device coupled to the wiring and operative to couple the at least one telephone device to at least one digitized voice channel.

Abstract: The present invention aims to provide a novel process for producing isomaltose and isomaltitol, and uses thereof, and it solves the object by establishing a process for producing isomaltose comprising a step of contacting a saccharide, having the ?-1,4 glucosidic linkage as the linkage of non-reducing end and a glucose polymerization degree of at least two, with an ?-isomaltosyl-transferring enzyme and an ?-isomaltosylglucosaccharide-forming enzyme derived from a specific microorganism; a process for producing isomaltitol using the isomaltose produced by the above process; saccharide compositions comprising the isomaltose and/or the isomaltitol produced by the above processes; and uses thereof.

Abstract: The invention relates to an electromechanical lock cylinder, comprising a first cylinder half (2), arranged on the outside of the door, with a key passage (8) for a security key (44) and a second cylinder half (3), arranged on the inside of the door, with a rotating knob rotor (4). Tumblers in the first cylinder half (2) are arranged for rotational release by a security key (44). An electronic device (17) is arranged in the rotating knob (24) for control of a locking device (43). The rotating knob (24) forms a unit with the electronic device (17) arranged therein, detachably mounted on an extension (4a) of the rotating knob rotor (4), projecting past the housing (6). The rotating knob rotor (24) may be adjusted for length by means of an exchangeable adapter (18a to 18c).

Abstract: Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune response to a vaccine by serving as an adjuvant.

Abstract: A carrier strip (1) for nails (3) or other securing elements to feed an automatic nailing machine, which is characterized by a series of cartridges (2), whereby each cartridge (2) holds a nail (3). The cartridges (2) have a cylindrical central body (4) finished off at the ends by a wider base (6) and crown (7), with a special feature in which the transition between the central body (4) and the base (6) and crown (7) is carried out by conic geometry. Furthermore, the vertical reinforcement of the cartridge (2) is provided by two lateral pillars (5), parallel to the longitudinal axis (18) of the central body (4), which links the base (6) and the crown (7) without coming into contact with the central body (4).

Abstract: The present invention concerns the use of an active ingredient selected from the group consisting of agonists of the adenosine receptor system, for inhibiting viral replication in cells. In particular, the invention provides a composition and method for inhibiting viral replication in cells, the method comprising presenting to the cells an effective amount of the active ingredient. According to one embodiment, the adenosine agonist is an A3 receptor agonist (A3RAg). The invention is particularly useful, for although not limited to, inhibiting the replication of HIV virus in human cells.

Abstract: The roll-up floor heating comprises an insulating layer, a heating element and a cladding. The insulating layer is intended for laying on a floor and the heating element extends between the cladding and the insulating layer. The cladding is intended to support a floor covering and comprises a force distribution layer for transmitting a force which is exerted on the cladding in a distributed manner to the insulating layer. In as far as (a part of) the heating element is at the location or in the vicinity of the exerted force, the load which will be exerted on it will be lower than the original load, due to the force being transmitted in a distributed manner. This lowers the risk of the heating element being damaged.

Abstract: The invention relates to a continuous strip of detachable consecutive interconnected products manufactured by folding, such as envelopes and the like, and to a process for manufacturing the said strip, two of those consecutive products being interconnected through a joint (22) which is not part of the products themselves and links up detachably, through successive lines of demarcation, with each of those two consecutive products in such a way that, on removing this joint (22), the said two consecutive products are entirely separated.