Abstract: Novel substituted indoloquinoxalines of formula wherein R1 is hydrogen or represents one or more similar or different substituents in the positions 7 to 10 selected from the group halogen, lower alkyl/alkoxy, hydroxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, R2 represents similar or different C1-C4 alkyl substituents, X is CO or CH2, Y is OH, NH2, NH—(CH2)n—R3 wherein R3 represents lower alkyl, OH, NH2, NHR4 or NR5R6 wherein R4, R5 and R6 independently are lower alkyl or cyclo-alkyl and n is an integer of from 2 to 4, with the provision that when X is CH2, Y is OH or NH—(CH2)n—OH, and pharmacologically acceptable salts thereof are described. The compounds are useful as drugs for preventing and/or treating autoimmune diseases.

Abstract: The present invention concerns the use of an active ingredient selected from the group consisting of agonists of the adenosine receptor system, for inhibiting viral replication in cells. In particular, the invention provides a composition and method for inhibiting viral replication in cells, the method comprising presenting to the cells an effective amount of the active ingredient. According to one embodiment, the adenosine agonist is an A3 receptor agonist (A3RAg). The invention is particularly useful, for although not limited to, inhibiting the replication of HIV virus in human cells.

Abstract: A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

Abstract: The roll-up floor heating comprises an insulating layer, a heating element and a cladding. The insulating layer is intended for laying on a floor and the heating element extends between the cladding and the insulating layer. The cladding is intended to support a floor covering and comprises a force distribution layer for transmitting a force which is exerted on the cladding in a distributed manner to the insulating layer. In as far as (a part of) the heating element is at the location or in the vicinity of the exerted force, the load which will be exerted on it will be lower than the original load, due to the force being transmitted in a distributed manner. This lowers the risk of the heating element being damaged.

Abstract: Highly sensitive fluorescent zinc or cadmium sensors are derived from 8-hydroxyquinaldine, a well-established fluorescent zinc probe, as a building block. High binding efficiency was achieved by incorporating two 8-hydroxyquninaldine moieties into a single ligand. Incorporation of sulfonamide groups further improved binding efficiency. The compounds make it possible to monitor zinc ion or cadmium ion concentration in the picomolar or femtomolar range.

Abstract: Network providing improved coverage based on a frequency shifting scheme. A wireless signal in a frequency band is shifted to another distinct band, and carried in the shifted band, using wired or wireless mediums, to another location, wherein the wireless signal is shifted back to the original frequency band. In one embodiment, the wireless signal is frequency shifted by converting it to other representing signals and forming the frequency-shifted signal from the representations. The medium may use dedicated wiring or existing service wiring in a residence or building, including LAN, telephone, AC power and CATV wiring. The system (in whole or in part) may be enclosed as a stand-alone unit, housed in integrated form as part of a service outlet or as a snap-on/plug-in module.

Abstract: An armrest with cup holder of the type where the cup holder is integral with a foam padding in a trim cover assembly through a foaming process, wherein the cup holder is inserted in a hole formed in the trim cover assembly. A uniform stretcher protrusion is defined in a given local peripheral region of the cup holder about which the afore-said hole is engaged, so that a substantially circular edge of that hole is uniformly stretched by and along the uniform stretcher protrusion, thereby causing a close contact of such substantially circular edge of the hole on and about the uniform stretcher protrusion, so as to insure preventing leakage of a liquid foaming agent from between that particular hole and the cup holder during the foaming process.

Abstract: The present invention relates to methods, a system, computer readable mediums and computer program products for recovering an application state of an electronic trading system including a first server and a second server after a fail of both of the servers, wherein the first server functions as a primary server for receiving incoming messages of the system and the second server as a secondary server during operation of the system, wherein each incoming message is processed in both servers. The method comprises the steps of: initiating a recovery procedure after a fail of both servers by restarting the first server and the second server; identifying the last message of respective server; and selecting a server as the primary server on basis of the latest messages.

Abstract: A lens assembly includes, in order from an object side toward an image side along an optical axis thereof, a first lens having positive refractive power, and a second lens. The lens assembly satisfies the following conditions: 0<|f1/f|<2 and 0<|f2/f|<7, wherein f is an effective focal length of the lens assembly, f1 is an effective focal length of the first lens, and f2 is an effective focal length of the second lens. The first lens has at least one spherical surface, thus effectively decreasing the production cost of the lens assembly.

Abstract: The structure of conformational, discontinuous binding surfaces that associate with a binding molecule, preferably the epitopes of monoclonal antibodies (mAbs) may be discovered. The binding molecule is used to select specific peptides from a peptide library that, in turn, are used as a binding surface (epitope) defining database that is applied via a novel computer algorithm to analyze the crystalline-structure of the original binding surface (antigen). An antigenic epitope-mimetic that is recognized by its original mAb may be reconstituted based on the segments of the epitope identified in the prediction. The basic elements of the binding domain on gp120 that is recognized by broadly neutralizing antibody b12 are disclosed, as in their use in making vaccines for preventing or treating HIV.

Abstract: Use of diaminopropanes, or of a composition thereof as a dispersing agent to prevent the formation or remove already formed deposits of ammonium salt in hydrocarbon process plants, such as petrochemical or refinery plants.

Abstract: Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and/or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS), to which group a PEG moiety is attached. In these pegylated drugs, the PEG moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of the scaffold Fmoc or FMS structure that is highly sensitive to bases and is removable under physiological conditions. The drugs are preferably drugs containing an amino group, most preferably peptides and proteins of low or medium molecular weight. Similar molecules are provided wherein a protein carrier or another polymer carrier replaces the PEG moiety.

Abstract: A folding treadmill includes a base frame provided with a stop member, a treadbase pivotally connected to the base frame and selectively set between a horizontal operative position and a vertical non-operative position, and a positioning structure. The positioning structure includes a stop member forced out of the treadbase by a spring member for stopping against the stop member of the base frame so as to hold the treadbase in the non-operative position, a control block operable to move a pull slider to pull the stop member of the positioning structure away from the stop member of the base frame through a link for enabling the treadbase to be turned from the non-operative position to the operative position.

Abstract: The invention relates to a curtain device mounted on a shaft (2) about which said curtain (1) can be wound to an open position and unwound into a closed position, a drive wheel (7) fixed coaxially to said shaft (2) and cooperating with said curtain (1) such as to displace the latter between said two positions. The device comprises an oblong flexible control body (11), cooperating with the drive wheel (7), said body (11) being embodied to permit the displacement of the curtain (1) between the open position and the closed position thereof, independently of the slack formed in the curtain (1) and to be able to be displaced along at least one of the lateral edges (4) of the curtain (1) and act upon the region (8) of the latter as opposed to that arranged on the shaft (2).

Abstract: The invention relates to a cosmetic preparation containing a metallic effect pigment which consists of a metal substrate having a layer enclosing the substrate. Said layer is produced in a sol/gel method, has a barrier effect against sweat and saliva and prevents a direct contact between skin and metallic substrate, the metallic pigment being hydrophilic. The inventive preparation can be in the form of a cream, a lotion, an eye shadow, a nail varnish, a lipstick, a mascara, a gel, a make-up formulation or a self-tanning cream or lotion.

Abstract: A cosmetic product replacement unit for a base stick module of a cosmetic stick has a replacement housing in which the cosmetic product is present in the form of a refill. A cap or sealing an extension opening for the refill is attached onto the replacement housing. The refill is in push connection with a piston guided in the replacement housing. A piston connecting component, connected to the piston, may be used with a complementary push rod connecting component of a piston push rod as part of a feed device of the base stick module to withdraw the refill. It is possible to bring the piston push rod into push connection with the piston and to position it on the side of the piston remote from the refill. In addition to the cosmetic product replacement unit, a set also has a plurality of base stick modules which have feed devices for the cosmetic product which differ from one another in their mechanical operating principles.

Abstract: Granulated bean paste or “miso” is made by partially drying uncooked bean paste by vacuum freeze drying, thoroughly mixing and then storing the semi-dried bean paste in an isothermal chamber at a substantially consistent temperature within the range of 15° C. to 20° C. for a few days to homogenize the water content in the semi-dried bean paste, then extruding the semi-dried bean paste into an elongated form, and finally cutting and breaking the bean past material to obtain fine particles of granulated bean paste.

Abstract: A method for the quick palletization of objects (100), comprising the steps of: arranging objects (100) to be palletized organized on a collection plane (400); loading said objects (100) onto a flexible support plane (31) suitable for advancing in the direction of transfer of the objects (100) in a position substantially coplanar to the collection plane (400) and in continuation of it, so that the support plane (31) receives said objects without sliding; transferring said objects (100) from the support plane (31) to a flexible moving plane (21) that can slide coplanar to the support plane (31) so as to replace the latter (31) below the objects (100) whilst they remain stationary, in which the transfer takes place by synchronously activating the harmonious sliding of the support plane (31) and transfer plane (21) arranged in contact with each other in continuation of one another; taking the transfer plane (21) with the objects (100) on top above a pallet; making the transfer plane (21) slide under the objec