Patents Represented by Attorney Bruce M. Collins
  • Patent number: 5756426
    Abstract: Described herein are compounds of the formula I ##STR1## and the isomers thereof, in which either a) X is an N atom andY is OR.sub.11 or N(R.sub.12)R.sub.13, orb) X is CH andY is OR.sub.11,and in which furthermore:R.sub.11 is C.sub.1 -C.sub.4 alkyl;R.sub.12 and R.sub.13, independently, are hydrogen or C.sub.1 -C.sub.4 alkyl;A is an O atom or the group NR.sub.4 ; and whereinR.sub.1, R.sub.2 and R.sub.3 are as defined herein, are pesticidal active ingredients. They can be used for pest control, in particular as microbicides, insecticides and acaricides in agriculture, horticulture and in the hygiene sector.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: May 26, 1998
    Assignee: Novartis Corporation
    Inventors: Hugo Ziegler, Stephan Trah, Saleem Farooq, Rene Zurfluh
  • Patent number: 5451521
    Abstract: This invention relates to recombinant Factor VIII:c variants, methods to produce the variants and pharmaceutical compositions containing same. The variants of this invention are characterized by modification of one or more specific proteolytic cleavage sites encompassing the arginine residues at positions 226, 336, 562, 740, 776, 1313, 1648, or 1721. The variants possess similar procoagulant activity to that of human Factor VIII:c.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: September 19, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: Randal J. Kaufman, Debra D. Pittman, John J. Toole, Jr.
  • Patent number: 5416102
    Abstract: A method of treating fleas on dogs and cats by orally administering a larvicidally or ovicidally effective amount of flea growth inhibiting benzoylurea.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: May 16, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Sharron H. Barnett, Roland H. Johnson, Douglas I. Hepler, Manfred Boger
  • Patent number: 5194365
    Abstract: Images are formed by the following process:(i) a substrate is treated with a layer of a liquid composition comprising(A) a residue that is polymerizable by means of free radicals, such as an acrylic ester,(B) a radiation-activated polymerization initiator for (A), such as a metallocene or a mixture of a Group IVA organometallic compound with a photoreducible dye.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: March 16, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Jonathan W. Goodin, Edward Irving, Christopher P. Banks
  • Patent number: 5112849
    Abstract: 3-Cyano-4-(2,3-dichlorophenyl)pyrrole is suitable for controlling phytopathogenic microorganisms and is markedly superior in activity to preparation of a similar structure. Said compound may be employed for seed dressing, either along or in the form of compositions.
    Type: Grant
    Filed: May 18, 1990
    Date of Patent: May 12, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Theodor Staub, Heide Dahmen, Robert Nyfeler, Robert J. Williams
  • Patent number: 4978383
    Abstract: N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal bases and alkaline earth metal bases or with quaternary ammonium bases, have good selective herbicidal and plant growth regulating properties when applied pre- and postemergence.In the formulaR.sub.1 is hydrogen, halogen, nitro, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.5 alkenyl or C.sub.1 -C.sub.4 alkoxycarbonyl,R.sub.2 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, each unsubstituted or substituted by 1 to 3 halogen atoms,R.sub.3 is halogen, hydrogen, --NR.sub.4 R.sub.5, C.sub.1 -C.sub.3 alkyl, unsubstituted or substituted by 1 to 3 halogen atoms or C.sub.1 -C.sub.4 alkoxy, or is C.sub.1 -C.sub.3 alkoxy, unsubstituted or substituted by methoxy, ethoxy, or 1 to 3 halogen atoms,R.sub.4 is hydrogen or methyl,R.sub.5 is hydrogen, C.sub.1 -C.sub.2 alkyl or methoxy,A is C.sub.1 -C.sub.4 alkylene or C.sub.2 -C.sub.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: December 18, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Erfinders K. Gass, Werner Fory, Willy Meyer, Werner Topfl
  • Patent number: 4973589
    Abstract: The present invention relates to a method of treating dogs and cats having topically disposed fleas. More particularly, the invention relates to such a method of treatment wherein the dog or cat is dosed with a larvicidally or ovicidally effective amount of flea growth inhibiting substance capable of reaching the flea via the hosts blood.
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: November 27, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Sharron H. Barnett, Roland H. Johnson, Douglas I. Hepler
  • Patent number: 4972011
    Abstract: Compositions comprising a halogen-free polymer and, as flame retardant, at least one aluminum salt of a phosphonic acid of the formula: ##STR1## in which R is a straight or branched chain alkyl group having 1 to 3 carbon atoms optionally substituted by one or more of halogen atoms or hydroxyl groups and R' is hydrogen or an alkyl group having 1 to 3 carbon atoms.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: November 20, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Joyce Richardson, Richard J. Dellar
  • Patent number: 4944794
    Abstract: N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal or alkaline-earth metal bases or with quaternary ammonium bases have good selective, pre- and post-emergence, herbicidal and growth-regulating properties.The symbols in this formula have the following meanings;A is a C.sub.1 -C.sub.6 -haloalkyl group,X is oxygen, sulfur, or a sulfinyl or sulfonyl bridge,Z is oxygen or sulfur,m is the number one or two,R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl, or a --Y--R.sub.6 group,R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl or C.sub.1 -C.sub.4 -haloalkyl, or a group --Y--R.sub.6, --COOR.sub.7, --NO.sub.2 or --CO--NR.sub.8 --R.sub.9,R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, halogen or alkoxyalkyl having at most 4 carbon atoms,R.sub.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: July 31, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Willy Meyer, Werner Fory, Karl Gass
  • Patent number: 4944793
    Abstract: N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal or alkaline-earth metal bases or with quaternary ammonium bases have good selective, pre- and post-emergence, herbicidal and growth-regulating properties.The symbols in this formula have the following meanings:A is a C.sub.3 -C.sub.6 -alkynyl group,X is oxygen, sulfur, or a sulfinyl or sulfonyl bridge,Z is oxygen or sulfur,m is the number one or two,R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl, or a --Y--R.sub.6 group,R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl or C.sub.1 -C.sub.4 -haloalkyl, or a group --Y--R.sub.6, --COOR.sub.7, --NO.sub.2 or --CO--NR.sub.8 --R.sub.9,R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, halogen or alkoxyalkyl having at most 4 carbon atoms,R.sub.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: July 31, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Willy Meyer, Werner Fory, Karl Gass
  • Patent number: 4944792
    Abstract: N-phenylsulfonyl-N'-pyrimidinyl- and -triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal or alkaline-earth metal bases or with quaternary ammonium bases have good selective, pre- and post-emergence, herbicidal and growth-regulating properties.The symbols in this formula have the following meanings:A is a C.sub.3 -C.sub.6 -alkynyl group, a C.sub.1 -C.sub.6 -alkyl group which is substituted by halogen, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkylsulfinyl, C.sub.1 -C.sub.4 -alkylsulfonyl, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -haloalkylthio, C.sub.1 -C.sub.4 -haloalkylsulfinyl or C.sub.1 -C.sub.4 -haloalkylsulfonyl, or it is a C.sub.2 -C.sub.6 -alkenyl group substituted by one of the above substituents,E is the methine group or nitrogen,X is oxygen, sulfur, or a sulfinyl or sulfonyl bridge,Z is oxygen or sulfur,m is the number one or two,R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.
    Type: Grant
    Filed: January 16, 1986
    Date of Patent: July 31, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Willy Meyer, Werner Fory, Karl Gass
  • Patent number: 4944790
    Abstract: 1,5-diphenylpyrazole-3-carboxylic acid derivatives of the formula ##STR1## in which each of R.sub.a and R.sub.b, independently of the other represents halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.2 -C.sub.5 -alkenyl, C.sub.2 -C.sub.5 -alkynyl or cyano, n represents zero or an integer from 1 to 3, and OR.sub.1 represents hydroxy, a plant-physiologically tolerable salt radical or any desired ester radical, are capable of antagonizing specifically the phytotoxic action of phenoxypropionic acid ester herbicides of the formula II ##STR2## in which G represents ##STR3## in which Hal.sub.1 represents fluorine, chlorine, bromine, iodine or trifluoromethyl, Hal.sub.2 represents hydrogen, fluorine, chlorine, bromine or trifluoromethyl, Z represents nitrogen or methine (--CH.dbd.), X represents an oxygen or sulphur atom, R.sub.1 ' represents halogen, trifluoromethyl, nitro, cyano, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: July 31, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Moser, Beat Bohner, Werner Fory
  • Patent number: 4940481
    Abstract: The invention relates to azolylpropane derivatives of the general formula I ##STR1## wherein R.sub.1 is an azolyl group,R.sub.2 and R.sub.3, each independently of the other, is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cyanoalkyl or alkoxycarbonylalkyl, and one of R.sub.2 and R.sub.3 always has a meaning other than hydrogen,R.sub.4 is C.sub.3 -C.sub.8 cycloalkyl, unsubstituted or substituted by alkyl; unsubstituted or substituted phenyl; or is C.sub.1 -C.sub.10 alkyl, unsubstituted or substituted by phenyl or substituted phenyl,R.sub.5 is an unsubstituted or a mono- or polysubstituted radical selected from the group consisting of C.sub.1 -C.sub.8 alky, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, phenyl, naphthyl, biphenyl, benzylphenyl, benzyloxyphenyl, phenoxyphenyl and aralkyl,R.sub.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: July 10, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Urs Muller, Hans Tobler, Hermann Rempfler, Alfred Meyer
  • Patent number: 4935051
    Abstract: There is described the novel 2-[4-(5-Chloro-3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid methyl ester and its (R)-enantiomer. ##STR1## These compounds are suitable for selectively controlling weeds in crops of cultivated plants, and for reducing the growth of grasses.
    Type: Grant
    Filed: May 2, 1986
    Date of Patent: June 19, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Schurter, Hermann Rempfler
  • Patent number: 4919709
    Abstract: The optically active isomer of S(-)-N-(1'methyl-2'-methoxyethyl)-N-chloroacetyl-2,6-dimethylaniline has improved action against problem weeds over the racemic mixture of isomers.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: April 24, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Moser, Christian Vogel
  • Patent number: 4897486
    Abstract: Substituted N-3-(5-trifluoromethyl-pyridyl-2-oxy)phenyl-N'-benzoylureas of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently of one another are each hydrogen, methyl, fluorine, chlorine or bromine, andR.sub.4 is hydrogen or chlorine, with the proviso that R.sub.3 is methyl, fluorine, chlorine or bromine when R.sub.4 is chlorine,are active substances having an insecticidal and, in particular, acaricidal action. They can be advantageously used to combat zooparasitic and phytoparasitic ectoparasites.
    Type: Grant
    Filed: June 23, 1988
    Date of Patent: January 30, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Manfred Boger
  • Patent number: 4886825
    Abstract: The invention relates to plant protection compositions based on a two-component system of plant fungicides, one of which is 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole and the other is Mancozeb, which is an [ethylenebis(dithiocarbamato)]manganese complex with [ethylene-bis(dithiocarbamato)]zinc of the formula II ##STR1## In the range from 1:3 to 1:100 the disclosed mixtures display enhanced fungicidal activities.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: December 12, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Wilhelm Ruess, Pierre Urech, Jurg Eberle, Theodor Staub
  • Patent number: 4886824
    Abstract: The invention relates to plant protection compositions based on a two-component system of plant fungicides, one of which is 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole and the other is an N-haloalkanesulfenylphthalimide derivative.In the range from 1:3 to 1:100 the disclosed mixtures display enhanced fungicidal activities.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: December 12, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Wilhelm Ruess, Pierre Urech, Jurg Eberle, Theodor Staub
  • Patent number: 4865650
    Abstract: Composition of matter containing:(a) a compound of the formula I ##STR1## in which A is one of the groups of the formulae ##STR2## in which B is --O--, --S--, --SO.sub.2 --, --N.dbd.N--, --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 --O-- ##STR3## --CONH--, --NHCONH-- or --CONHNHCO--, Q is --O' or --NH' and Z is --O-- or --S-- and R and R' are independently of each other hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or phenoxy, and (b) a compound of the formula II ##STR4## in which X.sup..sym. is H.sup..sym. or a group of the formulae ##EQU1## or N.sup..sym. (R.sub.1) (R.sub.2) (R.sub.3) (R.sub.4), M.sup.n.sym. is an n-valent metal cation, n is 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently of one another hydrogen, C.sub.1 -C.sub.18 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl, unsubstituted or C.sub.1 -C.sub.18 -alkyl-substituted phenyl or R.sub.3 and R.sub.4 together with the N atom form a pyrrolidine, imidazolidine, piperidine, piperazine or morpholine radical, or R.sub.
    Type: Grant
    Filed: December 16, 1987
    Date of Patent: September 12, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Jost von der Crone, Bernhard Medinger, Philippe Bugnon
  • Patent number: 4845216
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents. The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-)4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: July 4, 1989
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher