Patents Represented by Attorney Bruce M. Collins
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Patent number: 5756426Abstract: Described herein are compounds of the formula I ##STR1## and the isomers thereof, in which either a) X is an N atom andY is OR.sub.11 or N(R.sub.12)R.sub.13, orb) X is CH andY is OR.sub.11,and in which furthermore:R.sub.11 is C.sub.1 -C.sub.4 alkyl;R.sub.12 and R.sub.13, independently, are hydrogen or C.sub.1 -C.sub.4 alkyl;A is an O atom or the group NR.sub.4 ; and whereinR.sub.1, R.sub.2 and R.sub.3 are as defined herein, are pesticidal active ingredients. They can be used for pest control, in particular as microbicides, insecticides and acaricides in agriculture, horticulture and in the hygiene sector.Type: GrantFiled: September 11, 1995Date of Patent: May 26, 1998Assignee: Novartis CorporationInventors: Hugo Ziegler, Stephan Trah, Saleem Farooq, Rene Zurfluh
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Patent number: 5451521Abstract: This invention relates to recombinant Factor VIII:c variants, methods to produce the variants and pharmaceutical compositions containing same. The variants of this invention are characterized by modification of one or more specific proteolytic cleavage sites encompassing the arginine residues at positions 226, 336, 562, 740, 776, 1313, 1648, or 1721. The variants possess similar procoagulant activity to that of human Factor VIII:c.Type: GrantFiled: December 9, 1986Date of Patent: September 19, 1995Assignee: Genetics Institute, Inc.Inventors: Randal J. Kaufman, Debra D. Pittman, John J. Toole, Jr.
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Patent number: 5416102Abstract: A method of treating fleas on dogs and cats by orally administering a larvicidally or ovicidally effective amount of flea growth inhibiting benzoylurea.Type: GrantFiled: June 27, 1994Date of Patent: May 16, 1995Assignee: Ciba-Geigy CorporationInventors: Sharron H. Barnett, Roland H. Johnson, Douglas I. Hepler, Manfred Boger
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Patent number: 5194365Abstract: Images are formed by the following process:(i) a substrate is treated with a layer of a liquid composition comprising(A) a residue that is polymerizable by means of free radicals, such as an acrylic ester,(B) a radiation-activated polymerization initiator for (A), such as a metallocene or a mixture of a Group IVA organometallic compound with a photoreducible dye.Type: GrantFiled: June 14, 1989Date of Patent: March 16, 1993Assignee: Ciba-Geigy CorporationInventors: Jonathan W. Goodin, Edward Irving, Christopher P. Banks
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Patent number: 5112849Abstract: 3-Cyano-4-(2,3-dichlorophenyl)pyrrole is suitable for controlling phytopathogenic microorganisms and is markedly superior in activity to preparation of a similar structure. Said compound may be employed for seed dressing, either along or in the form of compositions.Type: GrantFiled: May 18, 1990Date of Patent: May 12, 1992Assignee: Ciba-Geigy CorporationInventors: Theodor Staub, Heide Dahmen, Robert Nyfeler, Robert J. Williams
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Patent number: 4978383Abstract: N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal bases and alkaline earth metal bases or with quaternary ammonium bases, have good selective herbicidal and plant growth regulating properties when applied pre- and postemergence.In the formulaR.sub.1 is hydrogen, halogen, nitro, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.5 alkenyl or C.sub.1 -C.sub.4 alkoxycarbonyl,R.sub.2 is C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, each unsubstituted or substituted by 1 to 3 halogen atoms,R.sub.3 is halogen, hydrogen, --NR.sub.4 R.sub.5, C.sub.1 -C.sub.3 alkyl, unsubstituted or substituted by 1 to 3 halogen atoms or C.sub.1 -C.sub.4 alkoxy, or is C.sub.1 -C.sub.3 alkoxy, unsubstituted or substituted by methoxy, ethoxy, or 1 to 3 halogen atoms,R.sub.4 is hydrogen or methyl,R.sub.5 is hydrogen, C.sub.1 -C.sub.2 alkyl or methoxy,A is C.sub.1 -C.sub.4 alkylene or C.sub.2 -C.sub.Type: GrantFiled: September 19, 1985Date of Patent: December 18, 1990Assignee: Ciba-Geigy CorporationInventors: Erfinders K. Gass, Werner Fory, Willy Meyer, Werner Topfl
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Patent number: 4973589Abstract: The present invention relates to a method of treating dogs and cats having topically disposed fleas. More particularly, the invention relates to such a method of treatment wherein the dog or cat is dosed with a larvicidally or ovicidally effective amount of flea growth inhibiting substance capable of reaching the flea via the hosts blood.Type: GrantFiled: February 13, 1989Date of Patent: November 27, 1990Assignee: Ciba-Geigy CorporationInventors: Sharron H. Barnett, Roland H. Johnson, Douglas I. Hepler
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Patent number: 4972011Abstract: Compositions comprising a halogen-free polymer and, as flame retardant, at least one aluminum salt of a phosphonic acid of the formula: ##STR1## in which R is a straight or branched chain alkyl group having 1 to 3 carbon atoms optionally substituted by one or more of halogen atoms or hydroxyl groups and R' is hydrogen or an alkyl group having 1 to 3 carbon atoms.Type: GrantFiled: September 8, 1989Date of Patent: November 20, 1990Assignee: Ciba-Geigy CorporationInventors: Joyce Richardson, Richard J. Dellar
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Patent number: 4944790Abstract: 1,5-diphenylpyrazole-3-carboxylic acid derivatives of the formula ##STR1## in which each of R.sub.a and R.sub.b, independently of the other represents halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.2 -C.sub.5 -alkenyl, C.sub.2 -C.sub.5 -alkynyl or cyano, n represents zero or an integer from 1 to 3, and OR.sub.1 represents hydroxy, a plant-physiologically tolerable salt radical or any desired ester radical, are capable of antagonizing specifically the phytotoxic action of phenoxypropionic acid ester herbicides of the formula II ##STR2## in which G represents ##STR3## in which Hal.sub.1 represents fluorine, chlorine, bromine, iodine or trifluoromethyl, Hal.sub.2 represents hydrogen, fluorine, chlorine, bromine or trifluoromethyl, Z represents nitrogen or methine (--CH.dbd.), X represents an oxygen or sulphur atom, R.sub.1 ' represents halogen, trifluoromethyl, nitro, cyano, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.Type: GrantFiled: March 20, 1989Date of Patent: July 31, 1990Assignee: Ciba-Geigy CorporationInventors: Hans Moser, Beat Bohner, Werner Fory
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Patent number: 4944793Abstract: N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal or alkaline-earth metal bases or with quaternary ammonium bases have good selective, pre- and post-emergence, herbicidal and growth-regulating properties.The symbols in this formula have the following meanings:A is a C.sub.3 -C.sub.6 -alkynyl group,X is oxygen, sulfur, or a sulfinyl or sulfonyl bridge,Z is oxygen or sulfur,m is the number one or two,R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl, or a --Y--R.sub.6 group,R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl or C.sub.1 -C.sub.4 -haloalkyl, or a group --Y--R.sub.6, --COOR.sub.7, --NO.sub.2 or --CO--NR.sub.8 --R.sub.9,R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, halogen or alkoxyalkyl having at most 4 carbon atoms,R.sub.Type: GrantFiled: September 19, 1985Date of Patent: July 31, 1990Assignee: Ciba-Geigy CorporationInventors: Willy Meyer, Werner Fory, Karl Gass
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Patent number: 4944792Abstract: N-phenylsulfonyl-N'-pyrimidinyl- and -triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal or alkaline-earth metal bases or with quaternary ammonium bases have good selective, pre- and post-emergence, herbicidal and growth-regulating properties.The symbols in this formula have the following meanings:A is a C.sub.3 -C.sub.6 -alkynyl group, a C.sub.1 -C.sub.6 -alkyl group which is substituted by halogen, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkylsulfinyl, C.sub.1 -C.sub.4 -alkylsulfonyl, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -haloalkylthio, C.sub.1 -C.sub.4 -haloalkylsulfinyl or C.sub.1 -C.sub.4 -haloalkylsulfonyl, or it is a C.sub.2 -C.sub.6 -alkenyl group substituted by one of the above substituents,E is the methine group or nitrogen,X is oxygen, sulfur, or a sulfinyl or sulfonyl bridge,Z is oxygen or sulfur,m is the number one or two,R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.Type: GrantFiled: January 16, 1986Date of Patent: July 31, 1990Assignee: Ciba-Geigy CorporationInventors: Willy Meyer, Werner Fory, Karl Gass
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Patent number: 4944794Abstract: N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts of these compounds with amines, alkali metal or alkaline-earth metal bases or with quaternary ammonium bases have good selective, pre- and post-emergence, herbicidal and growth-regulating properties.The symbols in this formula have the following meanings;A is a C.sub.1 -C.sub.6 -haloalkyl group,X is oxygen, sulfur, or a sulfinyl or sulfonyl bridge,Z is oxygen or sulfur,m is the number one or two,R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl, or a --Y--R.sub.6 group,R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl or C.sub.1 -C.sub.4 -haloalkyl, or a group --Y--R.sub.6, --COOR.sub.7, --NO.sub.2 or --CO--NR.sub.8 --R.sub.9,R.sub.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, halogen or alkoxyalkyl having at most 4 carbon atoms,R.sub.Type: GrantFiled: September 19, 1985Date of Patent: July 31, 1990Assignee: Ciba-Geigy CorporationInventors: Willy Meyer, Werner Fory, Karl Gass
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Patent number: 4940481Abstract: The invention relates to azolylpropane derivatives of the general formula I ##STR1## wherein R.sub.1 is an azolyl group,R.sub.2 and R.sub.3, each independently of the other, is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cyanoalkyl or alkoxycarbonylalkyl, and one of R.sub.2 and R.sub.3 always has a meaning other than hydrogen,R.sub.4 is C.sub.3 -C.sub.8 cycloalkyl, unsubstituted or substituted by alkyl; unsubstituted or substituted phenyl; or is C.sub.1 -C.sub.10 alkyl, unsubstituted or substituted by phenyl or substituted phenyl,R.sub.5 is an unsubstituted or a mono- or polysubstituted radical selected from the group consisting of C.sub.1 -C.sub.8 alky, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, phenyl, naphthyl, biphenyl, benzylphenyl, benzyloxyphenyl, phenoxyphenyl and aralkyl,R.sub.Type: GrantFiled: February 22, 1983Date of Patent: July 10, 1990Assignee: Ciba-Geigy CorporationInventors: Urs Muller, Hans Tobler, Hermann Rempfler, Alfred Meyer
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Patent number: 4935051Abstract: There is described the novel 2-[4-(5-Chloro-3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid methyl ester and its (R)-enantiomer. ##STR1## These compounds are suitable for selectively controlling weeds in crops of cultivated plants, and for reducing the growth of grasses.Type: GrantFiled: May 2, 1986Date of Patent: June 19, 1990Assignee: Ciba-Geigy CorporationInventors: Rolf Schurter, Hermann Rempfler
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Patent number: 4919709Abstract: The optically active isomer of S(-)-N-(1'methyl-2'-methoxyethyl)-N-chloroacetyl-2,6-dimethylaniline has improved action against problem weeds over the racemic mixture of isomers.Type: GrantFiled: December 7, 1984Date of Patent: April 24, 1990Assignee: Ciba-Geigy CorporationInventors: Hans Moser, Christian Vogel
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Patent number: 4897486Abstract: Substituted N-3-(5-trifluoromethyl-pyridyl-2-oxy)phenyl-N'-benzoylureas of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently of one another are each hydrogen, methyl, fluorine, chlorine or bromine, andR.sub.4 is hydrogen or chlorine, with the proviso that R.sub.3 is methyl, fluorine, chlorine or bromine when R.sub.4 is chlorine,are active substances having an insecticidal and, in particular, acaricidal action. They can be advantageously used to combat zooparasitic and phytoparasitic ectoparasites.Type: GrantFiled: June 23, 1988Date of Patent: January 30, 1990Assignee: Ciba-Geigy CorporationInventor: Manfred Boger
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Patent number: 4886825Abstract: The invention relates to plant protection compositions based on a two-component system of plant fungicides, one of which is 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole and the other is Mancozeb, which is an [ethylenebis(dithiocarbamato)]manganese complex with [ethylene-bis(dithiocarbamato)]zinc of the formula II ##STR1## In the range from 1:3 to 1:100 the disclosed mixtures display enhanced fungicidal activities.Type: GrantFiled: July 5, 1988Date of Patent: December 12, 1989Assignee: Ciba-Geigy CorporationInventors: Wilhelm Ruess, Pierre Urech, Jurg Eberle, Theodor Staub
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Patent number: 4886824Abstract: The invention relates to plant protection compositions based on a two-component system of plant fungicides, one of which is 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole and the other is an N-haloalkanesulfenylphthalimide derivative.In the range from 1:3 to 1:100 the disclosed mixtures display enhanced fungicidal activities.Type: GrantFiled: July 5, 1988Date of Patent: December 12, 1989Assignee: Ciba-Geigy CorporationInventors: Wilhelm Ruess, Pierre Urech, Jurg Eberle, Theodor Staub
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Patent number: 4865650Abstract: Composition of matter containing:(a) a compound of the formula I ##STR1## in which A is one of the groups of the formulae ##STR2## in which B is --O--, --S--, --SO.sub.2 --, --N.dbd.N--, --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 --O-- ##STR3## --CONH--, --NHCONH-- or --CONHNHCO--, Q is --O' or --NH' and Z is --O-- or --S-- and R and R' are independently of each other hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or phenoxy, and (b) a compound of the formula II ##STR4## in which X.sup..sym. is H.sup..sym. or a group of the formulae ##EQU1## or N.sup..sym. (R.sub.1) (R.sub.2) (R.sub.3) (R.sub.4), M.sup.n.sym. is an n-valent metal cation, n is 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently of one another hydrogen, C.sub.1 -C.sub.18 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl, unsubstituted or C.sub.1 -C.sub.18 -alkyl-substituted phenyl or R.sub.3 and R.sub.4 together with the N atom form a pyrrolidine, imidazolidine, piperidine, piperazine or morpholine radical, or R.sub.Type: GrantFiled: December 16, 1987Date of Patent: September 12, 1989Assignee: Ciba-Geigy CorporationInventors: Jost von der Crone, Bernhard Medinger, Philippe Bugnon
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Patent number: 4845216Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents. The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives. A typical embodiment is N-)4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.Type: GrantFiled: July 17, 1987Date of Patent: July 4, 1989Assignee: The Trustees of Princeton UniversityInventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher