Abstract: Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Abstract: The present invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one antihistamine, such as, for example, azelastine and/or levocabastine, for simultaneous, sequential or separate administration in the local treatment of allergies and airway disorders, for example of allergic rhinitis (rhinoconjunctivitis).

Abstract: A seat assembly for a vehicle comprising a four joint link mechanism for storing a seat into concave portion provided on a floor of the vehicle and a motor device driving the four joint link mechanism, wherein a wire harness connected to the motor device is wired in a space provided between a cover attached to a rear link which forms the four joint link mechanism and the rear link.

Abstract: A woven tubing for use in a stent type blood vascular prosthesis, using a monofilament having a flattening in the range of 1.2-5.0 and a size in the range of 11-250 dtex in at least part of the warp and a stent type blood vascular prosthesis using the tubing are disclosed. The prosthesis combines a shape retaining property that is capable of maintaining its tubular shape without being crushed by the flow of blood with a high liquid tightness that is capable of reducing the leakage of blood to the exterior and allows prevention of the inflow of blood into the lesion.

Abstract: It is disclosed a method for fabricating, modifying or repairing of single crystal or directionally solidified articles. Two single crystal or directionally solidified prefabricated parts are joint by isothermally brazing using a brazing material. After that an epitaxial or non-epitaxial layer on the surface of the created article and of the braze joint is applied using a laser metal forming process.

Abstract: This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and pharmaceutical compositions that are used in such methods.

Abstract: A system for detecting tactile information includes strain-gauge touch sensors and a controller. Based on the sum output from each of tough-sensor sensor units, an analyzer in the controller calculates touch force Fi(t) at each measurement point. An automatic gain control adjusts the voltage amplitude Ai(t) of a sine wave of frequency fi applied to the sensor units at each measurement point to bring the voltage amplitude measured at each measurement point in line with a target voltage. The adjusted voltage Ai(t) is applied to the bandpass filter with a composite sine wave y(t) which includes sine waves of each frequency corresponding to the adjusted voltage amplitude Ai(t). This makes it possible to reduce the number of lines between the controller and touch sensors that includes numerous measurement points, and enables the gain of the touch sensors constituted by strain gauges to be controlled within an appropriate range.

Abstract: Probes 1 for testing and outer connecting terminals 14a are electrically connected to a test socket for semiconductor devices. In use of a connecting sheet, fabricated by an elastically deformative insulating member and electrodes 202, flexibility is given, and good electrical contacts are obtainable. Further, because the connecting sheet 2 is exchangeable, contacting capability is recovered by exchange when solder debris is adhered and deposited to increase contact resistances. Accordingly, even though there is scattering of the heights of the outer connecting terminals, good electrical contact with the probes is obtainable, and even though the solder debris of the outer connecting terminals is adhered and deposited as a result of repeated usage, tests can be continuously conducted, wherein the test socket for semiconductor devices has good maintenance capability.

Abstract: Low-frequency duct noise is relatively difficult to deal with by passive methods such as porous duct lining. Reactive methods like expansion chamber are rather bulky, while compact resonators are to narrow-banded. This invention shows that a suitably stetched thin membrane backed by a slender cavity can achieve a satisfactory performance from low to medium frequencies over an octave band.

Abstract: The present invention relates to novel indigoid binsindole derivatives which can be used for the manufacture of a medicament for the treatment of solid cancers.

Abstract: A method for producing diffusion bonds between components formed of tungsten heavy alloy (WHA) uses aid material to accelerate diffusion across the joint surfaces. The aid material consists of an alloy of palladium (Pd) with one or more of the secondary elements of nickel (Ni), iron (Fe), or cobalt (Co). The secondary elements are selected to correspond to the secondary elements present in the components. The diffusion bonding is carried out by placing diffusion aid material between the joint surfaces of adjacent components, applying a pressure across the joint surfaces, and processing the assembly through a thermal profile. Structures of WHA with complex shapes, interior volumes and/or large sizes can be formed. The joint properties are equal to or superior to those of the parent material of the components.

Abstract: A device for perpendicular stratification of planary fibrous shapes, above all of fibrous web, comprising two synchronously moving elements, connected with the driving mechanism according to the invention consists in that the reciprocating moving elements are connected with their driving mechanism indirectly by the intermediary of at least one robust shaft rigidly fitted in bearings in a rigid framework of the machine, while one element is connected with the shaft rigidly or over flexible joints, and a second element is coupled by means of flexible joints with the same shaft or with another shaft. The driving mechanism can consist of one driving shaft with two crank assemblies arranged with a phase shift to one another. The flexible joints consist of flat steel springs with a width-to-thickness ratio more than 10.

Abstract: A brake hydraulic pressure generator is proposed in which the brake stroke fluctuate less when the amount of brake fluid consumed in the wheel brakes fluctuates. Even when the brake pedal force is increased after the brake assisting force has reached its maximum, the reaction force to the pedal force as well as the master cylinder pressure increases corresponding to the increased pedal force. The brake hydraulic pressure generator has a control valve including a spool and a cylinder and adapted to control the hydraulic pressure in a dynamic pressure chamber to a value corresponding to the stroke of an input shaft. It further includes a pressure sensor, a solenoid valve and a fluid chamber.

Abstract: A new and distinct cultivar of Argyranthemum plant named ‘OHAR01245’ characterized by its double inflorescence form with pink-colored ray florets and purple/yellow bi-colored disc florets, freely branching character, medium green-colored foliage and compact upright growth habit.

Abstract: A lens device which can be used as an objective lens in an optical pickup apparatus includes an objective lens provided along a light path facing a disc and having a predetermined effective diameter, and light controlling means provided along the light path for controlling the light in an intermediate region between near and far axes of an incident light beam, thus providing a simplified and inexpensive device for using discs of differing thickness in a single disc drive, by reducing the spherical aberration effect.

Abstract: Described herein are liposomes containing etherlipids of the formula: as well as a phosphatidylcholine, a sterol, and a headgroup-derivatized lipid. These liposomes are useful in a variety of therapeutic regimens, including the treatment of cancers and inflammatory disorders.

Abstract: Provided is a novel summer gasoline composition which is substantially free of ethers, contains less than 20 ppm sulfur, and is in compliance with the California Predictive Model. The gasoline composition is suitable for use in the summer, i.e., having a Reid vapor pressure of 7.2, and more preferably 7.0 or less, but also offers the advantages of low-emissions while being substantially free of ethers. The method for blending the gasoline comprises blending streams from a refinery in a controlled manner to maintain compliance with the California Predictive Model.