Patents Represented by Attorney C. M. Caruso
  • Patent number: 5336595
    Abstract: A novel recombinant human neurokinin-1 receptor short form (hereinafter identified as human NK1R sF) is disclosed which has been prepared by polymerase chain reaction techniques. Also disclosed is the complete sequence of human NK1R sF complementary DNA; expression systems, including a CHO (Chinese hamster ovarian cell line) stable expression system; and an assay using the CHO expression system.NK1R sF, can be used in an assay to identify and evaluate entities that bind substance P receptor or NK1R sF. The assay can also be used in conjunction with diagnosis and therapy to determine the body fluid concentration of substance P antagonists in arthritis patients.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: August 9, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Catherine D. Strader, Tung M. Fong
  • Patent number: 5324734
    Abstract: The compounds of formula (I) ##STR1## wherein R is selected from the group hydroxymethyl and carboxy, have been identified as metabolites of 5.alpha.-23-methyl-4-aza-21-nor-chol-1-ene-3,20-dione and are believed to be active as testosterone 5.alpha.-reductase inhibitors and would thus be useful for treatment of acne, seborrhea, female hirsutism or benign prostatic hypertrophy.
    Type: Grant
    Filed: September 15, 1992
    Date of Patent: June 28, 1994
    Assignee: Merck & Co., Inc.
    Inventors: John D. Gilbert, Timothy V. Olah
  • Patent number: 5286347
    Abstract: A method for inhibiting the deposition of pitch on and/or for removing pitch from the surfaces of pulping and papermaking machinery by adding an effective amount of a melamine formaldehyde-type polymer to a pulp slurry or furnish in contact with said machinery.
    Type: Grant
    Filed: May 5, 1992
    Date of Patent: February 15, 1994
    Assignee: Calgon Corporation
    Inventor: Paul F. Richardson
  • Patent number: 5286390
    Abstract: A method for treating an ink-laden wastewater stream comprising adding an effective amount of a melamine-aldehyde polymer to the ink laden stream being treated and segregating at least some portion of the resulting ink-laden agglomerated solids from the treated water.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: February 15, 1994
    Assignee: Calgon Corporation
    Inventors: Ross T. Gray, Denis E. Hassick
  • Patent number: 5284590
    Abstract: Method for controlling fouling in high efficiency cooling tower fill using low molecular weight 2-acrylamido-2-methylpropyl sulfonic acid/acrylic acid-type polymers.
    Type: Grant
    Filed: June 19, 1991
    Date of Patent: February 8, 1994
    Assignee: Calgon Corporation
    Inventors: John F. Kohlhofer, Patrick H. Gill
  • Patent number: 5256198
    Abstract: A method for increasing the porosity of fly ash comprising adding an effective amount of a polymer/nitrate composition to fly ash produced from the combustion of fuels such as coal.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: October 26, 1993
    Assignee: Calgon Corporation
    Inventor: Rabindra K. Sinha
  • Patent number: 5250189
    Abstract: Methods of treating circulating water containing oversprayed, water-borne paint, such as in a paint spray booth operation, with aluminum salts such as aluminum chloride or polyaluminum chloride and a flocculant, resulting in removal of sludge from the paint spray booth water.
    Type: Grant
    Filed: May 14, 1991
    Date of Patent: October 5, 1993
    Assignee: Calgon Corporation
    Inventor: Paul A. Rey
  • Patent number: 5240509
    Abstract: Methods of treating circulating water containing over-sprayed, water-borne paint, alone or in combination with over-sprayed solvent-borne paint, as in a paint spray booth operation, comprise maintaining the alkalinity of the paint spray booth water between about 50 and 2000 ppm, on a calcium carbonate basis, by adding an alkalinity source thereto, maintaining the pH between about 6.0 and 9.0, adding a melamine polymer to the water, adding an aluminum salt to the water, contacting the over-sprayed paints with the alkalinity-adjusted paint spray booth water before or after addition of the melamine polymer and aluminum salt, adding an effective amount of a flocculant to the paint spray booth water, and removing resulting sludge from the paint spray booth water.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: August 31, 1993
    Assignee: Calgon Corporation
    Inventors: Paul A. Rey, Robert J. Guerrini
  • Patent number: 5238505
    Abstract: Improved tellurium-containing coating compositions and a method for applying a tellurium-containing coating to a metallic surface characterized by the presence of tellurium and an organic acid solubilizing agent.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: August 24, 1993
    Assignee: Calgon Corporation
    Inventor: Herbert J. Kaiser
  • Patent number: 5236626
    Abstract: An alkoxybenzotriazole, in combination with mercaptobenzothiazole, tolyltriazole, benzotriazole, a substituted benzotriazole and/or 1-phenyl-5-mercaptotetrazole, is used to inhibit the corrosion of metallic surfaces, particularly copper surfaces, in contact with an aqueous system. Systems and compositions are also claimed.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: August 17, 1993
    Assignee: Calgon Corporation
    Inventors: Daniel P. Vanderpool, Charles Y. Cha
  • Patent number: 5236598
    Abstract: A novel method of treating circulating water containing over-sprayed, water-borne paint, such as in a paint spray booth operation, comprises adjusting the alkalinity of the paint spray booth water to between about 20 and 600 ppm, on a calcium carbonate basis, by adding a designated alkalinity source thereto, adding a cationic potato starch to the water, contacting the over-sprayed, water-borne paint with the alkalinity-adjusted paint spray booth water after addition of the cationic potato starch, adding an effective amount of a polymer floccing agent to the paint spray booth water, and removing resulting sludge from the paint spray booth water.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: August 17, 1993
    Assignee: Calgon Corporation
    Inventors: Wood E. Hunter, Lewis D. Morse
  • Patent number: 5225528
    Abstract: Disclosed are cyclic hexapeptides of the formula: ##STR1## These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarian delivery. Also disclosed are pharmaceutical compositions containing the compounds of formula I and methods of preparing these compounds.
    Type: Grant
    Filed: December 17, 1990
    Date of Patent: July 6, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Roger M. Freidinger, Roger D. Tung, Daniel F. Veber, Peter D. Williams
  • Patent number: 5219523
    Abstract: The use of alkoxybenzotriazoles to inhibit the corrosion of metallic surfaces in contact with an aqueous system. Systems and compositions containing alkoxybenzotriazole are also claimed.
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: June 15, 1993
    Assignee: Calgon Corporation
    Inventors: Daniel P. Vanderpool, Charles Y. Cha
  • Patent number: 5217686
    Abstract: An alkoxybenzotriazole, in combination with mercaptobenzothiazole, tolyltriazole, benzotriazole, a substituted benzotriazole and/or 1-phenyl-5-mercaptotetrazole, is used to inhibit the corrosion of metallic surfaces, particularly copper surfaces, in contact with an aqueous system. Systems and compositions are also claimed.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: June 8, 1993
    Assignee: Calgon Corporation
    Inventors: Daniel P. Vanderpool, Charles Y. Cha
  • Patent number: 5211928
    Abstract: A method for improving gypsum slurry filtration in the production of wet process phosphoric acid wherein an effective amount of carboxylic-type polymer having a portion of sulfonic functionality is used as the filtration aid. Preferred polymers are high molecular weight polymers of acrylic acid and acrylamido methylpropyl sulfonic acid.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: May 18, 1993
    Assignee: Calgon Corporation
    Inventors: Paul A. Rey, Wood E. Hunter
  • Patent number: 5192451
    Abstract: A method for controlling zebra mussels in ship ballast tanks comprising treating ballast water which contains zebra mussels or which is prone to zebra mussel infestation with an effective amount of a water-soluble dialkyl diallyl quaternary ammonium polymer (polyquat). A preferred polymer is a poly(quaternary ammonium) compound having the recurring structure [DMDAAX.sup.-- ] resulting from the polymerization of monomeric dimethyl diallyl ammonium X.sup.--, wherein X.sup.-- is any suitable anion.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: March 9, 1993
    Assignee: Calgon Corporation
    Inventor: Patrick H. Gill
  • Patent number: 5185036
    Abstract: Method for solubilizing tellurium over a wide pH range which uses a cyclodextrin as the solubilizing agent, and resulting compositions containing soluble tellurium.
    Type: Grant
    Filed: June 27, 1991
    Date of Patent: February 9, 1993
    Assignee: Calgon Corporation
    Inventor: Herbert J. Kaiser
  • Patent number: 5173280
    Abstract: A method for clarifying phosphoric acid by flocculation or coagulation of solids wherein an effective amount of a polymer having a predominantly sulfonic functionality is used as the clarification aid. Preferred polymers are high molecular weight acrylamide/acrylamido methylpropyl sulfonic acid-type (AM/AMPSA) polymers which are predominantly AMPSA.
    Type: Grant
    Filed: October 15, 1921
    Date of Patent: December 22, 1992
    Assignee: Calgon Corporation
    Inventors: Paul A. Rey, Wood E. Hunter
  • Patent number: 5167730
    Abstract: Improved tellurium-containing coating compositions and a method for applying a tellurium-containing coating to a metallic surface characterized by the presence of tellurium and a dextrin solubilizing agent.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: December 1, 1992
    Assignee: Calgon Corporation
    Inventor: Herbert J. Kaiser
  • Patent number: 5156769
    Abstract: A composition which is useful for inhibiting the corrosion of copper and copper alloy metals in contact with an aqueous system is disclosed. The composition comprises phenyl mercaptotetrazole and tolytriazole and/or benzotriazole.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: October 20, 1992
    Assignee: Calgon Corporation
    Inventors: Charles Y. Cha, Daniel P. Vanderpool