Patents Represented by Attorney Casimir Jones, S.C.

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  • L-lysine-inducible promoter
    Patent number: 7851198
    Abstract: Disclosed is a novel L-lysine-inducible promoter nucleic acid molecule. Also disclosed are a vector containing the nucleic acid molecule, a host cell transformed with the vector, and a method of inducing expression of a target gene using the L-lysine-inducible promoter nucleic acid molecule.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: December 14, 2010
    Assignee: CJ Cheiljedang Corporation
    Inventors: Young Hoon Park, Hyun Min Koo, Jun Ok Moon, Seong Jun Kim, Hyo Jin Kim, Jung Kee Lee
  • Detection of small nucleic acids
    Patent number: 7851150
    Abstract: The present invention relates to compositions and methods for the detection and characterization of interfering RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs) and other short nucleic acid molecules. More particularly, the present invention relates to methods for the detection and quantitation of interfering RNA expression. The present invention further provides for the detection of variants and types of miRNAs and siRNAs.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: December 14, 2010
    Assignee: Third Wave Technologies, Inc.
    Inventors: James E. Dahlberg, Hatim T. Allawi, Victor Lyamichev, Bruce P. Neri, Marilyn C. Olson-Munoz, LuAnne Chehak, Sarah M. Olson
  • Substrates, devices, and methods for cellular assays
    Patent number: 7842499
    Abstract: The present invention relates to the field of molecular diagnostics. In particular, the present invention provided improved substrates and methods of using liquid crystals and other biophotonically based assays for quantitating the amount of an analyte in a sample. The present invention also provides materials and methods for detecting non-specific binding of an analyte to a substrate by using a liquid crystal or other biophotonically based assay formats.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: November 30, 2010
    Assignee: Platypus Technologies, LLC
    Inventors: Christopher Murphy, Barbara Israel, Nicholas Abbott
  • Methods and compositions for reducing viral genome amounts in a target cell
    Patent number: 7838504
    Abstract: Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: November 23, 2010
    Assignee: The Board of Trustees of the Leland Standford Junior University
    Inventors: Peter Sarnow, Catherine L. Jopling, Alissa M. Lancaster
  • Device for chemical and biochemical reactions using photo-generated reagents
    Patent number: 7838466
    Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for selectively converting photogenerated reagent precursors to photogenerated reagents comprising a substrate comprising at least one solid surface containing a plurality of isolated reaction sites; and an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein the irradiation pattern selectively irradiates a plurality of reaction sites without use of a photolithographic mask. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: November 23, 2010
    Assignees: The Regents of the University of Michigan, University of Houston
    Inventors: Xiaolian Gao, Xiaochuan Zhou, Erdogan Gulari
  • NPH6 nucleic acids and proteins
    Patent number: 7838231
    Abstract: The present invention relates to Nephronophthisis, in particular to the NPHP6 protein (nephrocystin-6) and nucleic acids encoding the NPHP6 protein. The present invention also provides assays for the detection of NPHP6, and assays for detecting NPHP6 polymorphisms and mutations associated with disease states.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: November 23, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Friedhelm Hidebrandt, Edgar A. Otto, Hemant Khanna, Anand Swaroop
  • Target-dependent transcription using deletion mutants of N4 RNA polymerase
    Patent number: 7838270
    Abstract: The present invention comprises novel methods, compositions and kits that use N4 vRNAP deletion mutants to detect and quantify analytes comprising one or multiple target nucleic acid sequences, including target sequences that differ by as little as one nucleotide or non-nucleic acid analytes, by detecting a target sequence tag that is joined to an analyte-binding substance. The method consists of an annealing process, a DNA ligation process, an optional DNA polymerase extension process, a transcription process, and, optionally, a detection process.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: November 23, 2010
    Assignee: The University of Chicago
    Inventors: Elena K. Davydova, Krystyna Maria Kazmierczak, Lucia B. Rothman-Denes
  • Apparatus and method for calculating aiming point information
    Patent number: 7832137
    Abstract: The present invention relates to target acquisition and related devices, and more particularly to telescopic gunsights and associated equipment used to achieve shooting accuracy at, for example, close ranges, medium ranges and extreme ranges at stationary and moving targets.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: November 16, 2010
    Assignee: Horus Vision, LLC
    Inventors: Dennis J. Sammut, Lawrence Chao, Dickinson Buell
  • Compositions and methods for diagnosing, predicting therapeutic response of, and monitoring autoimmune disease
    Patent number: 7829292
    Abstract: The present invention provides methods of diagnosing the presence of an autoimmune disease in a patient, methods of predicting the response of an autoimmune diseased patient to therapeutic treatment, and methods of monitoring an autoimmune patient's response to therapy. In particular, these methods comprise the use of a glycoprotein from the inner-ear organ of Corti reactive with a KHRI-3 monoclonal antibody.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: November 9, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Thomas E. Carey, Thankam S. Nair, Jennifer Gray-Beckman
  • Cleavage of nucleic acids
    Patent number: 7829314
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: November 9, 2010
    Assignee: Third Wave Technologies, Inc.
    Inventors: James R. Prudent, Jeff G. Hall, Victor I. Lyamichev, Mary Ann D. Brow, James E. Dahlberg
  • Methods for analyzing nucleic acid
    Patent number: 7824862
    Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: November 2, 2010
    Assignee: Third Wave Technologies, Inc.
    Inventors: Fang Dong, Victor I. Lyamichev, James R. Prudent, Lance Fors, Bruce P. Neri, Mary Ann D. Brow, Todd A. Anderson, James E. Dahlberg
  • Reactions on a solid surface
    Patent number: 7820387
    Abstract: The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a solid support and cleaving the nucleic acid cleavage structure in a site-specific manner. For example, in some embodiments, a 5? nuclease activity from any of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: October 28, 2007
    Date of Patent: October 26, 2010
    Assignee: Third Wave Technologies, Inc.
    Inventors: Bruce P. Neri, Jeff G. Hall, Victor Lyamichev, Lloyd M. Smith
  • Preparation method for the production of active and soluble proteins in prokaryotes and polycistronic vectors therefor
    Patent number: 7811786
    Abstract: Disclosed are a method of producing a target protein in a biologically-active, soluble form in prokaryotic cells and polycistronic vectors therefor.
    Type: Grant
    Filed: June 11, 2004
    Date of Patent: October 12, 2010
    Assignee: Daewoong Co., Ltd.
    Inventors: Bong Yong Lee, Seung Kook Park, Shin Hye Park, Oh Byung Kwon, Chae Ha Yoon, Young Ju Kim, Song Young Kim, Kyung Hyun Min, Yoon Seok Lee, Tae Hee Lee, Tai Young Koo
  • Methods for repairing degraded DNA
    Patent number: 7811753
    Abstract: The present invention provides methods and kits for repair of degraded DNA which may then be used as a template for efficient amplification by a number of different amplification reactions. The method relies upon a series of enzymatic activities provided by DNA repair enzymes.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: October 12, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventor: Mark W. Eshoo
  • Biomarkers for prostate cancer
    Patent number: 7807393
    Abstract: The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the prostate. In particular, the present invention provides compositions and methods for using neuroligin biomarkers (e.g., NLGN-4Y) in the diagnosis, treatment, and empirical investigation of prostate disorders (e.g., prostate cancer, benign prostatic hypertrophy).
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: October 5, 2010
    Assignee: Northwestern University
    Inventors: Colby Shad Thaxton, Norm D. Smith, Joseph Pazona, Onisuru T. Okotie
  • RNA detection assays
    Patent number: 7807806
    Abstract: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5? nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: October 5, 2010
    Assignee: Third Wave Technologies, Inc.
    Inventors: Hatim T. Allawi, Brad T. Argue, Christian Tor Bartholomay, LuAnne Chehak, Michelle L. Curtis, Peggy S. Eis, Jeff G. Hall, Hon S. Ip, Lin Ji, Michael W. Kaiser, Robert W. Kwiatkowski, Andrew A. Lukowiak, Victor Lyamichev, Natalie E. Lyamicheva, Wupo Ma, Bruce P. Neri, Sarah M. Olson, Marilyn C. Olson-Munoz, James J. Schaefer, Zbigniev Skrzypczynski, Tsetska Y. Takova, Lisa C. Thompson, Kevin L. Vedvik
  • Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
    Patent number: 7807807
    Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: October 5, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
  • Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
    Patent number: 7807374
    Abstract: The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: October 5, 2010
    Assignees: The Regents of the University of Michigan, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Bruce Richardson, Qianjin Lu
  • Mixing cartridge
    Patent number: D625345
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: October 12, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rex O. Bare, Jeffrey C. Smith
  • Rotation assembly
    Patent number: D625428
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: October 12, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rex O. Bare, Jeffrey C. Smith