Patents Represented by Attorney Casimir Jones, S.C.

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  • Compositions and methods for free-solution conjugate nucleic acid analysis
    Patent number: 8114599
    Abstract: The present invention provides compositions and methods for performing free-solution conjugate analysis of nucleic acid molecules. For example, the present invention provides multiplexed single-base extension assays for genotyping. In particular, the present invention provides a series of disperse polyamide “drag tags” for use in achieving high-resolution separation of nucleic acid reaction products.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: February 14, 2012
    Assignee: Northwestern University
    Inventors: Robert J. Meagher, Wyatt N Vreeland, Annelise E. Barron
  • Self-assembling peptide amphiphiles for tissue engineering
    Patent number: 8114835
    Abstract: The present invention provides for compositions and methods for creating self-assembled peptide amphiphile (PA) structures. In particular, the present invention provides for two and three-dimensional structures of crosslinked PA microtexture structures useful for tissue engineering and drug discovery.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: February 14, 2012
    Assignee: Northwestern University
    Inventors: Alvaro Mata, Samuel I. Stupp
  • Self-assembling peptide amphiphiles
    Patent number: 8114834
    Abstract: The present invention provides for self-assembling peptide amphiphiles that are capable of forming nanofibers. In particular, the present invention provides for diacetylene peptide amphiphiles that find use as scaffolds for tissue growth or for drug delivery.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: February 14, 2012
    Assignee: Northwestern University
    Inventors: Lorraine Hsu, Samuel I. Stupp
  • Apparatus and method for calculating aiming point information
    Patent number: 8109029
    Abstract: The present invention relates to target acquisition and related devices, and more particularly to telescopic gunsights and associated equipment used to achieve shooting accuracy at, for example, close ranges, medium ranges and extreme ranges.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: February 7, 2012
    Assignee: Horus Vision, LLC
    Inventors: Dennis J. Sammut, Dickinson Buell, Lawrence Chao
  • Sample preparation apparatus
    Patent number: 8110397
    Abstract: A reconfigurable sample preparation device includes a rotary plunger device having a hollow body and a coupling device, provided above one end of the rotary plunger, and accommodating a sample. The device also includes at least one sealed reagent module. When the rotary plunger is rotated on the coupling device, a film of the reagent module is pierced, mixing the sample with a substance from the reagent module.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: February 7, 2012
    Assignee: Smiths Detection Inc.
    Inventor: Douglas Jason Green
  • DNA vaccine for treating or preventing cervical cancer comprising a gene encoding HPV protein
    Patent number: 8101342
    Abstract: Disclosed herein is a DNA vaccine for treating cervical cancer including an E5 gene of human papillomavirus (HPV). Also, disclosed is a combination DNA vaccine for preventing and treating cervical cancer including a gene encoding HPV L1 and/or L2 along with the HPV E5 gene.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: January 24, 2012
    Assignee: Sungkyunkwan University Foundation For Corporate Collaboration
    Inventors: Joo Sung Yang, Sang Woo Kim, Jung Ah Choi
  • Systems, methods and devices for improved imaging
    Patent number: 8098209
    Abstract: The present invention provides devices, systems and methods for imaging and transmitting images. In particular, the present invention provides, systems, methods and devices for free-space polarization modulation.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: January 17, 2012
    Assignee: Tera-X, LLC
    Inventors: Daniel van der Weide, John Grade
  • Methods for identification of sepsis-causing bacteria
    Patent number: 8097416
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: January 17, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Thomas A. Hall, Rangarajan Sampath, Vanessa Harpin, Steven A. Hofstadler, Yun Jiang
  • Compositions and methods for treating cancer
    Patent number: 8088749
    Abstract: The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target ATDC (TRIM29) expression in cancer with ATDC overexpression.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: January 3, 2012
    Assignee: The Regents of the University of Michigan
    Inventors: Diane Simeone, Mats Ljungman, Liang Xu, Lidong Wang, Fengtian He
  • Compositions for the use in identification of fungi
    Patent number: 8088582
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of fungi by molecular mass and base composition analysis.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: January 3, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker
  • Methods for the assessment of drug response
    Patent number: 8084210
    Abstract: The present invention provides methods for predicting or determining a subject's response to an antiplatelet agent, and methods for determining a subject's suitability to a treatment regime or intervention for a disease associated with platelet aggregation, using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's response to an antiplatelet agent. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: December 27, 2011
    Assignee: Theranostics Laboratory
    Inventors: Patrick A. Gladding, Arzu Gunes, Marja-Liisa Dahl, Mark W. Webster
  • HPV primers
    Patent number: 8080643
    Abstract: The present invention provides methods, kits, and compositions related to human papillomavirus (HPV) primers, which may be used, for example, in nucleic acid detection assays for use in basic research, clinical research, and for the development of clinical detection assays.
    Type: Grant
    Filed: September 5, 2007
    Date of Patent: December 20, 2011
    Assignee: Third Wave Technologies, Inc.
    Inventors: Joseph J. King, Angela Hudson
  • Encapsulated peptide amphiphile nanostructures
    Patent number: 8080262
    Abstract: The present invention provides compositions and methods for creating encapsulated peptide amphiphilic nanostructures useful in treating diseases. In particular, the present invention provides compositions and methods for preparing peptide amphiphile nanostructures that are encapsulated in liposomes by the application of light, and using such compositions in treating diseases, such as cancer.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: December 20, 2011
    Assignee: Northwestern University
    Inventors: Hyung-Kun Lee, Stephen Soukasene, Samuel I. Stupp
  • Compositions and methods for treatment of inflammatory bowel disease
    Patent number: 8080579
    Abstract: The present invention provides compositions and methods for treating inflammatory bowel disease. In particular, the present invention provides methods of therapeutically treating symptoms of inflammatory bowel disease using compositions comprising an angiotensin converting enzyme (ACE) inhibitor and polyethylene glycol.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: December 20, 2011
    Assignee: The Regents of The University of Michigan
    Inventors: Daniel H. Teitelbaum, Barbara E. Wildhaber, Hua Yang
  • System for indentification of pathogens
    Patent number: 8073627
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: December 6, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 8071309
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: December 6, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence Blyn, Ray Ranken, Thomas A. Hall
  • Determination of hepatitis C virus genotype
    Patent number: 8071750
    Abstract: The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, to determine HCV genotype.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: December 6, 2011
    Assignee: Third Wave Technologies, Inc.
    Inventors: Vecheslav A. Elagin, Scott M. Law, Bjork Hill
  • Analyte detection
    Patent number: 8067188
    Abstract: The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measuring the concentration of analytes in a sample.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: November 29, 2011
    Assignee: N2ITIVE1 Innovations
    Inventors: Anthony Toranto, Evan Singer, Brett Miller
  • RNA detection assays
    Patent number: 8063184
    Abstract: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5? nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: November 22, 2011
    Assignee: Third Wave Technologies, Inc.
    Inventors: Hatim Allawi, Brad T. Argue, Christian Tor Bartholomay, LuAnne Chehak, Michelle L. Curtis, Peggy S. Eis, Jeff G. Hall, Hon S. Ip, Lin Ji, Michael Kaiser, Robert W. Kwiatkowski, Jr., Andrew A. Lukowiak, Victor Lyamichev, Natalie E. Lyamicheva, WuPo Ma, Bruce P. Neri, Sarah M. Olson, Marilyn C. Olson-Munoz, James J. Schaefer, Zbigniev Skrzypczynski, Tsetska Y. Takova, Lisa C. Thompson, Kevin L. Vedvik
  • Methods for identification of coronaviruses
    Patent number: 8057993
    Abstract: The present invention provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids which are used to rapidly identify bacteria.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: November 15, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Christian Massire