Abstract: A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Abstract: According to the process of the invention, the hexahydropyridazine-3-carboxylic acid derivatives are prepared by reacting a compound of formula (II) with a compound of formula (III) in the presence of a base with a pK of greater than or equal to 8.5, in a ketone organic solvent, to obtain an intermediate compound that is not isolated and that is treated with a basic aqueous medium. By means of this process, the derivatives are obtained more quickly and more economically.

Abstract: A composition comprising at least one G protein inhibitor of the formula wherein the substituents are defined as in the specification and the salts thereof and at least one other antihypertensive agent for the treatment of arterial hypertension.

Abstract: A method of determining calciotropic activity of a preparation of algae of the genus Padina pavonica. The algae preparation may be in the form of a powder or an extract. The method consists of culturing human or animal osteoblasts in a culture medium containing calcium ions in a well plate. The preparation is added thereto and non-fixed calcium ions are eliminated in the culture medium. Further, the culture medium is acidified to destroy an extracellular matrix formed by the osteoblasts in the culture medium. Thereafter, filtering of the culture medium is carried out and then a concentration of fixed calcium ions in the osteoblasts is determined and compared with a calibration scale of a known activator of the fixation of calcium or in the presence of an inhibitor of the fixation of calcium or both.

Abstract: A process for selectively hydroformylating dicyclopentadiene to 8(9)-formyltricyclo-[5.2.1.02,6]dec-3-ene in a heterogeneous reaction system using an aqueous solution of transition metal compounds, containing water-soluble organic phosphorus(III) compounds in complex-bound form, of group VIII of the Periodic Table of the Elements, wherein the water-soluble organic phosphorus(III) compounds are alkali metal or alkaline earth metal salts of sulfonated arylphosphines and aryldiphosphines.

Abstract: Derivatives of purine having anti-proliferative properties and in particular, derivatives of purine endowed with an inhibitory effect vis-a-vis cycline-dependent kinase proteins i.e. abbreviated to “cdk”.

Abstract: A subject of the present application is new derivatives of 4-aminopiperidines of formula in which R1, R2 and R3 represent various radical, and their preparation processes by synthetic methods in parallel in liquid and solid phase. These products having a good affinity with certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) somatostatin receptors are involved.

Abstract: The invention relates to a method for the coupled production of two esters by reacting a mixture of aliphatic alcohols with an aliphatic carboxylic acid and then treating the resulting mixture by distillation. During the distillation process, a side flow that is taken from the distillation column that is connected downstream of the esterification reactor is fed back into said esterification reactor. The pure ester compounds are obtained from the bottom of the distillation columns that are connected downstream of the esterification reactor.

Abstract: In a linear rolling bearing comprising a guide carriage (1) that can be mounted through rolling bearing rollers (7) on a guide rail (2), said guide carriage (1) comprising at least one endless roller channel (8) for the rollers (7), said roller channel (8) comprising a load-bearing channel (9) for load-bearing rollers (7), a return channel (10) for returning rollers (7) and two deflecting channels (11) that connect the load-bearing channel (9) and the return channel (10) to each other, said guide carriage (1) further comprising a carrier body (3) in which said return channel (10) and said load-bearing channel (9) are arranged, and, on two front ends of the carrier body (3), end members (4) in which said deflecting channels (11) are arranged, said return channel (10) comprising a return tube (27) whose tube ends are connected to said end members (4), and said roller channel comprising raceways for the rollers and side surfaces for laterally delimiting the roller channel, the return tube (27) comprises tongues

Abstract: The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medicaments, in particular as anti-bacterial agents.

Abstract: A process for preparing sulfonated arylphosphines by reaction of arylphosphines with oleum, wherein, after reaction of the arylphosphines with oleum, the sulfonation mixture is firstly diluted with water, an inert gas stream is then passed through the diluted sulfonation mixture until SO2 is no longer liberated from the diluted sulfonation mixture and the latter is then worked up further in a customary manner and its use.

Abstract: A subject of the present invention is new compounds having a lanthanide and having a tridentate ligand, a process for their preparation and their use in particular as polymerization catalysts.

Abstract: The invention proposes a valve train of an internal combustion engine comprising a cam (1) and a directly driven cam follower (2), such as a roller tappet. This valve train is additionally designed for effecting an internal exhaust gas recirculation at an exhaust valve. A housing (4) of the cam follower (2) comprises two relatively displaceable elements (8, 9). The cam (1) is configured as a high lift cam (1a) for the inner element (8), and at least one low lift cam (1b) configured out-of-phase to the high lift cam (1a) is provided for the outer element (9). When it is desired to carry out an internal exhaust gas recirculation, the two elements (8, 9) are coupled to each other by a coupling element (10), so that, at the end of the base circle of the high lift cam (1a), the low lift cam (1b) protruding thereinto enables a slight post-opening of the gas exchange valve concerned and, thus also, an exhaust gas recirculation.

Abstract: The invention relates to a method for preparing polyesters A containing several mid-chain free acid functions by ring-opening polymerisation in the presence of a chain initiator: the benzyl diester of the tartaric acid, the phenyl radical of which is optionally substituted. A: aliphatic based on cyclic esters such as lactides and glycolides.

Abstract: A method of treating proliferative diseases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of at least one compound selected from the group consisting of mikanolide and dihydromikanolide sufficient to treat said disease.

Abstract: The invention relates to a hydroformylation method, whereby the homogeneous liquid reactor discharge is first supplied to a gas/liquid separator and then run through an extraction column with a counter-current of synthesis gas and finally fed to an evaporator. The invention is characterised in that the homogeneous liquid mass flow is supplied to the upper section of the extraction column at a temperature above 90° C.

Abstract: The invention concerns a mounting and anti-rotation device (mounting aid) (1) for roller tappets of a valve train of an internal combustion engine in which gas exchange valves are activated by roller tappets. The roller tappets comprising a substantially cylindrical tappet body are retained in receptions (7, 8) of the mounting aid (1) that is made of plastic. With the help of opposing parallel anti-rotation surfaces that are arranged symmetrically to the longitudinal axis of the roller tappet and are disposed on the end of the tappet body that is oriented away from a roller, the roller tappets are guided secured against rotation in the mounting aid during the operation of the internal combustion engine. This is achieved by the fact that the inner profile of the receptions (7, 8) is matched to the outer profile of the roller tappets.

Abstract: The use of stannylenes and germylenes of general formula (I) wherein: M represents a tin or geranium atom; L1 and L2 independently represent a group of formula: -E14(R14) (R?14) (R?14), -E15(R15) (R?15) or -E16(R16)) or together form a chain of formula -L?1-A- L?2; A represents a saturated or unsaturated chain comprising one, two or three elements of group 14; L?1 and L?2, represent, independently, a group of formula: -E14(R14) (R?14)-, E15(R15)- or -E16-; E14 is an element of group 14; E15 is an element of group 15; E16 is an element of group 16; R14, R?14, R?14, R15, R?15 and R16 represent variable groups as polymerization catalysts of heterocycles.

Abstract: The present invention relates to aqueous plastic material dispersions based on vinyl ester copolymers, having a solids content of up to 80% by weight and a minimum film formation temperature below 20° C., which is substantially stabilized by ionic components, the vinyl ester copolymers containing at least one homo- or copolymer A and at least one homo- or copolymer B, methods for producing the same and the use thereof.

Abstract: The invention relates to a process for the preparation of an ?-benzyl ester of an amino diacid, characterized in that the amino diacid is reacted with a benzyl alcohol derivative of formula (I) in which the R1 substituent or substituents, which are identical or different, represent a hydrogen atom, a C1 to C4 alkyl group, a C1 to C4 alkoxy group or a halogen atom and n is equal to 1, 2 or 3, in the presence of at least one mol per mole of the amino diacid of an alkanesulphonic acid, optionally in the presence of a solvent. The intermediate alkanesulphonates of the ?-benzyl esters of amino diacids and the ?-benzyl esters of amino diacids are obtained with a good yield and an excellent purity by virtue of this process.