Abstract: A desiccated, that is, dry absorbable synthetic surgical element of a polymer subject to hydrolytic degradation to non-toxic, tissue-compatible, absorbable components, such as polyglycolic acid suture, is packaged in an airtight sealed container which is substantially impervious to water vapor such as a laminate film having a metallic foil layer. The gaseous contents of the envelope are, prior to sealing the suture within the envelope, either evacuated or replaced with a gas which is inert towards said surgical element and which is substantially free from water. The water content should be below 0.5% by weight of the weight of the surgical element, and preferably is and remains below 0.05% by weight. Desiccated polyglycolic acid sutures and other elements thus packaged retain acceptable levels of strength for at least one year at storage temperatures of 72.degree. F. and ambient humidity outside the package. The contents may be sterilized by using ethylene oxide.

Abstract: A process for the preparation of dialkyl (p-aminobenzoyl) glutamates is disclosed. Dialkyl (p-Aminobenzoyl) glutamates are useful as intermediates in the synthesis of N-{p-([(2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as 4-amino-N.sup.10 -methylpteroylglutamic acid. The compound zinc N-(p-methylaminobenzoyl)-L-(+)-glutamate, is also disclosed.

Abstract: Tissue absorbable synthetic polymeric fibers, such as polyglycolic acid, are felted to form a thin mat with at least one, and preferably both, surfaces compacted by contact with a heated embossing surface such as a hot roller. Porosity is reduced but the compacted felt retains its flexibility, and conforms readily to the surface of a bleeding wound to give effective rapid hemostasis. The hemostatic felt is conveniently but not necessarily allowed to remain in place during the healing process and is absorbed by living tissue.

Abstract: The package consists of a card which holds the sutures. The sutures are loaded onto the card by holding them on needle retention slits or placing them on a layer of foam and then passing them through suture loading openings into suture retaining holes. When the sutures are longer than the card, the suture loop is held by suture retention slits through doublebackstringing.The card is enclosed in a suture sleeve comprising two needle side flaps and a needle protection flap. When the flaps are opened and the protection flap is lifted, the needle ends of the loaded sutures are exposed.A suture package comprising a strippable outer pouch is also described.

Abstract: A normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product of (A) a polyglycolic acid composition and (B) a polyester of diglycolic acid and an unhindered glycol and to the process of preparing the same and the use of said polymeric reaction product as a sterile surgical element and as a device for the controlled continuous administration of a predetermined dosage of a drug to a living animal.

Abstract: A normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product of (A) a polyglycolic acid composition and (B) a polyester of diglycolic acid and an unhindered glycol and to the process of preparing the same and the use of said polymeric reaction product as a sterile surgical element and as a device for the controlled continuous administration of a predetermined dosage of a drug to a living animal.

Abstract: This disclosure describes novel erythro 15,16-dioxy prostenoic acids and esters useful as bronchodilators, hypotensives and gastric acid secretion inhibitors.

Abstract: This disclosure describes novel 15,16-dioxy prostenoic acids and esters useful as bronchodilators, anti-inflammatory agents, hypotensives and gastric acid secretion inhibitors.

Abstract: Novel 1-(phenyl or p-chlorophenyl)-2,4-disubstituted-3-methylimidazolidines and a method for inducing diuresis and treating hyperaldosteronism by the administration thereof.

Abstract: A normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product of (A) a polyglycolic acid composition and (B) a polyester of diglycolic acid and an unhindered glycol and to the process of preparing the same and the use of said polymeric reaction product as a sterile surgical element and as a device for the controlled continuous administration of a predetermined dosage of a drug to a living animal.

Abstract: 5-Carboxy-phenylenebis(carbonylimino)benzene carboxylic and dicarboxylic acids and salts thereof useful as complement inhibitors.

Abstract: A direct dispensing surgical suture label comprising a strand back panel, a strand cover and a strand cover side flap. The needled or non-needled ends of the surgical suture are held in a needle pocket. The needle pocket consists of a needle panel which is adjacent to the top portion of the strand panel and connected to it by a diagonal score line. The needle pocket also consists of needle panel side flaps each consisting of an upper rounded portion and a lower triangular portion. The upper portions are connected to the needle panel and the lower portions are connected to the strand panel by score lines. The needle pocket is protected by a needle cover consisting of an upper and a lower portion which folds over the strand cover and under the needle pocket respectively.

Abstract: A solid biodegradable hydrolyzable polyester resin of diglycolic acid and an unhindered glycol having a molecular weight sufficiently high so as to provide a polymeric material possessing self-supporting film forming properties and the process of preparing the same and the use of the polymeric material as a sterile surgical suture or ligature.

Abstract: A pellet implanter for the subcutaneous implantation of one or more spherical or cylindrical pellets of a total size of up to about 1/8 inch by 1 inch (3 mm .times. 25 mm) through a hypodermic needle uses a transparent compact flat cartridge having parallel feed chambers permitting visual observation of the feed and 360.degree. rotation of the cartridge holder with respect to the pistol grip and plunger assembly. A collet holds a replaceable injection needle which permits injection of therapeutic agents in repository form beneath the skin of animals for therapeutic and/or growth control purposes.

Abstract: A normally solid biodegradable hydrolyzable polyester resin of diglycolic acid and an unhindered glycol having a molecular weight sufficiently high so as to provide a polymeric material possessing self-supporting film forming properties and the process of preparing the same and the use of the polymeric material as a device for the controlled continuous administration of a predetermined dosage of a drug to a living animal.

Abstract: Poly(N-acetyl-D-glucosamine) is soluble in hexafluoroisopropyl alcohol and hexafluoracetone sesquihydrate. The solutions formed may be wet or dry spun into filaments, or cast into films or solid articles, which may be used as absorbable surgical sutures, or other absorbable surgical elements. Poly(N-acetyl-D-glucosamine) is enzymatically degradable in living tissue, and is resistant to hydrolytic degradation, and, therefore, surgical elements thereof have good storage characteristics under a wide variety of conditions.

Abstract: Poly(N-acetyl-D-glucosamine) is soluble in hexafluoroisopropyl alcohol and hexafluoracetone sesquihydrate. The solutions formed may be wet or dry spun into filaments, or cast into films or solid articles, which may be used as absorbable surgical sutures, or other absorbable surgical elements. Poly(N-acetyl-D-glucosamine) is enzymatically degradable in living tissue, and is resistant to hydrolytic degradation, and, therefore, surgical elements thereof have good storage characteristics under a wide variety of conditions.

Abstract: Surgical needles are attached to sutures with controlled pull-out characteristics by a short crimp--that is a crimp whose length is markedly less than the length of the end of the suture in the needle; with an essentially undistorted portion of the needle adjacent to where the suture emerges from the needle, and an essentially undistorted portion around the front of the suture, so that only a short section of the needle is crimped around the suture. This leaves the suture uncrushed where it emerges from the needle and hence of superior strength where sharp bends occur during use. It also leaves an undistorted portion of the suture ahead of the crimp so that on pull-out, the suture is retained not only by frictional engagement of the crimp but also by the forces required for the distortion of the head of the suture so that it will pull through the reduced section of the crimp.

Abstract: A surgical suture label having a needle protection flap is disclosed which permits direct dispensing of the suture. An envelope having a tearing notch and a tear angle guideline across the face of the envelope is also disclosed. When the envelope is torn from the tear notch along the guideline, the needle protection flap is exposed for direct dispensing of the suture.

Abstract: A racemic mixture of dl-2-amino-1-butanol is resolved with separation of the d-2-amino-1-butanol by crystallizing as a salt with L(+)-tartaric acid from an essentially anhydrous solution in ethanol or methanol. The salt is decomposed with calcium hydroxide to yield the d-2-amino-1-butanol. Water may be added to the residual anhydrous solution to separate the l-2-amino-1-butanol. Other listed volatile solvents may be present in the anhydrous ethanol or methanol without inhibiting the sharp separation.