Abstract: A novel method for reducing an arteriosclerotic lesion is disclosed in which the electromagnetic energy directed at the lesion is selectively absorbed by a lesion component, e.g. cholesterol. The resulting decomposition of said lesion component leads to reduction of the lesion with minimal risk of damage to blood constituents and adjacent healthy blood vessel tissue. Preferably, monochromatic electromagnetic energy is generated by a laser and is conducted to the vicinity of the lesion by at least one optical fiber.

Abstract: An improved metallic bone prosthesis having a porous coating for bone ingrowth or interlocking with bone cement is disclosed. The porous coating comprises two layers of generally ball-shaped metallic particles bonded together at their points of contact, e.g. by sintering, and defining between them a plurality of connected interstitial pores having an average pore size of from about 350 microns to about 500 microns. A high resistance to failure at the coating-substrate and bone-coating (or cement-coating) interfaces is achieved with the use of the improved prosthesis. Also disclosed are a novel method for affixing the porous coating to a metal susbstrate, and a knee joint prosthesis having bearing portions designed so that the function of said prosthesis closely approximates that of the natural knee.

Abstract: A modular femoral internal implant system for use in the treatment of femoral disorders resulting from injury, disease or congenital defect includes at least three interconnectable components: 1) an elongated epiphyseal/metaphyseal implant, 2) an intramedullary rod and 3) an angled side plate having an elongated plate portion adapted to be secured to the outer cortical wall and a hollow sleeve adapted to extend into the femur. The epiphyseal/metaphyseal implant can be connected to either the angled side plate or the intramedullary rod. The system may also include an elongated bone plate connectable to the angled side plate, one or more additional epiphyseal/metaphyseal implants of variable length, an additional angled side plate, a distal buttress plate connectable to the elongated bone plate, and a plurality of bone screws of a universal design. Preferably, many or all of the components of the system are made of an inert, resilient titanium-base alloy.

Abstract: A hollow elongated medullary bone nail capable of being locked in place with at least a pair of transversely-disposed bone screws is disclosed. The radius in transverse cross-section of the outer surface of the nail varies over the circumference of the cross-sectional profile of the nail in such a manner that a steadily rounded contour results.

Abstract: A novel method for replacing a previously implanted knee joint prosthesis in a patient is disclosed in which the previously implanted femoral component is replaced with a revision femoral component having thicker distal and posterior bearing portions so as to restore the natural anatomic transverse joint plane and collateral ligamentous balance in extension and flexion of the prosthetic joint. Instrumentation for use in this method includes a novel revision cutting jig which is used in the preparation of the distal end of the femur for the implantation of the revision femoral component.

Abstract: An aiming apparatus for making transverse bores in a patient's bone in register with the holes or bores of an osteosynthesis aid in the bone, especially an interlocking nail, comprises an elongated holder for the accommodation of an aiming member adapted to be brought into the beam path of an X-ray apparatus, a reception head for receiving a drill or wire drill rotatably supported in the holder, and a power drive supported by the holder for rotatably driving the reception head. The reception head is made of a material transparent to X-ray radiation.

Abstract: An improved metallic bone prosthesis having a porous coating for bone ingrowth or interlocking with bone cement is disclosed. The porous coating comprises two layers of generally ball-shaped metallic particles bonded together at their points of contact, e.g. by sintering, and defining between them a plurality of connected interstitial pores having an average pore size of from about 350 microns to about 500 microns. A high resistance to failure at the coating-substrate and bone-coating (or cement-coating) interfaces is achieved with the use of the improved prosthesis. Also disclosed are a novel method for affixing the porous coating to a metal substrate, and a knee joint prosthesis having bearing portions designed so that the function of said prosthesis closely approximates that of the natural knee.

Abstract: A method for treating living tissues and/or cells consisting essentially of electromagnetically inducing in the tissues and/or cells alternating pulsating electrical signals having a wave form which comprises a positive portion with a duration of between 1 and 3 milliseconds, and a negative portion having a peak value less than that of the positive portion, followed by a region of exponential extension tending to the reference value zero.

Abstract: A catheter for opening constricted regions in the cardiovascular system includes an expandable dilatation zone comprising three dilatation elements arranged around a support tube. The dilatation elements are of tubular configuration, and each communicates at one end with a passage in the support tube leading to a pressure-suction pump. Constricted regions in the cardiovascular system may be enlarged or opened by introducing the dilatation zone into the affected site in a folded condition and expanding it peripherally therein. Upon expansion of the dilatation elements flow passages are formed between these elements, through which body fluid (for example blood) can pass with little resistance. The supply of body fluid to organs and tissues downstream of the affected site is thereby maintained. Interruption of the dilatation treatment is not required to insure this supply, thus permitting a substantial reduction in the overall duration of the medical procedure.

Abstract: A modular femoral internal implant system for use in the treatment of femoral disorders resulting from injury, disease or congenital defect includes at least three interconnectable components: (1) an elongated epiphyseal/metaphyseal implant, (2) an intramedullary rod and (3) an angled side plate having an elongated plate portion adapted to be secured to the outer cortical wall and a hollow sleeve adapted to extend into the femur. The epiphyseal/metaphyseal implant can be connected to either the angled side plate or the intramedullary rod. The system may also include an elongated bone plate connectable to the angled side plate, one or more additional epiphyseal/metaphyseal implants of variable length, an additional angled side plate, a distal buttress plate connectable to the elongated bone plate, and a plurality of bone screws of a universal design. Preferably, many or all of the components of the system are made of an inert, resilient titanium-base alloy.

Abstract: A dilatation catheter, in particular for expanding constrictions in coronary vessels, includes a balloon (2) capable of being enlarged by injecting a fluid through a tube (3). The tube (3) is arranged laterally offset from a segment of flexible tubing (7) by which a passage (8) for a guide wire (1) is formed in the balloon (2).

Abstract: The intestinal graft is a graft formed of a thin wall latex or silastic tube of various widths and lengths. The upper circular end of the tube and vertical seam are reinforced by fabric which contains a radiopaque filament. When the graft is joined to the submucosal layer of the bowel proximal to the usual anastomosis, it will prevent salivary esophago-gastrointestinal secretions, food, and fecal flow from coming in contact with the anastomotic closure site.The graft will thus prevent leakage from any intestinal anastomosis and will guarantee a healed anastomosis by the time the graft is naturally expelled from rectum.

Abstract: A bone nail for the treatment of fractures in the proximal femur zone is disclosed having a distal end portion adapted to be disposed at the outer surface of the femoral condyle, said end portion being provided with a coupling portion for engagement with a driving tool, a proximal end portion adapted to be seated in the proximal femur, and an arcuately curved portion between the ends, with the proximal end portion being provided with a rounded-off thickened portion at the free end thereof.

Abstract: A composite material comprising a layer of ferritic stainless steel of up to 0.005 inches thickness covered on both sides by a layer of austenitic stainless steel of up to 0.005 inches thickness and suitable for induction heating. A second composite material comprising the material above further bonded to an aluminum layer and another layer of austenitic stainless steel. Cookware made of both types of composite material.

Abstract: A charger for a battery-operated surgical machine includes a charging circuit and a housing. The housing contains the charging circuit and is provided with at least one plug receptacle means for the battery component of the surgical machine. The housing is also fitted with a selector switch connected to the charging circuit. In a first position of the selector switch the charging circuit charges the battery immediately, while in a second position of the switch the charging circuit first discharges the battery down to a predetermined lower potential and then charges it up to a predetermined higher potential.

Abstract: A series of novel 2-substituted 4-amino-6,7-dimethoxyquinoline derivatives have been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy as highly potent antihypertensive agents. Preferred member compounds include 4-amino-2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinoline, 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquin oline and 4-amino-6,7-dimethoxy-2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)qu inoline, respectively. Methods for preparing these compounds from known starting materials are provided.

Abstract: Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl oxindole-3-carboxylate.

Abstract: 7.alpha.-Hydroxyamino-7.beta.-[2-substituted-2-(acylamino)acetamido]cephalo sporin antibiotics, pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, a method of treating susceptible infections therewith, and intermediates therefor.

Abstract: A method for treating living tissues and/or cells consisting essentially of electromagnetically inducing in the tissue and/or cells alternating pulsating electrical signals having a wave form which comprises a positive portion with a duration of between 1 and 3 milliseconds, and a negative portion having a peak value less than that of the positive portion, followed by a region of exponential extension tending to the reference value zero.

Abstract: 7.alpha.-Hydroxyamino-7.beta.-[2-substituted-2-(acylamino)acetamido]-cephal osporin antibiotics, pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, a method of treating susceptible infections therewith, and intermediates therefor.