Patent number: 6762192
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and solvates:
where R1 is hydrogen, C1-6 alkyl (optionally substituted by hydroxy or C1-4alkoxy), phenyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl;
R2 is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, CF3O—, CF3S—, CF3CO—, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO—, C1-6alkylCO—, C3-6cycloalkylO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4alkylO—, C3-6cycloalkyl-C1-4alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS—, C1-6alkylSO2—, (C1-4alkyl)2NSO2—, (C1-4alkyl)NHSO2—, (C1-4alkyl)2NCO—, (C1-4alkyl)NHCO— or CONH2;
or —NR5R6 where R5 is hydrogen or C1-4 alkyl, and
R6 is hydrogen, C1-4alkyl, formyl, —CO2C1-4alkyl or —COC1-4alkyl;
or two R2 groups together form a carbocyclic ring that is saturated or unsaturated.
Type:
Grant
Filed:
May 23, 2002
Date of Patent:
July 13, 2004
Assignee:
SmithKline Beechum p.l.c.
Inventors:
John David Harling, Frank Peter Harrington, Mervyn Thompson