Patents Represented by Attorney, Agent or Law Firm Charles M. Kinzig
  • Sulfonamide derivatives as 5-HT7 receptor antagonists
    Patent number: 6660751
    Abstract: The invention relates to novel sulfonamide compounds having 5-HT7 receptor antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: December 9, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Peter John Lovell
  • Method for reducing or eliminating smoking
    Patent number: 6660754
    Abstract: This invention is an improved method for reducing or eliminating tobacco usage and the nicotine dependency associated with tobacco usage by gradually decreasing an individual's tobacco consumption over a time period while replacing nicotine from tobacco with an alternative nicotine source.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: December 9, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Theodore K. Kyle, Saul Shiffman
  • Vaccine against Mumps containing a Jeryl-Lynn virus strain
    Patent number: 6656476
    Abstract: A new mumps vaccine is presented, comprising a homogeneous pure isolate derived from the Jeryl-Lynn strain of mumps virus.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: December 2, 2003
    Assignee: SmithKline Beecham Biologicals (S.A.)
    Inventors: Nigel Maurice Harford, Brigitte Desiree Alberte Colau, Jean Didelez
  • IL-8 receptor antagonists
    Patent number: 6653347
    Abstract: This invention relates to the novel use of diphenyl sulfamido in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: November 25, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael R. Palovich, Joseph Weinstock, Katherine L. Widdowson
  • IL-8 receptor antagonists
    Patent number: 6653310
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: November 25, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael R. Palovich, Katherine L. Widdowson, Hong Nie
  • Compounds
    Patent number: 6649619
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: November 18, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Treatment for stroke management
    Patent number: 6649617
    Abstract: A method of treating a CNS injury to the brain, in a mammal in need of treatment, which comprises administering to said mammal an effective amount of a cytokine suppressive binding protein compound of formula I wherein the radicals are defined herein.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: November 18, 2003
    Assignee: SmithKline Beecham Corporation
    Inventor: Jerry Leroy Adams
  • Antifungal sordaricin derivatives
    Patent number: 6645960
    Abstract: A compound of general formula (I) and physiologically acceptable salts wherein R represents phthalidyl, (2-oxo-5-methyl-1,3-diox-olen-4-yl)methyl or the group CHR4 OCO(O)pR5 wherein R4 is hydrogen or C1-4 alcyl, p is zero or I, R5 is C1-6 alkly, C5-8 cycloalyl (optionally substituted by C1-3 alkyl or carboxyl), C1-4 alkyl substituted by C1-3 alkoxy or carboxy), C1-4 alkyl substituted by one or more groups selected from amino, (C1-4 alkylamino di(C1-4 alkyl)amino or carboxyl, phenyl (optionally substituted by carboxyl or aminoalkyl, C1-4 alkylaminoalkyl or di(C1-4 alkyl)aminoalcyl, or R5 is a 5-8 membered heterocyclic group containing 1 or 2 heteroatoms selected from oxygen or nitrogen, processes for their preparation, pharmaceutical compositions containing them and their use in medicine.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: November 11, 2003
    Assignee: Glaxo Wellcome S.A.
    Inventors: Jose Maria Fiandor, Sophie Huss
  • Compounds
    Patent number: 6645989
    Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: November 11, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, John C. Lee, John Richard White
  • Thrombopoietin mimetics
    Patent number: 6642265
    Abstract: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: November 4, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan I. Luengo, Kevin J. Duffy
  • Indole derivatives as 5-HT receptor antagonist
    Patent number: 6638953
    Abstract: The invention relates to heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders such as anxiety.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: October 28, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Laramie Mary Gaster, Paul Adrian Wyman, Keith Raymond Mulholland, David Thomas Davies, David Malcolm Duckworth, Ian Thomson Forbes, Graham Elgin Jones
  • Process for the preparation of substituted thiazolidinedione
    Patent number: 6632947
    Abstract: A process for preparing a compound of formula (I, I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, wherein: J represents O or S; T represents a substituted or unsubstituted aryl group and T1 is O or S; which process comprises reducing a compound of formula (II, II) or a tautomeric form thereof or a salt thereof or a solvate thereof, wherein T and T1 are as defined in relation to formula (I), with a complex hydride reducing agent or a source of a complex hydride reducing agent; and thereafter, as required, preparing a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate of the compound of formula (I) or a tautomeric form thereof.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: October 14, 2003
    Assignee: SmithKline Beecham plc
    Inventors: Robert Gordon Giles, Norman John Lewis, Stephen Moore, Colin Ripley Pool, John Kirby Quick, Michael Urquhart
  • G-CSF mimetics
    Patent number: 6630470
    Abstract: Invented are G-CSF mimetics. Also invented are selected octacyclic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compounds.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: October 7, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan I Luengo, Kevin J Duffy
  • Eprosartan arginyl charge-neutralization-complex and a process for its preparation and formulation
    Patent number: 6630498
    Abstract: This invention relates to (E)-&agr;-[2-n-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene-2-thiophenepropionic acid arginyl charge-neutralization-complex, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: October 7, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Manga R Gudipati, John M Jushchyshyn, Nageswara R Palepu, Gopadi M Venkatesh
  • Use of 5HT-6 antagonists
    Patent number: 6627661
    Abstract: Methods for treating ADHD, comprising administering 5-HT6 antagonists to subjects having ADHD, are disclosed.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: September 30, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Charles Alan Reavill, Carol Routledge
  • Process and intermediates for making 4-cyanosubstituted cyclohexanoic acids
    Patent number: 6624323
    Abstract: Herein is provided a process for preparing substituted cyclohexanoic acids of formula (I), where Ra is a carbon-containing group optionally linked by oxygen, sulfur or nitrogen to the phenyl ring and j is 1-5; and one of R and R* is hydrogen and the other is C(O)OH.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: September 23, 2003
    Assignee: SmithKline Beecham Corporation
    Inventor: Jose J. Conde
  • Vaccines
    Patent number: 6623739
    Abstract: The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent inducers of a range of immune responses.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: September 23, 2003
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventors: Patricia Marie Momin, Nathalie Marie-Josephe Garcon
  • Endothelin receptor antagonists
    Patent number: 6620826
    Abstract: Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: September 16, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Joseph Weinstock, Jia-Ning Xiang
  • 7-alkoxycoumarins as cytochrome p450 substrates
    Patent number: 6617124
    Abstract: Coumarin derivatives as substrates for cytochrome P450 enzyme.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: September 9, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Stephen Edward Clarke
  • Compounds and their use as PDE inhibitors
    Patent number: 6617357
    Abstract: This invention relates to certain benzenesulfonamides and their use as PDE7 inhibitors.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: September 9, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Kelly M. Aubart, Siegfried B. Christensen, IV, Jack D. Leber