Abstract: The present invention relates to a method of enhancing the bioavailability of a piperidinoalkanol antihistamine in a patient which comprises co-administering to said patient an effective antihistaminic amount of said piperidinoalkanol and an effective p-glycoprotein inhibiting amount of a p-glycoprotein inhibitor.
Type:
Grant
Filed:
July 13, 1999
Date of Patent:
September 17, 2002
Assignee:
Aventis Pharmaceuticals Inc.
Inventors:
Kin-Kai Hwang, Dennis H. Giesing, Gail H. Hurst
Abstract: The invention provides a pharmaceutical composition in solid unit dosage form, comprising, a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof; and, b) at least one inert ingredient.
Type:
Grant
Filed:
September 21, 1998
Date of Patent:
September 5, 2000
Assignee:
Aventis Pharmaceuticals Inc.
Inventors:
Thomas T. Ortyl, Paul F. Skultety, Kristen C. Mitchell, Deepak S. Phadke, Faraneh Attarchi, Marguerite L. Pierce, Aaron W. Schoeneman, Joseph M. Schnitz
Abstract: The present invention provides a pharmaceutical composition in the form of a bilayer tablet comprising,(a) a first discrete zone made with Formulation (A) which comprises, a therapeutically effective decongestant amount of a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, in an amount of about 18% to about 39% by weight of Formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of;(I) carnauba wax in an amount of about 59% to about 81% by weight of Formulation (A); and(ii) a suitable antiadherent in an amount of about 0.25% to about 2.
Type:
Grant
Filed:
July 31, 1998
Date of Patent:
March 21, 2000
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
David D. MacLaren, John R. Lefler, Sharon K. Minish
Abstract: The invention provides a pharmaceutical composition in solid unit dosage form, comprising, a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof; and, b) at least one inert ingredient.
Type:
Grant
Filed:
October 9, 1997
Date of Patent:
August 3, 1999
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Thomas T. Ortyl, Paul F. Skultety, Kristen C. Mitchell, Deepak S. Phadke, Faraneh Attarchi, Marguerite L. Pierce, Aaron W. Schoeneman, Joseph M. Schnitz
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
Type:
Grant
Filed:
May 1, 1995
Date of Patent:
October 7, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Chi-Hsin Richard King, Michele A. Kaminski
Abstract: The oligomers of the present invention are polyesters having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone with a predictable anion spacing, and are pharmaceutically-acceptable. The oligomers are useful for the treatment and/or diagnosis of HSV and HCMV.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
September 23, 1997
Assignees:
Merrell Pharmaceuticals Inc., The Dow Chemical Company
Inventors:
Alan D. Cardin, Richard L. Jackson, Michael J. Mullins
Abstract: The preferred oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geomentry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The oligomers are useful for the treatment and/or diagnosis of AIDS and ARC.
Type:
Grant
Filed:
May 19, 1995
Date of Patent:
September 23, 1997
Assignees:
Merrell Pharmaceuticals Inc., The Dow Chemical Company
Inventors:
Alan D. Cardin, Richard L. Jackson, Michael J. Mullins
Abstract: The present invention relates to heterocyclic benzenesulfonylimine derivatives and their use as inhibitors of Interleukin-1 (IL-1) action. Such inhibitors are useful in the treatment of various disease states as disclosed herein including rheumatoid arthritis, multiple sclerosis, diabetes mellitus, atherosclerosis, septic shock and pulmonary fibrosis.
Type:
Grant
Filed:
July 3, 1996
Date of Patent:
September 16, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
George Ku, Boyd L. Harrison, David M. Stemerick
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
Type:
Grant
Filed:
May 2, 1995
Date of Patent:
September 2, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Chi-Hsin Richard King, Michele A. Kaminski
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
Type:
Grant
Filed:
May 3, 1995
Date of Patent:
August 5, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Chi-Hsin Richard King, Michele A. Kaminski
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
Type:
Grant
Filed:
May 2, 1995
Date of Patent:
July 29, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Chi-Hsin Richard King, Michele A. Kaminski
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
Type:
Grant
Filed:
May 3, 1995
Date of Patent:
July 22, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Chi-Hsin Richard King, Michele A. Kaminski
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
Type:
Grant
Filed:
May 1, 1995
Date of Patent:
July 1, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Chi-Hsin Richard King, Michele A. Kaminski
Abstract: The present invention relates to certain novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and of ACE.These mercaptoacetylamide bicyclic lactam derivatives can be described by the following formula: ##STR1## wherein R is hydrogen, a C.sub.1 -C.sub.4 alkyl, an Ar--Y--group, --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 or diphenylmethyl;R.sub.1 is hydrogen, acetyl, --CH.sub.2 O--C(O)C(CH.sub.3).sub.3, benzoyl or a group of the formula ##STR2## R.sub.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, --CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 or an Ar--Y--group;A is --CH.sub.2 --, --O--, or --S--;B is --S--or --O--; andpharmaceutically acceptable salts thereof.
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators, these piperidine derivatives can be described by the following formulas: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy;R.sub.2 represents hydrogen; orR.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;n is an integer of from 1 to 5;R.sub.3 is --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched;each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts, hydrates and individual optical isomers thereof.
Type:
Grant
Filed:
January 6, 1995
Date of Patent:
May 20, 1997
Assignee:
Merrell Pharmaceuticals, Inc.
Inventors:
Chi-Hsin R. King, Michele A. Kaminski, Teng-Man Chen
Abstract: The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia.
Type:
Grant
Filed:
August 9, 1995
Date of Patent:
April 29, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Gary A. Flynn, John F. French, Richard C. Dage
Abstract: The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators.
Abstract: The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia.
Type:
Grant
Filed:
October 26, 1995
Date of Patent:
February 11, 1997
Assignee:
Merrell Pharmaceuticals Inc.
Inventors:
Gary A. Flynn, John F. French, Richard C. Dage