Patents Represented by Attorney, Agent or Law Firm Cheryl H. Agris
  • Patent number: 8338100
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase M and human mouse double minute 2 homolog, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human carboxypeptidase M and human mouse double minute 2 homolog and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: September 24, 2011
    Date of Patent: December 25, 2012
    Assignee: Ryogen LLC
    Inventor: James Ryan
  • Patent number: 8323884
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain SNARE YKT6, human glucokinase, AEBP1 protein and POLD2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: December 4, 2012
    Assignee: Ryogen LLC
    Inventor: James Ryan
  • Patent number: 8313910
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase M and human mouse double minute 2 homolog, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human carboxypeptidase M and human mouse double minute 2 homolog and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: November 20, 2012
    Assignee: Ryogen LLC
    Inventor: James W Ryan
  • Patent number: 8313899
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain SNARE YKT6, human glucokinase, AEBP1 protein and POLD2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: November 20, 2012
    Assignee: Ryogen LLC
    Inventor: James Ryan
  • Patent number: 8283118
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human resistin and human syntaxin binding protein 2, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human resistin and human syntaxin binding protein 2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: September 25, 2011
    Date of Patent: October 9, 2012
    Assignee: Ryogen LLC
    Inventor: James Ryan
  • Patent number: 8258273
    Abstract: The invention is directed to an isolated genomic polynucleotide fragment that encodes human soluble (cytosolic) aminopeptidase P, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human soluble aminopeptidase P and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: June 3, 2007
    Date of Patent: September 4, 2012
    Inventor: James W Ryan
  • Patent number: 8178662
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain SNARE YKT6, human glucokinase, AEBP1 protein and POLD2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: May 15, 2012
    Assignee: Ryogen LLC
    Inventor: James Ryan
  • Patent number: 8110196
    Abstract: The present invention relates to therapeutic and prophylactic methods for treating or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an infectious agent causing the disease. The methods comprise administering to the subject a plurality of compositions, each composition being administered to a different site of the subject, wherein each site is, or substantially drains to, an anatomically distinct lymph node, a group of lymph nodes, a nonencapsulated cluster of lymphoid tissue, or the spleen. Each composition comprises at least one antigenic molecule having one or more epitopes of the same infectious agent or a strain thereof. The antigenic molecules of each composition comprise in aggregate a set of epitopes distinct from that of any other composition that is administered to the subject.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: February 7, 2012
    Assignee: Polytopas LLC
    Inventors: Michael W. Deem, Jeong-Man Park, Hao Zhou
  • Patent number: 8057998
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human resistin and human syntaxin binding protein 2, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human resistin and human syntaxin binding protein 2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: November 15, 2011
    Assignee: Ryogen LLC
    Inventor: James W Ryan
  • Patent number: 8058052
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase M and human mouse double minute 2 homolog, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human carboxypeptidase M and human mouse double minute 2 homolog and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: November 15, 2011
    Assignee: Ryogen LLC
    Inventor: James W Ryan
  • Patent number: 8053195
    Abstract: The invention is directed to an isolated genomic nucleic acid molecule fragment that encodes human RhoC, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human RhoC and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: November 8, 2011
    Inventor: James W. Ryan
  • Patent number: 8039602
    Abstract: The invention is directed to isolated genomic polynucleotide fragments from the p15 arm of chromosome 11.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: October 18, 2011
    Assignee: Ryogen LLC
    Inventor: James W. Ryan
  • Patent number: 8012687
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human resistin and human syntaxin binding protein 2, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human resistin and human syntaxin binding protein 2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: September 6, 2011
    Assignee: Ryogen LLC
    Inventor: James Ryan
  • Patent number: 7985571
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase D, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human Carboxypeptidase D and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: July 26, 2011
    Assignee: Ryogen LLC
    Inventor: James W Ryan
  • Patent number: 7964357
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase M and human mouse double minute 2 homolog, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human carboxypeptidase M and human mouse double minute 2 homolog and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: June 21, 2011
    Assignee: Ryogen LLC
    Inventor: James W Ryan
  • Patent number: 7786280
    Abstract: The invention is directed to an isolated genomic polynucleotide fragment that encodes human soluble (cytosolic) aminopeptidase P, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human soluble aminopeptidase P and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: August 31, 2010
    Assignee: Ryogen LLC
    Inventor: James W Ryan
  • Patent number: 7754424
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase M and human mouse double minute 2 homolog, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human carboxypeptidase M and human mouse double minute 2 homolog and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: July 13, 2010
    Inventor: James W. Ryan
  • Patent number: 7622478
    Abstract: The invention is directed to 1-nitroacridine derivative(s)/tumor inhibitor(s) compositions as well as methods for using said compositions for inhibiting or preventing tumor growth, particularly, prostate cancer cell growth and metastases.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: November 24, 2009
    Inventors: Raj Tiwari, Daniel Miller, Jerzy Kazimierz Konopa, Barbara Wysocka-Skrzela
  • Patent number: 7588915
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain SNARE YKT6, human glucokinase, AEBP1 protein and POLD2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: September 15, 2009
    Inventor: James W. Ryan
  • Patent number: 7470522
    Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human resistin and human syntaxin binding protein 2, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human resistin and human syntaxin binding protein 2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: December 30, 2008
    Assignee: Ryogen LLC
    Inventor: James W. Ryan