Abstract: The invention is directed to isolated genomic polynucleotide fragments that encode human lipoprotein-associated phospholipase A2, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human lipoprotein-associated phospholipase A2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder.

Abstract: The invention is directed to novel IC chips containing substances used particularly in bioassays. Furthermore, the invention is directed to assay methods and kits using these chips.

Abstract: The invention is directed to an isolated genomic polynucleotide fragment that encodes human soluble (cytosolic) aminopeptidase P, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain human soluble aminopeptidase P and to diagnose, treat, prevent and/or ameliorate a pathological disorder.

Abstract: This patent describes a novel in vitro cell-based method for biological validation and pharmacological screening of drugs, new chemical entities (NCEs) and biologics, which is predictive of in vivo testing for efficacy and adverse events in patients, as occurs in clinical trials. The same method can be used to create an in vitro cell-based assay to identify the ‘right marketed medication for the right patient’ (personalized medicine), and to identify responders/non-responders in ongoing clinical trials with NCEs. In addition this approach can be used to identify new indications for existing medicines and new indications for NCEs that were unsuccessful in their intended uses.

Abstract: The present invention relates to a preparation method of a general library and a focused library from crude extracts of natural products including herbal drugs, said libraries, and the method for developing new drugs such as an anticancer drug and new substances using said libraries. The method comprises step of attaching crude extract of natural products to the solid phase resin, and step of washing the compounds and reactants that are not attached.

Abstract: Disclosed is a method of diagnosing the chances of pregnancy and the diagnostic kit for the method. In the present invention, follicular fluid is retrieved from the women who attended the in vitro fertilization program and matrix metalloproteinase activity is measured. According to the present invention, the chance of pregnancy in the group with low matrix metalloproteinase-9 activity is zero whereas in the group with high matrix metalloproteinase-9 activity, the chances are 50-60%. Therefore it is possible to predict the chances of pregnancy in assisted reproduction technology by measuring the degree of matrix metalloproteinase-9 expression by using the method and kit of the present invention enhancing the efficiency of assisted reproduction technology.

Abstract: Disclosed is a bit striking apparatus in an excavator capable of efficiently striking the entire area of the hammer bit under uniform pressure without exerting excessive load to the excavator so that the hammer bit may be free from damage owing to local concentration of striking force of the piston.

Abstract: The present invention relates to a lagoon partitioned for hog waste treatment, and the method of waste treatment in said lagoon. More particularly, the present invention relates to a lagoon for hog waste, which is partitioned into zones separated by walls, comprising a first zone for storing and settling hog waste, a second zone for carrying out sequence batch reaction onto the supernatant from the first zone, a third zone for storing processed liquid materials from the second zone, and a fourth zone for fermenting the solid materials from the first and second zones, wherein a passageway with a pump is installed between the respective two zones for transference of solid and liquid waste materials.

Abstract: Mechanically and biologically stable briquettes and pellets are obtained from either municipal solid waste (MSW), Refuse Derived Fuel (RDF) or municipal sewage sludge and their combination for purposes of disposing said briquettes and pellets as fuel in waste-to-energy processes such as the one described herein or to form geometric aggregates with such briquettes for their disposal at landfill sites. The use of binding material is not required whereas fuel additives such as crushed coal and petroleum residues may be added to enhance fuel performance but are not needed to improve waste processing or product stability and mechanical properties.

Abstract: This invention relates to instruments, particularly medical and research instruments that are used for assessing gas volumes of cavities, particularly, cavities that may exhibit a compliance to changes in pressure, such as in vivo volumes of the lung, thorax, oropharynx and/or nasopharynx.

Abstract: N-substituted azaheterocycyclic carboxylic acids and esters thereof of the formula I wherein Z, X, R1, R2 and r are defined in the specification. Compositions thereof and methods for preparing the compounds are disclosed. The compounds are useful for clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammations.

Abstract: Disclosed are compounds of formula I wherein A, R1, R2, R3, R4 and R5 are described in the specification, pharmaceutical formulations comprising these compounds, the use of these compounds are medicaments, the use of these medicaments in the treatment of and/or prevention of diabetes, especially non-insulin dependent diabetes (NIDDM or Type 2 diabetes), as well as methods for treating diabetes comprising administration of these compounds.

Abstract: The invention is directed to novel 9-hydroxyalkylamino-, 9-alkoxyalkylamino-1-nitroacridine derivatives. Methods of preparation, pharmaceutical compositions comprising said derivatives and their medical uses are also encompassed by this invention.

Abstract: The present invention describes a new compound, 2-Amino-N-[(1R)-2-[(3R)-3-benzyl-3-(N,N′,N′-trimethylhydrazinocarbonyl)piperidin-1-y]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]-2-methylpropionamide, having the formula: and pharmaceutically acceptable salts thereof, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.