Abstract: The present invention is related to a method for preparing polyether polyol or copolymerized polyether polyol, which uses an acid catalyst consisting of heteropoly acidic salts and oxides and/or binders. It allows tetrahydrofuran and/or cyclic ether compounds to carry out the ring-opening polymerization or ring-opening copolymerization with/without telogen, and obtains polyether polyol or copolymerized polyether polyol. An acid catalyst is used in the present invention because of its low solubility in organic solvent, so its process is simpler and the catalyst is easy to recycle for repeated use. As well, its preparation process is highly advantageous.

Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

Abstract: The present invention relates to a microgranule prepared by using an alkali compound as a stabilizer for a 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazole derivative having the following formula (1), which is a very effective antiulcerative but highly unstable under acidic conditions, and by using a water-soluble polymer as a binding agent. in which X, R1, R2, R3, R4 and R5 are defined as described in the specification.

Abstract: The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

Abstract: The present invention relates to composite solid polymer electrolyte membranes (SPEMs) which include a porous polymer substrate interpenetrated with an ion-conducting material. SPEMs of the present invention are useful in electrochemical applications, including fuel cells and electrodialysis.

Abstract: To provide a photosensitive resin composition and a photosensitive element using the resin composition with excellent sensitivity and adhesion as well as high resolution and plating resistance. A photosensitive resin composition, comprises (A) a polymer carrying carboxyl groups, (B) a compound carrying at least one ethylene-based unsaturated group in the molecule, and (C) a photopolymerization initiator, characterized by the fact that component (B) contains at least 60 weight % of methacrylate (B1) carrying at least one ethylene-based unsaturated group with respect to the total amount of component (B), that the amount of component (C) is in the range of 0.01-20 weight units with respect to 100 weight units of component (A) and component (B), and that component (C) contains 2-5 weight units of lophine dimer (C1) and 0.1-2.0 weight units of triphenylphosphine (C2) with respect to 100 weight units of component (A) and component (B), as well as a photosensitive element using the resin composition.

Abstract: The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

Abstract: The present invention provides novel, water soluble, carbohydrate derivatives of paclitaxel, methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such compounds. The compounds of the invention are modified at the 2′ or 7 position of paclitaxel and have the general formula [paclitaxel]-[link]1−2-[sugar]. These compounds show improved biological activity toward many cancer cell lines as compared to paclitaxel. Additionally, the conjugates are made from natural non-toxic materials which, when released, will be adsorbed as part of the body components.

Abstract: The invention provides novel anilide compounds and pharmaceutical compositions comprising them. The invention relates to compounds of a formula: where Ar is an optionally-substituted aryl group; R4 and R5 are the same or different, and each is a hydrogen atom, a lower alkyl group, or a lower alkoxy group; and R4 and R5 may together form a lower alkylene group of which one or more methylene moieties may optionally be substituted by oxygen and/or sulfur atoms; X is —NH—, or oxygen or sulfur atom; Y is —NH—, an oxygen or sulfur atom, or a sulfoxide or sulfone group; Z is a single bond, or —NH6—; R6 represents a hydrogen atom or a lower alkylene group; and n is an integer of from 0 to 15; and their salts and solvates. The compounds of the invention are useful as pharmaceutical compositions, especially as acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitors.

Abstract: Grasping devices and articles exhibit enhanced gripping or holding power to a variety of surfaces, including surfaces that are slippery or otherwise difficult to hold. The invention involves in some aspects the discovery and use of gripping materials that have the unexpected enhanced capability to provide enhanced holding power to a variety of surfaces, including surfaces that are wet, slippery or otherwise potentially difficult to manipulate effectively, or surfaces on which it may be difficult to maintain an effective grip or traction. The gripping material is smooth and has a relative surface area roughness of between about 1.03 and about 10.5.

Abstract: A foam break device and a system for use of the device. The system comprises an outlet tube for a filling machine using an air gap proportioner. The device has a plurality of vanes and beveled edges for positioning in the bottom of the outlet tube of the filling machine. The device reduces the amount of foam discharged from the system.

Abstract: An object of the invention is to provide a photosensitive glass paste for forming barriers for a PDP, which can be exposed to a great depth, and patterned with high accuracy without being adversely affected by oxygen. The present photosensitive glass paste comprises:a photosensitive resin material containing a resin-based material which can be cured by an acid and a photo-acid-generating agent; andan inorganic material containing a glass powder,the glass powder having the following composition in terms of oxides:PbO: 32 to 42 wt %Bi.sub.2 O.sub.3 : 18 wt % or lessZnO: 8 to 12 wt %B.sub.2 O.sub.3 : 15 to 25 wt %SiO.sub.2 : 10 to 25 wt %Al.sub.2 O.sub.3 : 5 wt % or less, andNa.sub.2 O+K.sub.2 O+Li.sub.2 O: 5 wt % or lesswherein a difference between a refractive index of said photosensitive resin material and a refractive index of said inorganic material is within 0.2.

Abstract: Machine for playing competition and leisure game between two participants who can compete by actuation of a chip which floats on a gameboard by means of air blown from orifices provided in the board itself and which has underneath a high pressure chamber forming part of a closed circuit of air pressures. The chip is actuated by means of control systems, which are comprised of linear displacement bodies incorporating impulsers which act controllably as a function of the situation of push-buttons and presence sensors of the control unit. The goals are obtained by succeeding in making the chip go beyond the goal lines which are defended by the control systems; once the chip has passed over the goal line, it goes into the corresponding goal area wherein the chip is detected and the point is accounted for whereafter the chip may be taken out back to the playboard.

Abstract: In toner 1 containing a binder resin 2, wax particles 3 and a coloring agent, the wax particles 3 are designed so that the ratio of major axis/minor axis is set in the range of 1.4 to 4.0 and so that the major axis L is not more than 6.0 .mu.m. Moreover, the melt index of the binder resin ranges from 5.0 to 11.0, and the dielectric loss tangent (tan .delta.) is not more than 5.0. This arrangement prevents the wax particles 3 inside the toner 1 or at the toner 1 surface layer from exposing to or sticking out of the toner 1 surface, thereby making it possible to provide a superior offset-reducing property during the fixing process and electrophotographing toner that can reduce wax contamination on the surface of the toner-bearing body.

Abstract: The invention provides a sapphire surgical contact lens to view interior structures and regions of an eye as well as methods for making and using such a surgical contact lens. The surgical contact lens includes a transparent member comprising sapphire and having a first and a second surface. The first surface may be configured in a variety of ways, e.g. with a geometry that complements the curvature of a cornea, in particular the cornea's radius of curvature. More particularly the first surface is suitably configured so as to be generally concave so as to form a portion of a spherical surface. The second surface is configured with a geometry that, in cooperation with the first surface geometry, yields a given optical configuration for viewing the interior of the eye. In a preferred aspect, the transparent member is made from a single crystal of sapphire.

Abstract: With respect to a single large substrate, a seal material and a spacer made of the same resist having pressure tightness are formed in one step using a photomask, and a plurality of small substrates are combined independently with the large substrate, the spacer being formed within a region of non-transmissive pattern on the large substrate. This prevents the seal material and the spacer from spreading from a predetermined pattern width, and maintains a constant value for a cell gap with respect to the entire liquid crystal layer. Alternatively, instead of the spacer, a fine first seal material may be formed by photolithography within a display region using a photoresist having adhesion, and a second seal material may be formed outside the display region using a heat curable adhesive. With this arrangement, the strength of the combined substrates is increased, and a highly reliable and high quality display screen is realized.

Abstract: The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT.sub.1A receptors.

Abstract: Disclosed is a parathyroid hormone (PTH) (1-34) derivative in which at least the amino acid residue at the 10-position is substituted by an acidic amino acid residue. The derivatives of the present invention showing potent cAMP-producing activity and bone formation activity, and thus are useful as therapeutic agents for bone diseases, etc.

Abstract: The disclosure describes a humectant, antistatic agent, film-forming agent or dispersant comprising an effective amount of a polysaccharide produced by two strains of Kliebsiella composed of D-glucuronic acid, L-rhamnose, D-galactose and D-glucose in a molar ratio of D-glucuronic acid:L-rhamnose:D-galactose:D-glucose=0.8-1.2:2.4-3.6:0.8-1.2:0.8-1.2.

Abstract: The disclosure describes a method of manufacturing a Group II-VI compound semiconductor thin film by a vapor-phase epitaxy using an organic metal compound of Group II element and a hydride or an organic metal compound of Group VI element as the raw material, which comprises repeating alternate introduction of an organic metal compound of Group II element and a halide gas, a halogen gas or a mixture thereof; or adding a halide gas, a halogen gas or a mixture thereof to a gas for vapor-phase epitaxy.