Patents Represented by Law Firm Cooley Godward Castro Huddleson & Tatum
  • Patent number: 5223393
    Abstract: The present invention provides reagents for a detectable label for use in specific binding assays. Specifically, modified .beta.-galactosidase enzyme donors (ED) and acceptors (EA) are utilized. Both ED and EA are modified to form separate ED and EA complexes by coupling each with a linking element and a binding moiety which is specific to a binding site in the analyte. The ED and EA complexes are incapable of forming active enzyme in the absence of the analyte. However, when analyte is present, ED and EA complexes which bind to a common analyte in a sample, active .beta.-galactosidase is formed.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: June 29, 1993
    Assignee: Microgenics Corporation
    Inventors: Pyare Khanna, Reuyming Loor
  • Patent number: 5218102
    Abstract: The subject of the present invention is a nucleic acid probe containing a nucleic acid sequence, wherein the said sequence is linked at its 5' end, via a divalent bifunctional chemical "arm" L, to a "labeling component" M, M being a synthetic or natural molecule which is directly or indirectly detectable in a non-isotopic manner, according to the formula I: ##STR1## in which J=H or OHn denotes the number of nucleotides from 1 to 100,000B is a purine or pyrimidine nucleic acid base, which varies according to the nucleotide, as appropriate.The subject of the invention is also a process for preparing such probes, employing an intermediate compound consisting of a nucleotide synthon of formula IV ##STR2## in which J, B, L and R.sub.1 have the meanings given above, B optionally being protected,R.sub.2 denotes H or any phosphorylated group, optionally protected, suited to the introduction of the compound of formula IV at the 5' end of another nucleotide, for a given type of internucleotide-assembling synthesis.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: June 8, 1993
    Assignee: Improbio
    Inventors: Alfredo Cravador, Marie-Joelle de Vos-Pierreux, Alex Bollen
  • Patent number: 5217827
    Abstract: An electrolyte composition for a solid state electrochemical cell comprising at least 65% by weight of a plasticizer, a thermoplastic or thermoset polymer derived from monomers containing a heteroatom and a dissolved alkali metal salt; this composition is useful in providing electrolyte layers less than 100 microns thick for solid state electrochemical cells having a very thin construction.
    Type: Grant
    Filed: January 16, 1992
    Date of Patent: June 8, 1993
    Assignee: MHB Joint Venture
    Inventors: Denis Fauteux, S. Yde-Andersen
  • Patent number: 5218099
    Abstract: Purified virus particles, antigens, antibodies reactive with viral antigens, and a viral genetic material associated with non-A, non-B hepatitis are provided by the present invention. Cloned genetic material useful both in identifying intact virus particles of the invention and for use in diagnostic techniques and/or production of antigens is also disclosed.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: June 8, 1993
    Assignees: The United States of America as represented by the Department of Health and Human Services, Genelabs Incorporated
    Inventors: Gregory R. Reyes, Daniel W. Bradley, Linda Rabin, Kirk Fry
  • Patent number: 5215917
    Abstract: Genetic material encoding the P22 peptide of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: June 1, 1993
    Assignee: Research Institute of Palo Alto Medical Foundation
    Inventors: Fausto G. De Araujo, Jeffrey B. Prince, Jack S. Remington
  • Patent number: 5213977
    Abstract: A human serine protease expressed in cytotoxic killer cells, having a mass of about 25.8kD, and having the amino acid residues of the serine protease charge-relay catalytic mechanism conserved is provided. The protease can be produced by recombinant DNA technology. The cDNA is also provided.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: May 25, 1993
    Assignee: The Board of trustees of the Leland Stanford Junior University
    Inventors: Irving L. Weissman, Howard K. Gershenfeld
  • Patent number: 5212064
    Abstract: Novel assays employing enzyme fragments which complex to form an active enzyme are provided. The reagents involved are a member of a specific binding pair bound to a solid surface, a first enzyme fragment conjugated to a member of a specific binding pair complementary or cross-reactive in relation to the analyte or antianalyte and a second enzyme fragment which binds to the conjugate to form an active enzyme, where the first enzyme fragment conjugate may be present in up to substantial excess to ensure at least substantially complete binding of all of the analyte. By distributing the conjugate between the solid surface and the medium in relation to the amount of analyte present, the enzyme activity may be determined in relation to the amount of analyte present, without separating the solid surface and the medium.
    Type: Grant
    Filed: May 9, 1990
    Date of Patent: May 18, 1993
    Assignee: Microgenics Corporation
    Inventors: Pyare L. Khanna, Imo-Jean C. Ford, Patricia A. Porreca
  • Patent number: 5212081
    Abstract: Enzyme-donor fragments and other unstructured peptides are stabilized against proteolytic degradation by including a mixture of soluble, random-sequence peptides in the assay medium or in the medium in which the enzyme-donor fragment or other peptide is stored.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: May 18, 1993
    Assignee: Microgenics Corporation
    Inventors: Bill Coty, Pyare Khanna
  • Patent number: 5212087
    Abstract: The present invention relates to ars sequences which are efficacious in Yarrowia lipolytica, as well as to plasmids carrying these sequences.The strains of Y. lipolytica transformed with the said plasmids may be used in fermentation processes enabling proteins of industrial importance to be prepared.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: May 18, 1993
    Assignee: Institut National de la Recherche Agronomique (INRA)
    Inventors: Phillippe Fournier, Claude Gaillardin, Bernard Kudla, Henri Heslot
  • Patent number: 5204525
    Abstract: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: April 20, 1993
    Assignee: Biotrack
    Inventors: Robert S. Hillman, Michael E. Cobb, Jimmy D. Allen, Ian Gibbons, Vladimir E. Ostoich, Laura J. Winfrey
  • Patent number: 5203108
    Abstract: An apparatus for killing insects in produce, which comprises an outer container; means for dividing a space enclosed by the outer container into first and second internal chambers; means for supporting a plurality of bulk produce bins in the first internal chamber; first and second air passage means for selectively allowing passage of air between the first internal chamber and the second internal chamber; means for circulating air in the second internal chamber successively through one of the air passage means, the first internal chamber, the other of the air passage means, and back into the second internal chamber; and means for heating the circulating air.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: April 20, 1993
    Inventor: Martin W. Washburn, Jr.
  • Patent number: 5200338
    Abstract: A newly discovered lignin peroxidase enzyme is provided. The enzyme is obtained from a bacterial source and is capable of degrading the lignin portion of lignocellulose in the presence of hydrogen peroxide. The enzyme is extracellular, oxidative, inducible by lignin, larch wood xylan, or related substrates and capable of attacking certain lignin substructure chemical bonds that are not degradable by fungal lignin peroxidases.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: April 6, 1993
    Assignee: Idaho Research Foundation, Incorporation
    Inventors: Donald L. Crawford, Muralidhara Ramachandra
  • Patent number: 5191261
    Abstract: A flash lamp power supply system, comprising (a) a simmer power supply circuit, comprising (i) a DC simmer power supply, (ii) means for connecting a flash lamp in series with the DC power supply, and (iii) a capacitor connected in parallel to the power supply and to the flash lamp connecting means, wherein the impedance and capacitance of the simmer power supply are selected so as to provide dV/dT for the simmer power supply circuit equal to or greater than the rate at which the lamp impedance changes during a flash cycle; and (b) a pulse power supply circuit, comprising (i) a DC pulse source voltage supply, (ii) a thyristor, and (iii) means for connecting the lamp in series with the DC pulse source voltage supply and the thyristor, wherein the pulse power supply circuit further comprises a capacitor connected in parallel with the pulse source voltage supply.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: March 2, 1993
    Assignee: Purus, Inc.
    Inventor: Barton Mass
  • Patent number: 5188938
    Abstract: Diagnostic assays are provided comprising complementary enzyme fragments of .beta.-galactosidase, where one of the fragments is bound to a support and the other fragment is conjugated to an immunologically cross-reactive epitope of the analyte or complementary to an analyte receptor. Binding to the receptor allows for discrimination between complexed enzyme fragment conjugate and uncomplexed enzyme fragment conjugate. The assay medium is then allowed to wick onto a support to which the complementary fragment is substantially uniformly bound in the detection region. The support is then developed, where color formation from the substrate in the detection region is used as a measure of the presence of analyte in the sample.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: February 23, 1993
    Assignee: Microgenics Corporation
    Inventors: Pyare L. Khanna, Glenda L. Choate
  • Patent number: 5183891
    Abstract: A method for the preparation of compounds of the formula ##STR1## wherein X represents a group of the formula OR.sub.1 or NR.sub.1 R.sub.2, wherein R.sub.1 and R.sub.2 independently represent H or an organic group that forms a stable covalent bond with the N or O of said X; Y is H or an organic group that forms a stable ester with the adjacent COO group; R is an alkyl or aryl group optionally substituted with one or more stable organic substituents; each R.sub.3 independently represents a stable organic group; and n is an integer from 0 to 3;the method using new intermediates of the formula ##STR2## wherein R.sub.3 and Y have the foregoing meanings; W is either F or Cl;and R.sub.9 is a hydrocarbon such as a C.sub.1 -C.sub.4 alkyl or alkenyl group.
    Type: Grant
    Filed: November 9, 1989
    Date of Patent: February 2, 1993
    Assignees: Orsan, Orsem
    Inventors: Jeffrey Labovitz, William J. Guilford, Lawrence Fang, Yi Liang
  • Patent number: 5175682
    Abstract: A method and structure are provided for processing checks in an extremely timely and cost-effective manner. A check recipient, such as a merchant, utility billing department, and the like, utilize hardware and software for quickly gathering data from checks received in order to allow prompt processing of those checks. Such hardware preferably includes a reader for reading the MICR account information printed on the check, and means for associating that data with information pertaining to the transaction at hand, including for example, the dollar amount of the transaction. This information is combined in a data record which is stored for future batch data transmission to a clearing house or the issuing bank itself. In an alternative embodiment, this data is communicated in real time to the clearing house or issuing bank. In another embodiment, one or more selection criteria are used to determine which checks will be processed in real time, with the remaining checks being processed in the batch mode.
    Type: Grant
    Filed: December 14, 1990
    Date of Patent: December 29, 1992
    Assignee: Verifone, Inc.
    Inventors: Connie Higashiyama, William Melton, Ashok Narasimhan
  • Patent number: 5169446
    Abstract: A process for forming a layer of metal on a substrate which comprises the steps of: (a) forming a bath of a molten metal in a vessel; (b) circulating said molten metal in said bath such that said molten metal is projected above the upper surface of said vessel (c) transporting a substrate along a path which traverses the upper surface of said vessel; and (d) transferring said molten metal to one surface of said substrate by directly or indirectly contracting said molten metal with said surface of said substrate, and an apparatus for performing the method is disclosed.
    Type: Grant
    Filed: June 18, 1991
    Date of Patent: December 8, 1992
    Assignee: MHB Joint Venture
    Inventors: Rene Koksbang, Gert L. Jensen
  • Patent number: 5168038
    Abstract: In situ transcription is provided by hybridizing cells or tissue with a primer, and extending the primer bound to any template mRNA or DNA with transverse transcriptase or DNA polymerase in the presence of labeled nucleotides, which allows for detection of cells containing the template. The resulting cDNA may be eluted and used in a polymerase chain reaction for isolation of the DNA, and/or the cDNA electrophoresed, which may provide for information concerning the sequence, or the like.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: December 1, 1992
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Laurence Tecott, Jack D. Barchas, James Eberwine
  • Patent number: 5164490
    Abstract: Genetic material encoding dihydrofolate reductase (DHFR) of Pneumocystis carinii has been isolated and characterized. This genetic material allows the production of peptides for use in the design of inhibitors specific for P. carinii DHFR (as opposed to DHFR in the host infected with P. carinii) or can itself be directly used in hybridization assays.
    Type: Grant
    Filed: November 15, 1989
    Date of Patent: November 17, 1992
    Assignee: The Regents of the University of California
    Inventors: Daniel V. Santi, Jeffrey Edman, Ursula Edman
  • Patent number: 5164598
    Abstract: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
    Type: Grant
    Filed: February 5, 1991
    Date of Patent: November 17, 1992
    Assignee: Biotrack
    Inventors: Robert S. Hillman, Michael E. Cobb, Jimmy D. Allen, Ian Gibbons, Vladimir E. Ostoich, Laura J. Winfrey