Patents Represented by Attorney, Agent or Law Firm Covington & Burling
  • Patent number: 8293871
    Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: October 23, 2012
    Assignees: Alkernnes Pharma Ireland Limited, Amylin Pharmaceuticals, Inc.
    Inventors: Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino, Christine Smith, David M. Lokensgard, Mark Fineman, John Ong
  • Patent number: 8263600
    Abstract: A liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I: at least one thickening agent, a non-ionic surfactant, and a pharmaceutically acceptable liquid carrier is disclosed.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: September 11, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Stefan Sharpe, Joel Sequeira, David Harris, Shashank Mahashabde
  • Patent number: 8221797
    Abstract: This invention discloses a wood preservative composition for the supplemental or remedial treatment of in-service poles, posts, piling, cross ties and other wooden structures. The wood preservative composition comprises copper 8-hydroxyquinolate (oxine copper) in combination with a boron compound or a fluoride compound.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: July 17, 2012
    Assignee: Osmose, Inc.
    Inventors: Jun Zhang, Douglas J. Herdman, Richard J. Ziobro
  • Patent number: 8222255
    Abstract: Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: July 17, 2012
    Assignees: Merck Sharp & Dohme Corp., Scynexis, Inc.
    Inventors: James M. Balkovec, Phieng Siliphaivanh, Frances A. Bouffard, Roland A. Bouffard, legal representative, Michael R. Peel, Weiming Fan, Ahmed Mamai, Sarah Dimick Gray
  • Patent number: 8197367
    Abstract: An improved expandable broadhead with rear deploying blades. The rear deploying blades deploy reliably upon impact of the blades with a target. The expandable broadhead resists deflection by the target regardless of the angle of entry. Consequently, the present expandable broadhead maximizes kinetic energy on impact and increases the probability of substantial penetration into the target.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: June 12, 2012
    Assignee: Out RAGE, LLC
    Inventors: Larry R. Pulkrabek, William Edward Pedersen, Bruce Barrie
  • Patent number: 8187600
    Abstract: The invention relates to the use of a polypeptide that comprises i) a first portion comprising the part of human Fc that binds to CD64, and ii) a second portion comprising one or more heterologous T cell epitopes for stimulating a cytotoxic T cell response. The polypeptide may be an antibody that may be used to stimulate a cytotoxic T cell response against pathogens and tumor cells in patients in need of such treatment.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: May 29, 2012
    Assignees: Scancell Limited, Cancer Research Technology Limited
    Inventors: Linda Gillian Durrant, Tina Parsons, Adrian Robins
  • Patent number: 8187672
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: May 29, 2012
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Patent number: 8188085
    Abstract: Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: May 29, 2012
    Assignees: Merck Sharp & Dohme Corp., Seynexis, Inc.
    Inventors: Mark L. Greenlee, Robert Wilkening, James Apgar, Donald Sperbeck, Kenneth J. Wildonger, Dongfang Meng, Dann L. Parker, Jr., Gregory J. Pacofsky, Brian H. Heasley, Ahmed Mamai, Kingsley Nelson
  • Patent number: 8182928
    Abstract: A method for the preparation of a composite product, as well as the composite product. The composite product comprises at least two layers. At least one of the layers is of wood or another cellulose-containing material. The process comprises differentially treating the layers prior to, during, or after the lamination of the layers into a composite product.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: May 22, 2012
    Assignee: Osmose, Inc.
    Inventor: John Horton
  • Patent number: 8168304
    Abstract: The present invention provides wood preservative and flame retardant compositions having low leachability comprising micronized boron compounds and, optionally, one or more organic biocides which may be micronized. Also provided is a method for applying the composition to wood and wood products comprising impregnating the wood with the composition.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: May 1, 2012
    Assignee: Osmose, Inc.
    Inventors: Jun Zhang, Wenjin Zhang, Robert M. Leach
  • Patent number: 8158208
    Abstract: The present invention is directed, in certain embodiments, to methods of preserving wood comprising the steps of providing an aqueous wood preservative slurry comprising a plurality of injectable particulates comprising at least 20% by weight of a sparingly soluble copper salt, wherein the first particulates have a d96 of about 1 micron or less, a d99 of about 1.5 microns or less, and a d50 of greater than 0.02 micron, and injecting the aqueous wood preservative slurry into wood.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: April 17, 2012
    Assignee: Osmose, Inc.
    Inventors: H. Wayne Richardson, Robert L. Hodge
  • Patent number: 8129339
    Abstract: The invention relates to compositions and methods for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein a biologically active polypeptide, and a corticosteroid to modify the release profile and provide increased bioavailability.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: March 6, 2012
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Henry R. Costantino, Joyce M. Hotz, James R. Dasch, M. Gary I. Riley, Paul A. Burke, Susan A. Steitz-Abadi, Stephen E. Zale
  • Patent number: 7966554
    Abstract: An apparatus and method for providing security disclosure information in at least two aligned formats, the apparatus including security disclosure data in an audio format, a processor for receiving the audio security disclosure data and for inserting a first marker therein and said processor for creating a text from the audio security disclosure data and for inserting a second marker in the text in a position corresponding to a location of the first marker in the audio security disclosure data.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 21, 2011
    Assignee: Thomson Financial LLC
    Inventors: Andre Lavoie, Mayer M. Danzig, Roland C. Beaulieu
  • Patent number: 7875310
    Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: January 25, 2011
    Assignee: Alkermes, Inc.
    Inventors: Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
  • Patent number: D640133
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: June 21, 2011
    Assignee: The Wine Group, Inc.
    Inventors: Laurie Jones, Doris Soper, John Bankerd, Glenn Spyksma, Sharon Ijams
  • Patent number: D664625
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: July 31, 2012
    Assignee: DoubleTake Archery LLC
    Inventor: Stuart Minica
  • Patent number: D669955
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: October 30, 2012
    Assignee: DoubleTake Archery LLC
    Inventor: Stuart Minica
  • Patent number: D669956
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: October 30, 2012
    Assignee: DoubleTake Archery LLC
    Inventor: Stuart Minica
  • Patent number: D672658
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: December 18, 2012
    Assignee: The Wine Group, Inc.
    Inventors: Casey F. Georgeson, James Eli, Laurie Jones, Todd Ziegenfus
  • Patent number: D672659
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: December 18, 2012
    Assignee: The Wine Group, Inc.
    Inventors: Casey F. Georgeson, Todd Ziegenfus, Laurie Jones, James Eli